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Health Sciences profile

Dr Chi Lynch-Sutherland

PositionPostdoctoral Fellow
DepartmentDepartment of Pathology (Dunedin)
QualificationsBSc(Hons) PhD
Research summaryShared mechanisms of early human development and cancer
Teaching
  • GENE221 Molecular and Microbial Genetics
  • GENE313 Medical Genetics
  • GENE314 Developmental Genetics
  • PHTY353 Principles of Pathology

Research

My research utilises early human development to further our understanding of cancer. I am particularly interested in deciphering the function of 'junk DNA' or transposable elements within the human genome.

My work investigates how transposable elements enable cancers to repurpose early developmental processes to drive malignancy. I employ bioinformatic analysis of transcriptome and epigenome datasets along with wet lab techniques to address this question. Overall my research seeks to discover new targets that can be used to improve the way we diagnose and treat cancer.

Publications

Hossain, S. M., Lynch-Sutherland, C., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). Can immune suppression and epigenome regulation in placenta offer novel insights into cancer immune evasion and immunotherapy resistance? Epigenomes, 5, 16. doi: 10.3390/epigenomes5030016

Stockwell, P. A., Lynch-Sutherland, C. F., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). RepExpress: A novel pipeline for the quantification and characterization of transposable element expression from RNA-seq data. Current Protocols, 1(8), e206. doi: 10.1002/cpz1.206

McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320

Lynch-Sutherland, C. F., Chatterjee, A., Stockwell, P. A., Eccles, M. R., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Frontiers in Oncology, 10, 468. doi: 10.3389/fonc.2020.00468

Jones, G. T., Marsman, J., Pardo, L. M., Nijsten, T., De Maeseneer, M., Phillips, V., Lynch-Sutherland, C., Horsfield, J., Krysa, J., & van Rij, A. M. (2019). A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease. Scientific Reports, 9, 14011. doi: 10.1038/s41598-019-50586-2