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Health Sciences profile

Associate Professor Kirk Hamilton

PositionAssociate Professor
DepartmentDepartment of Physiology
QualificationsMA (Texas) PhD (Utah State)
Research summaryIon channels and transport

Research

My main research interest is the molecular regulation, physiology and function of ion channels of epithelial tissues. My research is focused on the molecular regulation and trafficking of K+ channels, in particular, the human intermediate-conductance Ca2+-activated K+ channel, KCa3.1 and the one transmembrane domain K+ channels β-subunits KCNE1 and KCNE3. We are using biotin-ligase acceptor peptide (BLAP) technology to tagged K+ channels in order to examine their cellular and membrane fate. We hope to further understand the role of KCa3.1 in cell biology.

A new research avenue has emerged from collaboration with members of the Auckland Bioengineering Institute in which we are developing mathematical modeling approaches to understand the function of the nephron. The goal of this research is to develop a framework for the comprehensive model description of biophysically detailed multi-scale physiological model of multi-nephron complex.

Publications

Farquhar, R. E., Cheung, T. T., Logue, M. J. E., McDonald, F. J., Devor, D. C., & Hamilton, K. L. (2022). Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium. Frontiers in Physiology, 13, 905834. doi: 10.3389/fphys.2022.905834

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Studies of epithelial transporters and ion channels: Ion channels and transporters of epithelia in health and disease (Vol. 3) (2nd ed.). Cham, Switzerland: Springer, 1244p. doi: 10.1007/978-3-030-55454-5

Devor, D. C., Thibodeau, P. H., & Hamilton, K. L. (2020). KCa3.1 in epithelia. In K. L. Hamilton & D. C. Devor (Eds.), Studies of epithelial transporters and ion channels: Ion channels and transporters of epithelia in health and disease (Vol. 3). (2nd ed.) (pp. 893-948). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-55454-5_22

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Ion transport across epithelial tissues and disease: Ion channels and transporters of epithelia in health and disease (Vol. 2) (2nd ed.). Cham, Switzerland: Springer, 390p. doi: 10.1007/978-3-030-55310-4

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1) (2nd ed.). Cham, Switzerland: Springer, 563p. doi: 10.1007/978-3-030-52780-8

Farquhar, R. E., Cheung, T. T., Logue, M. J. E., McDonald, F. J., Devor, D. C., & Hamilton, K. L. (2022). Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium. Frontiers in Physiology, 13, 905834. doi: 10.3389/fphys.2022.905834

Journal - Research Article

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Studies of epithelial transporters and ion channels: Ion channels and transporters of epithelia in health and disease (Vol. 3) (2nd ed.). Cham, Switzerland: Springer, 1244p. doi: 10.1007/978-3-030-55454-5

Edited Book - Research

Devor, D. C., Thibodeau, P. H., & Hamilton, K. L. (2020). KCa3.1 in epithelia. In K. L. Hamilton & D. C. Devor (Eds.), Studies of epithelial transporters and ion channels: Ion channels and transporters of epithelia in health and disease (Vol. 3). (2nd ed.) (pp. 893-948). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-55454-5_22

Chapter in Book - Research

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Ion transport across epithelial tissues and disease: Ion channels and transporters of epithelia in health and disease (Vol. 2) (2nd ed.). Cham, Switzerland: Springer, 390p. doi: 10.1007/978-3-030-55310-4

Edited Book - Research

Hamilton, K. L., & Devor, D. C. (Eds.). (2020). Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1) (2nd ed.). Cham, Switzerland: Springer, 563p. doi: 10.1007/978-3-030-52780-8

Edited Book - Research

Hamilton, K. L. (2020). Techniques of epithelial transport physiology. In K. L. Hamilton & D. C. Devor (Eds.), Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1). (Second ed.) (pp. 1-52). Cham, Swizterland: Springer. doi: 10.1007/978-3-030-52780-8_1

Chapter in Book - Research

Nickerson, D. P., Noroozbabaee, L., Sarwar, D. M., Hamilton, K. L., & Hunter, P. J. (2020). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Basic epithelial ion transport principles and function: Ion channels and transporters of epithelia in health and disease (Vol. 1). (Second ed.) (pp. 115-133). Cham, Swizterland: Springer. doi: 10.1007/978-3-030-52780-8_4

Chapter in Book - Research

Cheung, T. T., Geda, A. C., Ware, A. W., Rasulov, S. R., Tenci, P., Hamilton, K. L., & McDonald, F. J. (2020). Retromer is involved in epithelial Na+ channel trafficking. American Journal of Physiology: Renal Physiology, 319, F895-F907. doi: 10.1152/ajprenal.00198.2019

Journal - Research Article

Hamilton, K. L. (2020). AJP-Cell Physiology begins a Theme of Reviews on "New Frontiers in Protein Trafficking". American Journal of Physiology: Cell Physiology, 319, C402-C403. doi: 10.1152/ajpcell.00347.2020

Journal - Research Other

Lozano-Gerona, J., Oliván-Viguera, A., Delgado-Wicke, P., Singh, V., Brown, B. M., Tapia-Casellas, E., … Hamilton, K. L., … Köhler, R. (2020). Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. PLoS ONE, 15(3), e0222619. doi: 10.1371/journal.pone.0222619

Journal - Research Article

Valero, M. S., Ramón-Gimenez, M., Lozano-Gerona, J., Delgado-Wicke, P., Calmarza, P., Oliván-Viguera, A., … Hamilton, K. L., … Köhler, R. (2019). KCa3.1 transgene induction in murine intestinal epithelium causes duodenal chyme accumulation and impairs duodenal contractility. International Journal of Molecular Sciences, 20(5), 1193. doi: 10.3390/ijms20051193

Journal - Research Article

Bertuccio, C. A., Wang, T. T., Hamilton, K. L., Rodriguez-Gil, D. J., Condliffe, S. B., & Devor, D. C. (2018). Plasma membrane insertion of KCa2.3 (SK3) is dependent upon the SNARE proteins, syntaxin-4 and SNAP23. PLoS ONE, 13(5). doi: 10.1371/journal.pone.0196717

Journal - Research Article

Olivan-Viguera, A., Garcia-Otin, A. L., Lozano-Gerona, J., Abarca-Lachen, E., Garcia-Malinis, A. J., Hamilton, K. L., … Köhler, R. (2018). Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE, 13(1), e0190307. doi: 10.1371/journal.pone.0190307

Journal - Research Article

Delpire, E., Hamilton, K. L., Hawke, T. J., Isenberg, J. S., Lotersztajn, S., Yuan, J. X.-J., & Adams, J. C. (2018). AJP-Cell Physiology begins landmark reviews in cell physiology: An editorial from the senior editors of AJP-Cell Physiology. American Journal of Physiology: Cell Physiology, 314(1), C1. doi: 10.1152/ajpcell.00256.2017

Journal - Research Other

Lee, B. S.-L., Devor, D. C., & Hamilton, K. L. (2017). Modulation of retrograde trafficking of KCa3.1 in a polarized epithelium. Frontiers in Physiology, 8, 489. doi: 10.3389/fphys.2017.00489

Journal - Research Article

Farquhar, R. E., Rodrigues, E., & Hamilton, K. L. (2017). The role of the cytoskeleton and Myosin-Vc in the targeting of KCa3.1 to the basolateral membrane of polarized epithelial cells. Frontiers in Physiology, 7, 639. doi: 10.3389/fphys.2016.00639

Journal - Research Article

Hamilton, K. L., & Moore, A. B. (2016). 50 years of renal physiology from one man and the perfused tubule: Maurice B. Burg. American Journal of Physiology: Renal Physiology, 311(2), F291-F304. doi: 10.1152/ajprenal.00198.2016

Journal - Research Article

Hamilton, K. L., & Devor, D. C. (Eds.). (2016). Ion channels and transporters of epithelia in health and disease. New York: Springer, 1019p. doi: 10.1007/978-1-4939-3366-2

Edited Book - Research

Devor, D. C., Bertuccio, C. A., & Hamilton, K. L. (2016). KCa3.1 in epithelia. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 659-705). New York: Springer. doi: 10.1007/978-1-4939-3366-2_20

Chapter in Book - Research

Nickerson, D. P., Hamilton, K. L., & Hunter, P. J. (2016). Mathematical modeling of epithelial ion transport. In K. L. Hamilton & D. C. Devor (Eds.), Ion channels and transporters of epithelia in health and disease. (pp. 265-278). New York: Springer. doi: 10.1007/978-1-4939-3366-2_6

Chapter in Book - Research

Hamilton, K. L. (2016). New life in overactive bladder: Focus on "Novel regulatory mechanism in human urinary bladder: Central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function". American Journal of Physiology: Cell Physiology, 310(7), C597-C599. doi: 10.1152/ajpcell.00039.2016

Journal - Research Other

Pilmore, E., & Hamilton, K. L. (2015). The role of microRNAs in the regulation of K+ channels in epithelial tissue. Frontiers in Physiology, 6, 352. doi: 10.3389/fphys.2015.00352

Journal - Research Article

Sun, H., Niisato, N., Nishio, K., Hamilton, K. L., & Marunaka, Y. (2014). Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl- secretion: Useful tools as regulators of Cl- secretion. BioMed Research International, 2014, 902735. doi: 10.1155/2014/902735

Journal - Research Article

Bertuccio, C. A., Lee, S.-L., Wu, G., Butterworth, M. B., Hamilton, K. L., & Devor, D. C. (2014). Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent. PLoS ONE, 9(3), e92013. doi: 10.1371/journal.pone.0092013

Journal - Research Article

Hamilton, K. L. (2014). Even an old technique is suitable in the molecular world of science: The everted sac preparation - turns 60 years old. American Journal of Physiology: Cell Physiology, 306(8), C715-C720. doi: 10.1152/ajpcell.00041.2014

Journal - Research Article

Hamilton, K. L. (2014). Cleavage: What’s up with prostasin and ENaC these days? American Journal of Physiology: Renal Physiology, 307(11), F1196-F1197. doi: 10.1152/ajprenal.00522.2014

Journal - Research Other

Hamilton, K. L., & Butt, A. G. (2013). Glucose transport into everted sacs of the small intestine of mice. Advances in Physiology Education, 37(4), 415-426. doi: 10.1152/advan.00017.2013

Journal - Research Article

Hamilton, K. L. (2013). Robert K. Crane: Na+-glucose cotransporter to cure? Frontiers in Physiology, 4, 53. doi: 10.3389/fphys.2013.00053

Journal - Research Other

Hamilton, K. L. (2013). Cyclosporine A and lovastatin: The Good and the bad, but who will be the winner? American Journal of Physiology: Renal Physiology, 305(5), F643-F644. doi: 10.1152/ajprenal.00321.2013

Journal - Research Other

Balut, C. M., Hamilton, K. L., & Devor, D. C. (2012). Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca2+-activated K+ channels: A novel target for medicinal chemistry efforts? ChemMedChem, 7(10), 1741-1755. doi: 10.1002/cmdc.201200226

Journal - Research Article

Hamilton, K. L., & Devor, D. C. (2012). Basolateral membrane K+ channels in renal epithelial cells. American Journal of Physiology: Renal Physiology, 302(9), F1069-F1081. doi: 10.1152/ajprenal.00646.2011

Journal - Research Article

Hamilton, K. L., & Pao, A. C. (2012). βPix is a new player in renal physiology. Frontiers in Physiology, 3, 268. doi: 10.3389/fphys.2012.00268

Journal - Research Article

Hamilton, K. L. (2012). BLAP-tags, TUBEs and DUB-Chips: Combined novel technologies will advance molecular epithelial physiology. Frontiers in Physiology, 3, 137. doi: 10.3389/fphys.2012.00137

Journal - Research Article

Millership, J. E., Devor, D. C., Hamilton, K. L., Balut, C. M., Bruce, J. I. E., & Fearon, I. M. (2011). Calcium-activated K+ channels increase cell proliferation independent of K+ conductance. American Journal of Physiology: Cell Physiology, 300(4), C792-C802. doi: 10.1152/ajpcell.00274.2010

Journal - Research Article

Hamilton, K. L. (2011). Ussing's ″little chamber″: 60 years+ old and counting. Frontiers in Physiology, 2, 6. doi: 10.3389/fphys.2011.00006

Journal - Research Other

Nickerson, D. P., Terkildsen, J. R., Hamilton, K. L., & Hunter, P. J. (2011). A tool for multi-scale modelling of the renal nephron. Interface Focus, 1, 417-425. doi: 10.1098/rsfs.2010.0032

Journal - Research Article

Hamilton, K. L. (2010). BLAP-tagged channel technology: A new direction trafficking toward epithelial physiology. Frontiers in Physiology, 1, 162. doi: 10.3389/fphys.2010.00162

Journal - Research Other

Chao, P.-C., & Hamilton, K. L. (2009). Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum. American Journal of Physiology: Cell Physiology, 297(3), C688-C698. doi: 10.1152/ajpcell.00152.2009

Journal - Research Article

Jones, H. M., Bailey, M. A., Baty, C. J., MacGregor, G. G., Syme, C. A., Hamilton, K. L., & Devor, D. C. (2007). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hlK1. Channels, 1(2), 80-91.

Journal - Research Article

Hamilton, K. L., & Kiessling, M. (2006). DCEBIO stimulates Cl- secretion in the mouse jejunum. American Journal of Physiology: Cell Physiology, 290, C152-C164. doi: 10.1152/ajpcell.00187.2005

Journal - Research Article

Jones, H. M., Hamilton, K. L., & Devor, D. C. (2005). Role of an S4-S5 linker lysine in the trafficking of the Ca2+ -activated K+ channels IK1 and SK3. Journal of Biological Chemistry, 280(44), 37257-37265.

Journal - Research Article

Jones, H. M., Hamilton, K. L., Papworth, G. D., Syme, C. A., Watkins, S. C., Bradbury, N. A., & Devor, D. C. (2004). Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. Journal of Biological Chemistry, 279(15), 15531-15540.

Journal - Research Article

Baker, M. J., & Hamilton, K. L. (2004). Genistein stimulates electrogenic Cl- secretion in mouse jejunum. American Journal of Physiology: Cell Physiology, 287, C1636-C1645.

Journal - Research Article

Hamilton, K. L., Syme, C. A., & Devor, D. C. (2003). Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. Journal of Biological Chemistry, 278, 16690-16697.

Journal - Research Article

Syme, C. A., Hamilton, K. L., Jones, H. M., Gerlach, A. C., Giltinan, L., Papworth, G. D., … Devor, D. C. (2003). Trafficking of the Ca2+ -activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper. Journal of Biological Chemistry, 278(10), 8476-8486.

Journal - Research Article

Hamilton, K. L., Butt, A. G., Cheng, S., & Carter, D. J. (2002). Methoxsalen stimulates electrogenic Cl- secretion in the mouse jejunum. Experimental Physiology, 87(4), 437-445.

Journal - Research Article

Taylor, J., Hamilton, K. L., & Butt, A. G. (2001). HCO3- potentiates the cAMP-dependent secretory response of the human distal colon through a DIDS-sensitive pathway. Pflügers Archiv: European Journal of Physiology, 442(2), 256-262.

Journal - Research Article

Samson, A., Hamilton, K. L., & Butt, A. G. (2000). Effect of somatostatin on electrogenic ion transport in the duodenum and colon of the mouse, Mus domesticus. Comparative Biochemistry & Physiology Part A, 125A, 459-468.

Journal - Research Article

Hamilton, K. L., & Butt, A. G. (2000). The molecular basis of renal tubular transport disorders. Comparative Biochemistry & Physiology Part A, 126A, 305-321.

Journal - Research Article

Hamilton, K. L., Meads, L., & Butt, A. G. (1999). 1-EBIO stimulates C1 secretion by activating a basolateral K channel in the mouse jejunum. Pflügers Archiv: European Journal of Physiology, 439, 158-166.

Journal - Research Article

Butt, A. G., & Hamilton, K. L. (1998). Ion channels in isolated mouse jejunal crypts. Pflügers Archiv: European Journal of Physiology, 435, 528-538.

Journal - Research Article

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