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Health Sciences profile

Professor Sarah Hook

PositionProfessor
QualificationsBSc(Hons) PhD(Otago)
Research summaryVaccine formulation and delivery
TeachingImmunology and infectious diseases to undergraduate and postgraduate students

Research

My area of interest is in the development and testing (physical, chemical and immunological) of novel vaccine formulations for the prevention and treatment of both communicable and non-communicable disease. My specific areas of interest are in the development of one-shot sustained release vaccines and in needle-free (transdermal or oral) vaccines for the treatment of tuberculosis and cancer.

My research focuses on:

  • Sustained release vaccines
  • Needle free vaccines
  • Therapeutic cancer vaccines
  • Identification and formulation of novel adjuvants

Professor Hook on Google Scholar

Publications

Dadhwal, S., Lee, A., Goswami, S. K., Hook, S., & Gamble, A. B. (2021). Synthesis and formulation of self-immolative PEG-aryl azide block copolymers and click-to-release reactivity with trans-cyclooctene. Journal of Polymer Science. Advance online publication. doi: 10.1002/pol.20210020

Azhari, H., Younus, M., Hook, S. M., Boyd, B. J., & Rizwan, S. B. (2021). Cubosomes enhance drug permeability across the blood-brain barrier in zebrafish. International Journal of Pharmaceutics, 600, 120411. doi: 10.1016/j.ijpharm.2021.120411

Bobbala, S., & Hook, S. (2020). Vaccine implants: Current status and recent advancements. Emerging Topics in Life Sciences. Advance online publication. doi: 10.1042/etls20200164

Fairhall, J. M., Murayasu, M., Dadhwal, S., Hook, S., & Gamble, A. B. (2020). Tuning activation and self-immolative properties of the bioorthogonal alkene-azide click-and-release strategy. Organic & Biomolecular Chemistry, 18, 4754-4762. doi: 10.1039/d0ob00936a

Naciute, M., Niemi, V., Kemp, R. A., & Hook, S. (2020). Lipid-encapsulated oral therapeutic peptide vaccines reduce tumour growth in an orthotopic mouse model of colorectal cancer. European Journal of Pharmaceutics & Biopharmaceutics, 153, 183-192. doi: 10.1016/j.ejpb.2020.04.020

Foged, C., Rades, T., Perrie, Y., & Hook, S. (Eds.). (2015). Subunit vaccine delivery. New York: Springer. doi: 10.1007/978-1-4939-1417-3

Edited Book - Research

Rattanapak, T., Foged, C., & Hook, S. (2015). Transcutaneous immunization. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 347-369). New York: Springer. doi: 10.1007/978-1-4939-1417-3

Chapter in Book - Research

Buchan, G. S., Lockhart, D., Slobbe, L., Chinn, N., Hook, S., Thomson, A., & Griffin, F. (1995). Vaccination: Can it be improved? In F. Griffin & G. de Lisle (Eds.), Tuberculosis in wildlife and domestic animals. (pp. 116-120). Dunedin: Otago University Press.

Chapter in Book - Research

Hook, S., Slobbe, L., Chinn, N., Griffin, J. F. T., & Hesketh, J. B. (1995). Measuring cytokine responses to vaccination with live and killed BCG. In F. Griffin & G. de Lisle (Eds.), Tuberculosis in wildlife and domestic animals. (pp. 128-130). Dunedin: Otago University Press.

Chapter in Book - Research

Lockhart, E., Slobbe, L., Hook, S., Griffin, F., & Mackintosh, C. G. (1995). The development of a new, multipurpose, animal model of tuberculosis. In F. Griffin & G. de Lisle (Eds.), Tuberculosis in wildlife and domestic animals. (pp. 158-160). Dunedin: Otago University Press.

Chapter in Book - Research

Azhari, H., Younus, M., Hook, S. M., Boyd, B. J., & Rizwan, S. B. (2021). Cubosomes enhance drug permeability across the blood-brain barrier in zebrafish. International Journal of Pharmaceutics, 600, 120411. doi: 10.1016/j.ijpharm.2021.120411

Journal - Research Article

Dadhwal, S., Lee, A., Goswami, S. K., Hook, S., & Gamble, A. B. (2021). Synthesis and formulation of self-immolative PEG-aryl azide block copolymers and click-to-release reactivity with trans-cyclooctene. Journal of Polymer Science. Advance online publication. doi: 10.1002/pol.20210020

Journal - Research Article

Bobbala, S., & Hook, S. (2020). Vaccine implants: Current status and recent advancements. Emerging Topics in Life Sciences. Advance online publication. doi: 10.1042/etls20200164

Journal - Research Article

Dadhwal, S., Fairhall, J. M., Hook, S., & Gamble, A. B. (2020). Tetrafluoroaryl azide as an N-terminal capping group for click-to-dissolve diphenylalanine hydrogels. RSC Advances, 10(16), 9234-9244. doi: 10.1039/d0ra01013h

Journal - Research Article

Fairhall, J. M., Murayasu, M., Dadhwal, S., Hook, S., & Gamble, A. B. (2020). Tuning activation and self-immolative properties of the bioorthogonal alkene-azide click-and-release strategy. Organic & Biomolecular Chemistry, 18, 4754-4762. doi: 10.1039/d0ob00936a

Journal - Research Article

Naciute, M., Niemi, V., Kemp, R. A., & Hook, S. (2020). Lipid-encapsulated oral therapeutic peptide vaccines reduce tumour growth in an orthotopic mouse model of colorectal cancer. European Journal of Pharmaceutics & Biopharmaceutics, 153, 183-192. doi: 10.1016/j.ejpb.2020.04.020

Journal - Research Article

Dadhwal, S., Fairhall, J. M., Goswami, S. K., Hook, S., & Gamble, A. B. (2019). Alkene-azide 1,3-dipolar cycloaddition as a trigger for ultrashort peptide hydrogel dissolution. Chemistry: An Asian Journal, 14, 1143-1150. doi: 10.1002/asia.201801184

Journal - Research Article

Vu, H. T. H., Streck, S., Hook, S. M., & McDowell, A. (2019). Utilization of microfluidics for the preparation of polymeric nanoparticles for the antioxidant rutin: A comparison with bulk production. Pharmaceutical Nanotechnology, 7, 469-483. doi: 10.2174/2211738507666191019141049

Journal - Research Article

von Halling Laier, C., Gibson, B., Moreno, J. A. S., Rades, T., Hook, S., Nielsen, L. H., & Boisen, A. (2019). Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation. Journal of Controlled Release, 294, 91-101. doi: 10.1016/j.jconrel.2018.11.030

Journal - Research Article

Bobbala, S., Gibson, B., Gamble, A. B., McDowell, A., & Hook, S. (2018). Poloxamer 407-chitosan grafted thermoresponsive hydrogels achieve synchronous and sustained release of antigen and adjuvant from single-shot vaccines. Immunology & Cell Biology, 96(6), 656-665. doi: 10.1111/imcb.12031

Journal - Research Article

Cooper, A. G., MacDonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2018). Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry, 145, 770-789. doi: 10.1016/j.ejmech.2017.11.076

Journal - Research Article

Cooper, A. G., Oyagawa, C. R. M., Manning, J. J., Singh, S., Hook, S., Grimsey, N. L., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2018). Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffold. MedChemComm, 9(12), 2055-2067. doi: 10.1039/c8md00448j

Journal - Research Article

Kaneko, K., McDowell, A., Ishii, Y., & Hook, S. (2018). Characterization and evaluation of stabilized particulate formulations as therapeutic oral vaccines for allergy. Journal of Liposome Research, 28(4), 296-304. doi: 10.1080/08982104.2017.1370472

Journal - Research Article

Matikonda, S. S., Fairhall, J. M., Fiedler, F., Sanhajariya, S., Tucker, R. A. J., Hook, S., Garden, A. L., & Gamble, A. B. (2018). Mechanistic evaluation of bioorthogonal decaging with trans-cyclooctene: The effect of fluorine substituents on aryl azide reactivity and decaging from the 1,2,3-triazoline. Bioconjugate Chemistry, 29(2), 324-334. doi: 10.1021/acs.bioconjchem.7b00665

Journal - Research Article

Vu, H. T. H., Hook, S. M., Siqueira, S. D., Müllertz, A., Rades, T., & McDowell, A. (2018). Are phytosomes a superior nanodelivery system for the antioxidant rutin? International Journal of Pharmaceutics, 548(1), 82-91. doi: 10.1016/j.ijpharm.2018.06.042

Journal - Research Article

Cooper, A., Singh, S., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2017). Chemical tools for studying lipid-binding class A G protein-coupled receptors. Pharmacological Reviews, 69(3), 316-353. doi: 10.1124/pr.116.013243

Journal - Research Article

Even, M.-P., Bobbala, S., Gibson, B., Hook, S., Winter, G., & Engert, J. (2017). Twin-screw extruded lipid implants containing TRP2 peptide for tumour therapy. European Journal of Pharmaceutics & Biopharmaceutics, 114, 79-87. doi: 10.1016/j.ejpb.2016.12.033

Journal - Research Article

Kaneko, K., McDowell, A., Ishii, Y., & Hook, S. (2017). Liposomal α-galactosylceramide is taken up by gut-associated lymphoid tissue and stimulates local and systemic immune responses. Journal of Pharmacy & Pharmacology, 69(12), 1724-1735. doi: 10.1111/jphp.12814

Journal - Research Article

Matikonda, S. S., Fairhall, J. M., Tyndall, J. D. A., Hook, S., & Gamble, A. B. (2017). Stability, kinetic, and mechanistic investigation of 1,8-self-immolative cinnamyl ether spacers for controlled release of phenols and generation of resonance and inductively stabilized methides. Organic Letters, 19(3), 528-531. doi: 10.1021/acs.orglett.6b03695

Journal - Research Article

Umair, S., Pernthaner, A., Deng, Q., Gibson, B., Hook, S., & Heath, D. (2017). Preliminary evaluation of a thermosensitive chitosan hydrogel for Echinococcus granulosus vaccine delivery. Veterinary Parasitology, 236, 117-120. doi: 10.1016/j.vetpar.2017.02.007

Journal - Research Article

Azhari, H., Strauss, M., Hook, S., Boyd, B. J., & Rizwan, S. B. (2016). Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier. European Journal of Pharmaceutics & Biopharmaceutics, 104, 148-155. doi: 10.1016/j.ejpb.2016.05.001

Journal - Research Article

Bobbala, S., & Hook, S. (2016). Is there an optimal formulation and delivery strategy for subunit vaccines? Pharmaceutical Research, 33(9), 2078-2097. doi: 10.1007/s11095-016-1979-0

Journal - Research Article

Bobbala, S., Tamboli, V., McDowell, A., Mitra, A. K., & Hook, S. (2016). Novel injectable pentablock copolymer based thermoresponsive hydrogels for sustained release vaccines. AAPS Journal, 18(1), 261-269. doi: 10.1208/s12248-015-9843-4

Journal - Research Article

Gauld, N. J., Braganza, C., Babalola, O. O., Huynh, T. T., & Hook, S. M. (2016). Reasons for use and non-use of the pertussis vaccine during pregnancy: An interview study. Journal of Primary Health Care, 8(4), 344-350. doi: 10.1071/HC15049

Journal - Research Article

Highton, A. J., Girardin, A., Bell, G. M., Hook, S. M., & Kemp, R. A. (2016). Chitosan gel vaccine protects against tumour growth in an intracaecal mouse model of cancer by modulating systemic immune responses. BMC Immunology, 17, 39. doi: 10.1186/s12865-016-0178-4

Journal - Research Article

Neumann, S., Shirley, S. A., Kemp, R. A., & Hook, S. M. (2016). Improved antitumor activity of a therapeutic melanoma vaccine through the use of the dual COX-2/5-LO inhibitor licofelone. Frontiers in Immunology, 7(537), 537. doi: 10.3389/fimmu.2016.00537

Journal - Research Article

Subharat, S., Shu, D., Zheng, T., Buddle, B. M., Kaneko, K., Hook, S., … Wedlock, D. N. (2016). Vaccination of sheep with a methanogen protein provides insight into levels of antibody in saliva needed to target ruminal methanogens. PLoS ONE, 11(7), e0159861. doi: 10.1371/journal.pone.0159861

Journal - Research Article

Bobbala, S., McDowell, A., & Hook, S. (2015). Quantitation of the immunological adjuvants, monophosphoryl lipid A and Quil A in poly (lactic-co-glycolic acid) nanoparticles using high performance liquid chromatography with evaporative light scattering detection. Journal of Chromatography B, 975, 45-51. doi: 10.1016/j.jchromb.2014.11.006

Journal - Research Article

Engelke, L., Winter, G., Hook, S., & Engert, J. (2015). Recent insights into cutaneous immunization: How to vaccinate via the skin. Vaccine, 33, 4663-4674. doi: 10.1016/j.vaccine.2015.05.012

Journal - Research Article

Even, M.-P., Bobbala, S., Kok, L. K., Hook, S., Winter, G., & Engert, J. (2015). Impact of implant composition of twin-screw extruded lipid implants on the release behavior. International Journal of Pharmaceutics, 493, 102-110. doi: 10.1016/j.ijpharm.2015.06.052

Journal - Research Article

Greatrex, B. W., Daines, A. M., Hook, S., Lenz, D. H., McBurney, W., Rades, T., & Rendle, P. M. (2015). Synthesis, formulation, and adjuvanticity of monodesmosidic saponins with olenanolic acid, hederagenin and gypsogenin aglycones, and some C-28 ester derivatives. ChemistryOpen, 4(6), 740-755. doi: 10.1002/open.201500149

Journal - Research Article

Highton, A. J., Kojarunchitt, T., Girardin, A., Hook, S., & Kemp, R. A. (2015). Chitosan hydrogel vaccine generates protective CD8 T cell memory against mouse melanoma. Immunology & Cell Biology, 93, 634-640. doi: 10.1038/icb.2015.14

Journal - Research Article

Kaneko, K., McDowell, A., Ishii, Y., & Hook, S. (2015). Selective quantitation of the incorporation of the immunomodulator α-galactosylceramide in liposomes using LC-MS/MS. International Journal of Mass Spectrometry, 392, 96-101. doi: 10.1016/j.ijms.2015.09.016

Journal - Research Article

Kojarunchitt, T., Baldursdottir, S., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2015). Modified thermoresponsive Poloxamer 407 and chitosan sol-gels as potential sustained-release vaccine delivery systems. European Journal of Pharmaceutics & Biopharmaceutics, 89, 74-81. doi: 10.1016/j.ejpb.2014.11.026

Journal - Research Article

Liau, J. J., Hook, S., Prestidge, C. A., & Barnes, T. J. (2015). A lipid based multi-compartmental system: Liposomes-in-double emulsion for oral vaccine delivery. European Journal of Pharmaceutics & Biopharmaceutics, 97, 15-21. doi: 10.1016/j.ejpb.2015.09.018

Journal - Research Article

Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. (2015). Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine, 33, 5838-5844. doi: 10.1016/j.vaccine.2015.08.083

Journal - Research Article

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S., & Hook, S. (2015). First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. International Journal of Pharmaceutics, 479(2), 408-415. doi: 10.1016/j.ijpharm.2015.01.015

Journal - Research Article

Even, M.-P., Young, K., Winter, G., Hook, S., & Engert, J. (2014). In vivo investigation of twin-screw extruded lipid implants for vaccine delivery. European Journal of Pharmaceutics & Biopharmaceutics, 87(2), 338-346. doi: 10.1016/j.ejpb.2014.02.014

Journal - Research Article

Hubert, M., Larsen, D. S., Hayman, C. M., Rades, T., & Hook, S. (2014). Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Molecular Pharmaceutics, 11(3), 913-921. doi: 10.1021/mp400588y

Journal - Research Article

Neumann, S., Burkert, K., Kemp, R., Rades, T., Dunbar, P. R., & Hook, S. (2014). Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants. Immunology & Cell Biology, 92, 535-542. doi: 10.1038/icb.2014.21

Journal - Research Article

Rattanapak, T., Birchall, J. C., Young, K., Kubo, A., Fujimori, S., Ishii, M., & Hook, S. (2014). Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS ONE, 9(2), e89503. doi: 10.1371/journal.pone.0089503

Journal - Research Article

Hubert, M., Compton, B. J., Hayman, C. M., Larsen, D. S., Painter, G. F., Rades, T., & Hook, S. (2013). Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues. Molecular Pharmaceutics, 10(5), 1928-1939. doi: 10.1021/mp300707a

Journal - Research Article

Rattanapak, T., Birchall, J., Young, K., Ishii, M., Meglinski, I., Rades, T., & Hook, S. (2013). Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and two-photon microscopy. Journal of Controlled Release, 172(3), 894-903. doi: 10.1016/j.jconrel.2013.08.018

Journal - Research Article

Rizwan, S. B., McBurney, W. T., Young, K., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2013). Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses. Journal of Controlled Release, 165(1), 16-21. doi: 10.1016/j.jconrel.2012.10.020

Journal - Research Article

Scherließ, R., Buske, S., Young, K., Weber, B., Rades, T., & Hook, S. (2013). In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine, 31(42), 4812-4819. doi: 10.1016/j.vaccine.2013.07.081

Journal - Research Article

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Journal - Research Article

Kamali, T., Doronin, A., Rattanapak, T., Hook, S., & Meglinski, I. (2012). Assessment of transcutaneous vaccine delivery by optical coherence tomography. Laser Physics Letters, 9(8), 607-610. doi: 10.7452/lapl.201210046

Journal - Research Article

Rattanapak, T., Young, K., Rades, T., & Hook, S. (2012). Comparative study of liposomes, transfersomes, ethosomes and cubosomes for transcutaneous immunisation: Characterisation and in vitro skin penetration. Journal of Pharmacy & Pharmacology, 64(11), 1560-1569. doi: 10.1111/j.2042-7158.2012.01535.x

Journal - Research Article

Hook, S. M., Phipps-Green, A. J., Faiz, F., McNoe, L., McKinney, C., Hollis-Moffatt, J. E., & Merriman, T. R. (2011). Smad2: A candidate gene for the murine autoimmune diabetes locus Idd21.1. Journal of Clinical Endocrinology & Metabolism, 96(12), E2072-E2077. doi: 10.1210/jc.2011-0463

Journal - Research Article

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2011). Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics, 408(1-2), 20-26. doi: 10.1016/j.ijpharm.2011.01.037

Journal - Research Article

Rizwan, S. B., Assmus, D., Boehnke, A., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2011). Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. European Journal of Pharmaceutics & Biopharmaceutics, 79(1), 15-22. doi: 10.1016/j.ejpb.2010.12.034

Journal - Research Article

Gordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., & Hook, S. (2010). In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences, 41(2), 360-368. doi: 10.1016/j.ejps.2010.07.004

Journal - Research Article

Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery, 7(10), 1133-1144. doi: 10.1517/17425247.2010.515584

Journal - Research Article

Braund, R., Hook, S. M., Greenhill, N., & Medlicott, N. J. (2009). Distribution of fibroblast growth factor-2 (FGF-2) within model excisional wounds following topical application. Journal of Pharmacy & Pharmacology, 61(2), 193-200. doi: 10.1211/jpp/61.02.0008

Journal - Research Article

Daines, A. M., Greatrex, B. W., Hayman, C. M., Hook, S. M., McBurney, W. T., Rades, T., … Sims, I. M. (2009). Mannosylated saponins based on oleanolic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems. Bioorganic & Medicinal Chemistry, 17(14), 5207-5218. doi: 10.1016/j.bmc.2009.05.043

Journal - Research Article

Ferderber, K., Hook, S., & Rades, T. (2009). Phosphatidyl choline-based colloidal systems for dermal and transdermal drug delivery. Journal of Liposome Research, 19(4), 267-277. doi: 10.3109/08982100902814006

Journal - Research Article

Graf, A., Rades, T., & Hook, S. M. (2009). Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation. European Journal of Pharmaceutical Sciences, 37(1), 53-61. doi: 10.1016/j.ejps.2008.12.017

Journal - Research Article

Greatrex, B. W., Brodie, S. J., Furneaux, R. H., Hook, S. M., McBurney, W. T., Painter, G. F., Rades, T., & Rendle, P. M. (2009). The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers. Tetrahedron, 65(15), 2939-2950. doi: 10.1016/j.tet.2009.02.018

Journal - Research Article

Myschik, J., Rades, T., & Hook, S. (2009). Advances in lipid-based subunit vaccine formulations. Current Immunology Reviews, 5(1), 42-48.

Journal - Research Article

Rizwan, S. B., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2009). Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: Characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98(11), 4191-4204. doi: 10.1002/jps.21724

Journal - Research Article

Gordon, S., Saupe, A., McBurney, W., Rades, T., & Hook, S. (2008). Comparison of chitosan nanoparticles and chitosan hydrogels for vaccine delivery. Journal of Pharmacy & Pharmacology, 60, 1591-1600. doi: 10.1211/jpp/60.12.0004

Journal - Research Article

Graf, A., Ablinger, E., Peters, S., Zimmer, A., Hook, S., & Rades, T. (2008). Microemulsions containing lecithin and sugar-based surfactants: Nanoparticle templates for delivery of proteins and peptides. International Journal of Pharmaceutics, 350, 351-360. doi: 10.1016/j.ijpharm.2007.08.053

Journal - Research Article

Graf, A., Jack, K. S., Whittaker, A. K., Hook, S. M., & Rades, T. (2008). Protein delivery using nanoparticles based on microemulsions with different structure-types. European Journal of Pharmaceutical Sciences, 33, 434-444.

Journal - Research Article

McBurney, W. T., Lendemans, D. G., Myschik, J., Hennessy, T., Rades, T., & Hook, S. (2008). In vivo activity of cationic immune stimulating complexes (PLUSCOMs). Vaccine, 26, 4549-4556. doi: 10.1016/j.vaccine.2008.06.024

Journal - Research Article

Myschik, J., Eberhardt, F., Rades, T., & Hook, S. (2008). Immunostimulatory biodegradable implants containing the adjuvant Quil-A - Part I: Physicochemical characterisation. Journal of Drug Targeting, 16(3), 213-223. doi: 10.1080/10611860701848860

Journal - Research Article

Myschik, J., McBurney, W. T., Hennessy, T., Phipps-Green, A., Rades, T., & Hook, S. (2008). Immunostimulatory biodegradable implants containing the adjuvant Quil-A - Part II: In vivo evaluation. Journal of Drug Targeting, 16(3), 224-232. doi: 10.1080/10611860701848886

Journal - Research Article

Myschik, J., McBurney, W. T., Hennessy, T., Rades, T., & Hook, S. (2008). Immunogenicity of lipid sustained release implants containing imiquimod, α-galactosylceramide, or Quil-A. Pharmazie, 63(9), 686-692. doi: 10.1691/ph.2008.8072

Journal - Research Article

Myschik, J., McBurney, W. T., Rades, T., & Hook, S. (2008). Immunostimulatory lipid implants containing Quil-A and DC-cholesterol. International Journal of Pharmaceutics, 363, 91-98. doi: 10.1016/j.ijpharm.2008.07.014

Journal - Research Article

Boyd, B. J., Rizwan, S. B., Dong, Y.-D., Hook, S., & Rades, T. (2007). Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: Hexosomes are not necessarily flat hexagonal prisms. Langmuir, 23(25), 12461-12464. doi: 10.1021/la7029714

Journal - Research Article

Braund, R., Hook, S., & Medlicott, N. J. (2007). The role of topical growth factors in chronic wounds. Current Drug Delivery, 4(3), 195-204. doi: 10.2174/156720107781023857

Journal - Research Article

Demana, P. H., Davies, N. M., Hook, S., & Rades, T. (2007). Analysis of Quil A-phospholipid mixtures using drift spectroscopy. International Journal of Pharmaceutics, 342, 49-61.

Journal - Research Article

Krauel, K., Girvan, L., Hook, S., & Rades, T. (2007). Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. Micron, 38, 796-803.

Journal - Research Article

Lendemans, D. G., Egert, A. M., Hook, S., & Rades, T. (2007). Cage-like complexes formed by DOTAP, Quil-A and cholesterol. International Journal of Pharmaceutics, 332, 192-195.

Journal - Research Article

Rizwan, S. B., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2007). Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM). Micron, 38, 478-485. doi: 10.1016/j.micron.2006.08.003

Journal - Research Article

Grimwood, K., Huang, Q. S., Cohet, C., Gosling, I. A., Hook, S. M., Teele, D. W., … Leadbitter, P., & Lennon, D. R. (2006). Rotavirus hospitalisation in New Zealand children under 3 years of age. Journal of Paediatrics & Child Health, 42(4), 196-203. doi: 10.1111/j.1440-1754.2006.00829.x

Journal - Research Article

Krauel, K., Graf, A., Hook, S. M., Davies, N. M., & Rades, T. (2006). Preparation of poly (alkylcyanoacrylate) nanoparticles by polymerization of water-free microemulsions. Journal of Microencapsulation, 23(5), 499-512.

Journal - Research Article

Lendemans, D. G., Egert, A. M., Myschik, J., Hook, S., & Rades, T. (2006). On the dilution behaviour of immuno-stimulating complexes (ISCOMs). Pharmazie, 61(8), 689-695.

Journal - Research Article

Myschik, J., Lendemans, D. G., McBurney, W. T., Demana, P. H., Hook, S., & Rades, T. (2006). On the preparation, microscopic investigation and application of ISCOMs. Micron, 37, 724-734.

Journal - Research Article

Saupe, A., McBurney, W., Rades, T., & Hook, S. (2006). Immunostimulatory colloidal delivery systems for cancer vaccines. Expert Opinion on Drug Delivery, 3(3), 345-354.

Journal - Research Article

Weir, C., McNeill, A., Hook, S., Harvie, M., La Flamme, A. C., Le Gros, G., & Bäckström, B. T. (2006). Critical role of preproenkephalin in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 179, 18-25.

Journal - Research Article

White, K. L., Rades, T., Furneaux, R. H., Tyler, P. C., & Hook, S. (2006). Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells. Journal of Pharmacy & Pharmacology, 58, 729-737.

Journal - Research Article

White, K., Rades, T., Kearns, P., Toth, I., & Hook, S. (2006). Immunogenicity of liposomes containing lipid core peptides and the adjuvant Quil A. Pharmaceutical Research, 23(7), 1473-1481.

Journal - Research Article

Armstrong, D. S., Hook, S. M., Jamsen, K. M., Nixon, G. M., Carzino, R., Carlin, J. B., … Grimwood, K. (2005). Lower airway inflammation in infants with cystic fibrosis detected by newborn screening. Pediatric Pulmonology, 40, 500-510.

Journal - Research Article

Chen, Y. E., Beasley, S., Grimwood, K., and the New Zealand Rotavirus Study Group, including Hook, S. (2005). Intussusception and rotavirus associated hospitalisation in New Zealand. Archives of Disease in Childhood, 90, 1077-1081. doi: 10.1136/adc.2005.074104

Journal - Research Article

Demana, P. H., Davies, N. M., Hook, S., & Rades, T. (2005). Quil A-lipid powder formulations releasing ISCOMs and related colloidal stuctures upon hydration. Journal of Controlled Release, 103, 45-59.

Journal - Research Article

Hollis-Moffatt, J. E., Hook, S. M., & Merriman, T. R. (2005). Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IddM6 (Human) and Iddm3 (Rat) [Brief Genetics Report]. Diabetes, 54, 2820-2825.

Journal - Research Article

Hook, S., Chan, L., Cutfield, H., Dean, R., Keir, A., Gordon, G., & Norris, P. (2005). Immunisation knowledge and beliefs of health science and non-health science students at the University of Otago. New Zealand Family Physician, 32(6), 394-398.

Journal - Research Article

Krauel, K., Davies, N. M., Hook, S., & Rades, T. (2005). Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization. Journal of Controlled Release, 106(1-2), 76-87. doi: 10.1016/j.jconrel.2005.04.013

Journal - Research Article

Lendemans, D. G., Myschik, J., Hook, S., & Rades, T. (2005). Cationic cage-like complexes formed by DC-cholestrol, Quil-A, and phospholipid. Journal of Pharmaceutical Sciences, 94(8), 1794-1807.

Journal - Research Article

Lendemans, D. G., Myschik, J., Hook, S., & Rades, T. (2005). Immuno-stimulating complexes prepared by ethanol injection. Journal of Pharmacy & Pharmacology, 57, 729-733.

Journal - Research Article

Demana, P. H., Fehske, C., White, K., Rades, T., & Hook, S. (2004). Effect of incorporation of the adjuvant Quil A on structure and immune stimulatory capacity of liposomes. Immunology & Cell Biology, 82, 547-554.

Journal - Research Article

Marsland, B. J., Harris, N. L., Camberis, M., Kopf, M., Hook, S. M., & Le Gros, G. (2004). Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells. PNAS, 101(16), 6116-6121.

Journal - Research Article

White, K., Kearns, P., Toth, I., & Hook, S. (2004). Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides. Immunology & Cell Biology, 82, 517-522. doi: 10.1111/j.0818-9641.2004.01269.x

Journal - Research Article

Hook, S. M., Camberis, M., Prout, M., & Le Gros, G. (2003). Absence of preproenkephalin increases the threshold for T cell activation. Journal of Neuroimmunology, 140, 61-68.

Journal - Research Article

Hook, S. M., & Le Gros, G. (2002). Immunomodulatory effects of preproenkephalin. Current Opinions in European Medicine, 3, 68-80.

Journal - Research Article

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