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Health Sciences profile

Diane Guévremont

PositionScientific Officer
DepartmentDepartment of Anatomy
QualificationsBSc(McGill)
Research summaryMolecular Neuroscience
MembershipsNeurological Research Committee

Research

I work in Dr Joanna Williams' lab identifying biomarkers within plasma which may be predictive of neurological diseases like Alzheimer's.

Additional details

I am the curator of our blood archive (Alzheimer’s Disease, Parkinson and Control human participants). I have a lot of experience in the following methodologies: protein isolation, protein synthesis assays, Western blotting, genotyping, RNA isolation and qPCR miRNA/mRNA arrays, bioinformatics and statistical analyses.

Publications

Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022). Plasma microRNA vary in association with the progression of Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, e12251. doi: 10.1002/dad2.12251

Potemkin, N., Cawood, S. M. F., Treece, J., Guévremont, D., Rand, C. J., McLean, C., Stanton, J.-A. L., & Williams, J. M. (2022). A method for simultaneous detection of small and long RNA biotypes by ribodepleted RNA-Seq. Scientific Reports, 12(621). doi: 10.1038/s41598-021-04209-4

Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757

Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385

Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022). Plasma microRNA vary in association with the progression of Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, e12251. doi: 10.1002/dad2.12251

Journal - Research Article

Potemkin, N., Cawood, S. M. F., Treece, J., Guévremont, D., Rand, C. J., McLean, C., Stanton, J.-A. L., & Williams, J. M. (2022). A method for simultaneous detection of small and long RNA biotypes by ribodepleted RNA-Seq. Scientific Reports, 12(621). doi: 10.1038/s41598-021-04209-4

Journal - Research Article

Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757

Journal - Research Article

Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019

Journal - Research Article

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385

Journal - Research Article

Ryan, M. M., Guévremont, D., Luxmanan, C., Abraham, W. C., & Williams, J. M. (2015). Aging alters long-term potentiation—related gene networks and impairs synaptic protein synthesis in the rat hippocampus. Neurobiology of Aging, 36(5), 1868-1880. doi: 10.1016/j.neurobiolaging.2015.01.012

Journal - Research Article

Smith, C. C., Guévremont, D., Williams, J. M., & Napper, R. M. A. (2015). Apoptotic cell death and temporal expression of apoptotic proteins Bcl-2 and Bax in the hippocampus, following binge ethanol in the neonatal rat model. Alcoholism, 39(1), 36-44. doi: 10.1111/acer.12606

Journal - Research Article

Joilin, G., Guévremont, D., Ryan, B., Claudianos, C., Cristino, A. S., Abraham, W. C., & Williams, J. M. (2014). Rapid regulation of microRNA following induction of long-term potentiation in vivo. Frontiers in Molecular Neuroscience, 7, 98. doi: 10.3389/fnmol.2014.00098

Journal - Research Article

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2014). Redistribution of ionotropic glutamate receptors detected by laser microdissection of the rat dentate gyrus 48 h following LTP induction in vivo. PLoS ONE, 9(3), e92972. doi: 10.1371/journal.pone.0092972

Journal - Research Article

Trotman, M., Barad, Z., Guévremont, D., Williams, J., & Leitch, B. (2014). Changes in the GRIP 1&2 scaffolding proteins in the cerebellum of the ataxic stargazer mouse. Brain Research, 1546, 53-62. doi: 10.1016/j.brainres.2013.12.027

Journal - Research Article

Eckert, M. J., Guévremont, D., Williams, J. M., & Abraham, W. C. (2013). Rapid visual stimulation increases extrasynaptic glutamate receptor expression but not visual-evoked potentials in the adult rat primary visual cortex. European Journal of Neuroscience, 37(3), 400-406. doi: 10.1111/ejn.12053

Journal - Research Article

Mockett, B. G., Guévremont, D., Wutte, M., Hulme, S. R., Williams, J. M., & Abraham, W. C. (2011). Calcium/calmodulin-dependent protein kinase II mediates Group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. Journal of Neuroscience, 31(20), 7380-7391. doi: 10.1523/JNEUROSCI.6656-10.2011

Journal - Research Article

Tenorio, G., Connor, S. A., Guévremont, D., Abraham, W. C., Williams, J., O'Dell, T. J., & Nguyen, P. V. (2010). 'Silent' priming of translation-dependent LTP by β-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors. Learning & Memory, 17(12), 627-638. doi: 10.1101/lm.1974510

Journal - Research Article

Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040

Journal - Research Article

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2009). Increased expression, but not postsynaptic localisation, of ionotropic glutamate receptors during the late-phase of long-term potentiation in the dentate gyrus in vivo. Neuropharmacology, 56(1), 66-72. doi: 10.1016/j.neuropharm.2008.07.044

Journal - Research Article

Leitch, B., Shevtsova, O., Guévremont, D., & Williams, J. (2009). Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse. Brain Research, 1279, 156-167. doi: 10.1016/j.brainres.2009.04.051

Journal - Research Article

Mockett, B. G., Guévremont, D., Williams, J. M., & Abraham, W. C. (2007). Dopamine D1/D5 receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampus. Journal of Neuroscience, 27(11), 2918-2926. doi: 10.1523/JNEUROSCI.0838-06.2007

Journal - Research Article

Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.

Journal - Research Article

Ireland, D. R., Guévremont, D., Williams, J. M., & Abraham, W. C. (2004). Metabotropic glutamate receptor-mediated depression of the slow afterhyperpolarization is gated by tyrosine phosphatases in hippocampal CA1 pyramidal neurons. Journal of Neurophysiology, 92, 2811-2819.

Journal - Research Article

Williams, J. M., Guévremont, D., Kennard, J. T. T., Mason-Parker, S. E., Tate, W. P., & Abraham, W. C. (2003). Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Neuroscience, 118, 1003-1013.

Journal - Research Article

Mansell, J. B., Guevremont, D., Poole, E. S., & Tate, W. P. (2001). A dynamic competition between release factor 2 and the tRNASec decoding UGA at the recoding site of Escherichia coli formate dehydrogenase H. EMBO Journal, 20, 7284-7293.

Journal - Research Article

Askarian-Amiri, M. E., Pel, H. J., Guevremont, D., McCaughan, K. K., Poole, E. S., Sumpter, V. G., & Tate, W. P. (2000). Functional characterization of yeast mitochondrial release factor 1. Journal of Biological Chemistry, 275, 17241-17248.

Journal - Research Article

Wilson, D. N., Guevremont, D., & Tate, W. P. (2000). The ribosomal binding and peptidyl-tRNA hydrolysis functions of Escherichia coli release factor 2 are linked through residue 246. RNA, 6, 1-10.

Journal - Research Article

Highton, J., Guevremont, D., Carlisle, B. H., & Tucker, I. G. (1999). A trial of clodronate-liposomes as anti-macrophage treatment in a sheep model of arthritis. Clinical & Experimental Rheumatology, 17(1), 43-48.

Journal - Research Article

Highton, J., Guevremont, D., Schofield, J. C., Schofield, L., & Cross, J. P. (1997). Antigen-induced (Dumonde Glynn) arthritis in the sheep: A large joint animal model of arthritis. Clinical & Experimental Rheumatology, 15(1), 25-31.

Journal - Research Article

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