Dr James Ussher
| Position | Senior Lecturer |
|---|---|
| Department | Department of Microbiology and Immunology |
| Qualifications | MBChB PhD FRCPA |
| Research summary | Applied and molecular immunology, medical microbiology, vaccines |
Research
My research interest is infection and immunity. In particular, I am interested in mucosal associated invariant T (MAIT) cells, their role in antibacterial immunity, and how they might be harnessed to prevent or treat bacterial infection. I have been involved in several fundamental discoveries in MAIT cell biology. I am also interested in the antimicrobial resistance, in particular its rapid detection, characterisation, and transmission, especially in Enterobacteriaceae. My clinical specialty is medical microbiology.Publications
Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., … Willberg, C. B. (2014). CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. European Journal of Immunology, 44(1), 195-203. doi: 10.1002/eji.201343509
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., … Klenerman, P. (2013). Early and nonreversible decrease of CD161++/MAIT cells in HIV infection. Blood, 121(6), 951-961. doi: 10.1182/blood-2012-06-436436
Sheppard, H. M., Ussher, J. E., Verdon, D., Chen, J., Taylor, J. A., & Dunbar, P. R. (2013). Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes. PLoS ONE, 8(4), e62753. doi: 10.1371/journal.pone.0062753
Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. (2011). Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering Part C: Methods, 17(9), 949-959. doi: 10.1089/ten.tec.2011.0153
Ussher, J. E., & Taylor, J. A. (2010). Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy, 21(12), 1675-1686. doi: 10.1089/hum.2010.087
Journal - Research Article
Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., … Willberg, C. B. (2014). CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. European Journal of Immunology, 44(1), 195-203. doi: 10.1002/eji.201343509
Ge, Y., Mansell, A., Ussher, J. E., Brooks, A. E. S., Manning, K., Wang, C. J. H., & Taylor, J. A. (2013). Rotavirus NSP4 triggers secretion of pro-inflammatory cytokines from macrophages via toll-like receptor 2. Journal of Virology, 87(20), 11160-11167. doi: 10.1128/JVI.03099-12
Sheppard, H. M., Ussher, J. E., Verdon, D., Chen, J., Taylor, J. A., & Dunbar, P. R. (2013). Recombinant adeno-associated virus serotype 6 efficiently transduces primary human melanocytes. PLoS ONE, 8(4), e62753. doi: 10.1371/journal.pone.0062753
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., … Klenerman, P. (2013). Early and nonreversible decrease of CD161++/MAIT cells in HIV infection. Blood, 121(6), 951-961. doi: 10.1182/blood-2012-06-436436
Locke, M., Ussher, J. E., Mistry, R., Taylor, J. A., & Dunbar, P. R. (2011). Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors. Tissue Engineering Part C: Methods, 17(9), 949-959. doi: 10.1089/ten.tec.2011.0153
Ussher, J. E., & Taylor, J. A. (2010). Optimized transduction of human monocyte-derived dendritic cells by recombinant adeno-associated virus serotype 6. Human Gene Therapy, 21(12), 1675-1686. doi: 10.1089/hum.2010.087
Briggs, S., Ussher, J., & Taylor, S. (2005). Extended-spectrum beta-lactamase-producing Enterobacteriaceae at Middlemore Hospital. New Zealand Medical Journal, 118(1218). Retrieved from http://journal.nzma.org.nz/journal/118-1218/1578/content.pdf
Chambers, S., Heckert, K. A., Bagshaw, S., Ussher, J., Birch, M., & Wilson, M. A. (2001). Maternity care providers' attitudes and practices concerning HIV testing during pregnancy: Results of a survey of the Canterbury and upper South Island region. New Zealand Medical Journal, 114(1144), 513-516.
Journal - Research Other
Smith, K., Pandey, S. K., & Ussher, J. E. (2012). Bacteraemia caused by Catabacter hongkongensis. Anaerobe, 18(3), 366-368. doi: 10.1016/j.anaerobe.2012.03.006
Ussher, J. E., Wilson, E., Campanella, S., Taylor, S. L., & Roberts, S. A. (2007). Haemophilus ducreyi causing chronic skin ulceration in children visiting Samoa. Clinical Infectious Diseases, 44, e85-e87. doi: 10.1086/515404
