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Health Sciences profile

Dr Blair Lawley

PositionScientific Officer
DepartmentDepartment of Microbiology and Immunology
QualificationsBSc (Hons) PhD
Research summaryGut microbiology

Research

Use of molecular and culture methods to study the structure and function of gut microbial communities in healthy and diseased individuals. Identification of functional genes, in gut microbes, using molecular probes.

Publications

Letchumanan, G., Abdullah, N., Marlini, M., Baharom, N., Lawley, B., Omar, M. R., … Pathmanathan, S. G. (2022). Gut microbiota composition in prediabetes and newly diagnosed type 2 diabetes: A systematic review of observational studies. Frontiers in Cellular & Infection Microbiology, 12, 943427. doi: 10.3389/fcimb.2022.943427

Bunga, S. J., Ahmmed, M. K., Lawley, B., Carne, A., & Bekhit, A. E.-D. A. (2022). Physicochemical, biochemical and microbiological changes of jeotgal-like fermented Chinook salmon (Oncorhynchus tshawytscha) roe. Food Chemistry, 133880. Advance online publication. doi: 10.1016/j.foodchem.2022.133880

Harfoot, R., Lawley, B., Hernández, L. C., Kuang, J., Grant, J., Treece, J. M., LeQueux, S., Day, R., Jack, S., Stanton, J.-A. L., Bostina, M., Ussher, J. E., & Quiñones‑Mateu, M. E. (2022). Characterization of the first SARS-CoV-2 isolates from Aotearoa New Zealand as part of a rapid response to the COVID-19 pandemic. Viruses, 14, 366. doi: 10.3390/v14020366

Joussef-Piña, S., Nankya, I., Nalukwago, S., Baseke, J., Rwambuya, S., Winner, D., … Lawley, B., … Quiñones‑Mateu, M. E. (2022). Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda. Retrovirology, 19, 1. doi: 10.1186/s12977-022-00587-3

Harfoot, R., Yung, D. B. Y., Anderson, W. A., Wild, C. E. K., Coetzee, N., Hernández, L. C., Lawley, B., Pletzer, D., Derraik, J. G. B., … Quiñones‑Mateu, M. E. (2022). Ultraviolet-C irradiation, heat, and storage as potential methods of inactivating SARS-CoV-2 and bacterial pathogens on filtering facepiece respirators. Pathogens, 11(1), 83. doi: 10.3390/pathogens11010083

Lawley, B., & Tannock, G. W. (2017). Analysis of 16S rRNA gene amplicon sequences using the QIIME software package. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 153-163). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_9

Chapter in Book - Research

Bunga, S. J., Ahmmed, M. K., Lawley, B., Carne, A., & Bekhit, A. E.-D. A. (2022). Physicochemical, biochemical and microbiological changes of jeotgal-like fermented Chinook salmon (Oncorhynchus tshawytscha) roe. Food Chemistry, 133880. Advance online publication. doi: 10.1016/j.foodchem.2022.133880

Journal - Research Article

Harfoot, R., Lawley, B., Hernández, L. C., Kuang, J., Grant, J., Treece, J. M., LeQueux, S., Day, R., Jack, S., Stanton, J.-A. L., Bostina, M., Ussher, J. E., & Quiñones‑Mateu, M. E. (2022). Characterization of the first SARS-CoV-2 isolates from Aotearoa New Zealand as part of a rapid response to the COVID-19 pandemic. Viruses, 14, 366. doi: 10.3390/v14020366

Journal - Research Article

Harfoot, R., Yung, D. B. Y., Anderson, W. A., Wild, C. E. K., Coetzee, N., Hernández, L. C., Lawley, B., Pletzer, D., Derraik, J. G. B., … Quiñones‑Mateu, M. E. (2022). Ultraviolet-C irradiation, heat, and storage as potential methods of inactivating SARS-CoV-2 and bacterial pathogens on filtering facepiece respirators. Pathogens, 11(1), 83. doi: 10.3390/pathogens11010083

Journal - Research Article

Joussef-Piña, S., Nankya, I., Nalukwago, S., Baseke, J., Rwambuya, S., Winner, D., … Lawley, B., … Quiñones‑Mateu, M. E. (2022). Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda. Retrovirology, 19, 1. doi: 10.1186/s12977-022-00587-3

Journal - Research Article

Lawley, B., Grant, J., Harfoot, R., Treece, J. M., Day, R., Hernández, L. C., Stanton, J.-A. L., Ussher, J. E., & Quiñones‑Mateu, M. E. (2021). Rapid response to SARS-CoV-2 in Aotearoa New Zealand: Implementation of a diagnostic test and characterization of the first COVID-19 cases in the South Island. Viruses, 13(11), 2222. doi: 10.3390/v13112222

Journal - Research Article

Stanton, J.-A. L., O'Brien, R., Hall, R. J., Chernyavtseva, A., Ha, H. J., Jelley, L., Mace, P. D., … Treece, J. M., … Ussher, J. E., … Hore, T. A., Moser, T. V., Harfoot, R., Lawley, B., Quiñones‑Mateu, M. E., … Blaikie, R. (2021). Uncoupling molecular testing for SARS-CoV-2 from international supply chains. Frontiers in Public Health, 9, 808751. doi: 10.3389/fpubh.2021.808751

Journal - Research Article

Leong, C., Haszard, J. J., Heath, A.-L. M., Tannock, G. W., Lawley, B., Cameron, S. L., Szymlek-Gay, E. A., Gray, A. R., Taylor, B. J., Galland, B. C., Lawrence, J. A., Otal, A., Hughes, A., & Taylor, R. W. (2020). Using compositional principal component analysis to describe children's gut microbiota in relation to diet and body composition. American Journal of Clinical Nutrition, 111(1), 70-78. doi: 10.1093/ajcn/nqz270

Journal - Research Article

Liu, Y., Heath, A.-L., Galland, B., Rehrer, N., Drummond, L., Wu, X.-Y., … Lawley, B., … Tannock, G. W. (2020). Substrate use prioritization by a coculture of five species of gut bacteria fed mixtures of arabinoxylan, xyloglucan, β-glucan, and pectin. Applied & Environmental Microbiology, 86, e01905-19. doi: 10.1128/aem.01905-19

Journal - Research Article

Xu, J., Lawley, B., Wong, G., Otal, A., Chen, L., Ying, T. J., … Karnani, N. (2020). Ethnic diversity in infant gut microbiota is apparent before the introduction of complementary diets. Gut Microbes, 11(5), 1362-1373. doi: 10.1080/19490976.2020.1756150

Journal - Research Article

Lawley, B., Otal, A., Moloney-Geany, K., Diana, A., Houghton, L., Heath, A.-L. M., Taylor, R. W., & Tannock, G. W. (2019). Fecal microbiotas of Indonesian and New Zealand children differ in complexity and bifidobacterial taxa during the first year of life. Applied & Environmental Microbiology, 85(19), e01105-1. doi: 10.1128/aem.01105-19

Journal - Research Article

Murphy, R., Morgan, X. C., Wang, X. Y., Wickens, K., Purdie, G., Fitzharris, P., Otal, A., Lawley, B., Stanley, T., Barthow, C., Crane, J., … Tannock, G. W. (2019). Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: Sub-sample analysis from a RCT. Beneficial Microbes, 10(1), 5-17. doi: 10.3920/bm2017.0191

Journal - Research Article

Centanni, M., Lawley, B., Butts, C. A., Roy, N. C., Lee, J., Kelly, W. J., & Tannock, G. W. (2018). Bifidobacterium pseudolongum in the ceca of rats fed Hi-Maize starch has characteristics of a keystone species in bifidobacterial blooms. Applied & Environmental Microbiology, 84(15), e00547-18. doi: 10.1128/AEM.00547-18

Journal - Research Article

Lawley, B., Centanni, M., Watanabe, J., Sims, I., Carnachan, S., Broadbent, R., Lee, P. S., … Tannock, G. W. (2018). tuf gene sequence variation in Bifidobacterium longum subsp. infantis detected in the fecal microbiota of Chinese infants. Applied & Environmental Microbiology, 84(13), e00336-18. doi: 10.1128/aem.00336-18

Journal - Research Article

Leong, C., Haszard, J. J., Lawley, B., Otal, A., Taylor, R. W., Szymlek-Gay, E. A., Fleming, E. A., Daniels, L., Fangupo, L. J., Tannock, G. W., & Heath, A.-L. M. (2018). Mediation analysis as a means of identifying dietary components that differentially affect the fecal microbiota of infants weaned by modified baby-led and traditional approaches. Applied & Environmental Microbiology, 84(18), e00914-18. doi: 10.1128/aem.00914-18

Journal - Research Article

Wilson, R., Willis, J., Gearry, R. B., Hughes, A., Lawley, B., Skidmore, P., Frampton, C., Fleming, E., Anderson, A., Jones, L., Tannock, G. W., & Carr, A. C. (2018). SunGold kiwifruit supplementation of individuals with prediabetes alters gut microbiota and improves Vitamin C status, anthropometric and clinical markers. Nutrients, 10, 895. doi: 10.3390/nu10070895

Journal - Research Article

Lawley, B., Munro, K., Hughes, A., Hodgkinson, A. J., Prosser, C. G., Lowry, D., … Tannock, G. W. (2017). Differentiation of Bifidobacterium longum subspecies longum and infantis by quantitative PCR using functional gene targets. PeerJ, 5, e3375. doi: 10.7717/peerj.3375

Journal - Research Article

Ranjitkar, S., Lawley, B., Tannock, G., & Engberg, R. M. (2016). Bacterial successions in the broiler gastrointestinal tract. Applied & Environmental Microbiology, 82(8), 2399-2410. doi: 10.1128/aem.02549-15

Journal - Research Article

Taylor, R. W., Heath, A.-L. M., Galland, B. C., Cameron, S. L., Lawrence, J. A., Gray, A. R., Tannock, G. W., Lawley, B., Healey, D., Sayers, R. M., Hanna, M., Meredith-Jones, K., Hatch, B., & Taylor, B. J. (2016). Three-year follow-up of a randomised controlled trial to reduce excessive weight gain in the first two years of life: Protocol for the POI follow-up study. BMC Public Health, 16, 771. doi: 10.1186/s12889-016-3383-4

Journal - Research Article

Tannock, G. W., Lawley, B., Munro, K., Sims, I. M., Lee, J., Butts, C. A., & Roy, N. (2014). RNA-stable isotope probing shows utilization of carbon from inulin by specific bacterial populations in the rat large bowel. Applied & Environmental Microbiology, 80(7), 2240-2247. doi: 10.1128/aem.03799-13

Journal - Research Article

Tannock, G. W., Taylor, C., Lawley, B., Loach, D., Gould, M., Dunn, A. C., McLellan, A. D., Black, M. A., McNoe, L., Dekker, J., … Collett, M. A. (2014). Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001. Applied & Environmental Microbiology, 80(9), 2851-2859. doi: 10.1128/aem.00336-14

Journal - Research Article

Wilson, C. M., Loach, D., Lawley, B., Bell, T., Sims, I. M., O'Toole, P. W., … Tannock, G. W. (2014). Lactobacillus reuteri 100-23 modulates urea hydrolysis in the murine stomach. Applied & Environmental Microbiology, 80(19), 6104-6113. doi: 10.1128/aem.01876-14

Journal - Research Article

Balan, P., Han, K.-S., Lawley, B., & Moughan, P. J. (2013). Orally administered ovine serum immunoglobulins modulate the intestinal levels of lactobacillus and enterobacteria in the growing rat. Journal of Animal Science, 91(8), 3724-3732. doi: 10.2527/jas2012-6028

Journal - Research Article

Lawley, B., Sims, I. M., & Tannock, G. W. (2013). Whole-transcriptome shotgun sequencing (RNA-seq) screen reveals upregulation of cellobiose and motility operons of Lactobacillus ruminis L5 during growth on tetrasaccharides derived from barley β-glucan. Applied & Environmental Microbiology, 79(18), 5661-5669. doi: 10.1128/aem.01887-13

Journal - Research Article

Oswari, H., Prayitno, L., Dwipoerwantoro, P. G., Firmansyah, A., Makrides, M., Lawley, B., … Tannock, G. W. (2013). Comparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula. Journal of Paediatrics & Child Health, 49, 1032-1039. doi: 10.1111/jpc.12307

Journal - Research Article

Tannock, G. W., Lawley, B., Munro, K., Pathmanathan, S. G., Zhou, S. J., Makrides, M., … Hodgkinson, A. J. (2013). Comparison of the compositions of the stool microbiotas of infants fed goat milk formula in comparison to cow milk-based formula, or breast milk. Applied & Environmental Microbiology, 79(9), 3040-3048. doi: 10.1128/aem.03910-12

Journal - Research Article

Young, W., Roy, N. C., Lee, J., Lawley, B., Otter, D., Henderson, G., & Tannock, G. W. (2013). Bowel microbiota moderate host physiological responses to dietary konjac in weanling rats1-3. Journal of Nutrition, 143, 1052-1060. doi: 10.3945/jn.113.174854

Journal - Research Article

Lawley, B., & Tannock, G. W. (2012). Nucleic acid-based methods to assess the composition and function of the bowel microbiota. Gastroenterology Clinics of North America, 41(4), 855-868. doi: 10.1016/j.gtc.2012.08.010

Journal - Research Article

Tannock, G. W., Lawley, B., Munro, K., Lay, C., Taylor, C., Daynes, C., … Thompson-Fawcett, M. (2012). Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches. Inflammatory Bowel Diseases, 18(5), 925-934. doi: 10.1002/ibd.21936

Journal - Research Article

Tannock, G. W., Wilson, C. M., Loach, D., Cook, G. M., Eason, J., O'Toole, P. W., … Lawley, B. (2012). Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach. ISME Journal, 6, 927-938. doi: 10.1038/ismej.2011.161

Journal - Research Article

Young, W., Roy, N. C., Lee, J., Lawley, B., Otter, D., Henderson, G., … Tannock, G. W. (2012). Changes in bowel microbiota induced by feeding weanlings resistant starch stimulate transcriptomic and physiological responses. Applied & Environmental Microbiology, 78(18), 6656-6664. doi: 10.1128/aem.01536-12

Journal - Research Article

Tannock, G. W., Munro, K., Taylor, C., Lawley, B., Young, W., Byrne, B., … Louie, T. (2010). A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin. Microbiology, 156(11), 3354-3359. doi: 10.1099/mic.0.042010-0

Journal - Research Article

Williamson, J. F., McLure, C. A., Baird, P. N., Male, D., Millman, J., Lawley, B., & et al (2008). Novel sequence elements define ancestral haplotypes of the region encompassing complement factor H. Human Immunology, 69, 207-219. doi: 10.1016/j.humimm.2008.01.016

Journal - Research Article

Letchumanan, G., Abdullah, N., Marlini, M., Baharom, N., Lawley, B., Omar, M. R., … Pathmanathan, S. G. (2022). Gut microbiota composition in prediabetes and newly diagnosed type 2 diabetes: A systematic review of observational studies. Frontiers in Cellular & Infection Microbiology, 12, 943427. doi: 10.3389/fcimb.2022.943427

Journal - Research Other

Heath, A.-L. M., Haszard, J. J., Galland, B. C., Lawley, B., Rehrer, N. J., Drummond, L. N., … Taylor, R. W., … Taylor, B., & Tannock, G. W. (2020). Association between the faecal short-chain fatty acid propionate and infant sleep [Brief communication]. European Journal of Clinical Nutrition, 74, 1362-1365. doi: 10.1038/s41430-019-0556-0

Journal - Research Other

Pathmanathan, S. G., Lawley, B., McConnell, M., Baird, M. A., & Tannock, G. W. (2020). Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells. Anaerobe, 61, 102112. doi: 10.1016/j.anaerobe.2019.102112

Journal - Research Other

Kindleysides, S., Kruger, R., Douwes, J., Tannock, G. W., Renall, N., Slater, J., Lawley, B., … Breier, B. H. (2019). PRedictors linking Obesity and the gut MIcrobiomE (the PROMISE study): Protocol and recruitment strategy for a cross-sectional study on pathways that affect the gut microbiome and its impact on obesity. JMIR Research Protocols, 8(8), e14529. doi: 10.2196/14529

Journal - Research Other

Tannock, G. W., Lee, P. S., Wong, K. H., & Lawley, B. (2016). Why don’t all infants have bifidobacteria in their stool? Frontiers in Microbiology, 7, 834. doi: 10.3389/fmicb.2016.00834

Journal - Research Other

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