Dr Benedict Seo
| Position | Senior Lecturer |
|---|---|
| Department | Department of Oral Diagnostic and Surgical Sciences |
| Research summary | Diagnostic oral pathology; unfolded protein response, ER stress, oral cancer; molecular biology; epithelial cell culture |
Research
Dr Seo investigates the pathogenesis of oral cancer, odontogenic lesions and immune-mediated oral diseases, with a particular focus on unfolded protein response (UPR) and endoplasmic reticulum (ER) stress. Techniques such as qRT2-PCR, IHC, histochemistry, western blot, cell culture and in vitro assays (viability, caspase-based, TUNEL) are employed in his research. He has an active research partnership with the University of Malaysia, Oral Cancer Research and Coordination Centre and the National University of Malaysia, as well as with Dunedin Public Hospital.
Dr Seo is also a reviewer for the Journal of Periodontal Research, Pathology and BMC Oral Health.
He received the Oral Presentation Award from the International Association of Oral Pathologists (IAOP), Elman Poole Fellowship, International Association for Dental Research-Colgate Postgraduate Award and Sir Thomas Hunter Scholarship, amongst others.
Publications
Hussaini, H. M., Seo, B., & Rich, A. M. (2023). Immunohistochemistry and immunofluorescence. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 439-450). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_26
Arora, S., Seo, B., Friedlander, L., & Hussaini, H. M. (2023). A cell culture method for the isolation and study of primary human dental pulp cells. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 393-405). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_22
Aziz, M. A., Seo, B., Hussaini, H. M., Hibma, M., & Rich, A. M. (2022). Comparing two methods for the isolation of exosomes. Journal of Nucleic Acids, 8648373. doi: 10.1155/2022/8648373
Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425
Oude-Alink, C., Hussaini, H. M., Seo, B., & Firth, F. (2022). Regulatory compliance of online vendor selling dental whitening products in New Zealand. Journal of the Royal Society of New Zealand. Advance online publication.
Arora, S., Seo, B., Friedlander, L., & Hussaini, H. M. (2023). A cell culture method for the isolation and study of primary human dental pulp cells. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 393-405). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_22
Chapter in Book - Research
Hussaini, H. M., Seo, B., & Rich, A. M. (2023). Immunohistochemistry and immunofluorescence. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 439-450). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_26
Chapter in Book - Research
Arora, S., Cooper, P. R., Friedlander, L. T., Seo, B., Rizwan, S. B., Rich, A. M., & Hussaini, H. M. (2022). Potentiality and inflammatory marker expression are maintained in dental pulp cell cultures from carious teeth. International Journal of Molecular Sciences, 23(16), 9425. doi: 10.3390/ijms23169425
Journal - Research Article
Aziz, M. A., Seo, B., Hussaini, H. M., Hibma, M., & Rich, A. M. (2022). Comparing two methods for the isolation of exosomes. Journal of Nucleic Acids, 8648373. doi: 10.1155/2022/8648373
Journal - Research Article
Oude-Alink, C., Hussaini, H. M., Seo, B., & Firth, F. (2022). Regulatory compliance of online vendor selling dental whitening products in New Zealand. Journal of the Royal Society of New Zealand. Advance online publication.
Journal - Research Article
Seo, B., Coates, D. E., Lewis, J., Seymour, G. J., & Rich, A. (2022). Unfolded protein response is involved in the metabolic and apoptotic regulation of oral squamous cell carcinoma. Pathology. Advance online publication. doi: 10.1016/j.pathol.2022.04.003
Journal - Research Article
Seo, B., Hussaini, H., & Rich, A. M. (2021). The effect of the COVID-19 pandemic lockdown on the oral and maxillofacial pathology diagnostic services in New Zealand. New Zealand Dental Journal, 117(2), 67-72.
Journal - Research Article
Firth, F. A., Milne, T. J., Seo, B., & Farella, M. (2020). An in-vitro mechanical strain three-dimensional culture model: Periodontal ligament cell viability, apoptosis, and endoplasmic reticulum stress response. European Journal of Oral Sciences, 128, 120-127. doi: 10.1111/eos.12681
Journal - Research Article
Guan, G., Mei, L., Polonowita, A., Hussaini, H., Seo, B., & Rich, A. M. (2020). Malignant transformation in oral lichen planus and lichenoid lesions: A 14-year longitudinal cohort study of 829 patients in New Zealand. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology, 130(4), 411-418. doi: 10.1016/j.oooo.2020.07.002
Journal - Research Article
McElroy, K. E., Seo, B. L., Hussaini, H. M., & Rich, A. M. (2020). Graft versus host disease: Cases from New Zealand with oral manifestations. New Zealand Dental Journal, 116(2), 47-54.
Journal - Research Article
Yu, Z., Seo, B., Hussaini, H. M., Meldrum, A. M., & Rich, A. M. (2020). The relative frequency of paediatric oral and maxillofacial pathology in New Zealand: A 10-year review of a national specialist centre. International Journal of Paediatric Dentistry, 30, 209-215. doi: 10.1111/ipd.12590
Journal - Research Article
Al-Hassiny, A., Hussani, H., Milne, T., Seo, B., Rich, A. M., & Friedlander, L. T. (2019). Vascularity and angiogenic signaling in the dentine-pulp complex of immature and mature permanent teeth. European Endodontic Journal, 4(2), 80-85. doi: 10.14744/eej.2019.26349
Journal - Research Article
Yakin, M., Seo, B., & Rich, A. (2019). Tunicamycin-induced endoplasmic reticulum stress up-regulates tumour-promoting cytokines in oral squamous cell carcinoma. Cytokine, 120, 130-143. doi: 10.1016/j.cyto.2019.04.013
Journal - Research Article
Al-Hassiny, A., Friedlander, L. T., Parachuru, V. P. B., Seo, B., Hussaini, H. M., & Rich, A. M. (2018). Upregulation of angiogenesis in oral lichen planus. Journal of Oral Pathology & Medicine, 47(2), 173-178. doi: 10.1111/jop.12665
Journal - Research Article
Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6
Journal - Research Article
Seo, B., Hussaini, H. M., & Rich, A. M. (2017). Second opinion oral pathology referrals in New Zealand. Pathology, 49(3), 277-284. doi: 10.1016/j.pathol.2016.11.007
Journal - Research Article
Seo, B., Coates, D. E., Seymour, G. J., & Rich, A. M. (2016). Unfolded protein response-related gene regulation in inflamed periodontal tissues with and without Russell bodies. Archives of Oral Biology, 69, 1-6. doi: 10.1016/j.archoralbio.2016.04.009
Journal - Research Article
Arora, S., Cooper, P. R., Ratnayake, J. T., Friedlander, L. T., Rizwan, S. B., Seo, B., & Hussaini, H. M. (2022). A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures. International Endodontic Journal, 55(Suppl. 1), 3-13. doi: 10.1111/iej.13684
Journal - Research Other
Goh, R., Tawse-Smith, A., Reid, I. P., Hussaini, H. M., & Seo, B. (2022). Fibrous epulis with ossification: A case report and review of the literature. Brazilian Journal of Periodontology, 31(3), 73-81. doi: 10.14436/0103-9393.31.3.073-081.oar
Journal - Research Other
Arora, S., Cooper, P. R., Friedlander, L. T., Rizwan, S., Seo, B., Rich, A. M., & Hussaini, H. M. (2021). Potential application of immunotherapy for modulation of pulp inflammation: Opportunities for vital pulp treatment. International Endodontic Journal, 54, 1263-1274. doi: 10.1111/iej.13524
Journal - Research Other
Rich, A. M., Hussaini, H. M., Seo, B., & Zain, R. B. (2020). Understanding the complex microenvironment in oral cancer: The contribution of the Faculty of Dentistry, University of Otago over the last 100 years. Journal of the Royal Society of New Zealand, 50(1), 15-34. doi: 10.1080/03036758.2020.1736586
Journal - Research Other
Yakin, M., Seo, B., Hussaini, H., Rich, A., & Hunter, K. (2019). Human papillomavirus and oral and oropharyngeal carcinoma: The essentials. Australian Dental Journal, 64, 11-18. doi: 10.1111/adj.12652
Journal - Research Other
Rich, A. M., Seo, B., Parachuru, V., & Hussaini, H. M. (2017). The nexus between periodontics and oral pathology. Periodontology 2000, 74(1), 176-181. doi: 10.1111/prd.12197
Journal - Research Other
Goldsmith, S. M., Seo, B. L., de Silva, R. K., Parachuru, P., Rich, A. M., & Seymour, G. J. (2014). Oral mycosis fungoides: Report with immune profile. Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology, 118(2), e48-e52. doi: 10.1016/j.oooo.2013.10.005
Journal - Research Other
