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Health Sciences profile

Christine Barthow

PositionResearch Fellow
DepartmentDepartment of Medicine (Wellington)
QualificationsRCompNs, MA(appl)
Research summaryAllergic disease

Research

I am a Registered Nurse and Research Fellow with the Wellington Asthma Research Group. Currently I am a co-investigator in the Maternal Probiotic Study (Studies of Probiotics and Allergic Disease). This is a randomized controlled trial clinical trial investigating the use of probiotics to prevent the development of allergic disease in infants, and reduce gestational diabetes and bacterial vaginal infections in pregnant women.

My current research interest is in the field of allergic disease. In the past four years I have worked on a series of quantitative studies related to both the prevention and treatment of allergic disease (eczema, hay fever and asthma). Previous to this work my research interest and experience was in the area of oncology/palliative care using qualitative approaches to research.

Publications

McKinlay, E., Hilder, J., Hood, F., Morgan, S., Barthow, C., Gray, B., Huthwaite, M., Weatherall, M., Crane, J., Krebs, J., & Pullon, S. (2022). Uncertainty and certainty: Perceptions and experiences of prediabetes in New Zealand primary care: A qualitative study. Journal of Primary Health Care, 14(2), 138-145. doi: 10.1071/HC21066

Barthow, C., Hood, F., Crane, J., Huthwaite, M., Weatherall, M., Parry-Strong, A., & Krebs, J. (2022). A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes. BMJ Open, 12, e055214. doi: 10.1136/bmjopen-2021-055214

Chen, Y., Lu, J., Wickens, K., Stanley, T., Maude, R. M., Stone, P., Barthow, C., Crane, J., … Murphy, R. (2021). Effect of Lactobacillus rhamnosus probiotic in early pregnancy on plasma conjugated bile acids in a randomised controlled trial. Nutrients, 13, 209. doi: 10.3390/nu13010209

Crane, J., Barthow, C., Kang, J., Hood, F., Stanley, T., & Wickens, K. (2020). Probiotics for humans: Hoax, hype, hope, or help. Journal of the Royal Society of New Zealand, 50(3), 456-469. doi: 10.1080/03036758.2019.1692364

Barthow, C., Hood, F., McKinlay, E., Hilder, J., Cleghorn, C., Huthwaite, M., Weatherall, M., Parry-Strong, A., Pullon, S., Gray, B., Wickens, K., Crane, J., & Krebs, J. (2019). Food 4 Health: He Oranga Kai: Assessing the efficacy, acceptability and economic implications of Lactobacillus rhamnosus HN001 and β-glucan to improve glycated haemoglobin, metabolic health, and general well-being in adults with pre-diabetes: Study protocol for a 2 x 2 factorial design, parallel group, placebo-controlled randomized controlled trial, with embedded qualitative study and economic analysis. Trials, 20, 464. doi: 10.1186/s13063-019-3553-7

Ballantyne, A., Barthow, C., & Wickens, K. (2016). Research into lifestyle changes in pregnancy. In F. Baylis & A. Ballantyne (Eds.), Clinical research involving pregnant women. (pp. 211-225). Springer. doi: 10.1007/978-3-319-26512-4_12

Chapter in Book - Research

Barthow, C., Hood, F., Crane, J., Huthwaite, M., Weatherall, M., Parry-Strong, A., & Krebs, J. (2022). A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes. BMJ Open, 12, e055214. doi: 10.1136/bmjopen-2021-055214

Journal - Research Article

McKinlay, E., Hilder, J., Hood, F., Morgan, S., Barthow, C., Gray, B., Huthwaite, M., Weatherall, M., Crane, J., Krebs, J., & Pullon, S. (2022). Uncertainty and certainty: Perceptions and experiences of prediabetes in New Zealand primary care: A qualitative study. Journal of Primary Health Care, 14(2), 138-145. doi: 10.1071/HC21066

Journal - Research Article

Chen, Y., Lu, J., Wickens, K., Stanley, T., Maude, R. M., Stone, P., Barthow, C., Crane, J., … Murphy, R. (2021). Effect of Lactobacillus rhamnosus probiotic in early pregnancy on plasma conjugated bile acids in a randomised controlled trial. Nutrients, 13, 209. doi: 10.3390/nu13010209

Journal - Research Article

Murphy, R., Morgan, X. C., Wang, X. Y., Wickens, K., Purdie, G., Fitzharris, P., Otal, A., Lawley, B., Stanley, T., Barthow, C., Crane, J., … Tannock, G. W. (2019). Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: Sub-sample analysis from a RCT. Beneficial Microbes, 10(1), 5-17. doi: 10.3920/bm2017.0191

Journal - Research Article

Pullon, S., Ballantyne, A., Macdonald, L., Barthow, C., Wickens, K., & Crane, J. (2019). Daily decision-making about food during pregnancy: A New Zealand study. Health Promotion International, 34(3), 469-478. doi: 10.1093/heapro/dax098

Journal - Research Article

Slykerman, R. F., Coomarasamy, C., Wickens, K., Thompson, J. M. D., Stanley, T. V., Barthow, C., Kang, J., Crane, J., & Mitchell, E. A. (2019). Exposure to antibiotics in the first 24 months of life and neurocognitive outcomes at 11 years of age. Psychopharmacology, 236, 1573-1582. doi: 10.1007/s00213-019-05216-0

Journal - Research Article

Slykerman, R. F., Kang, J., Van Zyl, N., Barthow, C., Wickens, K., Stanley, T., … Purdie, G., … Crane, J., & Mitchell, E. A. (2018). Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo-controlled trial. Acta Paediatrica, 107, 2172-2178. doi: 10.1111/apa.14590

Journal - Research Article

Wickens, K., Barthow, C., Mitchell, E. A., Kang, J., Van Zyl, N., Purdie, G., Stanley, T., … Crane, J. (2018). Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years. Pediatric Allergy & Immunology, 29, 808-814. doi: 10.1111/pai.12982

Journal - Research Article

Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Purdie, G., Rowden, J., Kang, J., Hood, F., … Franklin, I., Barnes, P., … Abels, P., … Crane, J. (2018). Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema. Pediatric Allergy & Immunology, 29(3), 296-302. doi: 10.1111/pai.12874

Journal - Research Article

Ballantyne, A., Pullon, S., Macdonald, L., Barthow, C., Wickens, K., & Crane, J. (2017). The experiences of pregnant women in an interventional clinical trial: Research in Pregnancy Ethics (RIPE) study. Bioethics, 31(6), 476-483. doi: 10.1111/bioe.12361

Journal - Research Article

McKinlay, E., Gallagher, P., Jones, B., Macdonald, L., & Barthow, C. (2017). Crossing professional cultures: A qualitative study of nurses working in a medical school. Contemporary Nurse, 53(6), 633-646. doi: 10.1080/10376178.2017.1416304

Journal - Research Article

Slykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., … Crane, J., Stanley, T., Abels, P., Purdie, G., … the Probiotic in Pregnancy Study Group. (2017). Effect of Lactobacillus rhamnosus HN001 in pregnancy on postpartum symptoms of depression and anxiety: A randomised double-blind placebo-controlled trial. EBioMedicine, 24, 159-165. doi: 10.1016/j.ebiom.2017.09.013

Journal - Research Article

Wickens, K. L., Barthow, C. A., Murphy, R., Abels, P. R., Maude, R. M., Stone, P. R., … Stanley, T. V., Purdie, G. L., Kang, J. M., Hood, F. E., … Barnes, P. K., … Crane, J. (2017). Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: A randomised controlled trial. British Journal of Nutrition, 117(6), 804-813. doi: 10.1017/S0007114517000289

Journal - Research Article

Barthow, C., Jones, B., Macdonald, L., Vernall, S., Gallagher, P., & McKinlay, E. (2015). Researching in the community: The value and contribution of nurses to community based or primary health care research. Primary Health Care Research & Development, 16, 224-234. doi: 10.1017/s1463423614000097

Journal - Research Article

Marlow, G., Han, D. Y., Wickens, K., Stanley, T., Crane, J., Mitchell, E. A., … Barthow, C., … Morgan, A. R. (2015). Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatric Allergy & Immunology, 26(3), 262-271. doi: 10.1111/pai.12371

Journal - Research Article

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Journal - Research Article

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Journal - Research Article

Wickens, K., Black, P., Stanley, T. V., Mitchell, E., Barthow, C., Fitzharris, P., Purdie, G., & Crane, J. (2012). A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clinical & Experimental Allergy, 42(7), 1071-1079. doi: 10.1111/j.1365-2222.2012.03975.x

Journal - Research Article

McCullough, L., McKinlay, E., Barthow, C., Moss, C., & Wise, D. (2010). A model of treatment decision making when patients have advanced cancer: How do cancer treatment doctors and nurses contribute to the process? European Journal of Cancer Care, 19(4), 482-491. doi: 10.1111/j.1365-2354.2009.01074.x

Journal - Research Article

Barthow, C., Moss, C., McKinlay, E., McCullough, L., & Wise, D. (2009). To be involved or not: Factors that influence nurses' involvement in providing treatment decisional support in advanced cancer. European Journal of Oncology Nursing, 13(1), 22-28. doi: 10.1016/j.ejon.2008.09.004

Journal - Research Article

Crane, J., Barthow, C., Kang, J., Hood, F., Stanley, T., & Wickens, K. (2020). Probiotics for humans: Hoax, hype, hope, or help. Journal of the Royal Society of New Zealand, 50(3), 456-469. doi: 10.1080/03036758.2019.1692364

Journal - Research Other

Barthow, C., Hood, F., McKinlay, E., Hilder, J., Cleghorn, C., Huthwaite, M., Weatherall, M., Parry-Strong, A., Pullon, S., Gray, B., Wickens, K., Crane, J., & Krebs, J. (2019). Food 4 Health: He Oranga Kai: Assessing the efficacy, acceptability and economic implications of Lactobacillus rhamnosus HN001 and β-glucan to improve glycated haemoglobin, metabolic health, and general well-being in adults with pre-diabetes: Study protocol for a 2 x 2 factorial design, parallel group, placebo-controlled randomized controlled trial, with embedded qualitative study and economic analysis. Trials, 20, 464. doi: 10.1186/s13063-019-3553-7

Journal - Research Other

Crane, J., Barthow, C., Mitchell, E. A., Stanley, T. V., Purdie, G., Rowden, J., Kang, J., Hood, F., Barnes, P., … Wickens, K. (2018). Is yoghurt an acceptable alternative to raw milk for reducing eczema and allergy in infancy? Clinical & Experimental Allergy, 48(5), 604-606. doi: 10.1111/cea.13121

Journal - Research Other

Barthow, C., Wickens, K., Stanley, T., Mitchell, E. A., Maude, R., Abels, P., Purdie, G., … Kang, J., Hood, F., … Barnes, P., Fitzharris, P., … Crane, J. (2016). The Probiotics in Pregnancy Study (PiP Study): Rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy. BMC Pregnancy & Childbirth, 16, 133. doi: 10.1186/s12884-016-0923-y

Journal - Research Other

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