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Health Sciences profile

Dr Jeff Erickson

PositionSenior Lecturer
DepartmentDepartment of Physiology
QualificationsPhD
Research summaryHeart disease

Research

My research focuses on investigating the molecular mechanisms that underlie structural heart disease and heart failure, particularly in the context of aging and diabetes. To this end, we have developed a number of novel tools to assess cardiac signaling pathways.

These include

  • FRET-based biosensors to measure kinase activity and localization in living cells
  • custom antibodies to measure biochemical modifications of proteins
  • a variety of animal models with enhanced or reduced susceptibility to cardiac pathology.
With this research, we hope to contribute new understanding to the molecular basis of cardiac signaling that will culminate in potential clinical therapies for heart disease.

Publications

Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710

Bussey, C. T., Babakr, A. A., Iremonger, R. R., van Hout, I., Wilkins, G. T., Lamberts, R. R., & Erickson, J. R. (2020). Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes. Physiological Reports, 8(5), e14394. doi: 10.14814/phy2.14394

Popescu, I., Yin, G., Velmurugan, S., Erickson, J. R., Despa, F., & Despa, S. (2019). Lower sarcoplasmic reticulum Ca2+ threshold for triggering afterdepolarizations in diabetic rat hearts. Heart Rhythm, 16(5), 765-772. doi: 10.1016/j.hrthm.2018.11.001

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Curl, C. L., Danes, V. R., Bell, J. R., Raaijmakers, A. J. A., Ip, W. T. K., Chandramouli, C., … Erickson, J. R., … Delbridge, L. M. D. (2018). Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive: A new preclinical model. Journal of the American Heart Association, 7(11), e007451. doi: 10.1161/jaha.117.007451

Journal - Research Article

Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020). A timing effect of 17-β estradiol on atherosclerotic lesion development in female ApoE−/− mice. International Journal of Molecular Sciences, 21(13), 4710. doi: 10.3390/ijms21134710

Bussey, C. T., Babakr, A. A., Iremonger, R. R., van Hout, I., Wilkins, G. T., Lamberts, R. R., & Erickson, J. R. (2020). Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes. Physiological Reports, 8(5), e14394. doi: 10.14814/phy2.14394

Popescu, I., Yin, G., Velmurugan, S., Erickson, J. R., Despa, F., & Despa, S. (2019). Lower sarcoplasmic reticulum Ca2+ threshold for triggering afterdepolarizations in diabetic rat hearts. Heart Rhythm, 16(5), 765-772. doi: 10.1016/j.hrthm.2018.11.001

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Curl, C. L., Danes, V. R., Bell, J. R., Raaijmakers, A. J. A., Ip, W. T. K., Chandramouli, C., … Erickson, J. R., … Delbridge, L. M. D. (2018). Cardiomyocyte functional etiology in heart failure with preserved ejection fraction is distinctive: A new preclinical model. Journal of the American Heart Association, 7(11), e007451. doi: 10.1161/jaha.117.007451

Pereira, L., Rehman, H., Lao, D. H., Erickson, J. R., Bossuyt, J., Chen, J., & Bers, D. M. (2015). Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. PNAS, 112(13), 3991-3996. doi: 10.1073/pnas.1416163112

Erickson, J. R., Nichols, C. B., Uchinoumi, H., Stein, M. L., Bossuyt, J., & Bers, D. M. (2015). S-nitrosylation induces both autonomous activation and inhibition of calcium/calmodulin-dependent protein kinase II δ. Journal of Biological Chemistry, 290(42), 25646-25656. doi: 10.1074/jbc.M115.650234

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Bell, J. R., Raaijmakers, A. J. A., Curl, C. L., Reichelt, M. E., Harding, T. W., Bei, A., … Erickson, J. R., … Delbridge, L. M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159

Grimm, M., Ling, H., Willeford, A., Pereira, L., Gray, C. B. B., Erickson, J. R., … Brown, J. H. (2015). CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation. Journal of Molecular & Cellular Cardiology, 85, 282-291. doi: 10.1016/j.yjmcc.2015.06.007

Jian, Z., Han, H., Zhang, T., Puglisi, J., Izu, L. T., Shaw, J. A., … Erickson, J. R., … Chen-Izu, Y. (2014). Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling, 7(317), ra27. doi: 10.1126/scisignal.2005046

Erickson, J. R. (2014). Mechanisms of CaMKII activation in the heart. Frontiers in Pharmacology, 5, 59. doi: 10.3389/fphar.2014.00059

Bell, J. R., Erickson, J. R., & Delbridge, L. M. D. (2014). Ca2+/calmodulin dependent kinase II: A critical mediator in determining reperfusion outcomes in the heart? Clinical & Experimental Pharmacology & Physiology, 41(11), 940-946. doi: 10.1111/1440-1681.12301

Zhang, D.-M., Chai, Y., Erickson, J. R., Brown, J. H., Bers, D. M., & Lin, Y.-F. (2014). Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. Journal of Physiology, 592(5), 971-990. doi: 10.1113/jphysiol.2013.264697

Erickson, J. R., Pereira, L., Wang, L., Han, G., Ferguson, A., Dao, K., … Bers, D. M. (2013). Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature, 502, 372-376. doi: 10.1038/nature12537

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Journal - Research Other

Bussey, C. T., & Erickson, J. R. (2018). Physiology and pathology of cardiac CaMKII. Current Opinion in Physiology, 1, 52-58. doi: 10.1016/j.cophys.2017.07.003

Ebenebe, O. V., Heather, A., & Erickson, J. R. (2018). CaMKII in vascular signalling: “Friend or foe”? Heart, Lung & Circulation, 27(5), 560-567. doi: 10.1016/j.hlc.2017.12.003

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