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Health Sciences profile

Dr Mani Ekambaram

PositionSenior Lecturer
DepartmentDepartment of Oral Sciences
QualificationsBDS(India) MDS(HK) PhD(HK) FDS RCSEd MPaed Dent RCSEd MRACDS(Paed)
Research summaryEnamel remineralisation and adhesion, dentine adhesion, MIH, paediatric oral health
TeachingPaediatric Dentistry at undergraduate and postgraduate levels

Research

Dr Mani's research expertise is in remineralisation of early enamel caries lesions, enamel and dentine adhesion, molar incisor hypomineralisation (MIH), and paediatric oral health.

Through his research, he has established a niche in experimental strategies for enhancing dentine bond durability, enhancing bonding to developmentally hypomineralised enamel, studying the remineralisation potential of various contemporary remineralisation agents on early enamel carious lesions. Additionally, his ongoing research projects are aiming at other novel experimental strategies to remineralise such lesions.

Dr Mani has ongoing research collaborations with The University of Hong Kong and University of Western Australia. Dr Mani's research interest also includes prevention and management of early childhood caries.

Publications

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). The enamel remineralization potential of fluoride varnishes containing arginine. Journal of Dentistry, 99, 103411. doi: 10.1016/j.jdent.2020.103411

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Synbiotics in caries prevention: A scoping review. PLoS ONE, 15(8), e0237547. doi: 10.1371/journal.pone.0237547

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Antibacterial and mechanical properties of arginine-containing glass ionomer cements. Dental Materials, 36, 1226-1240. doi: 10.1016/j.dental.2020.05.012

Botelho, M. G., Ekambaram, M., Bhuyan, S. Y., Yeung, A. W. K., Tanaka, R., Bornstein, M. M., & Li, K. Y. (2020). A comparison of visual identification of dental radiographic and nonradiographic images using eye tracking technology. Clinical & Experimental Dental Research, 6, 59-68. doi: 10.1002/cre2.249

Bijle, M. N., Neelakantan, P., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Effect of a novel synbiotic on Streptococcus mutans. Scientific Reports, 10, 7951. doi: 10.1038/s41598-020-64956-8

Journal - Research Article

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). The enamel remineralization potential of fluoride varnishes containing arginine. Journal of Dentistry, 99, 103411. doi: 10.1016/j.jdent.2020.103411

Bijle, M. N., Neelakantan, P., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Effect of a novel synbiotic on Streptococcus mutans. Scientific Reports, 10, 7951. doi: 10.1038/s41598-020-64956-8

Botelho, M. G., Ekambaram, M., Bhuyan, S. Y., Yeung, A. W. K., Tanaka, R., Bornstein, M. M., & Li, K. Y. (2020). A comparison of visual identification of dental radiographic and nonradiographic images using eye tracking technology. Clinical & Experimental Dental Research, 6, 59-68. doi: 10.1002/cre2.249

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Antibacterial and mechanical properties of arginine-containing glass ionomer cements. Dental Materials, 36, 1226-1240. doi: 10.1016/j.dental.2020.05.012

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Synbiotics in caries prevention: A scoping review. PLoS ONE, 15(8), e0237547. doi: 10.1371/journal.pone.0237547

Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). The combined antimicrobial effect of arginine and fluoride toothpaste. Scientific Reports, 9(1), 8405. doi: 10.1038/s41598-019-44612-6

Sardana, D., Zhang, J., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Effectiveness of professional fluorides against enamel white spot lesions during fixed orthodontic treatment: A systematic review and meta-analysis. Journal of Dentistry, 82, 1-10. doi: 10.1016/j.jdent.2018.12.006

Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Effectiveness of self-applied topical fluorides against enamel white spot lesions from multi-bracketed fixed orthodontic treatement: A systematic review. European Journal of Orthodontics, 41(6), 661-668. doi: 10.1093/ejo/cjz015

Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Prevention of demineralization around orthodontic brackets using sealants: A systematic review and meta-analysis. Pediatric Dentistry, 41(6), 430-531.

Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). A meta-epidemiological review of meta-analysis on anti-caries effect of arginine-containing formulations. Journal of Evidence-Based Dental Practice, 19(1), 28-33. doi: 10.1016/j.jebdp.2018.06.008

Uy, E., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2019). Remineralization potential of calcium and phosphate-based agents and their effects on bonding of orthodontic brackets. Journal of Adhesive Dentistry, 21(3), 219-228. doi: 10.3290/j.jad.a42305

Bijle, M. N. A., Tung, L. P., Wong, J., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). Enhancing the remineralization potential of child formula dentifrices: An in vitro study. Journal of Clinical Pediatric Dentistry, 43(5), 337-344. doi: 10.17796/1053-4625-43.5.6

Tan, C., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2019). Unerupted permanent incisors and associated dental anomalies. Journal of Investigative & Clinical Dentistry, 10, e12395. doi: 10.1111/jicd.12395

Bijle, M. N. A., Yiu, C. K. Y., & Ekambaram, M. (2018). Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis. Clinical Oral Investigations, 22(2), 583-596. doi: 10.1007/s00784-017-2322-9

Bijle, M. N. A., Yiu, C. K. Y., & Ekambaram, M. (2018). Calcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis. Journal of Evidence-Based Dental Practice, 18(3), 203-217. doi: 10.1016/j.jebdp.2017.09.003

Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2018). The combined enamel remineralization potential of arginine and fluoride toothpaste. Journal of Dentistry, 76, 75-82. doi: 10.1016/j.jdent.2018.06.009

Gamboa, G. C. S., Lee, G. H. M., Ekambaram, M., & Yiu, C. K. Y. (2018). Knowledge, perceptions, and clinical experiences on molar incisor hypomineralization among dental care providers in Hong Kong. BMC Oral Health, 18(1), 217. doi: 10.1186/s12903-018-0678-0

Mohd Said, S. N. B., Ekambaram, M., & Yiu, C. K. Y. (2017). Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions. International Journal of Paediatric Dentistry, 27(3), 163-173. doi: 10.1111/ipd.12243

Wong, S., Anthonappa, R. P., Ekambaram, M., McGrath, C., King, N. M., & Winters, J. C. (2017). Quality of life changes in children following emergency dental extractions under general anaesthesia. International Journal of Paediatric Dentistry, 27(2), 80-86. doi: 10.1111/ipd.12241

Ekambaram, M., Anthonappa, R. P., Govindool, S. R., & Yiu, C. K. Y. (2017). Comparison of deproteinization agents on bonding to developmentally hypomineralized enamel. Journal of Dentistry, 67, 94-101. doi: 10.1016/j.jdent.2017.10.004

Yawary, R., Anthonappa, R. P., Ekambaram, M., McGrath, C., & King, N. M. (2016). Changes in the oral health-related quality of life in children following comprehensive oral rehabilitation under general anaesthesia. International Journal of Paediatric Dentistry, 26(5), 322-329. doi: 10.1111/ipd.12200

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Bonding of adhesive resin to intraradicular dentine: A review of the literature. International Journal of Adhesion & Adhesives, 60, 92-103. doi: 10.1016/j.ijadhadh.2015.04.003

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Bonding of resin adhesives to caries-affected dentin: A systematic review. International Journal of Adhesion & Adhesives, 61, 23-34. doi: 10.1016/j.ijadhadh.2015.04.011

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Effect of solvents on dentin collagen cross-linking potential of carbodiimide. Journal of Adhesive Dentistry, 17(3), 219-226. doi: 10.3290/j.jad.a34137

Ekambaram, M., Epasinghe, D. J., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Effect of solvents on inhibition of collagen-bound proteases by chlorhexidine. International Journal of Adhesion & Adhesives, 60, 83-87. doi: 10.1016/j.ijadhadh.2015.03.010

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). An overview of solvents in resin-dentin bonding. International Journal of Adhesion & Adhesives, 57, 22-33. doi: 10.1016/j.ijadhadh.2014.09.007

Ekambaram, M., Yiu, C. K. Y., Matinlinna, J. P., King, N. M., & Tay, F. R. (2014). Adjunctive application of chlorhexidine and ethanol-wet bonding on durability of bonds to sound and caries-affected dentine. Journal of Dentistry, 42(6), 709-719. doi: 10.1016/j.jdent.2014.04.001

Ekambaram, M., Yiu, C. K. Y., Matinlinna, J. P., Chang, J. W. W., Tay, F. R., & King, N. M. (2014). Effect of chlorhexidine and ethanol-wet bonding with a hydrophobic adhesive to intraradicular dentine. Journal of Dentistry, 42(7), 872-882. doi: 10.1016/j.jdent.2014.02.006

Ekambaram, M., Itthagarun, A., & King, N. M. (2011). Comparison of the remineralizing potential of child formula dentifrices. International Journal of Paediatric Dentistry, 21(2), 132-140. doi: 10.1111/j.1365-263X.2010.01101.x

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Journal - Research Other

Dissanayake, S. S. M., Ekambaram, M., Li, K. C., Harris, P. W. R., & Brimble, M. A. (2020). Identification of key functional motifs of native amelogenin protein for dental enamel remineralisation. Molecules, 25(18), 4214. doi: 10.3390/molecules25184214

Bijle, M. N., Ekambaram, M., & Yiu, C. K. Y. (2020). A scoping review on arginine in caries prevention. Journal of Evidence-Based Dental Practice. Advance online publication. doi: 10.1016/j.jebdp.2020.101470

Lam, P. P. Y., Sardana, D., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2020). Effectiveness of pit and fissure sealants for preventing and arresting occlusal caries in primary molars: A systematic review and meta-analysis. Journal of Evidence-Based Dental Practice, 20(2), 101404. doi: 10.1016/j.jebdp.2020.101404

Gopalakrishnan, V., Anthonappa, R., Ekambaram, M., & King, N. M. (2019). Qualitative assessment of published studies on pulpotomy medicaments for primary molar teeth. Journal of Investigative & Clinical Dentistry, 10(2), e12389. doi: 10.1111/jicd.12389

Anthonappa, R. P., Ekambaram, M., Neboda, C. N. G., King, N. M., & Rabie, A.-B. M. (2018). Genetic basis of dentigerous cysts associated with supernumerary teeth: A narrative review. Journal of Investigative & Clinical Dentistry, 9(1), e122667. doi: 10.1111/jicd.12267

Ekambaram, M., Mohd Said, S. N. B., & Yiu, C. K. Y. (2017). A review of enamel remineralisation potential of calcium- and phosphate-based remineralisation systems. Oral Health & Preventive Dentistry, 15(5), 415-420. doi: 10.3290/j.ohpd.a38779

Ekambaram, M. (2016). Williams syndrome: Review of clinical features and its medical considerations in dental treatment. HSOA Journal of Dentistry, 1(1), 003. doi: 10.24966/DOHC-6783/100003

Ekambaram, M., & Yiu, C. K. Y. (2016). Bonding to hypomineralized enamel: A systematic review. International Journal of Adhesion & Adhesives, 69, 27-32. doi: 10.1016/j.ijadhadh.2016.03.016

Ekambaram, M., Itthagarun, A., & King, N. M. (2011). Ingestion of fluoride from dentifrices by young children and fluorosis of the teeth-a literature review. Journal of Clinical Pediatric Dentistry, 36(2), 111-122. doi: 10.17796/jcpd.36.2.3106602470287130

Ekambaram, M., Yiu, C. K. Y., & King, N. M. (2008). An unusual case of double teeth with facial and lingual talon cusps. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontology, 105(4), e63-e67. doi: 10.1016/j.tripleo.2007.11.033

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