Dr Indranil Basak
| Position | Research Fellow |
|---|---|
| Department | Department of Biochemistry |
| Research summary | Batten Disease; Neurodegeneration |
Research
Indranil is a postdoctoral fellow in Dr Stephanie Hughes's lab in the Department of Biochemistry. He joined the University of Otago in June 2018 with an aim to understand the underlying mechanisms involved in neurodegeneration in Batten disease. Indranil has a PhD in Biological Sciences from St. John's University, New York, focusing on neurodegeneration in Parkinson's disease.
Indranil has a keen interest in non-coding RNAs, especially microRNAs. After the completion of his PhD, Indranil pursued a postdoctoral training at the University of Utah on microRNAs in hematology.
Indranil moved to New Zealand to reunite with his family and to follow his passion to study genetics and neurodegeneration.
At the University of Otago, he is investigating differential proteomic, epigenetic and transcriptomic profiles in Batten disease, using induced pluripotent stem cell derived neurons and CRISPR-Cas9 technologies, with an aim to identify potential therapeutic targets for this devastating childhood brain disease.
Publications
Stoller, M. L., Basak, I., Denorme, F., Rowley, J. W., Alsobrooks, J., Parsawar, K., … Campbell, R. A. (2021). Neutrophil cathepsin G proteolysis of protease activated receptor 4 generates a novel, functional tethered ligand. Blood Advances. Advance online publication. doi: 10.1182/bloodadvances.2021006133
Basak, I., Hansen, R. A., Ward, M. E., & Hughes, S. M. (2021). Deficiency of the lysosomal protein CLN5 alters lysosomal function and movement. Biomolecules, 11, 1412. doi: 10.3390/biom11101412
Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences. Advance online publication. doi: 10.1007/s00018-021-03813-x
Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., … Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood, 136(15), 1760-1772. doi: 10.1182/blood.2020005230
Basak, I., Bhatlekar, S., Manne, B. K., Stoller, M., Hugo, S., Kong, X., … Bray, P. F. (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of Thrombosis & Haemostasis, 17(3), 511-524. doi: 10.1111/jth.14382
Basak, I., & Møller, S. G. (2018). Plant thermotolerance proteins, misfolded proteins, and neurodegenerative diseases. In A. R. Kermode & L. Jiang (Eds.), Molecular pharming: Applications, challenges, and emerging areas. (pp. 457-474). Hoboken, NJ: John Wiley & Sons. doi: 10.1002/9781118801512.ch18
Chapter in Book - Research
Basak, I., Hansen, R. A., Ward, M. E., & Hughes, S. M. (2021). Deficiency of the lysosomal protein CLN5 alters lysosomal function and movement. Biomolecules, 11, 1412. doi: 10.3390/biom11101412
Journal - Research Article
Stoller, M. L., Basak, I., Denorme, F., Rowley, J. W., Alsobrooks, J., Parsawar, K., … Campbell, R. A. (2021). Neutrophil cathepsin G proteolysis of protease activated receptor 4 generates a novel, functional tethered ligand. Blood Advances. Advance online publication. doi: 10.1182/bloodadvances.2021006133
Journal - Research Article
Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., … Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin bundling protein L-plastin. Blood, 136(15), 1760-1772. doi: 10.1182/blood.2020005230
Journal - Research Article
Basak, I., Bhatlekar, S., Manne, B. K., Stoller, M., Hugo, S., Kong, X., … Bray, P. F. (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of Thrombosis & Haemostasis, 17(3), 511-524. doi: 10.1111/jth.14382
Journal - Research Article
Bhatlekar, S., Basak, I., Edelstein, L. C., Campbell, R. A., Lindsey, C. R., Italiano, Jr, J. E., … Bray, P. F. (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083. doi: 10.3324/haematol.2018.204685
Journal - Research Article
Patil, K. S., Basak, I., Dalen, I., Hoedt, E., Lange, J., Lunde, K. A., … Møller, S. G. (2019). Combinatory microRNA serum signatures as classifiers of Parkinson's disease. Parkinsonism & Related Disorders, 64, 202-210. doi: 10.1016/j.parkreldis.2019.04.010
Journal - Research Article
Abdullah, R., Patil, K. S., Rosen, B., Pal, R., Prabhudesai, S., Lee, S., Basak, I., … Møller, S. G. (2017). Subcellular Parkinson’s disease-specific alpha-synuclein species show altered behavior in neurodegeneration. Molecular Neurobiology, 54(10), 7639-7655. doi: 10.1007/s12035-016-0266-8
Journal - Research Article
Basak, I., Patil, K. S., Alves, G., Larsen, J. P., & Møller, S. G. (2016). MicroRNAs as neuroregulators, biomarkers and therapeutic agents in neurodegenerative diseases. Cellular & Molecular Life Sciences, 73(4), 811-827. doi: 10.1007/s00018-015-2093-x
Journal - Research Article
Prabhudesai, S., Bensabeur, F. Z., Abdullah, R., Basak, I., Baez, S., Alves, G., … Møller, S. G. (2016). LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Journal of Neuroscience Research, 94(8), 717-735. doi: 10.1002/jnr.23754
Journal - Research Article
Patil, K. S., Basak, I., Pal, R., Ho, H.-P., Alves, G., Chang, E. J., … Møller, S. G. (2015). A proteomics approach to investigate miR-153-3p and miR-205-5p targets in neuroblastoma cells. PLoS ONE, 10(12), e0143969. doi: 10.1371/journal.pone.0143969
Journal - Research Article
Basak, I., Pal, R., Patil, K. S., Dunne, A., Ho, H.-P., Lee, S., … Møller, S. G. (2014). Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins. Journal of Biological Chemistry, 289(21), 14458-14469. doi: 10.1074/jbc.M114.548156
Journal - Research Article
Patil, K. S., Basak, I., Lee, S., Abdullah, R., Larsen, J. P., & Møller, S. G. (2014). PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons. Journal of Neuroscience Research, 92(9), 1167-1177. doi: 10.1002/jnr.23396
Journal - Research Article
Basak, I., Wicky, H. E., McDonald, K. O., Xu, J. B., Palmer, J. E., Best, H. L., … Schoderboeck, L., & Hughes, S. M. (2021). A lysosomal enigma CLN5 and its significance in understanding neuronal ceroid lipofuscinosis. Cellular & Molecular Life Sciences. Advance online publication. doi: 10.1007/s00018-021-03813-x
Journal - Research Other
Basak, I., & Møller, S. G. (2013). Emerging facets of plastid division regulation. Planta, 237(2), 389-398. doi: 10.1007/s00425-012-1743-6
Journal - Research Other
