Dr Clint Gray
Position | Senior Research Fellow |
---|---|
Department | Department of Paediatrics and Child Health (Wellington) |
Research summary | Prematurity; cardiovascular risk |
Research
Dr Gray's current research projects involve using pressure myography to examine preterm vascular function in offspring and placenta. He is also working on projects looking at the effects of maternal diet on the uterine environment, blastocyst development, microRNA and gene expression. Utilising Proteomics and metabolomics he is also looking at the effects of preterm birth on liver function and the effects of maternal fructose (sugar-sweetened beverage) consumption on offspring liver development and predisposition to NAFLD.Publications
Sixtus, R. P., Gray, C., Berry, M. J., & Dyson, R. M. (2023). Preterm-born individuals: A vulnerable population at risk of cardiovascular morbidity and mortality during thermal extremes? [Review]. Experimental Physiology. Advance online publication. doi: 10.1113/ep091152
Sixtus, R. P., Berry, M. J., Gray, C. L., & Dyson, R. M. (2023). A novel whole-body thermal stress test for monitoring cardiovascular responses in Guinea pigs. Journal of Thermal Biology. Advance online publication. doi: 10.1016/j.jtherbio.2023.103500
Smith, E. V. L. R., Dyson, R. M., Weth, F. R., Berry, M. J., & Gray, C. (2022). Maternal fructose intake, programmed mitochondrial function and predisposition to adult disease. International Journal of Molecular Sciences, 23, 12215. doi: 10.3390/ijms232012215
Saito-Benz, M., Bennington, K., Gray, C. L., Murphy, W. G., Flanagan, P., Steiner, F., … Berry, M. J. (2022). Effects of freshly irradiated vs irradiated and stored red blood cell transfusion on cerebral oxygenation in preterm infants: A randomized clinical trial. JAMA Pediatrics. Advance online publication. doi: 10.1001/jamapediatrics.2022.0152
Smith, E. V. L. R., Dyson, R. M., Vanderboor, C. M. G., Sarr, O., Anderson, J., Berry, M. J., … Gray, C. (2022). Maternal fructose intake causes developmental reprogramming of hepatic mitochondrial catalytic activity and lipid metabolism in weanling and young adult offspring. International Journal of Molecular Sciences, 23, 999. doi: 10.3390/ijms23020999
Sixtus, R. P., Berry, M. J., Gray, C. L., & Dyson, R. M. (2023). A novel whole-body thermal stress test for monitoring cardiovascular responses in Guinea pigs. Journal of Thermal Biology. Advance online publication. doi: 10.1016/j.jtherbio.2023.103500
Journal - Research Article
Sixtus, R. P., Gray, C., Berry, M. J., & Dyson, R. M. (2023). Preterm-born individuals: A vulnerable population at risk of cardiovascular morbidity and mortality during thermal extremes? [Review]. Experimental Physiology. Advance online publication. doi: 10.1113/ep091152
Journal - Research Article
Saito-Benz, M., Bennington, K., Gray, C. L., Murphy, W. G., Flanagan, P., Steiner, F., … Berry, M. J. (2022). Effects of freshly irradiated vs irradiated and stored red blood cell transfusion on cerebral oxygenation in preterm infants: A randomized clinical trial. JAMA Pediatrics. Advance online publication. doi: 10.1001/jamapediatrics.2022.0152
Journal - Research Article
Smith, E. V. L. R., Dyson, R. M., Vanderboor, C. M. G., Sarr, O., Anderson, J., Berry, M. J., … Gray, C. (2022). Maternal fructose intake causes developmental reprogramming of hepatic mitochondrial catalytic activity and lipid metabolism in weanling and young adult offspring. International Journal of Molecular Sciences, 23, 999. doi: 10.3390/ijms23020999
Journal - Research Article
Sixtus, R. P., Gray, C., Berry, M. J., & Dyson, R. M. (2021). Nitrous oxide improves cardiovascular, respiratory, and thermal stability during prolonged isoflurane anesthesia in juvenile guinea pigs. Pharmacology Research & Perspectives, 9, e00713. doi: 10.1002/prp2.713
Journal - Research Article
Sixtus, R. P., Pacharinsak, C., Gray, C. L., Berry, M. J., & Dyson, R. M. (2021). Differential effects of four intramuscular sedatives on cardiorespiratory stability in juvenile guinea pigs (Cavia porcellus). PLoS ONE, 16(11), e0259559. doi: 10.1371/journal.pone.0259559
Journal - Research Article
Smith, E. V. L. R., Dyson, R. M., Berry, M. J., & Gray, C. (2020). Fructose consumption during pregnancy influences milk lipid composition and offspring lipid profiles in guinea pigs. Frontiers in Endocrinology, 11, 550. doi: 10.3389/fendo.2020.00550
Journal - Research Article
Soo, J. Y., Wiese, M. D., Dyson, R. M., Gray, C. L., Clarkson, A. N., Morrison, J. L., & Berry, M. J. (2020). Methamphetamine administration increases hepatic CYP1A2 but not CYP3A activity in female guinea pigs. PLoS ONE, 15(5), e0233010. doi: 10.1371/journal.pone.0233010
Journal - Research Article
Fan, J.-L., O'Donnell, T., Gray, C. L., Croft, K., Noakes, A. K., Koch, H., & Tzeng, Y.-C. (2019). Dietary nitrate supplementation enhances cerebrovascular CO2 reactivity in a sex-specific manner. Journal of Applied Physiology, 127, 760-769. doi: 10.1152/japplphysiol.01116.2018
Journal - Research Article
Shaw, J. C., Dyson, R. M., Palliser, H. K., Gray, C., Berry, M. J., & Hirst, J. J. (2019). Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs. Pediatric Research, 85, 86-96. doi: 10.1038/s41390-018-0185-7
Journal - Research Article
Morrison, J. L., Botting, K. J., Darby, J. R. T., David, A. L., Dyson, R. M., Gatford, K. L., Gray, C., … Berry, M. J. (2018). Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic. Journal of Physiology, 596(23), 5535-5569. doi: 10.1113/JP274948
Journal - Research Article
Albert, B. B., Vickers, M. H., Gray, C., Reynolds, C. M., Segovia, S. A., Derraik, J. G. B., … Cutfield, W. S. (2017). Fish oil supplementation to rats fed high-fat diet during pregnancy prevents development of impaired insulin sensitivity in male adult offspring. Scientific Reports, 7, 5595. doi: 10.1038/s41598-017-05793-0
Journal - Research Article
Berry, M. J., Saito-Benz, M., Gray, C., Dyson, R. M., Dellabarca, P., Ebmeier, S., … Elder, D. E., & Richardson, V. F. (2017). Outcomes of 23- and 24-weeks gestation infants in Wellington, New Zealand: A single centre experience. Scientific Reports, 7, 12769. doi: 10.1038/s41598-017-12911-5
Journal - Research Article
Gray, C., McCowan, L. M., Patel, R., Taylor, R. S., & Vickers, M. H. (2017). Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: A pilot study. Scientific Reports, 7, 815. doi: 10.1038/s41598-017-00713-8
Journal - Research Article
Segovia, S. A., Vickers, M. H., Gray, C., Zhang, X., & Reynolds, C. M. (2017). Conjugated linoleic acid supplementation improves maternal high fat diet-induced programming of metabolic dysfunction in adult male rat offspring. Scientific Reports, 7, 6663. doi: 10.1038/s41598-017-07108-9
Journal - Research Article
Albert, B. B., Vickers, M. H., Gray, C., Reynolds, C. M., Segovia, S. A., Derraik, J. G. B., … Cutfield, W. S. (2016). Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 311(3), R497-R504. doi: 10.1152/ajpregu.00005.2016
Journal - Research Article
Gray, C., Gardiner, S. M., Elmes, M., & Gardner, D. S. (2016). Excess maternal salt or fructose intake programmes sex-specific, stress- and fructose-sensitive hypertension in the offspring. British Journal of Nutrition, 115(4), 594-604. doi: 10.1017/S0007114515004936
Journal - Research Article
Mumme, K., Gray, C., Reynolds, C. M., Vickers, M. H., Harrison, C. J., Stanley, J. L., … Sulek, K. (2016). Maternal-fetal hepatic and placental metabolome profiles are associated with reduced fetal growth in a rat model of maternal obesity. Metabolomics, 12(5), 83. doi: 10.1007/s11306-016-1014-9
Journal - Research Article
Pileggi, C. A., Hedges, C. P., Segovia, S. A., Markworth, J. F., Durainayagam, B. R., Gray, C., … Cameron-Smith, D. (2016). Maternal high fat diet alters skeletal muscle mitochondrial catalytic activity in adult male rat offspring. Frontiers in Physiology, 7, 546. doi: 10.3389/fphys.2016.00546
Journal - Research Article
Pileggi, C. A., Segovia, S. A., Markworth, J. F., Gray, C., Zhang, X. D., Milan, A. M., … Roy, N. C., … Cameron-Smith, D. (2016). Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 310(5), R432-R439. doi: 10.1152/ajpregu.00351.2015
Journal - Research Article
Berry, M., Gray, C., Wright, K., Dyson, R., & Wright, I. (2015). Premature guinea pigs: A new paradigm to investigate the late-effects of preterm birth. Journal of Developmental Origins of Health & Disease, 6(2), 143-148. doi: 10.1017/S2040174414000592
Journal - Research Article
Gray, C., Harrison, C. J., Segovia, S. A., Reynolds, C. M., & Vickers, M. H. (2015). Maternal salt and fat intake causes hypertension and sustained endothelial dysfunction in fetal, weanling and adult male resistance vessels. Scientific Reports, 5, 09753. doi: 10.1038/srep09753
Journal - Research Article
Gray, C., Vickers, M. H., Dyson, R. M., Reynolds, C. M., & Berry, M. J. (2015). Magnesium sulfate has sex-specific, dose-dependent vasodilator effects on preterm placental vessels. Biology of Sex Differences, 6, 22. doi: 10.1186/s13293-015-0040-z
Journal - Research Article
Gray, C., Vickers, M. H., Segovia, S. A., Zhang, X. D., & Reynolds, C. M. (2015). A maternal high fat diet programmes endothelial function and cardiovascular status in adult male offspring independent of body weight, which is reversed by maternal conjugated linoleic acid (CLA) supplementation. PLoS ONE, 10(2), e0115994. doi: 10.1371/journal.pone.0115994
Journal - Research Article
Li, M., Reynolds, C. M., Gray, C., & Vickers, M. H. (2015). Preweaning GH treatment normalizes body growth trajectory and reverses metabolic dysregulation in adult offspring after maternal undernutrition. Endocrinology, 156(9), 3228-3238. doi: 10.1210/en.2015-1041
Journal - Research Article
Li, M., Reynolds, C. M., Segovia, S. A., Gray, C., & Vickers, M. H. (2015). Developmental programming of nonalcoholic fatty liver disease: The effect of early life nutrition on susceptibility and disease severity in later life. BioMed Research International, 2015, 437107. doi: 10.1155/2015/437107
Journal - Research Article
Li, M., Reynolds, C. M., Sloboda, D. M., Gray, C., & Vickers, M. H. (2015). Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring. Journal of Nutritional Biochemistry, 26(3), 267-276. doi: 10.1016/j.jnutbio.2014.10.015
Journal - Research Article
Reynolds, C. M., Gray, C., Li, M., Segovia, S. A., & Vickers, M. H. (2015). Early life nutrition and energy balance disorders in offspring in later life. Nutrients, 7(9), 8090-8111. doi: 10.3390/nu7095384
Journal - Research Article
Reynolds, C. M., Segovia, S. A., Zhang, X. D., Gray, C., & Vickers, M. H. (2015). Conjugated linoleic acid supplementation during pregnancy and lactation reduces maternal high-fat-diet-induced programming of early-onset puberty and hyperlipidemia in female rat offspring. Biology of Reproduction, 92(2), 40. doi: 10.1095/biolreprod.114.125047
Journal - Research Article
Reynolds, C. M., Segovia, S. A., Zhang, X. D., Gray, C., & Vickers, M. H. (2015). Maternal high-fat diet-induced programing of gut taste receptor and inflammatory gene expression in rat offspring is ameliorated by CLA supplementation. Physiological Reports, 3(10), e12588. doi: 10.14814/phy2.12588
Journal - Research Article
Reynolds, C. M., Vickers, M. H., Harrison, C. J., Segovia, S. A., & Gray, C. (2015). Maternal high fat and/or salt consumption induces sex‐specific inflammatory and nutrient transport in the rat placenta. Physiological Reports, 3(5), e12399. doi: 10.14814/phy2.12399
Journal - Research Article
Segovia, S. A., Vickers, M. H., Zhang, X. D., Gray, C., & Reynolds, C. M. (2015). Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring. Journal of Nutritional Biochemistry, 26(12), 1448-1457. doi: 10.1016/j.jnutbio.2015.07.013
Journal - Research Article
Gray, C., Li, M., Patel, R., Reynolds, C. M., & Vickers, M. H. (2014). Let-7 miRNA profiles are associated with the reversal of left ventricular hypertrophy and hypertension in adult male offspring from mothers undernourished during pregnancy after preweaning growth hormone treatment. Endocrinology, 155(12), 4808-4817. doi: 10.1210/en.2014-1567
Journal - Research Article
Reynolds, C. M., Li, M., Gray, C., & Vickers, M. H. (2014). Early-life growth hormone treatment to offspring of undernourished mothers alters metabolic parameters in primary adipocytes in adulthood. Growth Factors, 32(1), 34-40. doi: 10.3109/08977194.2013.870169
Journal - Research Article
Reynolds, C. M., Vickers, M. H., Harrison, C. J., Segovia, S. A., & Gray, C. (2014). High fat and/or high salt intake during pregnancy alters maternal meta-inflammation and offspring growth and metabolic profiles. Physiological Reports, 2(8), e12110. doi: 10.14814/phy2.12110
Journal - Research Article
Segovia, S. A., Vickers, M. H., Gray, C., & Reynolds, C. M. (2014). Maternal obesity, inflammation, and developmental programming. BioMed Research International, 2014, 418975. doi: 10.1155/2014/418975
Journal - Research Article
Gray, C., Al-Dujaili, E. A., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J. M., & Gardner, D. S. (2013). Excess maternal salt intake produces sex-specific hypertension in offspring: Putative roles for kidney and gastrointestinal sodium handling. PLoS ONE, 8(8), e72682. doi: 10.1371/journal.pone.0072682
Journal - Research Article
Gray, C., Li, M., Reynolds, C. M., & Vickers, M. H. (2013). Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy. PLoS ONE, 8(1), e53505. doi: 10.1371/journal.pone.0053505
Journal - Research Article
Gray, C., Long, S., Green, C., Gardiner, S. M., Craigon, J., & Gardner, D. S. (2013). Maternal fructose and/or salt intake and reproductive outcome in the rat: Effects on growth, fertility, sex ratio, and birth order. Biology of Reproduction, 89(3), 51. doi: 10.1095/biolreprod.113.109595
Journal - Research Article
Li, M., Reynolds, C. M., Sloboda, D. M., Gray, C., & Vickers, M. H. (2013). Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity. PLoS ONE, 8(10), e76961. doi: 10.1371/journal.pone.0076961
Journal - Research Article
Reynolds, C. M., Li, M., Gray, C., & Vickers, M. H. (2013). Pre-weaning growth hormone treatment ameliorates bone marrow macrophage inflammation in adult male rat offspring following maternal undernutrition. PLoS ONE, 8(7), e68262. doi: 10.1371/journal.pone.0068262
Journal - Research Article
Reynolds, C. M., Li, M., Gray, C., & Vickers, M. H. (2013). Preweaning growth hormone treatment ameliorates adipose tissue insulin resistance and inflammation in adult male offspring following maternal undernutrition. Endocrinology, 154(8), 2676-2686. doi: 10.1210/en.2013-1146
Journal - Research Article
Rhodes, P., Craigon, J., Gray, C., Rhind, S. M., Loughna, P. T., & Gardner, D. S. (2009). Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PLoS ONE, 4(10), e7393. doi: 10.1371/journal.pone.0007393
Journal - Research Article
Smith, E. V. L. R., Dyson, R. M., Weth, F. R., Berry, M. J., & Gray, C. (2022). Maternal fructose intake, programmed mitochondrial function and predisposition to adult disease. International Journal of Molecular Sciences, 23, 12215. doi: 10.3390/ijms232012215
Journal - Research Other
Saito-Benz, M., Gray, C., Tzeng, Y.-C., Atkinson, G., & Berry, M. J. (2019). Cerebral oxygenation and cardiorespiratory stability following liberal transfusion in preterm neonates [Brief report]. Acta Paediatrica, 108, 559-561. doi: 10.1111/apa.14631
Journal - Research Other
Morrison, J. L., Berry, M. J., Botting, K. J., Darby, J. R. T., Frasch, M. G., Gatford, K. L., … Gray, C. L., … Tellam, R. L. (2018). Improving pregnancy outcomes in humans through studies in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 315, R1123-R1153. doi: 10.1152/ajpregu.00391.2017
Journal - Research Other