Dr Braeden Donaldson
| Position | Professional Practice Fellow |
|---|---|
| Department | Department of Pathology (Dunedin) |
| Qualifications | BMLSc, PGDipMLSc |
| Research summary | The development of immunotherapeutic vaccines as novel cancer therapies |
| Teaching | My teaching commitments include roles in pathology, medical laboratory science, medicine, and several other health sciences courses. |
| Memberships |
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| Clinical | Interests in current clinical therapies for cancer, and novel advancements in drug development, surgical intervention procedures, and patient management and care. |
Research
Under the supervision of Associate Professor Sarah Young and Professor Vernon Ward, I have been using rabbit haemorrhagic disease virus (RHDV) virus-like particles (VLP) as a vaccine scaffold for the chemical conjugation and recombinant insertion of tumour-associated antigens (TAAs). These vaccines have previously proven effective at inducing potent anti-tumour immune responses in murine models of melanoma, lung cancer, and colorectal cancer. We are currently adapting this vaccine for prostate cancer and breast cancer, in addition to developing the vaccine for use in human clinical trials.
Publications
Campbell, K., Young, V. L., Donaldson, B. C., Woodall, M. J., Shields, N. J., Walker, G. F., Ward, V. K., & Young, S. L. (2021). Delivering two tumour antigens survivin and mucin-1 on virus-like particles enhances anti-tumour immune responses. Vaccines, 9(5), 463. doi: 10.3390/vaccines9050463
Donaldson, B., Lateef, Z., Walker, G. F., Young, S. L., & Ward, V. K. (2018). Virus-like particle vaccines: Immunology and formulation for clinical translation. Expert Review of Vaccines, 17(9), 833-849. doi: 10.1080/14760584.2018.1516552
Li, K., Donaldson, B., Young, V., Ward, V., Jackson, C., Baird, M., & Young, S. (2017). Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes. Clinical & Translational Immunology, 6(10), e160. doi: 10.1038/cti.2017.37
Donaldson, B., Al-Barwani, F., Pelham, S. J., Young, K., Ward, V. K., & Young, S. L. (2017). Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. Journal for ImmunoTherapy of Cancer, 5, 69. doi: 10.1186/s40425-017-0270-1
Donaldson, B., Al-Barwani, F., Young, V., Scullion, S., Ward, V., & Young, S. (2015). Virus-like particles, a versatile subunit vaccine platform. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 159-180). New York: Springer. doi: 10.1007/978-1-4939-1417-3
Donaldson, B., Al-Barwani, F., Young, V., Scullion, S., Ward, V., & Young, S. (2015). Virus-like particles, a versatile subunit vaccine platform. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 159-180). New York: Springer. doi: 10.1007/978-1-4939-1417-3
Chapter in Book - Research
Campbell, K., Young, V. L., Donaldson, B. C., Woodall, M. J., Shields, N. J., Walker, G. F., Ward, V. K., & Young, S. L. (2021). Delivering two tumour antigens survivin and mucin-1 on virus-like particles enhances anti-tumour immune responses. Vaccines, 9(5), 463. doi: 10.3390/vaccines9050463
Journal - Research Article
Donaldson, B., Al-Barwani, F., Pelham, S. J., Young, K., Ward, V. K., & Young, S. L. (2017). Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. Journal for ImmunoTherapy of Cancer, 5, 69. doi: 10.1186/s40425-017-0270-1
Journal - Research Article
Li, K., Donaldson, B., Young, V., Ward, V., Jackson, C., Baird, M., & Young, S. (2017). Adoptive cell therapy with CD4+ T helper 1 cells and CD8+ cytotoxic T cells enhances complete rejection of an established tumour, leading to generation of endogenous memory responses to non-targeted tumour epitopes. Clinical & Translational Immunology, 6(10), e160. doi: 10.1038/cti.2017.37
Journal - Research Article
Al Barwani, F., Donaldson, B., Pelham, S. J., Young, S. L., & Ward, V. K. (2014). Antigen delivery by virus-like particles for immunotherapeutic vaccination. Therapeutic Delivery, 5(11), 1223-1240. doi: 10.4155/TDE.14.74
Journal - Research Article
Donaldson, B., Lateef, Z., Walker, G. F., Young, S. L., & Ward, V. K. (2018). Virus-like particle vaccines: Immunology and formulation for clinical translation. Expert Review of Vaccines, 17(9), 833-849. doi: 10.1080/14760584.2018.1516552
Journal - Research Other
