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Health Sciences profile

Dr Matthew McNeil

PositionSenior Research Fellow
DepartmentDepartment of Microbiology and Immunology
Research summaryAntimicrobial drug resistance

Research

My research is focused on the use of bacterial genetics and functional genomics to investigate bacterial metabolism and antimicrobial drug resistance. Ultimately, the goal of this work is to identify new therapeutics and treatment strategies to combat antimicrobial resistance.

My current work places an emphasis on M. tuberculosis and we are extending these approaches to other bacterial pathogens.

Publications

McNeil, M. B., Cheung, C.-Y., Waller, N. J. E., Adolph, C., Chapman, C. L., Seeto, N. E. J., Jowsey, W., … Cook, G. M. (2022). Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis. Frontiers in Cellular & Infection Microbiology, 12, 980844. doi: 10.3389/fcimb.2022.980844

Adolph, C., McNeil, M. B., & Cook, G. M. (2022). Impaired succinate oxidation prevents growth and influences drug susceptibility in Mycobacterium tuberculosis. mBio. Advance online publication. doi: 10.1128/mbio.01672-22

Harold, L. K., Jinich, A., Hards, K., Cordeiro, A., Keighley, L. M., Cross, A., McNeil, M. B., … Cook, G. M. (2022). Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. Journal of Biological Chemistry. Advance online publication. doi: 10.1016/j.jbc.2022.101859

Cheung, C.-Y., McNeil, M. B., & Cook, G. M. (2022). Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infection. Journal of Antimicrobial Chemotherapy, 77, 615-619. doi: 10.1093/jac/dkab437

Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8

Adolph, C., McNeil, M. B., & Cook, G. M. (2022). Impaired succinate oxidation prevents growth and influences drug susceptibility in Mycobacterium tuberculosis. mBio. Advance online publication. doi: 10.1128/mbio.01672-22

Journal - Research Article

Cheung, C.-Y., McNeil, M. B., & Cook, G. M. (2022). Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infection. Journal of Antimicrobial Chemotherapy, 77, 615-619. doi: 10.1093/jac/dkab437

Journal - Research Article

Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8

Journal - Research Article

Harold, L. K., Jinich, A., Hards, K., Cordeiro, A., Keighley, L. M., Cross, A., McNeil, M. B., … Cook, G. M. (2022). Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. Journal of Biological Chemistry. Advance online publication. doi: 10.1016/j.jbc.2022.101859

Journal - Research Article

McNeil, M. B., Keighley, L. M., Cook, J. R., Cheung, C.-Y., & Cook, G. M. (2021). CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis. Molecular Microbiology, 116, 1033-1043. doi: 10.1111/mmi.14790

Journal - Research Article

McNeil, M. B., Ryburn, H. W., Tirados, J., Cheung, C.-Y., & Cook, G. M. (2021). Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes. iScience. Advance online publication. doi: 10.1016/j.isci.2021.103573

Journal - Research Article

Shelton, C. D., McNeil, M. B., Early, J. V., Ioerger, T. R., & Parish, T. (2021). Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 65, e02334-20. doi: 10.1128/aac.02334-20

Journal - Research Article

McNeil, M. B., O'Malley, T., Dennison, D., Shelton, C. D., Sunde, B., & Parish, T. (2020). Multiple mutations in Mycobacterium tuberculosis MmpL3 increase resistance to MmpL3 inhibitors. mSphere, 5(5), e00985-20. doi: 10.1128/mSphere.00985-20

Journal - Research Article

McNeil, M. B., Ryburn, H. W. K., Harold, L. K., Tirados, J. F., & Cook, G. M. (2020). Transcriptional inhibition of the F1F0-type ATP synthase has bactericidal consequences on the viability of mycobacteria. Antimicrobial Agents & Chemotherapy, 64(8), e00492-20. doi: 10.1128/aac.00492-20

Journal - Research Article

Shao, M., McNeil, M., Cook, G. M., & Lu, X. (2020). MmpL3 inhibitors as antituberculosis drugs. European Journal of Medicinal Chemistry, 200, 112390. doi: 10.1016/j.ejmech.2020.112390

Journal - Research Article

McNeil, M. B., Dennison, D. D., Shelton, C. D., & Parish, T. (2017). In vitro isolation and characterization of oxazolidinone-resistant Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 61(10), e01296-17. doi: 10.1128/aac.01296-17

Journal - Research Article

McNeil, M. B., Dennison, D., Shelton, C., Flint, L., Korkegian, A., & Parish, T. (2017). Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA. Tuberculosis, 107, 133-136. doi: 10.1016/j.tube.2017.09.003

Journal - Research Article

Hampton, H. G., McNeil, M. B., Paterson, T. J., Ney, B., Williamson, N. R., Easingwood, R. A., Bostina, M., … Fineran, P. C. (2016). CRISPR-Cas gene-editing reveals RsmA and RsmC act through FlhDC to repress the SdhE flavinylation factor and control motility and prodigiosin production in Serratia. Microbiology, 162(6), 1047-1058. doi: 10.1099/mic.0.000283

Journal - Research Article

McNeil, M. B., Hampton, H. G., Hards, K. J., Watson, B. N. J., Cook, G. M., & Fineran, P. C. (2014). The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria. FEBS Letters, 588(3), 414-421. doi: 10.1016/j.febslet.2013.12.019

Journal - Research Article

Richter, C., Dy, R. L., McKenzie, R. E., Watson, B. N. J., Taylor, C., Chang, J. T., McNeil, M. B., Staals, R. H. J., & Fineran, P. C. (2014). Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer. Nucleic Acids Research, 42(13), 8516-8526. doi: 10.1093/nar/gku527

Journal - Research Article

Fineran, P. C., Iglesias Cans, M. C., Ramsay, J. P., Wilf, N. M., Cossyleon, D., McNeil, M. B., … Stanton, J.-A. L., … Salmond, G. P. C. (2013). Draft genome sequence of Serratia sp. strain ATCC 39006, a model bacterium for analysis of the biosynthesis and regulation of prodigiosin, a carbapenem, and gas vesicles. Genome Announcements, 1(6), e01039-13. doi: 10.1128/genomeA.01039-13

Journal - Research Article

McNeil, M. B., & Fineran, P. C. (2013). Prokaryotic assembly factors for the attachment of flavin to complex II. Biochimica et Biophysica Acta: Bioenergetics, 1827, 637-647. doi: 10.1016/j.bbabio.2012.09.003

Journal - Research Article

McNeil, M. B., & Fineran, P. C. (2013). The conserved RGxxE motif of the bacterial FAD assembly factor SdhE is required for succinate dehydrogenase flavinylation and activity. Biochemistry, 52, 7628-7640. doi: 10.1021/bi401006a

Journal - Research Article

McNeil, M. B., Iglesias Cans, M. C., Clulow, J. S., & Fineran, P. C. (2013). YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY). Microbiology, 159, 1352-1365. doi: 10.1099/mic.0.068510-0

Journal - Research Article

McNeil, M. B., Clulow, J. S., Wilf, N. M., Salmond, G. P. C., & Fineran, P. C. (2012). SdhE is a conserved protein required for the flavinylation of succinate dehydrogenase in bacteria. Journal of Biological Chemistry, 287(22), 18418-18428. doi: 10.1074/jbc.M111.293803

Journal - Research Article

Gristwood, T., McNeil, M. B., Clulow, J. S., Salmond, G. P. C., & Fineran, P. C. (2011). PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules. Journal of Bacteriology, 193(5), 1076-1085. doi: 10.1128/JB.00352-10

Journal - Research Article

McNeil, M. B., Cheung, C.-Y., Waller, N. J. E., Adolph, C., Chapman, C. L., Seeto, N. E. J., Jowsey, W., … Cook, G. M. (2022). Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis. Frontiers in Cellular & Infection Microbiology, 12, 980844. doi: 10.3389/fcimb.2022.980844

Journal - Research Other

Hards, K., Adolph, C., Harold, L. K., McNeil, M. B., Cheung, C.-Y., Jinich, A., … Cook, G. M. (2020). Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents. Progress in Biophysics & Molecular Biology, 152, 35-44. doi: 10.1016/j.pbiomolbio.2019.11.003

Journal - Research Other

McNeil, M. B., & Cook, G. M. (2019). Utilization of CRISPR interference to validate MmpL3 as a drug target in Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 63(8), e00629-19. doi: 10.1128/aac.00629-19

Journal - Research Other

McNeil, M. B., Dennison, D., & Parish, T. (2017). Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis [Short communication]. Microbiology, 163(7), 1065-1070. doi: 10.1099/mic.0.000498

Journal - Research Other

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