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Health Sciences profile

Dr Katrin Kramer

PositionResearch Fellow
QualificationsBSc PhD
Research summaryImmune therapies for cancer

Research

My research interest focusses on the development of cancer immunotherapies. I am especially interested in understanding how the delivery form of immunotherapies influences their efficacy and how novel therapies can be combined to induce an effective anti-cancer immune response.

During my PhD at the School of Pharmacy, University of Otago, I worked on generating and comparing different linking mechanisms between cancer antigen and vaccine adjuvants and how they influence the generation of anti-tumour immune responses. My current project as a Postdoctoral Fellow in the Department of Pathology focuses on developing an immunotherapy for breast cancer. For this I use virus-like particles (VLP) delivering tumour antigens in order to prime immune cells to selectively recognise and destroy cancer cells while sparing healthy cells. Furthermore I work on understanding how successful immunotherapies are in a diverse patient population and whether specific patient groups benefit from different treatment combinations.

Publications

Neumann, S., Campbell, K., Woodall, M. J., Evans, M., Clarkson, A. N., & Young, S. L. (2021). Obesity has a systemic effect on immune cells in naïve and cancer-bearing mice. International Journal of Molecular Sciences, 22, 8803. doi: 10.3390/ijms22168803

Campbell, K., Young, V. L., Donaldson, B. C., Woodall, M. J., Shields, N. J., Walker, G. F., Ward, V. K., & Young, S. L. (2021). Delivering two tumour antigens survivin and mucin-1 on virus-like particles enhances anti-tumour immune responses. Vaccines, 9(5), 463. doi: 10.3390/vaccines9050463

Dowlath, S., Campbell, K., Al-Barwani, F., Young, V. L., Young, S. L., Walker, G. F., & Ward, V. K. (2021). Dry formulation of virus-like particles in electrospun nanofibers. Vaccines, 9(3), 213. doi: 10.3390/vaccines9030213

Nguyen, H. V., Campbell, K., Painter, G. F., Young, S. L., & Walker, G. F. (2021). Data on the uptake of CpG-loaded amino-dextran nanoparticles by antigen-presenting cells [Data article]. Data in Brief. Advance online publication. doi: 10.1016/j.dib.2021.106883

Nguyen, H. V., Campbell, K., Painter, G. F., Young, S. L., & Walker, G. F. (2020). Nanoparticle system based on amino-dextran as a drug delivery vehicle: Immune-stimulatory CpG-oligonucleotide loading and delivery. Pharmaceutics, 12, 1150. doi: 10.3390/pharmaceutics12121150

Campbell, K., Young, V. L., Donaldson, B. C., Woodall, M. J., Shields, N. J., Walker, G. F., Ward, V. K., & Young, S. L. (2021). Delivering two tumour antigens survivin and mucin-1 on virus-like particles enhances anti-tumour immune responses. Vaccines, 9(5), 463. doi: 10.3390/vaccines9050463

Journal - Research Article

Dowlath, S., Campbell, K., Al-Barwani, F., Young, V. L., Young, S. L., Walker, G. F., & Ward, V. K. (2021). Dry formulation of virus-like particles in electrospun nanofibers. Vaccines, 9(3), 213. doi: 10.3390/vaccines9030213

Journal - Research Article

Neumann, S., Campbell, K., Woodall, M. J., Evans, M., Clarkson, A. N., & Young, S. L. (2021). Obesity has a systemic effect on immune cells in naïve and cancer-bearing mice. International Journal of Molecular Sciences, 22, 8803. doi: 10.3390/ijms22168803

Journal - Research Article

Nguyen, H. V., Campbell, K., Painter, G. F., Young, S. L., & Walker, G. F. (2020). Nanoparticle system based on amino-dextran as a drug delivery vehicle: Immune-stimulatory CpG-oligonucleotide loading and delivery. Pharmaceutics, 12, 1150. doi: 10.3390/pharmaceutics12121150

Journal - Research Article

Kramer, K., Al-Barwani, F., Baird, M. A., Young, V. L., Larsen, D. S., Ward, V. K., & Young, S. L. (2019). Functionalisation of virus-like particles enhances antitumour immune responses. Journal of Immunology Research, 2019, 5364632. doi: 10.1155/2019/5364632

Journal - Research Article

Grant, M. L., Shields, N., Neumann, S., Kramer, K., Bonato, A., Jackson, C., Baird, M. A., & Young, S. L. (2017). Combining dendritic cells and B cells for presentation of oxidised tumour antigens to CD8+ T cells. Clinical & Translational Immunology, 6(7), e149. doi: 10.1038/cti.2017.28

Journal - Research Article

Kramer, K., Shields, N. J., Poppe, V., Young, S. L., & Walker, G. F. (2017). Intracellular cleavable CpG oligodeoxynucleotide-antigen conjugate enhances anti-tumor immunity. Molecular Therapy, 25(1), 62-70. doi: 10.1016/j.ymthe.2016.10.001

Journal - Research Article

Kramer, K., Young, S. L., & Walker, G. F. (2017). Comparative study of 5′- and 3′-linked CpG–antigen conjugates for the induction of cellular immune responses. ACS Omega, 2(1), 227-235. doi: 10.1021/acsomega.6b00368

Journal - Research Article

Nguyen, H. V., Campbell, K., Painter, G. F., Young, S. L., & Walker, G. F. (2021). Data on the uptake of CpG-loaded amino-dextran nanoparticles by antigen-presenting cells [Data article]. Data in Brief. Advance online publication. doi: 10.1016/j.dib.2021.106883

Journal - Research Other

Woodall, M. J., Neumann, S., Campbell, K., Pattison, S. T., & Young, S. L. (2020). The effects of obesity on anti-cancer immunity and cancer immunotherapy. Cancers, 12(5), 1230. doi: 10.3390/cancers12051230

Journal - Research Other

Kramer, K., Young, S. L., & Walker, G. F. (2019). Data on the uptake of reducible antigen-adjuvant conjugates by dendritic cells [Data article]. Data in Brief, 23, 103759. doi: 10.1016/j.dib.2019.103759

Journal - Research Other

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