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Health Sciences profile

Dr Sunali Mehta

PositionSenior Research Fellow
DepartmentDepartment of Pathology (Dunedin)
Research summaryCancer research

Research

Current research interests include:

Publications

Mehta, S., Wright, D., Black, M. A., Merrie, A., Anjomshoaa, A., Munro, F., Reeve, A., McCall, J., & Print, C. (2022). Impact of clinical data veracity on cancer genomic research. JNCI Cancer Spectrum. doi: 10.1093/jncics/pkac070

Shields, N. J., Peyroux, E. M., Campbell, K., Mehta, S., Woolley, A. G., Counoupas, C., Neumann, S., & Young, S. L. (2022). Calpains released from necrotic tumor cells enhance antigen cross-presentation to activate CD8+ T cells in vitro. Journal of Immunology. Advance online publication. doi: 10.4049/jimmunol.2100500

Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394

Nezbedova, L., McGhie, T., Christensen, M., Heyes, J., Ahmed Nasef, N., & Mehta, S. (2021). Onco-preventive and chemo-protective effects of apple bioactive compounds. Nutrients, 13(11), 4025. doi: 10.3390/nu13114025

Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085

Mehta, S., Wright, D., Black, M. A., Merrie, A., Anjomshoaa, A., Munro, F., Reeve, A., McCall, J., & Print, C. (2022). Impact of clinical data veracity on cancer genomic research. JNCI Cancer Spectrum. doi: 10.1093/jncics/pkac070

Journal - Research Article

Shields, N. J., Peyroux, E. M., Campbell, K., Mehta, S., Woolley, A. G., Counoupas, C., Neumann, S., & Young, S. L. (2022). Calpains released from necrotic tumor cells enhance antigen cross-presentation to activate CD8+ T cells in vitro. Journal of Immunology. Advance online publication. doi: 10.4049/jimmunol.2100500

Journal - Research Article

Ali, A., Mehta, S., Starck, C., Wong, M., O'Brien, W. J., Haswell, C., … Nasef, N. A. (2021). Effect of SunGold kiwifruit and vitamin C consumption on ameliorating exercise-induced stress response in women. Molecular Nutrition & Food Research, 65, 2001219. doi: 10.1002/mnfr.202001219

Journal - Research Article

Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2

Journal - Research Article

Hong, C. R., Mehta, S. Y., Liyanage, H. D. S., McManaway, S. P., Lee, H. H., Jaiswal, J. K., … Hicks, K. O. (2021). Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug. Cancer Chemotherapy & Pharmacology, 88, 673-687. doi: 10.1007/s00280-021-04320-3

Journal - Research Article

Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G. (2021). Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays. Cancers, 13(7), 1531. doi: 10.3390/cancers13071531

Journal - Research Article

McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540

Journal - Research Article

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Journal - Research Article

Lasham, A., Fitzgerald, S. J., Knowlton, N., Robb, T., Tsai, P., Black, M. A., … Mehta, S. Y., Harris, G., … Print, C. G. (2020). A predictor of early disease recurrence in patients with breast cancer using a cell-free RNA and protein liquid biopsy. Clinical Breast Cancer, 20(2), 108-116. doi: 10.1016/j.clbc.2019.07.003

Journal - Research Article

Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G. (2020). Accessing a new dimension in TP53 biology: Multiplex long amplicon digital PCR to specifically detect and quantitate individual TP53 transcripts. Cancers, 12(3), 769. doi: 10.3390/cancers12030769

Journal - Research Article

Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473

Journal - Research Article

Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315

Journal - Research Article

Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Journal - Research Article

Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0

Journal - Research Article

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Journal - Research Article

Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635

Journal - Research Article

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Journal - Research Article

Tercel, M., Lee, H. H., Mehta, S. Y., Tendoung, J.-J. Y., Bai, S. Y., Liyanage, H. D. S., & Pruijn, F. B. (2017). Influence of a basic side chain on the properties of hypoxia-selective nitro analogues of the duocarmycins: Demonstration of substantial anticancer activity in combination with irradiation or chemotherapy. Journal of Medicinal Chemistry, 60(13), 5834-5856. doi: 10.1021/acs.jmedchem.7b00563

Journal - Research Article

Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137

Journal - Research Article

Mehta, S., Tsai, P., Lasham, A., Campbell, H., Reddel, R., Braithwaite, A., & Print, C. (2016). A study of TP53 RNA splicing illustrates pitfalls of RNA-seq methodology. Cancer Research, 76(24), 7151-7159. doi: 10.1158/0008-5472.can-16-1624

Journal - Research Article

Nasef, N. A., Mehta, S., Powell, P., Marlow, G., Wileman, T., & Ferguson, L. R. (2015). Extracts of feijoa inhibit toll-like receptor 2 signaling and activate autophagy implicating a role in dietary control of IBD. PLoS ONE, 10(6), e0130910. doi: 10.1371/journal.pone.0130910

Journal - Research Article

Nasef, N. A., Mehta, S., & Ferguson, L. R. (2014). Dietary interventions with the bacterial sensing machinery in the intestine: The plant polyphenol case. Frontiers in Genetics, 5, 64. doi: 10.3389/fgene.2014.00064

Journal - Research Article

Nasef, N. A., Mehta, S., Murray, P., Marlow, G., & Ferguson, L. R. (2014). Anti-inflammatory activity of fruit fractions in vitro, mediated through toll-like receptor 4 and 2 in the context of inflammatory bowel disease. Nutrients, 6(11), 5265-5279. doi: 10.3390/nu6115265

Journal - Research Article

Richter, S., Richter, J. P., Mehta, S. Y., Gribble, A. M., Sutherland-Smith, A. J., Stowell, K. M., … Wilson, W. R. (2012). Expression and role in glycolysis of human ADP-dependent glucokinase. Molecular & Cellular Biochemistry, 364(1), 131-145. doi: 10.1007/s11010-011-1212-8

Journal - Research Article

Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394

Journal - Research Other

Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085

Journal - Research Other

Nezbedova, L., McGhie, T., Christensen, M., Heyes, J., Ahmed Nasef, N., & Mehta, S. (2021). Onco-preventive and chemo-protective effects of apple bioactive compounds. Nutrients, 13(11), 4025. doi: 10.3390/nu13114025

Journal - Research Other

Ahmed Nasef, N., & Mehta, S. (2020). Role of inflammation in pathophysiology of colonic disease: An update. International Journal of Molecular Sciences, 21(13), 4748. doi: 10.3390/ijms21134748

Journal - Research Other

Nasef, N. A., Mehta, S., & Ferguson, L. R. (2017). Susceptibility to chronic inflammation: An update. Archives of Toxicology, 9(3), 1131-1141. doi: 10.1007/s00204-016-1914-5

Journal - Research Other

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