Dr Christoph Goebl

Position	Senior Research Fellow
Department	Department of Pathology and Biomedical Science (Christchurch)
Qualifications	PhD (Graz)

Research

Dr Christoph Goebl obtained his Bachelor and Master's degrees in Chemistry from the Karl-Franzens-University of Graz in Austria, and then his PhD in molecular biology from the same institute with Prof Klaus Zangger. During his PhD, he was a recipient of a DOC-fellowship of the Austrian Academy of Sciences and performed a one-year research stay with Dr Nico Tjandra at the NIH in Bethesda, USA, focusing on NMR spectroscopy of proteins. After his PhD, Dr Goebl joined Prof Tobias Madl as a PFP Helmholtz Fellow at the Technical University of Munich and the Helmholtz Center Munich, Germany where he became interested in the molecular basis of reactive oxygen species in biology. He then carried out a cell-biology focused post-doctoral position with Prof Tak W. Mak and Dr Chiara Gorrini at the Princess Margaret Cancer Centre in Toronto, Canada, working on cancer-pathways and redox signalling.

Dr Goebl combines expertise in structural biology (using NMR spectroscopy, small-angle X-ray scattering (SAXS) and X-ray crystallography) with experience in biochemical methods in oxidative stress signalling. He is exploring oxidative stress pathways of the Aryl hydrcarbon receptor (AhR) with focus on its metabolomic signalling in cancers. He also discovered redox-mediated amyloid formation of the tumour suppressor protein p16, and is currently investigating its role in melanoma.

Dr Goebl’s work is currently supported by a Sir Charles Hercus Fellowship from the Health Research Council and a Marsden project grant.

Publications

Pulido, S., Rückert, H., Falsone, S. F., Göbl, C., Meyer, N. H., & Zangger, K. (2023). The membrane-binding bacterial toxin long direct repeat D inhibits protein translation. Biophysical Chemistry, 298, 107040. doi: 10.1016/j.bpc.2023.107040

Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 104792. Advance online publication. doi: 10.1016/j.jbc.2023.104792

Nechanitzky, R., Nechanitzky, D., Ramachandran, P., Duncan, G. S., Zheng, C., Göbl, C., … Mak, T. W. (2023). Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis. Cell Death & Differentiation, 30, 407-416. doi: 10.1038/s41418-022-01092-y

Gubensäk, N., Schrank, E., Hartlmüller, C., Göbl, C., Falsone, F. S., Becker, W., … Zangger, K. (2021). Structural and DNA binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR. Journal of Biological Chemistry, 297(4), 101167. doi: 10.1016/j.jbc.2021.101167

Crowther, J. M., Gilmour, L. H., Porebski, B. T., Heath, S. G., Pattinson, N. R., Owen, M. C., … Göbl, C., & Dobson, R. C. J. (2021). Molecular basis of a redox switch: Molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen. Biochemical Journal, 478, 3319-3330. doi: 10.1042/bcj20210476

Journal - Research Article

Harjes, E., Jameson, G. B., Tu, Y.-H., Burr, N., Loo, T., Goroncy, A. K., … Göbl, C., … Norris, G. E. (2021). Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2. FEBS Letters, 595, 324-340. doi: 10.1002/1873-3468.13990

Journal - Research Article

Peskin, A. V., Meotti, F. C., Kean, K. M., Göbl, C., Peixoto, A. S., Pace, P. E., … Winterbourn, C. C. (2021). Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2. Journal of Biological Chemistry, 296, 100494. doi: 10.1016/j.jbc.2021.100494

Journal - Research Article

Göbl, C., Morris, V. K., van Dam, L., Visscher, M., Polderman, P. E., Hartlmüller, C., … Dansen, T. B. (2020). Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16^INK4A. Redox Biology, 28, 101316. doi: 10.1016/j.redox.2019.101316

Journal - Research Article

Hartlmüller, C., Spreitzer, E., Göbl, C., Falsone, F., & Madl, T. (2019). NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins. Journal of Biomolecular NMR, 73(6-7), 305-317. doi: 10.1007/s10858-019-00248-2

Journal - Research Article

Kubli, S. P., Bassin, C., Roux, C., Wakeham, A., Göbl, C., Zhou, W., … Gorrini, C. (2019). AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer. PNAS, 116(9), 3604-3613. doi: 10.1073/pnas.1815126116

Journal - Research Article

Cristóvão, J. S., Morris, V. K., Cardoso, I., Leal, S. S., Martínez, J. M., Botelho, H. M., Göbl, C., … Gomes, C. M. (2018). The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation. Science Advances, 4(6), eaaq1702. doi: 10.1126/sciadv.aaq1702

Journal - Research Article

Göbl, C., & Madl, T. (2018). Entspannte Moleküle: NMR-Ober- flächen daten zur Strukturbestimmung. Biospektrum, 24(2), 161-163. doi: 10.1007/s12268-018-0898-5

Journal - Research Article

Weber, B., Hora, M., Kazman, P., Göbl, C., Camilloni, C., Reif, B., & Buchner, J. (2018). The antibody light-chain linker regulates domain orientation and amyloidogenicity. Journal of Molecular Biology, 430(24), 4925-4940. doi: 10.1016/j.jmb.2018.10.024

Journal - Research Article

Gourinchas, G., Etzl, S., Göbl, C., Vide, U., Madl, T., & Winkler, A. (2017). Long-range allosteric signaling in red light–regulated diguanylyl cyclases. Science Advances, 3(3), e1602498. doi: 10.1126/sciadv.1602498

Journal - Research Article

Rodriquez Camargo, D. C., Tripsianes, K., Buday, K., Franko, A., Göbl, C., Hartlmüller, C., … Reif, B. (2017). The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes. Scientific Reports, 7, 44041. doi: 10.1038/srep44041

Journal - Research Article

Göbl, C., Resch, M., Strickland, M., Hartlmüller, C., Viertler, M., Tjandra, N., & Madl, T. (2016). Increasing the chemical-shift dispersion of unstructured proteins with a covalent lanthanide shift reagent [Communication]. Angewandte Chemie International Edition, 55(47), 14847-14851. doi: 10.1002/anie.201607261

Journal - Research Article

Strickland, M., Schwieters, C. D., Göbl, C., Opina, A. C. L., Strub, M.-P., Swenson, R. E., … Tjandra, N. (2016). Characterizing the magnetic susceptibility tensor of lanthanide-containing polymethylated-DOTA complexes. Journal of Biomolecular NMR, 66(2), 125-139. doi: 10.1007/s10858-016-0061-x

Journal - Research Article

Suárez-Calvet, M., Neumann, M., Arzberger, T., Abou-Ajram, C., Funk, E., Hartmann, H., … Göbl, C., … Haass, C. (2016). Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathologica, 131(4), 587-604. doi: 10.1007/s00401-016-1544-2

Journal - Research Article

Chromikova, V., Mader, A., Hofbauer, S., Göbl, C., Madl, T., Gach, J. S., … Kunert, R. (2015). Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM. Biochimica et Biophysica Acta: Proteins & Proteomics, 1854(10, Pt A), 1536-1544. doi: 10.1016/j.bbapap.2015.02.018

Journal - Research Article

Gersch, M., Famulla, K., Dahmen, M., Göbl, C., Malik, I., Richter, K., … Sieber, S. A. (2015). AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control. Nature Communications, 6, 6320. doi: 10.1038/ncomms7320

Journal - Research Article

Hacker, C., Christ, N. A., Duchardt-Ferner, E., Korn, S., Göbl, C., Berninger, L., … Wöhnert, J. (2015). The solution structure of the lantibiotic immunity protein NisI and its interactions with nisin. Journal of Biological Chemistry, 290(48), 28869-28886. doi: 10.1074/jbc.M115.679969

Journal - Research Article

Göbl, C., Madl, T., Simon, B., & Sattler, M. (2014). NMR approaches for structural analysis of multidomain proteins and complexes in solution. Progress in Nuclear Medicine Resonance Spectroscopy, 80, 26-63. doi: 10.1016/j.pnmrs.2014.05.003

Journal - Research Article

Kosol, S., Schrank, E., Bukvić Krajačić, M., Wagner, G. E., Meyer, N. H., Göbl, C., … Novak, P. (2012). Probing the interactions of macrolide antibiotics with membrane-mimetics by NMR spectroscopy. Journal of Medicinal Chemistry, 55(11), 5632-5636. doi: 10.1021/jm300647f

Journal - Research Article

Göbl, C., Dulle, M., Hohlweg, W., Grossauer, J., Falsone, S. F., Glatter, O., & Zangger, K. (2010). Influence of phosphocholine alkyl Chain length on peptide—micelle interactions and micellar size and shape. Journal of Physical Chemistry B, 114(13), 4717-4724. doi: 10.1021/jp9114089

Journal - Research Article

Göbl, C., Kosol, S., Stockner, T., Rückert, H. M., & Zangger, K. (2010). Solution structure and membrane binding of the toxin Fst of the par addiction module. Biochemistry, 49(31), 6567-6575. doi: 10.1021/bi1005128

Journal - Research Article

Pieber, B., Schober, S., Goebl, C., & Mittelbach, M. (2010). Novel sensitive determination of steryl glycosides in biodiesel by gas chromatography–mass spectroscopy. Journal of Chromatography A, 1217(42), 6555-6561. doi: 10.1016/j.chroma.2010.08.006

Journal - Research Article

Zangger, K., Respondek, M., Göbl, C., Hohlweg, W., Rasmussen, K., Grampp, G., & Madl, T. (2009). Positioning of micelle-bound peptides by paramagnetic relaxation enhancements. Journal of Physical Chemistry B, 113(13), 4400-4406. doi: 10.1021/jp808501x

Journal - Research Article

Respondek, M., Madl, T., Göbl, C., Golser, R., & Zangger, K. (2007). Mapping the orientation of helices in micelle-bound peptides by paramagnetic relaxation waves. Journal of the American Chemical Society, 129(16), 5228-5234. doi: 10.1021/ja069004f

Journal - Research Article

Göbl, C., Focke-Teikl, M., Najafi, N., Schrank, E., Madl, T., Kosol, S., … Tjandra, N. (2017). Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity. Journal of Allergy & Clinical Immunology, 140(4), 1187-1191. doi: 10.1016/j.jaci.2017.05.005

Journal - Research Other

Hartlmüller, C., Göbl, C., & Madl, T. (2016). Prediction of protein structure using surface accessibility data [Communication]. Angewandte Chemie International Edition, 55(39), 11970-11974. doi: 10.1002/anie.201604788

Journal - Research Other

Göbl, C., & Tjandra, N. (2012). Application of solution NMR spectroscopy to study protein dynamics. Entropy, 14(3), 581-598. doi: 10.3390/e14030581

Journal - Research Other

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Dr Christoph Goebl

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