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Health Sciences profile

Dr Tim Prickett

PositionResearch Fellow
DepartmentDepartment of Medicine (UOC)
QualificationsMSc PhD
Research summaryCardioendocrinology

Research

Tim is a member of the Cardioendocrine Research Group

Publications

Woodward, Z., Prickett, T. C. R., Espiner, E. A., & Anderson, T. J. (2017). Central and systemic C-type Natriuretic Peptide are both reduced in Parkinson's Disease. Parkinsonism & Related Disorders, 43, 15-19. doi: 10.1016/j.parkreldis.2017.06.019

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2017). Molecular forms of C-type natriuretic peptide in cerebrospinal fluid and plasma reflect differential processing in brain and pituitary tissues. Peptides. Advance online publication. doi: 10.1016/j.peptides.2017.10.007

Wilson, M. O., McNeill, B. A., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2017). Dexamethasone increases production of C-type natriuretic peptide in the sheep brain. Journal of Endocrinology, 235(1), 15-25. doi: 10.1530/joe-17-0148

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Chapter in Book - Research

Prickett, T. C. R., & Espiner, E. A. (2012). C-type natriuretic peptide (CNP) and postnatal linear growth. In V. R. Preedy (Ed.), Handbook of growth and growth monitoring in health and disease. (pp. 2789-2809). New York: Springer. doi: 10.1007/978-1-4419-1795-9

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Journal - Research Article

Woodward, Z., Prickett, T. C. R., Espiner, E. A., & Anderson, T. J. (2017). Central and systemic C-type Natriuretic Peptide are both reduced in Parkinson's Disease. Parkinsonism & Related Disorders, 43, 15-19. doi: 10.1016/j.parkreldis.2017.06.019

Prickett, T. C. R., Doughty, R. N., Troughton, R. W., Frampton, C. M., Whalley, G. A., Ellis, C. J., Espiner, E. A., & Richards, A. M. (2017). C-type natriuretic peptides in coronary disease. Clinical Chemistry, 63(1), 316-324. doi: 10.1373/clinchem.2016.257816

Lewis, L. K., Raudsepp, S. D., Yandle, T. G., Prickett, T. C., & Richards, A. M. (2017). Development of a BNP1-32 immunoassay that does not cross-react with proBNP. Clinical Chemistry, 63(6), 1110-1117. doi: 10.1373/clinchem.2016.269712

Wilson, M. O., McNeill, B. A., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2017). Dexamethasone increases production of C-type natriuretic peptide in the sheep brain. Journal of Endocrinology, 235(1), 15-25. doi: 10.1530/joe-17-0148

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2017). Molecular forms of C-type natriuretic peptide in cerebrospinal fluid and plasma reflect differential processing in brain and pituitary tissues. Peptides. Advance online publication. doi: 10.1016/j.peptides.2017.10.007

Prickett, T. C. R., Darlow, B. A., Troughton, R. W., Cameron, V. A., Elliott, J. M., Martin, J., Horwood, L. J., & Espiner, E. A. (2017). New insights into cardiac and vascular natriuretic peptides: Findings from young adults born with very low birth weight. Clinical Chemistry. Advance online publication. doi: 10.1373/clinchem.2017.280354

Spiroski, A. M., Oliver, M. H., Jaquiery, A. L., Prickett, T. C. R., Espiner, E. A., Harding, J. E., & Bloomfield, F. H. (2017). Postnatal effects of intrauterine treatment of the growth-restricted ovine fetus with intra-amniotic insulin-like growth factor-1. Journal of Physiology. Advance online publication. doi: 10.1113/jp274999

Madhavan, S., Prickett, T. C. R., Espiner, E. A., & Barrell, G. K. (2017). Nutrient restriction in early ovine pregnancy stimulates C-type natriuretic peptide production. Reproduction, Fertility & Development, 29(3), 575-584. doi: 10.1071/RD15192

Olney, R. C., Salehi, P., Prickett, T. C. R., Lima, J. J., Espiner, E. A., Sikes, K. M., & Geffner, M. E. (2016). Dynamic response of C-type natriuretic peptide and its aminoterminal propeptide (NTproCNP) to growth hormone treatment in children with short stature. Clinical Endocrinology, 85(4), 561-568. doi: 10.1111/cen.13103

Olney, R. C., Prickett, T. C. R., Espiner, E. A., Mackenzie, W. G., Duker, A. L., Ditro, C., … Bober, M. B. (2015). C-type natriuretic peptide plasma levels are elevated in subjects with achondroplasia, hypochondroplasia, and thanatophoric dysplasia. Journal of Clinical Endocrinology & Metabolism, 100(2), E355-E359. doi: 10.1210/jc.2014-2814

Espiner, E. A., Prickett, T. C. R., Taylor, R. S., Reid, R. A., & McCowan, L. M. (2015). Effects of pre-eclampsia and fetal growth restriction on C-type natriuretic peptide. BJOG, 122(9), 1236-1243. doi: 10.1111/1471-0528.13397

Wilson, M. O., Barrell, G. K., Prickett, T. C. R., & Espiner, E. A. (2015). Sustained increases in plasma C-type natriuretic peptides fail to increase concentrations in cerebrospinal fluid: Evidence from pregnant sheep. Peptides, 69, 103-108. doi: 10.1016/j.peptides.2015.04.016

Espiner, E. A., Dalrymple-Alford, J. C., Prickett, T. C. R., Alamri, Y., & Anderson, T. J. (2014). C-type natriuretic peptide in Parkinson's disease: Reduced secretion and response to deprenyl. Journal of Neural Transmission, 121(4), 371-378. doi: 10.1007/s00702-013-1123-9

Reid, R. A., Prickett, T. C. R., Pullar, B. E., Darlow, B. A., Gullam, J. E., & Espiner, E. A. (2014). C-type natriuretic peptide in complicated pregnancy: Increased secretion precedes adverse events. Journal of Clinical Endocrinology & Metabolism, 99(4), 1470-1478. doi: 10.1210/jc.2013-3758

Prickett, T. C. R., Wellby, M., Barrell, G. K., Richards, A. M., & Espiner, E. A. (2014). Differential response of C-type natriuretic peptide to estrogen and dexamethasone in adult bone. Steroids, 87, 1-5. doi: 10.1016/j.steroids.2014.05.007

Hannema, S. E., Duyvenvoorde, H. A., Premsler, T., Yang, R.-B., Mueller, T. D., Gassner, B., … Prickett, T., … Espiner, E. A., … Wit, J. M. (2013). An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. Journal of Clinical Endocrinology & Metabolism, 98(12), E1988-E1998. doi: 10.1210/jc.2013-2358

Prickett, T. C. R., Hector-Taylor, J., Olney, R. C., Darlow, B. A., & Espiner, E. A. (2013). Acute inflammation in young children inhibits C-type natriuretic peptide. Pediatric Research, 74(2), 191-195. doi: 10.1038/pr.2013.92

Prickett, T. C. R., Olney, R. C., Cameron, V. A., Ellis, M. J., Richards, A. M., & Espiner, E. A. (2013). Impact of age, phenotype and cardio-renal function on plasma C-type and B-type natriuretic peptide forms in an adult population. Clinical Endocrinology, 78(5), 783-789. doi: 10.1111/cen.12035

Reh, C. S., Olney, R. C., Azen, C., Prickett, T. C., Espiner, E. A., & Geffner, M. E. (2012). Plasma C-type natriuretic peptide forms and thyroid status in prepubertal children with acquired thyroid disease. Clinical Endocrinology, 76(2), 228-235. doi: 10.1111/j.1365-2265.2011.04187.x

Schouten, B. J., Prickett, T. C., Hunt, P. J., Richards, A. M., Geffner, M. E., Olney, R. C., & Espiner, E. A. (2012). C-type natriuretic peptide forms in adult hyperthyroidism: Correlation with thyroid hormones and markers of bone turnover. Clinical Endocrinology, 76(6), 790-796. doi: 10.1111/j.1365-2265.2011.04295.x

Prickett, T. C. R., Lyver, A., Wilson, R., Espiner, E. A., & Sullivan, M. J. (2012). C-type natriuretic peptide: A novel biomarker of steroid induced bone toxicity in children with acute lymphoblastic leukemia (ALL). Peptides, 36(1), 54-59. doi: 10.1016/j.peptides.2012.04.017

Olney, R. C., Permuy, J. W., Prickett, T. C. R., Han, J. C., & Espiner, E. A. (2012). Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) predicts height velocity in healthy children. Clinical Endocrinology, 77(3), 416-422. doi: 10.1111/j.1365-2265.2012.04392.x

Olney, R. C., Prickett, T. C. R., Espiner, E. A., & Ross, J. L. (2012). C-Type natriuretic peptide (CNP) levels are altered in boys with Klinefelter syndrome. Journal of Clinical Endocrinology & Metabolism, 97(11), 4206-4211. doi: 10.1210/jc.2012-2598

McNeill, B. A., Barrell, G. K., Ridgway, M. J., Wellby, M. P., Prickett, T. C. R., & Espiner, E. A. (2012). Caloric restriction, but not caloric loading, affects circulating fetal and maternal C-type natriuretic peptide concentrations in late ovine gestation. Reproduction, Fertility & Development, 24(8), 1063-1070. doi: 10.1071/rd11312

Prickett, T. C. R., Bothwell, J. C., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Pharmacodynamic responses of plasma and tissue C-type natriuretic peptide to GH: Correlation with linear growth in GH-deficient rats. Journal of Endocrinology, 15, 217-225. doi: 10.1530/joe-11-0387

Schouten, B. J., Prickett, T. C. R., Hooper, A. A., Hooper, G. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2011). Central and peripheral forms of C-type natriuretic peptide (CNP): Evidence for differential regulation in plasma and cerebrospinal fluid. Peptides, 32(4), 797-804. doi: 10.1016/j.peptides.2011.01.013

McNeill, B. A., Barrell, G. K., Wooding, F. B. P., Prickett, T. C. R., & Espiner, E. A. (2011). The trophoblast binucleate cell is the source of maternal circulating C-type natriuretic peptide during ovine pregnancy. Placenta, 32(9), 645-650. doi: 10.1016/j.placenta.2011.06.001

Prickett, T. C. R., Ryan, J. F., Wellby, M., Barrell, G. K., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2010). Effect of nutrition on plasma C-type natriuretic peptide forms in adult sheep: Evidence for enhanced C-type natriuretic peptide degradation during caloric restriction. Metabolism, 59(6), 796-801. doi: 10.1016/j.metabol.2009.09.026

Prickett, T. C. R., McNeill, B. A., Oliver, M. H., Harding, J. E., & Espiner, E. A. (2010). Effect of cortisol on C-type natriuretic peptide in ovine pregnancy: Differential responses in fetal and placental tissues. Pediatric Research, 68(6), 462-465. doi: 10.1203/PDR.0b013e3181f9039d

McNeill, B. A., Barrell, G. K., Wellby, M., Prickett, T. C. R., Yandle, T. G., & Espiner, E. A. (2009). C-type natriuretic peptide forms in pregnancy: Maternal plasma profiles during ovine gestation correlate with placental and fetal maturation. Endocrinology, 150(10), 4777-4783. doi: 10.1210/en.2009-0176

Palmer, S. C., Prickett, T. C. R., Espiner, E. A., Yandle, T. G., & Richards, A. M. (2009). Regional release and clearance of C-type natriuretic peptides in the human circulation and relation to cardiac function. Hypertension, 54(3), 612-618. doi: 10.1161/HYPERTENSIONAHA.109.135608

Prickett, T. C. R., Charles, C. J., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2009). Skeletal contributions to plasma CNP forms: Evidence from regional sampling in growing lambs. Peptides, 30(12), 2343-2347. doi: 10.1016/j.peptides.2009.07.023

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2008). Effect of sex steroids on plasma C-type natriuretic peptide forms: Stimulation by oestradiol in lambs and adult sheep. Journal of Endocrinology, 199(3), 481-487. doi: 10.1677/JOE-08-0267

Prickett, T. C. R., Dixon, B., Frampton, C., Yandle, T. G., Richards, A. M., Espiner, E. A., & Darlow, B. A. (2008). Plasma amino-terminal pro C-type natriuretic peptide in the neonate: Relation to gestational age and postnatal linear growth. Journal of Clinical Endocrinology & Metabolism, 93(1), 225-232. doi: 10.1210/jc.2007-1815

Dixon, B., Darlow, B., & Prickett, T. (2008). How useful is knemometry in measuring neonatal growth? Journal of Paediatrics & Child Health, 44(7-8), 444-448. doi: 10.1111/j.1440-1754.2008.01328.x

Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2007). Response of plasma CNP forms to acute anabolic and catabolic interventions in growing lambs. American Journal of Physiology: Endocrinology & Metabolism, 292, E1395-E1400. doi: 10.1152/ajpendo.00469.2006

Prickett, T. C. R., Rumball, C. W. H., Buckley, A. J., Bloomfield, F. H., Yandle, T. G., Harding, J. E., & Espiner, E. A. (2007). C-type natriuretic peptide forms in the ovine fetal and maternal circulations: Evidence for independent regulation and reciprocal response to undernutrition. Endocrinology, 148(8), 4015-4022.

Olney, R. C., Prickett, T. C. R., Yandle, T. G., Espiner, E. A., Han, J. C., & Mauras, N. (2007). Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: Effects of puberty, testosterone, and growth hormone. Journal of Clinical Endocrinology & Metabolism, 92(11), 4294-4298. doi: 10.1210/jc.2007-0567

Charles, C. J., Prickett, T. C. R., Espiner, E. A., Rademaker, M. T., Richards, A. M., & Yandle, T. G. (2006). Regional sampling and the effects of experimental heart failure in sheep: Differential responses in A, B and C-type natriuretic peptides. Peptides, 27(1), 62-68. doi: 10.1016/j.peptides.2005.06.019

Obineche, E. N., Pathan, J. Y., Fisher, S., Prickett, T. C. R., Yandle, T. G., Frampton, C. M., Cameron, V. A., & Nicholls, M. G. (2006). Natriuretic peptide and adrenomedullin levels in chronic renal failure and effects of peritoneal dialysis. Kidney International, 69(1), 152-156.

Olney, R. C., Bükülmez, H., Bartels, C. F., Prickett, T. C. R., Espiner, E. A., Potter, L. R., & Warman, M. L. (2006). Heterozygous mutations in natriuretic peptide receptor-B (NPR2) are associated with short stature. Journal of Clinical Endocrinology & Metabolism, 91(4), 1229-1232.

Prickett, T. C. R., Lynn, A. M., Barrell, G. K., Darlow, B. A., Cameron, V. A., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2005). Amino-terminal proCNP: A putative marker of cartilage activity in postnatal growth. Pediatric Research, 58(2), 334-340.

Inder, W. J., Prickett, T. C. R., & Mulder, R. T. (2005). Normal opioid tone and hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome despite marked functional impairment. Clinical Endocrinology, 62, 343-348.

Prickett, T. C., Kaaja, R. J., Nicholls, M. G., Espiner, E. A., Richards, A. M., & Yandle, T. G. (2004). N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation. Clinical Science, 106(5), 535-540.

Wright, S. P., Prickett, T. C., Doughty, R. N., Frampton, C., Gamble, G. D., Yandle, T. G., … Richards, M. (2004). Amino-terminal pro-C-type natriuretic peptide in heart failure. Hypertension, 43(1), 94-100.

Ellis, M. J., Livesey, J. H., Inder, W. J., Prickett, T., & Reid, R. A. (2002). Plasma corticotropin-releasing hormone and unconjugated estriol in human pregnancy: gestational patterns and ability to predict preterm delivery. American Journal of Obstetrics & Gynecology, 186(1), 94-99.

Inder, W. J., Prickett, T., Ellis, M. J., Reid, R. A., Hull, L., Livesey, J. H., … Donald, R. A. (2001). The Utility of Plasma Corticotropin-releasing Hormone as a Predictor of Preterm Delivery. Journal of Clinical Endocrinology & Metabolism, 86(12), 5706-5710.

Inder, W. J., Prickett, T., Mulder, R. T., Donald, R. A., & Joyce, P. R. (2001). Reduction in basal afternoon plasma ACTH during early treatment of depression with fluoxetine. Journal of Psychopharmacology, 156(1), 73-78.

Prickett, T., Yandle, T. G., Nicholls, M. G., Espiner, E. A., & Richards, A. M. (2001). Identification of amino-terminal pro-C-type natriuretic peptide in human plasma. Biochemical & Biophysical Research Communications, 286(3), 513-517.

Prickett, T., Inder, W. J., Evans, M. J., & Donald, R. A. (2000). Interleukin-1 potentiates basal and AVP-stimulated ACTH secretion in vitro - the role of CRH pre-incubation. Hormone & Metabolic Research, 32, 350-354.

Inder, W. J., Hellemans, J., Swanney, M. P., Prickett, T., & Donald, R. A. (1999). Prolonged exercise increases peripheral plasma ACTH, CRH and AVP in male athletes. Journal of Applied Physiology, 85(3), 835-841.

Charles, C. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1998). Arginine vasopressin V1 receptor antagonism in an ovine model of acute myocardial infarction. Journal of Cardiovascular Pharmacology, 32(5), 777-782.

Murton, S. A., Tan, S. T., Prickett, T., Frampton, C. M., & Donald, R. A. (1998). Hormone responses to stress in patients with major burns. British Journal of Plastic Surgery, 51(5), 388-392.

Inder, W. J., Swanney, M. P., Donald, R. A., Prickett, T., & Hellemans, J. (1998). The effects of glycerol and desmopressin on exercise performance and hydration in triathletes. Medicine & Science in Sports & Exercise, 30, 1263-1269.

Charles, C. J., Rogers, S. J., Donald, R. A., Ikram, H., Prickett, T., & Richards, A. M. (1997). Hypothalamo-pituitary-adrenal axis response to coronary artery embolization: An ovine model of acute myocardial infarction. Journal of Endocrinology, 152(3), 489-493.

Inder, W. J., Donald, R. A., Prickett, T., Frampton, C. M., Sullivan, P. F., Mulder, R. T., & Joyce, P. R. (1997). Arginine Vasopressin is Associated with Hypercortisolemia and Suicide Attempts in Depression. Biological Psychiatry, 42(8), 744-747.

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Journal - Research Other

Bayes-Genis, A., Prickett, T. C., Richards, A. M., Barallat, J., & Lupón, J. (2016). Soluble neprilysin retains catalytic activity in heart failure. Journal of Heart & Lung Transplantation, 35(5), 684-685. doi: 10.1016/j.healun.2015.12.015

Espiner, E. A., Prickett, T. C., Yandle, T. G., Barrell, G. K., Wellby, M., Sullivan, M. J., & Darlow, B. A. (2007). ABCs of natriuretic peptides: Growth. Hormone Research, 67(Suppl. 1), 81-90.

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