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Health Sciences profile

Associate Professor Michelle McConnell

PositionResearch Associate Professor
DepartmentDepartment of Microbiology and Immunology
QualificationsMSc PhD (Otago)
Research summaryMedical Microbiology

Research

A/P McConnell is a Senior Research Fellow in the Department of Microbiology and Immunology. Current research is primarily centered on the immunomodulatory effects of sheep milk in comparison with cow and goat milk, along with the microbiological status of the sheep milk. The sheep industry is a relatively young industry in New Zealand and the milk is predominantly used for cheese making in addition to some baby formula for the Chinese market.

Publications

Burrow, K., Young, W., McConnell, M., Carne, A., Barr, D., Reid, M., & Bekhit, A. E.-D. (2020). The effect of sheep and cow milk supplementation of a low calcium diet on the distribution of macro and trace minerals in the organs of weanling rats. Nutrients, 12(3), 594. doi: 10.3390/nu12030594

Hou, Y., Carne, A., McConnell, M., Mros, S., Vasileva, E. A., Mishchenko, N. P., Burrow, K., Wang, K., … Bekhit, A. E.-D. A. (2020). PHNQ for Evechinus chloroticus sea urchin supplemented with calcium promotes mineralization in Saos-2 human bone cell line. Marine Drugs, 18(7), 373. doi: 10.3390/md18070373

Turner, P. R., Murray, E., McAdam, C. J., McConnell, M. A., & Cabral, J. D. (2020). Peptide chitosan/dextran core/shell vascularized 3D constructs for wound healing. ACS Applied Materials & Interfaces. Advance online publication. doi: 10.1021/acsami.0c07212

Hou, Y., Carne, A., McConnell, M., Mros, S., Bekhit, A. A., & Bekhit, A. E.-D. A. (2020). Macroporous resin extraction of PHNQs from Evechinus chloroticus sea urchin and their in vitro antioxidant, anti-bacterial and in silico anti-inflammatory activities. LWT. Advance online publication. doi: 10.1016/j.lwt.2020.109817

Hou, Y., Carne, A., McConnell, M., Bekhit, A. A., Mros, S., Amagase, K., & Bekhit, A. E.-D. A. (2020). In vitro antioxidant and antimicrobial activities, and in vivo anti-inflammatory activity of crude and fractionated PHNQs from sea urchin (Evechinus chloroticus). Food Chemistry, 316, 126339. doi: 10.1016/j.foodchem.2020.126339

Chapter in Book - Research

Shavandi, A., Hou, Y., Carne, A., McConnell, M., & Bekhit, A. E.-D. A. (2019). Marine waste utilization as a source of functional and health compounds. In F. Toldrá (Ed.), Advances in food and nutrition research. (pp. 187-254). Cambridge, MA: Academic Press. doi: 10.1016/bs.afnr.2018.08.001

Burrow, K., Young, W., Carne, A., McConnell, M., & Bekhit, A. E.-D. (2018). Interactions of milk proteins with minerals. In G. W. Smithers (Ed.), Reference module in food science. Elsevier. doi: 10.1016/B978-0-08-100596-5.22489-X

Chia, J., Burrow, K., Carne, A., McConnell, M., Samuelsson, L., Day, L., … Bekhit, A. E.-D. A. (2017). Minerals in sheep milk. In R. R. Watson, R. J. Collier & V. R. Preedy (Eds.), Nutrients in dairy and their implications for health and disease. (pp. 345-362). London, UK: Elsevier. doi: 10.1016/B978-0-12-809762-5.00027-9

Brooks, H. J. L., McConnell, M. A., & Broadbent, R. S. (2013). Microbes and the inflammatory response in necrotising enterocolitis. In O. Erez (Ed.), Preterm birth. (pp. 137-174). London, UK: InTech. doi: 10.5772/55039

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Journal - Research Article

Burrow, K., Young, W., McConnell, M., Carne, A., Barr, D., Reid, M., & Bekhit, A. E.-D. (2020). The effect of sheep and cow milk supplementation of a low calcium diet on the distribution of macro and trace minerals in the organs of weanling rats. Nutrients, 12(3), 594. doi: 10.3390/nu12030594

Hou, Y., Carne, A., McConnell, M., Bekhit, A. A., Mros, S., Amagase, K., & Bekhit, A. E.-D. A. (2020). In vitro antioxidant and antimicrobial activities, and in vivo anti-inflammatory activity of crude and fractionated PHNQs from sea urchin (Evechinus chloroticus). Food Chemistry, 316, 126339. doi: 10.1016/j.foodchem.2020.126339

Hou, Y., Carne, A., McConnell, M., Mros, S., Bekhit, A. A., & Bekhit, A. E.-D. A. (2020). Macroporous resin extraction of PHNQs from Evechinus chloroticus sea urchin and their in vitro antioxidant, anti-bacterial and in silico anti-inflammatory activities. LWT. Advance online publication. doi: 10.1016/j.lwt.2020.109817

Turner, P. R., Murray, E., McAdam, C. J., McConnell, M. A., & Cabral, J. D. (2020). Peptide chitosan/dextran core/shell vascularized 3D constructs for wound healing. ACS Applied Materials & Interfaces. Advance online publication. doi: 10.1021/acsami.0c07212

Hou, Y., Carne, A., McConnell, M., Mros, S., Vasileva, E. A., Mishchenko, N. P., Burrow, K., Wang, K., … Bekhit, A. E.-D. A. (2020). PHNQ for Evechinus chloroticus sea urchin supplemented with calcium promotes mineralization in Saos-2 human bone cell line. Marine Drugs, 18(7), 373. doi: 10.3390/md18070373

McGowan, J. E., Harper, A. D., Davison, E. K., Jeong, J. Y., Mros, S., Harbison-Price, N., Van Zuylen, E. M., Knottenbelt, M. K., Heikal, A., Ferguson, S. A., McConnell, M. A., Cook, G. M., Krittaphol, W., Walker, G. F., … Rennison, D. (2020). Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds. Bioorganic & Medicinal Chemistry Letters, 30, 127110. doi: 10.1016/j.bmcl.2020.127110

Liu, Y.-F., Oey, I., Bremer, P., Silcock, P., Carne, A., & McConnell, M. (2019). Pulsed electric fields treatment at different pH enhances the antioxidant and anti-inflammatory activity of ovomucin-depleted egg white. Food Chemistry, 276, 164-173. doi: 10.1016/j.foodchem.2018.10.009

Burrow, K., Young, W., Carne, A., McConnell, M., Hammer, N., Scholze, M., & Bekhit, A. E.-D. (2019). Consumption of sheep milk compared to cow milk can affect trabecular bone ultrastructure in a rat model. Food & Function, 10, 163-171. doi: 10.1039/c8fo01598h

Ferguson, S. A., Menorca, A., Van Zuylen, E. M., Cheung, C.-Y., McConnell, M. A., Rennison, D., … Cook, G. M., & Heikal, A. (2019). Microtiter screening reveals oxygen-dependent antimicrobial activity of natural products against mastitis-causing bacteria. Frontiers in Microbiology, 10, 1995. doi: 10.3389/fmicb.2019.01995

Ilesanmi-Oyelere, B. L., Schollum, L., Kuhn-Sherlock, B., McConnell, M., Mros, S., Coad, J., … Roy, N. C., & Kruger, M. C. (2019). Inflammatory markers and bone health in postmenopausal women: A cross-sectional overview. Immunity & Ageing, 16, 15. doi: 10.1186/s12979-019-0155-x

Bekhit, A. E.-D. A., Cheng, V. J., Zhang, H., Mros, S., Mohamed Ahmed, I. A., Al-Juhaimi, F. Y., … McConnell, M. (2019). Effect of extraction system and grape variety on anti-influenza compounds from wine production residue. Food Control, 99, 180-189. doi: 10.1016/j.foodcont.2018.12.036

Hewitt, E., Mros, S., McConnell, M., Cabral, J. D., & Ali, A. (2019). Melt-electrowriting with novel milk protein/PCL biomaterials for skin regeneration. Biomedical Materials, 14, 055013. doi: 10.1088/1748-605X/ab3344

Hou, Y., Vasileva, E. A., Mishchenko, N. P., Carne, A., McConnell, M., & Bekhit, A. E.-D. A. (2019). Extraction, structural characterization and stability of polyhydroxylated naphthoquinones from shell and spine of New Zealand sea urchin (Evechinus chloroticus). Food Chemistry, 272, 379-387. doi: 10.1016/j.foodchem.2018.08.046

Burrow, K., Young, W., McConnell, M., Carne, A., Barr, D., Reid, M., & Bekhit, A. E.-D. (2018). The distribution of essential, trace, and nonessential minerals in weanling male rats fed sheep or cow milk. Molecular Nutrition & Food Research, 62, 1800482. doi: 10.1002/mnfr.201800482

Hou, Y., Vasileva, E. A., Carne, A., McConnell, M., Bekhit, A. E.-D. A., & Mishchenko, N. P. (2018). Naphthoquinones of the spinochrome class: Occurrence, isolation, biosynthesis and biomedical applications [Review]. RSC Advances, 8(57), 32637-32650. doi: 10.1039/c8ra04777d

Burrow, K., Young, W., McConnell, M., Carne, A., & Bekhit, A. E.-D. (2018). Do dairy minerals have a positive effect on bone health? Comprehensive Reviews in Food Science & Food Safety, 17(4), 989-1005. doi: 10.1111/1541-4337.12364

Intini, C., Elviri, L., Cabral, J., Mros, S., Bergonzi, C., Bianchera, A., … McConnell, M. (2018). 3D-printed chitosan-based scaffolds: An in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats. Carbohydrate Polymers, 199, 593-602. doi: 10.1016/j.carbpol.2018.07.057

Welsh, G., Ryder, K., Brewster, J., Walker, C., Mros, S., Bekhit, A. E.-D. A., McConnell, M., & Carne, A. (2017). Comparison of bioactive peptides prepared from sheep cheese whey using a food-grade bacterial and a fungal protease preparation. International Journal of Food Science & Technology, 52(5), 1252-1259. doi: 10.1111/ijfs.13392

Mros, S., Carne, A., Ha, M., Bekhit, A. E.-D., Young, W., & McConnell, M. (2017). Comparison of the bioactivity of whole and skimmed digested sheep milk with that of digested goat and cow milk in functional cell culture assays. Small Ruminant Research, 149, 202-208. doi: 10.1016/j.smallrumres.2017.02.018

Bah, C. S. F., Carne, A., McConnell, M. A., Mros, S., & Bekhit, A. E.-D. A. (2016). Production of bioactive peptide hydrolysates from deer, sheep, pig and cattle red blood cell fractions using plant and fungal protease preparations. Food Chemistry, 202, 458-466. doi: 10.1016/j.foodchem.2016.02.020

Bah, C. S. F., Bekhit, A. E.-D. A., Carne, A., & McConnell, M. A. (2016). Composition and biological activities of slaughterhouse blood from red deer, sheep, pig and cattle. Journal of the Science of Food & Agriculture, 96(1), 79-89. doi: 10.1002/jsfa.7062

Bah, C. S. F., Bekhit, A. E.-D. A., Fang, E. F., Ng, T. B., McConnell, M. A., Bekhit, A. A., & Morton, J. D. (2016). Physicochemical properties and bioactivity of extracts from the roe of New Zealand hoki and southern blue whiting. Journal of Aquatic Food Product Technology, 25(8), 1234-1248. doi: 10.1080/10498850.2015.1052604

Bah, C. S. F., Bekhit, A. E.-D. A., McConnell, M. A., & Carne, A. (2016). Generation of bioactive peptide hydrolysates from cattle plasma using plant and fungal proteases. Food Chemistry, 213, 98-107. doi: 10.1016/j.foodchem.2016.06.065

Ryder, K., Bekhit, A. E.-D., McConnell, M., & Carne, A. (2016). Towards generation of bioactive peptides from meat industry waste proteins: Generation of peptides using commercial microbial proteases. Food Chemistry, 208, 42-50. doi: 10.1016/j.foodchem.2016.03.121

Cabral, J. D., McConnell, M. A., Fitzpatrick, C., Mros, S., Williams, G., Wormald, P. J., Moratti, S. C., & Hanton, L. R. (2015). Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part A, 103(8), 2611-2620. doi: 10.1002/jbm.a.35395

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., McConnell, M. A., Fitzpatrick, C., Hanton, L. R., & Moratti, S. C. (2015). In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part B, 103(2), 332-341. doi: 10.1002/jbm.b.33206

Ha, M., Sabherwal, M., Duncan, E., Stevens, S., Stockwell, P., McConnell, M., Bekhit, A. E.-D., & Carne, A. (2015). In-depth characterization of sheep (Ovis aries) milk whey proteome and comparison with cow (Bos taurus). PLoS ONE, 10(10), e0139774. doi: 10.1371/journal.pone.0139774

Bah, C. S. F., Bekhit, A. E.-D. A., Carne, A., & McConnell, M. A. (2015). Production of bioactive peptide hydrolysates from deer, sheep and pig plasma using plant and fungal protease preparations. Food Chemistry, 176, 54-63. doi: 10.1016/j.foodchem.2014.12.025

Cabral, J. D., Roxburgh, M., Shi, Z., Liu, L., McConnell, M., Williams, G., … Hanton, L. R., Simpson, J., Moratti, S. C., Robinson, B. H., … Robinson, S. (2014). Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Materials Science: Materials in Medicine, 25(12), 2743-2756. doi: 10.1007/s10856-014-5292-3

Ha, M., Bekhit, A. E.-D., McConnell, M., Mason, S., & Carne, A. (2014). Fractionation of whey proteins from red deer (Cervus elaphus) milk and comparison with whey proteins from cow, sheep and goat milks. Small Ruminant Research, 120(1), 125-134. doi: 10.1016/j.smallrumres.2014.04.012

Poppitt, S. D., McGregor, R. A., Wiessing, K. R., Goyal, V. K., Chitkara, A. J., Gupta, S., … McConnell, M. A. (2014). Bovine complex milk lipid containing gangliosides for prevention of rotavirus infection and diarrhoea in northern Indian infants. Journal of Pediatric Gastroenterology & Nutrition, 59(2), 167-171. doi: 10.1097/mpg.0000000000000398

Bah, C. S. F., Bekhit, A. E.-D. A., Carne, A., & McConnell, M. A. (2013). Slaughterhouse blood: An emerging source of bioactive compounds. Comprehensive Reviews in Food Science & Food Safety, 12(3), 314-331. doi: 10.1111/1541-4337.12013

Cheng, V. J., Bekhit, A. E.-D. A., McConnell, M., Mros, S., & Zhao, J. (2012). Effect of extraction solvent, waste fraction and grape variety on the antimicrobial and antioxidant activities of extracts from wine residue from cool climate. Food Chemistry, 134(1), 474-482. doi: 10.1016/j.foodchem.2012.02.103

Bah, C. S. F., Fang, E. F., Ng, T. B., Mros, S., McConnell, M., & Bekhit, A. E.-D. A. (2011). Purification and characterization of a rhamnose-binding chinook salmon roe lectin with antiproliferative activity toward tumor cells and nitric oxide-inducing activity toward murine macrophages. Journal of Agricultural & Food Chemistry, 59(10), 5720-5728. doi: 10.1021/jf2004578

Bekhit, A. E.-D. A., Cheng, V. J., McConnell, M., Zhao, J. H., Sedcole, R., & Harrison, R. (2011). Antioxidant activities, sensory and anti-influenza activity of grape skin tea infusion. Food Chemistry, 129, 837-845. doi: 10.1016/j.foodchem.2011.05.032

Brooks, H. J. L., McConnell, M. A., Corbett, J., Buchan, G. S., Fitzpatrick, C. E., & Broadbent, R. S. (2006). Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: An in vitro study on bacterial attachment, antibody levels and cytokine production. FEMS Immunology & Medical Microbiology, 48(3), 347-354.

Davies, C., McConnell, M., Slobbe, L., Haggarty, N., & Buchan, G. (2005). Murine antigen-presenting cells are multifunctional in vitro biosensors for detecting the immunoactive potential of bovine milk products. Journal of Nutrition, 135(11), 2651-2656.

Brooks, H. J. L., Ahmed, D., McConnell, M. A., & Barbezat, G. O. (2004). Diagnosis of Helicobacter pylori infection by polymerase chain reaction: Is it worth it? Diagnostic Microbiology & Infectious Disease, 50, 1-5. doi: 10.1016/j.diagmicrobio.2003.11.010

Ahmed, D., Brooks, H., McConnell, M., & Barbezat, G. (2004). Antibiotic resistance in Helicobacter pylori: Is it a problem in New Zealand? New Zealand Medical Journal, 117(1200). Retrieved from http://journal.nzma.org.nz/journal/117-1200/1022/content.pdf

Mahoney, P. M., Hurst, P. R., McLeod, B. J., McConnell, M. A., & Thompson, E. G. (2003). Effect of oestradiol treatment on mast cell populations and microflora in the vaginal cul-de-sac of seasonally anoestrous brushtail possums (Trichosurus vulpecula). Reproduction, 125, 733-741.

Mahoney, P. M., Hurst, P. R., McLeod, B., & McConnell, M. A. (2002). Quantification of mast cells and microflora in the vaginal cul-de-sac of the brushtail possum (Trichosurus vulpecula). Reproduction, 124, 399-408.

McConnell, M. A., Buchan, G. S., Borissenko, M. V., & Brooks, H. J. (2001). A comparative study of IgG and IgG1 activity in an early milk concentrate from non-immunised cows and a milk from hyperimmunised animals. Food Research International, 34(2-3), 255-261.

McBurney, W. T., McCartney, A. L., Apun, K., McConnell, M. A., & Tannock, G. W. (1999). Perturbation of the enterobacterial microflora detected by molecular analysis. Microbial Ecology in Health & Disease, 11, 175-179.

Bateup, J., Dobbinson, S., McConnell, M. A., Munro, K., & Tannock, G. W. (1998). Molecular analysis of the composition of Lactobacillus populations inhabiting the stomach and caecum of pigs. Microbial Ecology in Health & Disease, 10, 95-102.

Kimura, K., McCartney, A. L., McConnell, M. A., & Tannock, G. W. (1997). Analysis of fecal populations of bifidobacteria and lactobacilli and investigation of the immunological responses of their human hosts to the predominant strains. Applied & Environmental Microbiology, 63(9), 3394-3398.

Bateup, J. M., McConnell, M. A., Jenkinson, H. F., & Tannock, G. W. (1995). Comparison of Lactobacillus strains with respect to bile salt hydrolase activity, colonization of the gastrointestinal tract, and growth rate of the murine host. Applied & Environmental Microbiology, 61(3), 1147-1149.

Tannock, G. W., & McConnell, M. A. (1994). Lactobacilli inhabiting the digestive tract of mice do not influence serum cholesterol concentration. Microbial Ecology in Health & Disease, 7(6), 331-334.

Tannock, G. W., Tangerman, A., Van Schaik, A., & McConnell, M. A. (1994). Deconjugation of bile acids by lactobacilli in the mouse small bowel. Applied & Environmental Microbiology, 60(9), 3419-3420.

Rodtong, S., Dobbinson, S., Thode-Andersen, S., McConnell, M. A., & Tannock, G. W. (1993). Derivation of DNA probes for enumeration of a specific strain of Lactobacillus acidophilus in piglet digestive tract samples. Applied & Environmental Microbiology, 59(11), 3871-3877.

McConnell, M. A., & Tannock, G. W. (1993). Lactobacilli do not influence enzyme activities of duodenal enterocytes of mice. Microbial Ecology in Health & Disease, 6(6), 315-318.

Tannock, G. W., McConnell, M. A., & Fuller, R. (1992). A note on the use of a plasmid as a DNA probe in the detection of a Lactobacillus fermentum strain in porcine stomach contents. Journal of Applied Microbiology, 73(1), 60-62. doi: 10.1111/j.1365-2672.1992.tb04969.x

McConnell, M. A., & Tannock, G. W. (1991). Lactobacilli and azoreductase activity in the murine cecum. Applied & Environmental Microbiology, 57(12), 3664-3665.

McConnell, M. A., Mercer, A. A., & Tannock, G. W. (1991). Transfer of plasmid pAMβl between members of the normal microflora inhabiting the murine digestive tract and modification of the plasmid in a Lactobacillus reuteri host. Microbial Ecology in Health & Disease, 4(6), 343-355.

Brockett, M., & Tannock, G. W. (1982). Dietary influence on microbial activities in the caecum of mice. Canadian Journal of Microbiology, 28(5), 493-499.

Brockett, M., & Tannock, G. W. (1981). Dietary components influence tissue-associated lactobacilli in the mouse stomach. Canadian Journal of Microbiology, 27(4), 452-455.

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Journal - Research Other

Pathmanathan, S. G., Lawley, B., McConnell, M., Baird, M. A., & Tannock, G. W. (2020). Gut bacteria characteristic of the infant microbiota down-regulate inflammatory transcriptional responses in HT-29 cells. Anaerobe, 61, 102112. doi: 10.1016/j.anaerobe.2019.102112

Rajabi, M., Ali, A., McConnell, M., & Cabral, J. (2020). Keratinous materials: Structures and functions in biomedical applications. Materials Science & Engineering: C, 110, 110612. doi: 10.1016/j.msec.2019.110612

McConnell, M. A., & Tannock, G. W. (1993). A note on lactobacilli and β-glucuronidase activity in the intestinal contents of mice. Journal of Applied Bacteriology, 74(6), 649-651. doi: 10.1111/j.1365-2672.1993.tb05198.x

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