Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Health Sciences profile

Dr James Ussher

PositionSenior Lecturer
DepartmentDepartment of Microbiology and Immunology
QualificationsMBChB PhD FRCPA
Research summaryApplied and molecular immunology, medical microbiology, vaccines

Research

My research interest is infection and immunity. In particular, I am interested in mucosal associated invariant T (MAIT) cells, their role in antibacterial immunity, and how they might be harnessed to prevent or treat bacterial infection. I have been involved in several fundamental discoveries in MAIT cell biology. I am also interested in the antimicrobial resistance, in particular its rapid detection, characterisation, and transmission, especially in Enterobacteriaceae. My clinical specialty is medical microbiology.

Publications

Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., … Willberg, C. B. (2014). CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. European Journal of Immunology, 44(1), 195-203. doi: 10.1002/eji.201343509

Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., … Klenerman, P. (2013). Early and nonreversible decrease of CD161++/MAIT cells in HIV infection. Blood, 121(6), 951-961. doi: 10.1182/blood-2012-06-436436

Sheppard, H. M., Ussher, J. E., Verdon, D., Chen, J., Taylor, J. A., & Dunbar, P. R. (2013). Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes. PLoS ONE, 8(4), e62753. doi: 10.1371/journal.pone.0062753

Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. (2011). Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering Part C: Methods, 17(9), 949-959. doi: 10.1089/ten.tec.2011.0153

Ussher, J. E., & Taylor, J. A. (2010). Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy, 21(12), 1675-1686. doi: 10.1089/hum.2010.087

Journal - Research Article

Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., … Willberg, C. B. (2014). CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. European Journal of Immunology, 44(1), 195-203. doi: 10.1002/eji.201343509

Ge, Y., Mansell, A., Ussher, J. E., Brooks, A. E. S., Manning, K., Wang, C. J. H., & Taylor, J. A. (2013). Rotavirus NSP4 triggers secretion of pro-inflammatory cytokines from macrophages via toll-like receptor 2. Journal of Virology, 87(20), 11160-11167. doi: 10.1128/JVI.03099-12

Sheppard, H. M., Ussher, J. E., Verdon, D., Chen, J., Taylor, J. A., & Dunbar, P. R. (2013). Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes. PLoS ONE, 8(4), e62753. doi: 10.1371/journal.pone.0062753

Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., … Klenerman, P. (2013). Early and nonreversible decrease of CD161++/MAIT cells in HIV infection. Blood, 121(6), 951-961. doi: 10.1182/blood-2012-06-436436

Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. (2011). Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering Part C: Methods, 17(9), 949-959. doi: 10.1089/ten.tec.2011.0153

Ussher, J. E., & Taylor, J. A. (2010). Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy, 21(12), 1675-1686. doi: 10.1089/hum.2010.087

Briggs, S., Ussher, J., & Taylor, S. (2005). Extended-spectrum beta-lactamase-producing Enterobacteriaceae at Middlemore Hospital. New Zealand Medical Journal, 118(1218). Retrieved from http://journal.nzma.org.nz/journal/118-1218/1578/content.pdf

Chambers, S., Heckert, K. A., Bagshaw, S., Ussher, J., Birch, M., & Wilson, M. A. (2001). Maternity care providers' attitudes and practices concerning HIV testing during pregnancy: Results of a survey of the Canterbury and upper South Island region. New Zealand Medical Journal, 114(1144), 513-516.

^ Top of page

Journal - Research Other

Smith, K., Pandey, S. K., & Ussher, J. E. (2012). Bacteraemia caused by Catabacter hongkongensis. Anaerobe, 18(3), 366-368. doi: 10.1016/j.anaerobe.2012.03.006

Ussher, J. E., Wilson, E., Campanella, S., Taylor, S. L., & Roberts, S. A. (2007). Haemophilus ducreyi causing chronic skin ulceration in children visiting Samoa. Clinical Infectious Diseases, 44, e85-e87. doi: 10.1086/515404

More publications...