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Health Sciences profile

Associate Professor Rebecca Campbell

PositionAssociate Professor
DepartmentDepartment of Physiology
QualificationsBSc PhD
Research summaryNeuroendocrinology

Research

I am interested in defining how the gonadotrophin releasing hormone (GnRH) neurons, well established as the ultimate downstream regulators of the central control of reproductive function, are regulated by the multitude of external and internal cues necessary for successful fertility. I am investigating the synaptic regulation of GnRH neurons, with particular emphasis on the innervation to their lengthy dendrites, through a variety of morphological imaging and transgenic mouse model approaches. In addition to understanding the regulation of normal fertility, I am also interested in addressing the central neuroendocrine abnormalities of polycystic ovarian syndrome (PCOS), the leading cause of infertility in women.

Publications

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neuro-humoral regulation of oxytocin neuron activity in pregnancy and lactation. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12569

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Marshall, C. J., Desroziers, E., McLennan, T., & Campbell, R. E. (2017). Defining subpopulations of arcuate nucleus GABA neurons in male, female, and prenatally androgenized female mice. Neuroendocrinology, 105(2), 157-169. doi: 10.1159/000452105

Moore, A. M., & Campbell, R. E. (2017). Polycystic ovary syndrome: Understanding the role of the brain. Frontiers in Neuroendocrinology, 46, 1-14. doi: 10.1016/j.yfrne.2017.05.002

Chapter in Book - Research

Clarke, I. J., Campbell, R., Smith, J. T., Prevot, V., & Wray, S. (2012). Neuroendocrine control of reproduction. In G. Fink, D. W. Pfaff & J. Levine (Eds.), Handbook of Neuroendocrinology. (pp. 197-235). Elsevier. doi: 10.1016/b978-0-12-375097-6.10009-5

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Journal - Research Article

Silva, M. S. B., Prescott, M., & Campbell, R. E. (2018). Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS. JCI Insight, 3(7), e399405. doi: 10.1172/jci.insight.99405

Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051

Moore, A. M., & Campbell, R. E. (2017). Polycystic ovary syndrome: Understanding the role of the brain. Frontiers in Neuroendocrinology, 46, 1-14. doi: 10.1016/j.yfrne.2017.05.002

Marshall, C. J., Desroziers, E., McLennan, T., & Campbell, R. E. (2017). Defining subpopulations of arcuate nucleus GABA neurons in male, female, and prenatally androgenized female mice. Neuroendocrinology, 105(2), 157-169. doi: 10.1159/000452105

Kunovac-Kallak, T., Hellgren, C., Skalkidou, A., Sandelin-Francke, L., Ubhayasekhera, K., Bergquist, J., … Campbell, R. E., & Sundström Poromaa, I. (2017). Maternal and female fetal testosterone levels are associated with maternal age and gestational weight gain. European Journal of Endocrinology, 177, 379-388. doi: 10.1530/eje-17-0207

Cimino, I., Casoni, F., Liu, X., Messina, A., Parkash, J., Jamin, S. P., … Prescott, M., Campbell, R., Herbison, A. E., … Giacobini, P. (2016). Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nature Communications, 7, 10055. doi: 10.1038/ncomms10055

Moore, A. M., & Campbell, R. E. (2016). The neuroendocrine genesis of polycystic ovary syndrome: A role for arcuate nucleus GABA neurons. Journal of Steroid Biochemistry & Molecular Biology, 160, 106-117. doi: 10.1016/j.jsbmb.2015.10.002

Czieselsky, K., Prescott, M., Porteous, R., Campos, P., Clarkson, J., Steyn, F. J., Campbell, R. E., & Herbison, A. E. (2016). Pulse and surge profiles of luteinizing hormone secretion in the mouse. Endocrinology, 157(12), 4794-4802. doi: 10.1210/en.2016-1351

Moore, A. M., Prescott, M., Marshall, C. J., Yip, S. H., & Campbell, R. E. (2015). Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. PNAS, 112(2), 596-601. doi: 10.1073/pnas.1415038112

Yip, S. H., Boehm, U., Herbison, A. E., & Campbell, R. E. (2015). Conditional viral tract tracing delineates the projections of the distinct kisspeptin neuron populations to gonadotropin-releasing hormone (GnRH) neurons in the mouse. Endocrinology, 156(7), 2582-2594. doi: 10.1210/en.2015-1131

Campbell, R. E., & Herbison, A. E. (2014). Gonadal steroid neuromodulation of developing and mature hypothalamic neuronal networks. Current Opinion in Neurobiology, 29, 96-102. doi: 10.1016/j.conb.2014.06.003

Shin, J., Prescott, M., Mair, J., & Campbell, R. E. (2014). Roles for primary cilia in gonadotropin-releasing hormone neurons in the mouse. Journal of Neuroendocrinology, 26(1), 18-25. doi: 10.1111/jne.12122

Moore, A. M., Prescott, M., & Campbell, R. E. (2013). Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology, 154(2), 796-806. doi: 10.1210/en.2012-1954

Norberg, R., Campbell, R., & Suter, K. J. (2013). Ion channels and information processing in GnRH neuron dendrites. Channels, 7(3), 135-145. doi: 10.4161/chan.24228

Campbell, R. E., Ducret, E., Porteous, R., Liu, X., Herde, M. K., Wellerhaus, K., … Herbison, A. E. (2011). Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles in the mouse. Endocrinology, 152(6), 2290-2301. doi: 10.1210/en.2010-1311

Herde, M. K., Geist, K., Campbell, R. E., & Herbison, A. E. (2011). Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology, 152(10), 3832-3841. doi: 10.1210/en.2011-1228

Chan, H., Prescott, M., Ong, Z. Y., Herde, M. K., Herbison, A. E., & Campbell, R. E. (2011). Dendritic spine plasticity in gonadatropin-releasing hormone (GnRH) neurons activated at the time of the preovulatory surge. Endocrinology, 152(12), 4906-4914. doi: 10.1210/en.2011-1522

Lee, K., Porteous, R., Campbell, R. E., Lüscher, B., & Herbison, A. E. (2010). Knockdown of GABAA receptor signaling in GnRH neurons has minimal effects upon fertility. Endocrinology, 151(9), 4428-4436. doi: 10.1210/en.2010-0314

Campbell, R. E., & Suter, K. J. (2010). Redefining the gonadotrophin-releasing hormone neurone dendrite. Journal of Neuroendocrinology, 22, 650-658. doi: 10.1111/j.1365-2826.2010.02032.x

Campbell, R. E., Gaidamaka, G., Han, S.-K., & Herbison, A. E. (2009). Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons. PNAS, 106(26), 10835-10840. doi: 10.1073/pnas.0903463106

Roberts, C. B., Campbell, R. E., Herbison, A. E., & Suter, K. J. (2008). Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons. Endocrinology, 149(7), 3355-3360.

Campbell, R. E., & Herbison, A. E. (2007). Definition of brainstem afferents to gonadotropin-releasing hormone neurons in the mouse using conditional viral tract tracing. Endocrinology, 148(12), 5884-5890.

Campbell, R. E. (2007). Defining the gonadotrophin-releasing hormone neuronal network: Transgenic approaches to understanding neurocircuitry. Journal of Neuroendocrinology, 19(7), 561-573. doi: 10.1111/j.1365-2826.2007.01568.x

Wintermantel, T. M., Campbell, R. E., Porteous, R., Bock, D., Gröne, H.-J., Todman, M. G., … Herbison, A. E. (2006). Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron, 52, 271-280.

Cottrell, E. C., Campbell, R. E., Han, S.-K., & Herbison, A. E. (2006). Postnatal remodeling of dendritic structure and spine density in gonadotropin-releasing hormone neurons. Endocrinology, 147(8), 3652-3661.

Campbell, R. E., Han, S.-K., & Herbison, A. E. (2005). Biocytin filling of adult gonadotropin-releasing hormone neurons in situ reveals extensive, spiny, dendritic processes. Endocrinology, 146(3), 1163-1169.

Campbell, R. E., Grove, K. L., & Smith, S. (2003). Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers. Endocrinology, 144(4), 1542-1548.

Campbell, R. E., Grove, K. L., & Smith, S. (2003). Distribution of corticotropin releasing hormone receptor immunoreactivity in the rat hypothalamus: Coexpression in neuropeptide Y and dopamine neurons in the arcuate nucleus. Brain Research, 973, 223-232.

Campbell, R. E., Smith, S., Allen, S. E., Grayson, B. E., ffrench-Mullen, J. M. H., & Grove, K. L. (2003). Orexin neurons express a functional pancreatic polypeptide Y4 receptor. Journal of Neuroscience, 23(4), 1487-1497.

Campbell, R. E., ffrench-Mullen, J. M. H., Cowley, M. A., Smith, M. S., & Grove, K. L. (2001). Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype. Neuroendocrinology, 73, 106-119.

Grove, K. L., Campbell, R. E., French-Mullen, J. M. H., Cowley, M. A., & Smith, M. S. (2000). Neuropeptide Y Y5 receptor expression in the cortical/limbic system and brainstem of the rat: Expression on γ-Aminobutyric acid and corticotropin-releasing hormone neurons. Neuroscience, 100(4), 731-740.

Lu, N. Z., Shales, T. A., Dziennis, S. E., Campbell, R. E., & Bethea, C. L. (1999). Ovarian steroid action on tryptophan hydroxylase protein and serotonin compared to localization of ovarian steroid receptors in midbrain of guinea pigs. Endocrine, 11(3), 257-267.

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Journal - Research Other

Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neuro-humoral regulation of oxytocin neuron activity in pregnancy and lactation. Journal of Neuroendocrinology. Advance online publication. doi: 10.1111/jne.12569

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