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Health Sciences profile

Dr Shane Ohline

PositionPostdoctoral Fellow
DepartmentDepartment of Physiology
Research summaryThe role of ryanodine receptors in Alzheimer's disease

Research

The ryanodine receptor has been shown to be faulty in both Alzheimer’s (AD) and heart disease.

We study the receptor in neurons by determining how it is organised and trafficked in a mouse model of AD. Additionally, we will study the effects of already approved heart medications on the brain of this model mouse using patch clamp electrophysiology.

We aim to understand the function, and dysfunction, of this receptor in the brain and to find some way to restore its normal function in AD.

Publications

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Ohline, S. M., & Abraham, W. C. (2019). Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons [Invited]. Neuropharmacology, 145(A), 3-12. doi: 10.1016/j.neuropharm.2018.04.007

Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Journal - Research Article

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Journal - Research Article

Singh, A., Jones, O. D., Mockett, B. G., Ohline, S. M., & Abraham, W. C. (2019). Tumor necrosis factor-α-mediated metaplastic inhibition of LTP is constitutively engaged in an Alzheimer's disease model. Journal of Neuroscience, 39(46), 9083-9097. doi: 10.1523/jneurosci.1492-19.2019

Journal - Research Article

Ohline, S. M., Wake, K. L., Hawkridge, M.-V., Dinnunhan, M. F., Hegemann, R. U., Wilson, A., Schoderboeck, L., Logan, B. J., … Hughes, S. M., & Abraham, W. C. (2018). Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience. Brain Structure & Function, 223(7), 3213-3228. doi: 10.1007/s00429-018-1685-2

Journal - Research Article

Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9

Journal - Research Article

Xiong, M., Jones, O. D., Peppercorn, K., Ohline, S. M., Tate, W. P., & Abraham, W. C. (2017). Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats. Neurobiology of Learning & Memory, 138, 291-299. doi: 10.1016/j.nlm.2016.08.002

Journal - Research Article

Taylor, C. J., Ohline, S. M., Moss, T., Ulrich, K., & Abraham, W. C. (2016). The persistence of long-term potentiation in the ventral hippocampus to medial prefrontal cortex projection in awake rats. European Journal of Neuroscience, 43(6), 811-822. doi: 10.1111/ejn.13167

Journal - Research Article

Ohline, S. M., Reid, M. R., Husheer, S. L. G., Currie, K. I., & Hunter, K. A. (2007). Spectrophotometric determination of pH in seawater off Taiaroa Head, Otago, New Zealand: Full-spectrum modelling and prediction of pCO2 levels. Marine Chemistry, 107, 143-155.

Journal - Research Article

Ohline, S. M., Campbell, M. L., Turnbull, M. T., & Kohler, S. J. (2001). Differential scanning calorimetric study of bilayer membrane phase transitions: A biophysical chemistry experiment. Journal of Chemical Education, 78(9), 1251.

Journal - Research Article

Ohline, S. M., Lee, S., Williams, S., & Chang, C. (2001). Quantification of methylene blue aggregation on a fused silica surface and resolution of individual absorbance spectra. Chemical Physics Letters, 346, 9-15.

Journal - Research Article

Joireman, P. W., Ohline, S. M., & Felker, P. M. (1998). Structural characterization of aromatic-aromatic complexes by rotational coherence spectroscopy. Journal of Physical Chemistry A, 102, 4481-4494. doi: 10.1021/jp9808678

Journal - Research Article

Hamm, P., Ohline, S. M., & Zinth, W. (1997). Vibrational cooling after ultrafast photoisomerization of azobenzene measured by femtosecond infrared spectroscopy. Journal of Chemical Physics, 106(2), 519-529. doi: 10.1063/1.473392

Journal - Research Article

Ohline, S. M., Romascan, J., & Felker, P. M. (1995). Rotational coherence spectroscopy of aromatic-(Ar)n clusters: Geometries of anthracene-(Ar)n, 9,10-dichloroanthracene-Ar, and Tetracen-Ar. Journal of Physical Chemistry, 99, 7311-7319. doi: 10.1021/j100019a014

Journal - Research Article

Maxton, P. M., Schaeffer, M. W., Ohline, S. M., Kim, W., Venturo, V. A., & Felker, P. M. (1994). The raman and vibronic activity of intermolecular vibrations in aromatic-containing complexes and clusters. Journal of Chemical Physics, 101, 8391-8408. doi: 10.1063/1.468102

Journal - Research Article

Joireman, P. W., Ohline, S. M., Connell, L. L., & Felker, P. M. (1993). Picosecond methods applied to a structural study of N-H—X hydrogen bonds: Geometries of carbazole-water and carbazole-ammonia by rotational coherence spectroscopy. Journal of Physical Chemistry, 97, 12504-12508. doi: 10.1021/j100150a010

Journal - Research Article

Ohline, S. M., Romascan, J., & Felker, P. M. (1993). Time-resolved ionization depletion: A new picosecond method for molecular beam studies. Chemical Physics Letters, 207(4-6), 563-568. doi: 10.1016/0009-2614(93)89048-M

Journal - Research Article

Connell, L. L., Ohline, S. M., Joireman, P. W., Corcoran, T. C., & Felker, P. M. (1992). Rotational coherence spectroscopy and structure of phenol dimer. Journal of Chemical Physics, 96, 2585-2593. doi: 10.1063/1.462009

Journal - Research Article

Joireman, P. W., Connell, L. L., Ohline, S. M., & Felker, P. M. (1992). Characterization of asymmetry transients in rotational coherence spectroscopy. Journal of Chemical Physics, 96, 4118-4130. doi: 10.1063/1.461867

Journal - Research Article

Ohline, S. M., Connell, L. L., Joireman, P. W., Venturo, V. A., & Felker, P. M. (1992). The geometry of carbazole-(Ar)2 from rotational coherence spectroscopy. Chemical Physics Letters, 193(5), 335-341. doi: 10.1016/0009-2614(92)85640-V

Journal - Research Article

Ohline, S. M., Joireman, P. W., Connell, L. L., & Felker, P. M. (1992). Structural characterization of clusters of perylene with argon and neon by rotational coherence spectroscopy. Chemical Physics Letters, 191(3-4), 362-370. doi: 10.1016/0009-2614(92)85315-2

Journal - Research Article

Connell, L. L., Ohline, S. M., Joireman, P. W., Corcoran, T. C., & Felker, P. M. (1991). Rotational coherence spectroscopy of 1-naphthol-(water)2 clusters: Structural evidence for a cyclic hydrogen-bonded trimer. Journal of Chemical Physics, 94, 4668-4671. doi: 10.1063/1.460597

Journal - Research Article

Joireman, P. W., Connell, L. L., Ohline, S. M., & Felker, P. M. (1991). Rotational coherence spectroscopy and structure of the perylene-benzene van der Waals complex. Chemical Physics Letters, 182(5), 385-392. doi: 10.1016/0009-2614(91)90095-Q

Journal - Research Article

Joireman, P. W., Connell, L. L., Ohline, S. M., & Felker, P. M. (1991). Structure of fluorene-benzene aromatic dimer from rotational coherence spectroscopy. Journal of Physical Chemistry, 95, 4935-4939. doi: 10.1021/j100166a006

Journal - Research Article

Ohline, S. M., & Abraham, W. C. (2019). Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons [Invited]. Neuropharmacology, 145(A), 3-12. doi: 10.1016/j.neuropharm.2018.04.007

Journal - Research Other

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