Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Health Sciences profile

Associate Professor Mani Ekambaram

PositionAssociate Professor
DepartmentDepartment of Oral Sciences
QualificationsBDS(India) MDS(HK) PhD(HK) FDS RCSEd MPaed Dent RCSEd MRACDS(Paed)
Research summaryEnamel remineralisation and adhesion, dentine adhesion, MIH, paediatric oral health
TeachingPaediatric Dentistry at undergraduate and postgraduate levels

Research

Associate Professor Mani's research expertise is in remineralisation of early enamel caries lesions, enamel and dentine adhesion, molar incisor hypomineralisation (MIH), and paediatric oral health.

Through his research, he has established a niche in experimental strategies for enhancing dentine bond durability, enhancing bonding to developmentally hypomineralised enamel, studying the remineralisation potential of various contemporary remineralisation agents on early enamel carious lesions. Additionally, his ongoing research projects are aiming at other novel experimental strategies to remineralise such lesions.

Associate Professor Mani has ongoing research collaborations with The University of Hong Kong and University of Western Australia. His research interest also includes prevention and management of early childhood caries.

Publications

Sardana, D., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2022). Caries-preventive effectiveness of two different fluoride varnishes: A randomised clinical trial in patients with multi-bracketed fixed orthodontic appliances. International Journal of Paediatric Dentistry. Advance online publication. doi: 10.1111/ipd.13013

Lam, P. P. Y., Chua, H., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2022). Risk predictors of Early Childhood Caries increment: A systematic review and meta-analysis. Journal of Evidence-Based Dental Practice. Advance online publication. doi: 10.1016/j.jebdp.2022.101732

Sardana, D., Li, K. Y., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2022). Validation of clinical photography and a laser fluorescence device for assessment of enamel demineralization during multi-bracketed fixed orthodontic treatment. Photodiagnosis & Photodynamic Therapy, 38, 102828. doi: 10.1016/j.pdpdt.2022.102828

Lee, Y.-L., Li, K. C., Yiu, C. K. Y., Boyd, D. H., Waddell, J. N., & Ekambaram, M. (2021). Bonding universal dental adhesive to developmentally hypomineralised enamel. Journal of Adhesive Dentistry, 23(6), 513-525. doi: 10.3290/j.jad.b2288247

Lee, Y.-L., Li, K. C., Yiu, C. K. Y., Boyd, D. H., & Ekambaram, M. (2021). Evaluation of developmentally hypomineralised enamel after surface pretreatment with Papacarie Duo gel and different etching modes: An in vitro SEM and AFM study. European Archives of Paediatric Dentistry. Advance online publication. doi: 10.1007/s40368-021-00671-w

Lam, P. P. Y., Chua, H., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2022). Risk predictors of Early Childhood Caries increment: A systematic review and meta-analysis. Journal of Evidence-Based Dental Practice. Advance online publication. doi: 10.1016/j.jebdp.2022.101732

Journal - Research Article

Sardana, D., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2022). Caries-preventive effectiveness of two different fluoride varnishes: A randomised clinical trial in patients with multi-bracketed fixed orthodontic appliances. International Journal of Paediatric Dentistry. Advance online publication. doi: 10.1111/ipd.13013

Journal - Research Article

Sardana, D., Li, K. Y., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2022). Validation of clinical photography and a laser fluorescence device for assessment of enamel demineralization during multi-bracketed fixed orthodontic treatment. Photodiagnosis & Photodynamic Therapy, 38, 102828. doi: 10.1016/j.pdpdt.2022.102828

Journal - Research Article

Al-Kindi, F., Al-Harrasi, R., Coimbatore, H., Aziz, S., Thomson, W. M., & Ekambaram, M. (2021). The selection and clinical application of dental adhesives by general dental practitioners in New Zealand. New Zealand Dental Journal, 117(2), 74-79.

Journal - Research Article

Bijle, M. N., Abdalla, M. M., Ashraf, U., Ekambaram, M., & Yiu, C. K. Y. (2021). Enamel remineralization potential of arginine-fluoride varnish in a multi-species bacterial pH-cycling model. Journal of Dentistry, 104, 103528. doi: 10.1016/j.jdent.2020.103528

Journal - Research Article

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2021). Combined effect of arginine and fluoride on the growth of Lactobacillus rhamnosus GG. Scientific Reports, 11, 973. doi: 10.1038/s41598-020-79684-2

Journal - Research Article

bin Haji Awang Masri, A. A., Khang, K. K. Y., Low Wei Shen, L., Ekambaram, M., & Loch, C. (2021). Knowledge of dental enamel defects among undergraduate dental students a cross sectional survey. European Journal of Dental Education, 25, 711-716. doi: 10.1111/eje.12650

Journal - Research Article

Cheng, M. S., Hsu, K.-H., Thomson, W. M., & Ekambaram, M. (2021). General dental practitioners’ opinions on universal publicly-funded dental care in New Zealand. New Zealand Dental Journal, 117(1), 35-39.

Journal - Research Article

Lam, P. P. Y., Sardana, D., Luo, W., Ekambaram, M., Lee, G. H. M., Lo, E. C. M., & Yiu, C. K. Y. (2021). Glass ionomer sealant versus fluoride varnish application to prevent occlusal caries in primary second molars among preschool children: A randomized controlled trial. Caries Research, 55, 322-332. doi: 10.1159/000517390

Journal - Research Article

Lee, Y.-L., Li, K. C., Yiu, C. K. Y., Boyd, D. H., & Ekambaram, M. (2021). Evaluation of developmentally hypomineralised enamel after surface pretreatment with Papacarie Duo gel and different etching modes: An in vitro SEM and AFM study. European Archives of Paediatric Dentistry. Advance online publication. doi: 10.1007/s40368-021-00671-w

Journal - Research Article

Lee, Y.-L., Li, K. C., Yiu, C. K. Y., Boyd, D. H., Waddell, J. N., & Ekambaram, M. (2021). Bonding universal dental adhesive to developmentally hypomineralised enamel. Journal of Adhesive Dentistry, 23(6), 513-525. doi: 10.3290/j.jad.b2288247

Journal - Research Article

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Antibacterial and mechanical properties of arginine-containing glass ionomer cements. Dental Materials, 36, 1226-1240. doi: 10.1016/j.dental.2020.05.012

Journal - Research Article

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Synbiotics in caries prevention: A scoping review. PLoS ONE, 15(8), e0237547. doi: 10.1371/journal.pone.0237547

Journal - Research Article

Bijle, M. N., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). The enamel remineralization potential of fluoride varnishes containing arginine. Journal of Dentistry, 99, 103411. doi: 10.1016/j.jdent.2020.103411

Journal - Research Article

Bijle, M. N., Ekambaram, M., Lo, E., & Yiu, C. (2020). Physicochemical characteristics of arginine enriched naf varnish: An in vitro study. Polymers, 12, 2998. doi: 10.3390/polym12122998

Journal - Research Article

Bijle, M. N., Neelakantan, P., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2020). Effect of a novel synbiotic on Streptococcus mutans. Scientific Reports, 10, 7951. doi: 10.1038/s41598-020-64956-8

Journal - Research Article

Bijle, M. N., Tsoi, J., Ekambaram, M., Lo, E. C. M., Carey, C. M., & Yiu, C. K. Y. (2020). Enhanced fluoride bioavailability with incorporation of arginine in child dentifrices. Journal of Clinical Pediatric Dentistry, 44(5), 332-341. doi: 10.17796/1053-4625-44.5.7

Journal - Research Article

Bijle, M. N., Tsoi, J., Ekambaram, M., Lo, E. C. M., Carey, C. M., & Yiu, C. K. Y. (2020). Inter-method reliability for determining total and soluble fluorides in child low-fluoride formula dentifrices. Scientific Reports, 10(1), 20880. doi: 10.1038/s41598-020-77920-3

Journal - Research Article

Botelho, M. G., Ekambaram, M., Bhuyan, S. Y., Yeung, A. W. K., Tanaka, R., Bornstein, M. M., & Li, K. Y. (2020). A comparison of visual identification of dental radiographic and nonradiographic images using eye tracking technology. Clinical & Experimental Dental Research, 6, 59-68. doi: 10.1002/cre2.249

Journal - Research Article

Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). A meta-epidemiological review of meta-analysis on anti-caries effect of arginine-containing formulations. Journal of Evidence-Based Dental Practice, 19(1), 28-33. doi: 10.1016/j.jebdp.2018.06.008

Journal - Research Article

Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). The combined antimicrobial effect of arginine and fluoride toothpaste. Scientific Reports, 9(1), 8405. doi: 10.1038/s41598-019-44612-6

Journal - Research Article

Bijle, M. N. A., Tung, L. P., Wong, J., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2019). Enhancing the remineralization potential of child formula dentifrices: An in vitro study. Journal of Clinical Pediatric Dentistry, 43(5), 337-344. doi: 10.17796/1053-4625-43.5.6

Journal - Research Article

Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Effectiveness of self-applied topical fluorides against enamel white spot lesions from multi-bracketed fixed orthodontic treatement: A systematic review. European Journal of Orthodontics, 41(6), 661-668. doi: 10.1093/ejo/cjz015

Journal - Research Article

Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Prevention of demineralization around orthodontic brackets using sealants: A systematic review and meta-analysis. Pediatric Dentistry, 41(6), 430-531.

Journal - Research Article

Sardana, D., Zhang, J., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2019). Effectiveness of professional fluorides against enamel white spot lesions during fixed orthodontic treatment: A systematic review and meta-analysis. Journal of Dentistry, 82, 1-10. doi: 10.1016/j.jdent.2018.12.006

Journal - Research Article

Tan, C., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2019). Unerupted permanent incisors and associated dental anomalies. Journal of Investigative & Clinical Dentistry, 10, e12395. doi: 10.1111/jicd.12395

Journal - Research Article

Uy, E., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2019). Remineralization potential of calcium and phosphate-based agents and their effects on bonding of orthodontic brackets. Journal of Adhesive Dentistry, 21(3), 219-228. doi: 10.3290/j.jad.a42305

Journal - Research Article

Bijle, M. N. A., Ekambaram, M., Lo, E. C. M., & Yiu, C. K. Y. (2018). The combined enamel remineralization potential of arginine and fluoride toothpaste. Journal of Dentistry, 76, 75-82. doi: 10.1016/j.jdent.2018.06.009

Journal - Research Article

Bijle, M. N. A., Yiu, C. K. Y., & Ekambaram, M. (2018). Calcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis. Journal of Evidence-Based Dental Practice, 18(3), 203-217. doi: 10.1016/j.jebdp.2017.09.003

Journal - Research Article

Bijle, M. N. A., Yiu, C. K. Y., & Ekambaram, M. (2018). Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis. Clinical Oral Investigations, 22(2), 583-596. doi: 10.1007/s00784-017-2322-9

Journal - Research Article

Gamboa, G. C. S., Lee, G. H. M., Ekambaram, M., & Yiu, C. K. Y. (2018). Knowledge, perceptions, and clinical experiences on molar incisor hypomineralization among dental care providers in Hong Kong. BMC Oral Health, 18(1), 217. doi: 10.1186/s12903-018-0678-0

Journal - Research Article

Ekambaram, M., Anthonappa, R. P., Govindool, S. R., & Yiu, C. K. Y. (2017). Comparison of deproteinization agents on bonding to developmentally hypomineralized enamel. Journal of Dentistry, 67, 94-101. doi: 10.1016/j.jdent.2017.10.004

Journal - Research Article

Mohd Said, S. N. B., Ekambaram, M., & Yiu, C. K. Y. (2017). Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions. International Journal of Paediatric Dentistry, 27(3), 163-173. doi: 10.1111/ipd.12243

Journal - Research Article

Wong, S., Anthonappa, R. P., Ekambaram, M., McGrath, C., King, N. M., & Winters, J. C. (2017). Quality of life changes in children following emergency dental extractions under general anaesthesia. International Journal of Paediatric Dentistry, 27(2), 80-86. doi: 10.1111/ipd.12241

Journal - Research Article

Yawary, R., Anthonappa, R. P., Ekambaram, M., McGrath, C., & King, N. M. (2016). Changes in the oral health-related quality of life in children following comprehensive oral rehabilitation under general anaesthesia. International Journal of Paediatric Dentistry, 26(5), 322-329. doi: 10.1111/ipd.12200

Journal - Research Article

Ekambaram, M., Epasinghe, D. J., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Effect of solvents on inhibition of collagen-bound proteases by chlorhexidine. International Journal of Adhesion & Adhesives, 60, 83-87. doi: 10.1016/j.ijadhadh.2015.03.010

Journal - Research Article

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). An overview of solvents in resin-dentin bonding. International Journal of Adhesion & Adhesives, 57, 22-33. doi: 10.1016/j.ijadhadh.2014.09.007

Journal - Research Article

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Bonding of adhesive resin to intraradicular dentine: A review of the literature. International Journal of Adhesion & Adhesives, 60, 92-103. doi: 10.1016/j.ijadhadh.2015.04.003

Journal - Research Article

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Bonding of resin adhesives to caries-affected dentin: A systematic review. International Journal of Adhesion & Adhesives, 61, 23-34. doi: 10.1016/j.ijadhadh.2015.04.011

Journal - Research Article

Ekambaram, M., Yiu, C. K. Y., & Matinlinna, J. P. (2015). Effect of solvents on dentin collagen cross-linking potential of carbodiimide. Journal of Adhesive Dentistry, 17(3), 219-226. doi: 10.3290/j.jad.a34137

Journal - Research Article

Ekambaram, M., Yiu, C. K. Y., Matinlinna, J. P., Chang, J. W. W., Tay, F. R., & King, N. M. (2014). Effect of chlorhexidine and ethanol-wet bonding with a hydrophobic adhesive to intraradicular dentine. Journal of Dentistry, 42(7), 872-882. doi: 10.1016/j.jdent.2014.02.006

Journal - Research Article

Ekambaram, M., Yiu, C. K. Y., Matinlinna, J. P., King, N. M., & Tay, F. R. (2014). Adjunctive application of chlorhexidine and ethanol-wet bonding on durability of bonds to sound and caries-affected dentine. Journal of Dentistry, 42(6), 709-719. doi: 10.1016/j.jdent.2014.04.001

Journal - Research Article

Ekambaram, M., Itthagarun, A., & King, N. M. (2011). Comparison of the remineralizing potential of child formula dentifrices. International Journal of Paediatric Dentistry, 21(2), 132-140. doi: 10.1111/j.1365-263X.2010.01101.x

Journal - Research Article

Chua, H., Sardana, D., Turner, R., Ting, G., & Ekambaram, M. (2021). Effectiveness of oral health education methods on oral hygiene in children and adolescents with visual impairment: A systematic review. International Journal of Paediatric Dentistry. Advance online publication. doi: 10.1111/ipd.12788

Journal - Research Other

Sardana, D., Manchanda, S., Ekambaram, M., Yang, Y., McGrath, C. P., & Yiu, C. K. Y. (2021). Prevention of demineralization during multi-bracketed fixed orthodontic treatment: An overview of systematic reviews. International Journal of Paediatric Dentistry. Advance online publication. doi: 10.1111/ipd.12927

Journal - Research Other

Bijle, M. N., Ekambaram, M., & Yiu, C. K. Y. (2020). A scoping review on arginine in caries prevention. Journal of Evidence-Based Dental Practice, 20(3), 101470. doi: 10.1016/j.jebdp.2020.101470

Journal - Research Other

Dissanayake, S. S. M., Ekambaram, M., Li, K. C., Harris, P. W. R., & Brimble, M. A. (2020). Identification of key functional motifs of native amelogenin protein for dental enamel remineralisation. Molecules, 25(18), 4214. doi: 10.3390/molecules25184214

Journal - Research Other

Lam, P. P. Y., Sardana, D., Ekambaram, M., Lee, G. H. M., & Yiu, C. K. Y. (2020). Effectiveness of pit and fissure sealants for preventing and arresting occlusal caries in primary molars: A systematic review and meta-analysis. Journal of Evidence-Based Dental Practice, 20(2), 101404. doi: 10.1016/j.jebdp.2020.101404

Journal - Research Other

Gopalakrishnan, V., Anthonappa, R., Ekambaram, M., & King, N. M. (2019). Qualitative assessment of published studies on pulpotomy medicaments for primary molar teeth. Journal of Investigative & Clinical Dentistry, 10(2), e12389. doi: 10.1111/jicd.12389

Journal - Research Other

Anthonappa, R. P., Ekambaram, M., Neboda, C. N. G., King, N. M., & Rabie, A.-B. M. (2018). Genetic basis of dentigerous cysts associated with supernumerary teeth: A narrative review. Journal of Investigative & Clinical Dentistry, 9(1), e122667. doi: 10.1111/jicd.12267

Journal - Research Other

Ekambaram, M., Mohd Said, S. N. B., & Yiu, C. K. Y. (2017). A review of enamel remineralisation potential of calcium- and phosphate-based remineralisation systems. Oral Health & Preventive Dentistry, 15(5), 415-420. doi: 10.3290/j.ohpd.a38779

Journal - Research Other

Ekambaram, M. (2016). Williams syndrome: Review of clinical features and its medical considerations in dental treatment. HSOA Journal of Dentistry, 1(1), 003. doi: 10.24966/DOHC-6783/100003

Journal - Research Other

Ekambaram, M., & Yiu, C. K. Y. (2016). Bonding to hypomineralized enamel: A systematic review. International Journal of Adhesion & Adhesives, 69, 27-32. doi: 10.1016/j.ijadhadh.2016.03.016

Journal - Research Other

Ekambaram, M., Itthagarun, A., & King, N. M. (2011). Ingestion of fluoride from dentifrices by young children and fluorosis of the teeth-a literature review. Journal of Clinical Pediatric Dentistry, 36(2), 111-122. doi: 10.17796/jcpd.36.2.3106602470287130

Journal - Research Other

Ekambaram, M., Yiu, C. K. Y., & King, N. M. (2008). An unusual case of double teeth with facial and lingual talon cusps. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontology, 105(4), e63-e67. doi: 10.1016/j.tripleo.2007.11.033

Journal - Research Other

More publications...