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Health Sciences profile

Dr Karen Reader

PositionSenior Lecturer
DepartmentDepartment of Pathology (Dunedin)
QualificationsPhD
Research summaryOvarian cancer

Research

Karen is a reproductive biologist with broad interests in the areas of assisted reproductive technologies in humans and livestock, and ovarian and prostate cancer. Her research aims to identify factors important for oocyte quality that can be manipulated to improve oocyte in vitro maturation and embryo quality.

Karen also investigates the role of members of the transforming growth factor beta (TGFB) family of proteins in reproductive biology. Her cancer research is focused on the role of activins in ovarian and prostate cancer development. The aim is to identify biomarkers that can predict disease outcome and inform treatment decisions, as well as discovering novel therapeutic targets.

Karen’s laboratory works with human tissue, human cancer cell lines and sheep ovarian cells, and utilises techniques such as cell culture, in vitro embryo production, electron and confocal microscopy, immunohistochemistry and molecular biology.

Publications

Reader, K. L., John-McHaffie, S., Zellhuber-McMillan, S., Jowett, T., Mottershead, D. G., Cunliffe, H. E., & Gold, E. J. (2023). Activin B and activin C have opposing effects on prostate cancer progression and cell growth. Cancers, 15, 147. doi: 10.3390/cancers15010147

Reader, K. L., Pilbrow, B. G., Zellhuber-McMillan, S., Mitchell, A. J., Juengel, J. L., & Morbeck, D. (2022). High pressure frozen oocytes have improved ultrastructure but reduced cleavage rates compared to conventionally fixed or vitrified oocytes. Reproduction, Fertility & Development, 34(18), 1135-1144. doi: 10.1071/rd22118

Seo, S., Sizemore, R. J., Reader, K. L., Smither, R. A., Wicky, H. E., Hughes, S. M., Bilkey, D. K., Parr-Brownlie, L. C., & Oorschot, D. E. (2021). A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. Journal of Comparative Neurology, 529, 3946-3973. doi: 10.1002/cne.25225

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Reader, K. L., John-McHaffie, S., Zellhuber-McMillan, S., Jowett, T., Mottershead, D. G., Cunliffe, H. E., & Gold, E. J. (2023). Activin B and activin C have opposing effects on prostate cancer progression and cell growth. Cancers, 15, 147. doi: 10.3390/cancers15010147

Journal - Research Article

Reader, K. L., Pilbrow, B. G., Zellhuber-McMillan, S., Mitchell, A. J., Juengel, J. L., & Morbeck, D. (2022). High pressure frozen oocytes have improved ultrastructure but reduced cleavage rates compared to conventionally fixed or vitrified oocytes. Reproduction, Fertility & Development, 34(18), 1135-1144. doi: 10.1071/rd22118

Journal - Research Article

Seo, S., Sizemore, R. J., Reader, K. L., Smither, R. A., Wicky, H. E., Hughes, S. M., Bilkey, D. K., Parr-Brownlie, L. C., & Oorschot, D. E. (2021). A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. Journal of Comparative Neurology, 529, 3946-3973. doi: 10.1002/cne.25225

Journal - Research Article

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Journal - Research Article

Reader, K. L., Marino, F. E., Nicholson, H. D., Risbridger, G. P., & Gold, E. J. (2018). Role of activin C in normal ovaries and granulosa cell tumours of mice and humans. Reproduction, Fertility & Development, 30(7), 958-968. doi: 10.1071/RD17250

Journal - Research Article

Croxford, K. P., Reader, K. L., & Nicholson, H. D. (2017). The potential role of transforming growth factor beta family ligand interactions in prostate cancer. AIMS Molecular Science, 4(1), 41-61. doi: 10.3934/molsci.2017.1.41

Journal - Research Article

McNatty, K. P., Heath, D. A., Clark, Z., Reader, K., Juengel, J. L., & Pitman, J. L. (2017). Ovarian characteristics in sheep with multiple fecundity genes. Reproduction, 153, 233-240. doi: 10.1530/rep-16-0587

Journal - Research Article

Ottley, E. C., Reader, K. L., Lee, K., Marino, F. E., Nicholson, H. D., Risbridger, G. P., & Gold, E. (2017). Over-expression of activin-βC is associated with murine and human prostate disease. Hormones & Cancer, 8(2), 100-107. doi: 10.1007/s12672-017-0283-8

Journal - Research Article

O'Connell, A. R., Demmers, K. J., Smaill, B., Reader, K. L., & Juengel, J. L. (2016). Early embryo loss, morphology, and effect of previous immunization against adrostenedione in the ewe. Theriogenology, 86(5), 1285-1293. doi: 10.1016/j.theriogenology.2016.04.069

Journal - Research Article

O'Connell, A. R., McNatty, K. P., Hurst, P. R., Spencer, T. E., Bazer, F. W., Reader, K. L., … Juengel, J. L. (2016). Activin A and follistatin during the oestrous cycle and early pregnancy in ewes. Journal of Endocrinology, 228(3), 193-203. doi: 10.1530/joe-15-0367

Journal - Research Article

Reader, K. L., Mottershead, D. G., Martin, G. A., Gilchrist, R. B., Heath, D. A., McNatty, K. P., & Juengel, J. L. (2016). Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15. Reproduction, Fertility & Development, 28, 491-498. doi: 10.1071/RD14099

Journal - Research Article

Reader, K. L., & Gold, E. (2015). Activins and activin antagonists in the human ovary and ovarian cancer. Molecular & Cellular Endocrinology, 415, 126-132. doi: 10.1016/j.mce.2015.08.011

Journal - Research Article

Reader, K. L., Cox, N. R., Stanton, J.-A. L., & Juengel, J. L. (2015). Effects of acetyl-L-carnitine on lamb oocyte blastocyst rate, ultrastructure, and mitochondrial DNA copy number. Theriogenology, 83, 1484-1492. doi: 10.1016/j.theriogenology.2015.01.028

Journal - Research Article

Reader, K. L., Cox, N. R., Stanton, J.-A. L., & Juengel, J. L. (2015). Mitochondria and vesicles differ between adult and prepubertal sheep oocytes during IVM. Reproduction, Fertility & Development, 27(3), 513-522. doi: 10.1071/RD13359

Journal - Research Article

Reader, K. L., Haydon, L. J., Littlejohn, R. P., Juengel, J. L., & McNatty, K. P. (2012). Booroola BMPR1B mutation alters early follicular development and oocyte ultrastructure in sheep. Reproduction, Fertility & Development, 24(2), 353-361. doi: 10.1071/RD11095

Journal - Research Article

Cree, A. M., Guillette, Jr, L. J., & Reader, K. (1996). Eggshell formation during prolonged gravidity of the Tuatara (Sphenodon punctatus). Journal of Morphology, 230(2), 129-144.

Journal - Research Article

Reader, K. L., Stanton, J.-A. L., & Juengel, J. L. (2017). The role of oocyte organelles in determining developmental competence. Biology, 6(3), 35. doi: 10.3390/biology6030035

Journal - Research Other

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