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Health Sciences profile

Associate Professor Patries Herst

PositionAssociate Professor
DepartmentDepartment of Radiation Therapy (Wellington)
QualificationsMSc (Nijmegen) MPhil (Waik) PhD(Otago)
Research summaryCancer Treatment

Research

Patries leads a clinical cancer research platform consisting of a series of randomized controlled trials (5 completed RCTs and two RCTs in development) that investigate the management of acute radiation-induced side effects. Data collection is done primarily by qualified RTs as part of the BRT(Hons) in collaboration with radiation oncologists, charge RTs, staff RTs, oncology nurses and medical physicists. This research platform gives RTs the opportunity to take part in clinical research relevant to their profession, it has also put NZ at the forefront of world class research in radiation toxicities. The clinical trials have been funded by grants from UORG, FRST, Regional Divisions of the Cancer Society, Health Otago Charitable Trust and the Breast Cancer Foundation. Various companies have supplied free product.

Soft silicone dressings for skin reactions
Radiation-induced skin reactions are an unavoidable side effect of external beam radiation therapy, particularly in areas prone to friction and excess moisture such as the axilla, head and neck region, perineum and skin folds. Clinical studies investigating interventions for preventing or managing these reactions have largely focussed on formulations with moisturizing, anti-inflammatory, anti-microbial and wound healing properties. However, none of these interventions has emerged as a consistent candidate for best practice. We have conducted three RCTs in the last 5 years that have shown that preventing friction of radiation-damaged skin caused by items of clothing or other body parts is very successful in decreasing the severity of these skin reactions. Soft silicone dressings were shown to reduce skin reaction severity by 30-40% (Diggelmann et al, 2010; Paterson et al, 2012). The most recent trial reported that if a thin transparent silicone film is used from the very start of radiation treatment, this prevents severe skin reactions from developing altogether (Herst et al, 2014).

Honey for oral mucositis
Oral mucositis is an unavoidable side effect of radiation therapy to the head and neck. This painful condition adversely affects patients’ ability to speak and eat, often resulting in weight loss, and decreased quality of life. In extreme cases, treatment must be delayed to allow for healing; this may compromise local tumour control and thus patient survival. There is currently no gold standard for the prevention or treatment of oral mucositis. In contrast to previous honey trials in Malaysia, Egypt, Iran and India, diluted manuka honey did not decrease the extent and onset of radiation-induced oral mucositis (Parsons et al, 2012).

Cranberries for cystitis
Radiation induced cystitis is a sterile form of cystitis and is often experienced by men who receive radiation therapy for prostate cancer. A pilot study in Dunedin hospital showed that cranberry capsules were superior to placebo capsules in decreasing the incidence of cystitis as well as the pain associated with cystitis (manuscript in preparation)

Publications

Tang, J. S., Cait, A., Li, Y., Abolins-Thompson, H., Gell, K., Herst, P. M., … Gasser, O. (2021). Practical approach to explore the effects of polyphenols on aryl hydrocarbon receptor regulated immune function. Journal of Agricultural & Food Chemistry, 69, 8625-8633. doi: 10.1021/acs.jafc.1c02095

Grasso, C., Eccles, D. A., Boukalova, S., Fabre, M.-S., Dawson, R. H., Neuzil, J., Herst, P. M., & Berridge, M. V. (2020). Mitochondrial DNA affects the expression of nuclear genes involved in immune and stress responses in a breast cancer model. Frontiers in Physiology, 11, 543962. doi: 10.3389/fphys.2020.543962

Herst, P. M., Grasso, C., Fabre, M.-S., Boukalova, S., Ezrova, Z., Neuzil, J., & Berridge, M. V. (2020). A simple indirect colorimetric assay for measuring mitochondrial energy metabolism based on uncoupling sensitivity. Biochemistry & Biophysics Reports, 24, 100858. doi: 10.1016/j.bbrep.2020.100858

Berridge, M. V., Herst, P. M., & Grasso, C. (2020). Mitochondrial movement between mammalian cells: An emerging physiological phenomenon. In G. Gasparre & A. M. Porcelli (Eds.), The human mitochondrial genome: From basic biology to disease. (pp. 515-546). London, UK: Academic Press. doi: 10.1016/B978-0-12-819656-4.00020-6

Yan, J., Yuan, L., Wang, J., Li, S., Yao, M., Wang, K., & Herst, P. M. (2020). Mepitel Film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: A randomised intra-patient controlled clinical trial. Journal of Medical Radiation Sciences, 67(3), 208-216. doi: 10.1002/jmrs.397

Berridge, M. V., Herst, P. M., & Grasso, C. (2020). Mitochondrial movement between mammalian cells: An emerging physiological phenomenon. In G. Gasparre & A. M. Porcelli (Eds.), The human mitochondrial genome: From basic biology to disease. (pp. 515-546). London, UK: Academic Press. doi: 10.1016/B978-0-12-819656-4.00020-6

Chapter in Book - Research

Berridge, M. V., & Herst, P. M. (2015). Tumor cell complexity and metabolic flexibility in tumorigenesis and metastasis. In S. Mazurek & M. Shoshan (Eds.), Tumor cell metabolism: Pathways, regulation and biology. (pp. 23-43). Wien: Springer. doi: 10.1007/978-3-7091-1824-5

Chapter in Book - Research

Tang, J. S., Cait, A., Li, Y., Abolins-Thompson, H., Gell, K., Herst, P. M., … Gasser, O. (2021). Practical approach to explore the effects of polyphenols on aryl hydrocarbon receptor regulated immune function. Journal of Agricultural & Food Chemistry, 69, 8625-8633. doi: 10.1021/acs.jafc.1c02095

Journal - Research Article

Grasso, C., Eccles, D. A., Boukalova, S., Fabre, M.-S., Dawson, R. H., Neuzil, J., Herst, P. M., & Berridge, M. V. (2020). Mitochondrial DNA affects the expression of nuclear genes involved in immune and stress responses in a breast cancer model. Frontiers in Physiology, 11, 543962. doi: 10.3389/fphys.2020.543962

Journal - Research Article

Herst, P. M., Aumata, A., Sword, V., Jones, R., Purdie, G., & Costello, S. (2020). Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: A phase III double blinded randomised placebo controlled clinical trial. Radiotherapy & Oncology, 149, 117-123. doi: 10.1016/j.radonc.2020.05.006

Journal - Research Article

Herst, P. M., Grasso, C., Fabre, M.-S., Boukalova, S., Ezrova, Z., Neuzil, J., & Berridge, M. V. (2020). A simple indirect colorimetric assay for measuring mitochondrial energy metabolism based on uncoupling sensitivity. Biochemistry & Biophysics Reports, 24, 100858. doi: 10.1016/j.bbrep.2020.100858

Journal - Research Article

Yan, J., Yuan, L., Wang, J., Li, S., Yao, M., Wang, K., & Herst, P. M. (2020). Mepitel Film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: A randomised intra-patient controlled clinical trial. Journal of Medical Radiation Sciences, 67(3), 208-216. doi: 10.1002/jmrs.397

Journal - Research Article

Herst, P. M., Grasso, C., & Berridge, M. V. (2018). Metabolic reprogramming of mitochondrial respiration in metastatic cancer. Cancer & Metastasis Reviews, 37, 643-653. doi: 10.1007/s10555-018-9769-2

Journal - Research Article

Leong, A., Herst, P., & Kane, P. (2018). VERT, a virtual clinical environment, enhances understanding of radiation therapy planning concepts. Journal of Medical Radiation Sciences, 65(2), 97-105. doi: 10.1002/jmrs.272

Journal - Research Article

Moore, S. J., Herst, P. M., & Louwe, R. J. W. (2018). Review of the patient positioning reproducibility in head-and-neck radiotherapy using Statistical Process Control. Radiotherapy & Oncology, 127(2), 183-189. doi: 10.1016/j.radonc.2018.01.006

Journal - Research Article

Wooding, H., Yan, J., Yuan, L., Chyou, T.-Y., Gao, S., Ward, I., & Herst, P. M. (2018). The effect of Mepitel Film on acute radiation-induced skin reactions in head and neck cancer patients: A feasibility study. British Journal of Radiology, 91(1081), 20170298. doi: 10.1259/bjr.20170298

Journal - Research Article

Castro, M. L., Carson, G. M., McConnell, M. J., & Herst, P. M. (2017). High dose ascorbate causes both genotoxic and metabolic stress in glioma cells. Antioxidants, 6(3), 58. doi: 10.3390/antiox6030058

Journal - Research Article

Feldman, L. A., Fabre, M.-S., Grasso, C., Reid, D., Broaddus, W. C., Lanza, G. M., … Herst, P. M. (2017). Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas. PLoS ONE, 12(9), e0184250. doi: 10.1371/journal.pone.0184250

Journal - Research Article

Herst, P. M., Rowe, M. R., Carson, G. M., & Berridge, M. V. (2017). Functional mitochondria in health and disease. Frontiers in Endocrinology, 8, 296. doi: 10.3389/fendo.2017.00296

Journal - Research Article

Sutherland, A. E., Bennett, N. C., & Herst, P. M. (2017). Psychological stress affects the severity of radiation-induced acute skin reactions in breast cancer patients. European Journal of Cancer Care, 26(6), e12737. doi: 10.1111/ecc.12737

Journal - Research Article

Kane, P., Jasperse, M., Egan, R., McBain, L., McKinlay, E., Pullon, S., & Herst, P. (2016). Continuity of cancer patient care in New Zealand: The general practitioner perspective. New Zealand Medical Journal, 129(1440), 55-63. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Hamilton, K., Bennett, N. C., Purdie, G., & Herst, P. M. (2015). Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: A randomized double blinded, placebo controlled pilot study. Supportive Care in Cancer, 23(1), 95-102. doi: 10.1007/s00520-014-2335-8

Journal - Research Article

O'Donovan, A., Coleman, M., Harris, R., & Herst, P. (2015). Prophylaxis and management of acute radiation-induced skin toxicity: A survey of practice across Europe and the USA. European Journal of Cancer Care, 24(3), 425-435. doi: 10.1111/ecc.12213

Journal - Research Article

Castro, M. L., McConnell, M. J., & Herst, P. M. (2014). Radio-sensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific. Free Radical Biology & Medicine, 74, 200-209. doi: 10.1016/j.freeradbiomed.2014.06.022

Journal - Research Article

Coleman, K., Jasperse, M., Herst, P., & Yielder, J. (2014). Establishing radiation therapy advanced practice in New Zealand. Journal of Medical Radiation Sciences, 61, 38-44. doi: 10.1002/jmrs.33

Journal - Research Article

Grasso, C., Fabre, M.-S., Collis, S. V., Castro, M. L., Field, C. S., Schleich, N., McConnell, M. J., & Herst, P. M. (2014). Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model. Frontiers in Oncology, 4, 356. doi: 10.3389/fonc.2014.00356

Journal - Research Article

Herst, P. M. (2014). Protecting the radiation-damaged skin from friction: A mini review. Journal of Medical Radiation Sciences, 61(2), 119-125. doi: 10.1002/jmrs.46

Journal - Research Article

Herst, P. M., Bennett, N. C., Sutherland, A. E., Peszynski, R. I., Paterson, D. B., & Jasperse, M. L. (2014). Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. Radiotherapy & Oncology, 110(1), 137-143. doi: 10.1016/j.radonc.2014.01.005

Journal - Research Article

Jasperse, M., Herst, P., & Dungey, G. (2014). Evaluating stress, burnout and job satisfaction in New Zealand radiation oncology departments. European Journal of Cancer Care, 23(1), 82-88. doi: 10.1111/ecc.12098

Journal - Research Article

Kane, P., Jasperse, M., Boland, P., & Herst, P. (2014). A pathway to empowerment: Evaluating a cancer education and support programme in New Zealand. European Journal of Cancer Care, 23(5), 668-674. doi: 10.1111/ecc.12188

Journal - Research Article

McConnell, M. J., & Herst, P. M. (2014). Ascorbate combination therapy: New tool in the anticancer toolbox? Science Translational Medicine, 6(222), 222fs6. doi: 10.1126/scitranslmed.3008488

Journal - Research Article

Herst, P. M., & Berridge, M. V. (2013). Cell hierarchy, metabolic flexibility and systems approaches to cancer treatment. Current Pharmaceutical Biotechnology, 14(3), 289-299.

Journal - Research Article

Herst, P. M., Broadley, K. W. R., Harper, J. L., & McConnell, M. J. (2012). Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest. Free Radical Biology & Medicine, 52(8), 1486-1493. doi: 10.1016/j.freeradbiomed.2012.01.021

Journal - Research Article

Jasperse, M. L., Herst, P. M., & Kane, J. P. (2012). Evaluation of the training and support received by facilitators of a cancer education and support programme in New Zealand. European Journal of Cancer Care, 21(2), 224-232. doi: 10.1111/j.1365-2354.2011.01303.x

Journal - Research Article

Leong, A. G., Herst, P. M., & Harper, J. L. (2012). Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immunity, 18(3), 459-466. doi: 10.1177/1753425911422263

Journal - Research Article

Parsons, E., Begley, A., & Herst, P. (2012). Manuka honey mouthwash does not affect oral mucositis in head and neck cancer patients in New Zealand. Journal of Radiotherapy in Practice, 11, 249-256. doi: 10.1017/S1460396911000410

Journal - Research Article

Paterson, D. B., Poonam, P., Bennett, N. C., Peszynski, R. I., Van Beekhuizen, M. J., Jasperse, M. L., & Herst, P. M. (2012). Randomized intra-patient controlled trial of Mepilex Lite dressings versus aqueous cream in managing radiation-induced skin reactions post-mastectomy. Journal of Cancer Science & Therapy, 4(11), 347-356. doi: 10.4172/1948-5956.1000166

Journal - Research Article

Broadley, K., Larsen, L., Herst, P. M., Smith, R. A. J., Berridge, M. V., & McConnell, M. J. (2011). The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. Journal of Cellular Biochemistry, 112(7), 1869-1879. doi: 10.1002/jcb.23107

Journal - Research Article

Herst, P. M., Howman, R. A., Neeson, P. J., Berridge, M. V., & Ritchie, D. S. (2011). The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome. Journal of Leukocyte Biology, 89(1), 51-55. doi: 10.1189/jlb.0710417

Journal - Research Article

Jasperse, M., Herst, P., & Dungey, G. (2011). Workplace challenges and coping strategies in a small cohort of radiation therapists in New Zealand: A pilot study. Shadows, 54(3), 4-9.

Journal - Research Article

Berridge, M. V., Herst, P. M., & Tan, A. S. (2010). Metabolic flexibility and cell heirarchy in metastatic cancer. Mitochondrion, 10(6), 584-588. doi: 10.1016/j.mito.2010.08.002

Journal - Research Article

Diggelmann, K. V., Zytkovicz, A. E., Tuaine, J. M., Bennett, N. C., Kelly, L. E., & Herst, P. M. (2010). Mepilex Lite dressings for the management of radiation-induced erythema: A systematic inpatient controlled clinical trial. British Journal of Radiology, 83(995), 971-978. doi: 10.1259/bjr/62011713

Journal - Research Article

Jasperse, M., Herst, P., & Coleman, K. (2010). Evaluation of an 'in house' RT-led treatment review programme. Shadows, 53(2), 4-7.

Journal - Research Article

Berridge, M. V., Herst, P. M., & Lawen, A. (2009). Targeting mitochondrial permeability in cancer drug development. Molecular Nutrition & Food Research, 53(1), 76-86. doi: 10.1002/mnfr.200700493

Journal - Research Article

Coleman, K., Herst, P., & Sycamore, C. (2009). Role extension for radiation therapists in New Zealand: A survey of radiation oncologists and radiation therapists. Shadows, 52(1), 11-18.

Journal - Research Article

Herst, P. M., Davis, J. E., Neeson, P., Berridge, M. V., & Ritchie, D. S. (2009). The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells. Haematologica, 94(7), 928-934. doi: 10.3324/haematol.2008.003996

Journal - Research Article

Martin, W. J., Herst, P. M., Chia, E. W., & Harper, J. L. (2009). Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation. Free Radical Biology & Medicine, 47(5), 616-621. doi: 10.1016/j.freeradbiomed.2009.05.035

Journal - Research Article

Herst, P. M., Hesketh, E. L., Ritchie, D. S., & Berridge, M. V. (2008). Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells. Leukemia Research, 32(2), 327-333.

Journal - Research Article

Herst, P. M., Perrone, G. G., Dawes, I. W., Bircham, P. W., & Berridge, M. V. (2008). Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Research, 8(6), 897-905.

Journal - Research Article

Herst, P. M., & Berridge, M. V. (2007). Cell surface oxygen consumption: A major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochimica et Biophysica Acta: Bioenergetics, 1767, 170-177.

Journal - Research Article

Herst, P. M., Petersen, T., Jerram, P., Baty, J., & Berridge, M. V. (2007). The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Biochemical Pharmacology, 74(11), 1587-1595.

Journal - Research Article

Herst, P. M., & Berridge, M. V. (2006). Plasma membrane electron transport: A new target for cancer drug development. Current Molecular Medicine, 6, 895-904.

Journal - Research Article

Berridge, M. V., Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction. Biotechnology Annual Review, 11, 127-152. doi: 10.1016/S1387-2656(05)11004-7

Journal - Research Article

Herst, P. M., Levine, D. M., & Berridge, M. V. (2005). Mitochondrial gene knockout HL60ρ0 cells show preferential differentiation into monocytes/macrophages. Leukemia Research, 29(10), 1163-1170. doi: 10.1016/j.leukres.2005.03.013

Journal - Research Article

Scarlett, D.-J. G., Herst, P. M., & Berridge, M. V. (2005). Mulitple proteins with single activities or a single protein with multiple activities: The conundrum of cell surface NADH oxidoreductases. Biochimica et Biophysica Acta: Bioenergetics, 1708(1), 108-119.

Journal - Research Article

Herst, P. M., Tan, A. S., Scarlett, D.-J. G., & Berridge, M. V. (2004). Cell surface oxygen consumption in mitochondrial gene knockout cells. Biochimica et Biophysica Acta: Bioenergetics, 1656, 79-87.

Journal - Research Article

Scarlett, D.-J., Herst, P., Tan, A., Prata, C., & Berridge, M. (2004). Mitochondrial gene-knockout (rho0) cells: A versatile model for exploring the secrets of trans-plasma membrane electron transport. BioFactors, 20(4), 199-206.

Journal - Research Article

Patel, B. K. C., Jasperse-Herst, P. M., Morgan, H. W., & Daniel, R. M. (1986). Isolation of anaerobic, extremely thermophilic, sulphur metabolising archaebacteria from New Zealand hot springs. New Zealand Journal of Marine & Freshwater Research, 20(3), 439-445. doi: 10.1080/00288330.1986.9516163

Journal - Research Article

Janssen, D. B., Joosten, H. M. L. J., Herst, P. M., & van der Drift, C. (1982). Characterization of glutamine-requiring mutants of Pseudomonas aeruginosa. Journal of Bacteriology, 151(3), 1176-1183.

Journal - Research Article

Wan, B. A., Chan, S., Herst, P., Yee, C., Popovic, M., Lee, J., … Chow, E. (2019). Mepitel Film and Mepilex Lite for the prophylaxis and treatment of skin toxicities from breast radiation [Short communication]. The Breast, 46, 87-89. doi: 10.1016/j.breast.2019.05.012

Journal - Research Other

Berridge, M. V., Herst, P. M., Rowe, M. R., Schneider, R., & McConnell, M. J. (2018). Mitochondrial transfer between cells: Methodological constraints in cell culture and animal models. Analytical Biochemistry, 552, 75-80. doi: 10.1016/j.ab.2017.11.008

Journal - Research Other

Herst, P. M., Dawson, R. H., & Berridge, M. V. (2018). Intercellular communication in tumor biology: A role for mitochondrial transfer. Frontiers in Oncology, 8, 344. doi: 10.3389/fonc.2018.00344

Journal - Research Other

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