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Health Sciences profile

Professor Madhav Bhatia

PositionProfessor
DepartmentDepartment of Pathology and Biomedical Science(UOC)
QualificationsBSc(Hons), MSc, PhD
Research summaryInflammation

Research

I am the Leader of the Inflammation Research Group. My current research focuses on inflammation. The research strengths that I have brought to the University of Otago are experimental models of inflammation. These models of diseases were missing at the University, even though these diseases are major health problems in New Zealand and worldwide. My group uses these models to investigate disease mechanisms and develop novel therapeutic approaches. The long term goal of this research is to translate this knowledge to the clinic, and early results in this direction have been promising.

Research in my group is supported by research grants from Lottery Health, University of Otago Research Grant, and Health Reseach Council of New Zealand Singapore Networking Grant.

Publications

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Chapter in Book - Research

Lv, J., Bhatia, M., & Wang, X. (2017). Roles of mitochondrial DNA in energy metabolism. In H. Sun & X. Wang (Eds.), Mitochondrial DNA and diseases: Advances in experimental medicine and biology (Vol. 1038). (pp. 71-83). Singapore: Springer Nature. doi: 10.1007/978-981-10-6674-0_6

Bhatia, M. (2015). H2S and substance P in Inflammation. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen sulfide in redox biology, Part B (Vol. 555). (pp. 195-205). Elsevier. doi: 10.1016/bs.mie.2014.11.024

Bhatia, M. (2015). H2S and inflammation: An overview. In P. K. Moore & M. Whiteman (Eds.), Chemistry, biochemistry and pharmacology of hydrogen sulfide (Handbook of experimental pharmacology, Vol. 230). (pp. 165-180). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-18144-8_8

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Journal - Research Article

Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472

Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762

Gillies, N. A., Pendharkar, S. A., Singh, R. G., Windsor, J. A., Bhatia, M., & Petrov, M. S. (2017). Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines. Archives of Physiology & Biochemistry. Advance online publication. doi: 10.1080/13813455.2017.1308382

Singh, P., Reid, K., Gaddam, R., Bhatia, M., Smith, S., Jacob, A., & Chambers, P. (2017). Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep. Veterinary Anaesthesia & Analgesia. Advance online publication. doi: 10.1016/j.vaa.2017.01.002

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z

Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Deng, Y.-Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13(5), 3881-3885. doi: 10.3892/mmr.2016.5008

Shamoon, M., Deng, Y., Chen, Y. Q., Bhatia, M., & Sun, J. (2016). Therapeutic implications of innate immune system in acute pancreatitis. Expert Opinion on Therapeutic Targets, 20(1), 73-87. doi: 10.1517/14728222.2015.1077227

Dong, Z., Shang, H., Chen, Y. Q., Pan, L.-L., Bhatia, M., & Sun, J. (2016). Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxidative Medicine & Cellular Longevity, 2016, 7864150. doi: 10.1155/2016/7864150

Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007

Badiei, A., Gieseg, S., Davies, S., Othman, M. I., & Bhatia, M. (2015). LPS up-regulates cystathionine γ-lyase gene expression in Primary human macrophages via NF-κB/ERK pathway. Inflammation & Allergy Drug Targets, 14(2), 99-104. doi: 10.2174/1871528114666151201201719

Badiei, A., Rivers-Auty, J., Ang, A. D., & Bhatia, M. (2013). Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Applied Microbiology & Biotechnology, 97(17), 7845-7852. doi: 10.1007/s00253-013-5080-x

Ang, A. D., Rivers-Auty, J., Hegde, A., Ishii, I., & Bhatia, M. (2013). The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. American Journal of Physiology: Gastrointestinal & Liver Physiology, 305, G712-G721. doi: 10.1152/ajpgi.00044.2013

Rivers, J. R., Badiei, A., & Bhatia, M. (2012). Hydrogen sulfide as a therapeutic target for inflammation. Expert Opinion on Therapeutic Targets, 16(5), 439-449. doi: 10.1517/14728222.2012.673591

Ang, A. D., Konigstorfer, A., Giles, G. I., & Bhatia, M. (2012). Measuring free tissue sulfide. Advances in Biological Chemistry, 2(4), 360-365. doi: 10.4236/abc.2012.24044

Koh, Y.-H., Moochhala, S., Bian, J.-S., & Bhatia, M. (2012). Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 16(7), 1582-1592. doi: 10.1111/j.1582-4934.2011.01475.x

Bhatia, M., Zemans, R. L., & Jeyaseelan, S. (2012). Role of chemokines in the pathogenesis of acute lung injury. American Journal of Respiratory Cell & Molecular Biology, 46(5), 566-572. doi: 10.1165/rcmb.2011-0392TR

Sidhapuriwala, J. N., Hegde, A., Ang, A. D., Zhu, Y. Z., & Bhatia, M. (2012). Effects of S-Propargyl-Cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS ONE, 7(3), e32574. doi: 10.1371/journal.pone.0032574

Koh, Y.-H., Moochhala, S., & Bhatia, M. (2011). The role of neutral endopeptidase in caerulein-induced acute pancreatitis. Journal of Immunology, 187, 5429-5439. doi: 10.4049/jimmunol.1102011

Ang, S.-F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: Involvement of substance P and ERK-NF-κB signaling. PLoS ONE, 6(9), e24535. doi: 10.1371/journal.pone.0024535

Hegde, A., & Bhatia, M. (2011). Hydrogen sulfide in inflammation: Friend or foe? Inflammation & Allergy Drug Targets, 10(2), 118-122.

Ang, S.-F., Sio, S. W. S., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. Journal of Immunology, 187(9), 4778-4787. doi: 10.4049/jimmunol.1101559

Koh, Y.-H., Tamizhselvi, R., Moochhala, S., Bian, J.-S., & Bhatia, M. (2011). Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 15(10), 2139-2149. doi: 10.1111/j.1582-4934.2010.01205.x

Ang, S.-F., Moochhala, S. M., & Bhatia, M. (2010). Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Critical Care Medicine, 38(2), 619-628. doi: 10.1097/CCM.0b013e3181c0df00

Koh, Y.-H., Tamizhselvi, R., & Bhatia, M. (2010). Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-κB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 332(3), 940-948. doi: 10.1124/jpet.109.160416

Zhang, J., Sio, S. W. S., Moochhala, S., & Bhatia, M. (2010). Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Molecular Medicine, 16(9-10), 417-424. doi: 10.2119/molmed.2010.00027

Ramnath, R. D., Sun, J., & Bhatia, M. (2010). PKC δ mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. Journal of Molecular Medicine, 88, 1055-1063. doi: 10.1007/s00109-010-0647-9

Sio, S. W. S., Moochhala, S., Lu, J., & Bhatia, M. (2010). Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. American Journal of Respiratory & Critical Care Medicine, 181(1), 36-46. doi: 10.1164/rccm.200907-1073OC

Tamizhselvi, R., Koh, Y.-H., Sun, J., Zhang, H., & Bhatia, M. (2010). Hydrogen sulfide-induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-κB and Src-family kinases pathway. Experimental Cell Research, 316, 1625-1636. doi: 10.1016/j.yexcr.2010.02.044

Bhatia, M. (2010). Hydrogen sulfide and substance P in inflammation. Antioxidants & Redox Signaling, 12(10), 1191-1202. doi: 10.1089/ars.2009.2927

Shrivastava, P., & Bhatia, M. (2010). Essential role of monocytes and macrophages in the progression of acute pancreatitis. World Journal of Gastroenterology, 16(32), 3995-4002. doi: 10.3748/wjg.v16.i32.3995

Sowmya, S., Swathi, Y., Yeo, A. L., Shoon, M. L., Moore, P. K., & Bhatia, M. (2010). Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vascular Pharmacology, 53, 138-143. doi: 10.1016/j.vph.2010.05.004

Hegde, A., Tamizhselvi, R., Manikandan, J., Melendez, A. J., Moochhala, S. M., & Bhatia, M. (2010). Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Molecular Medicine, 16, 188-198. doi: 10.2119/molmed.2009.00166

Sio, S. W. S., Ang, S. F., Lu, J., Moochhala, S., & Bhatia, M. (2010). Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-κB in a mouse model of burn-induced remote acute lung injury. Journal of Immunology, 185(10), 6265-6276. doi: 10.4049/jimmunol.1001739

Hegde, A., Uttamchandani, M., Bhatia, M., & Moochhala, S. M. (2010). Plasma cytokine profiles in Preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Molecular Medicine, 16(1-2), 45-52. doi: 10.2119/molmed.2009.00112

Ynsa, M. D., Ren, M. Q., Rajendran, R., Sidhapuriwala, J. N., van Kan, J. A., Bhatia, M., & Watt, F. (2009). Zinc mapping and density imaging of rabbit pancreas endocrine tissue sections using nuclear microscopy. Microscopy & Microanalysis, 15, 345-352. doi: 10.1017/S1431927609090795

Ang, A. D., Adhikari, S., Ng, S. W., & Bhatia, M. (2009). Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury. Pancreatology, 9(1-2), 150-159. doi: 10.1159/000178886

Zhang, H., & Bhatia, M. (2009). Role of hydrogen sulfide in acute lung injury and acute respiratory distress syndrome. Open Critical Care Medicine Journal, 2, 13-17. doi: 10.2174/1874828700902010013

Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2009). Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages. FASEB Journal, 23, 997-1010. doi: 10.1096/fj.08-121756

Tamizhselvi, R., Sun, J., Koh, Y.-H., & Bhatia, M. (2009). Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 329, 1166-1178. doi: 10.1124/jpet.109.150532

Sidhapuriwala, J. N., Ng, S. W., & Bhatia, M. (2009). Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. Journal of Inflammation, 6, 35. doi: 10.1186/1476-9255-6-35

Ramnath, R. D., Sun, J., & Bhatia, M. (2009). Involvement of Src family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. Journal of Pharmacology & Experimental Therapeutics, 329, 418-428. doi: 10.1124/jpet.108.148684

Ramnath, R. D., Ng, S. W., Guglielmotti, A., & Bhatia, M. (2008). Role of MCP-1 in endotoxemia and sepsis. International Immunopharmacology, 8(6), 810-818. doi: 10.1016/j.intimp.2008.01.033

Webb, G. D., Lim, L. H., Oh, V. M. S., Yeo, S. B., Cheong, Y. P., Ali, M. Y., … Bhatia, M., … Moore, P. K. (2008). Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. Journal of Pharmacology & Experimental Therapeutics, 324, 876-882. doi: 10.1124/jpet.107.133538

Adhikari, S., Ramnath, R. D., Wallig, M., & Bhatia, M. (2008). Role of mitogen-activated protein kinases in crambene-induced pancreatic acinar cell apoptosis. International Journal of Integrative Biology, 3(1), 25-35.

Bhatia, M., Landolfi, C., Basta, F., Bovi, G., Ramnath, R. D., Capezzone de Joannon, A., & Guglielmotti, A. (2008). Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis. Inflammation Research, 57(10), 464-471. doi: 10.1007/s00011-008-7210-y

Zhang, H., Moochhala, S. M., & Bhatia, M. (2008). Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. Journal of Immunology, 181, 4320-4331.

Ramnath, R. D., Sun, J., & Bhatia, M. (2008). Role of calcium in substance P-induced chemokine synthesis in mouse pancreatic acinar cells. British Journal of Pharmacology, 154(6), 1339-1348. doi: 10.1038/bjp.2008.188

Ramnath, R. D., Sun, J., Adhikari, S., Zhi, L., & Bhatia, M. (2008). Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells. American Journal of Physiology: Cell Physiology, 294, C683-C692. doi: 10.1152/ajpcell.00360.2007

Sio, S. W. S., Puthia, M. K., Lu, J., Moochhala, S., & Bhatia, M. (2008). The neuropeptide substance P is a critical mediator of burn-induced acute lung injury. Journal of Immunology, 180, 8333-8341.

Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2008). Neurokinin A engages neurokinin-1 receptor to induce NF-κB-dependent gene expression in murine macrophages: Implications of ERK1/2 and PI 3-kinase/Akt pathways. American Journal of Physiology: Cell Physiology, 295, C679-C691. doi: 10.1152/ajpcell.00042.2008

Zhang, H., & Bhatia, M. (2008). Hydrogen sulfide: A novel mediator of leukocyte activation. Immunopharmacology & Immunotoxicology, 30, 631-645. doi: 10.1080/08923970802278045

Ng, S. W., Zhang, H., Hegde, A., & Bhatia, M. (2008). Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia. Journal of Leukocyte Biology, 83, 288-295. doi: 10.1189/jlb.0807575

Sun, J., Ramnath, R. D., Zhi, L., Tamizhselvi, R., & Bhatia, M. (2008). Substance P enhances NF-κB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. American Journal of Physiology: Cell Physiology, 294, C1586-C1596. doi: 10.1152/ajpcell.00129.2008

Ang, A. D., Adhikari, S., Wei, N. S., & Bhatia, M. (2008). NFkappaB mediated expression of iNOS in pancreatic acinar cells contributes to the severity of acute pancreatitis and associated lung injury. International Journal of Integrative Biology, 2(2), 70-78.

He, M., Horuk, R., Moochhala, S. M., & Bhatia, M. (2007). Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1173-G1180. doi: 10.1152/ajpgi.00420.2006

Zhang, H., Hegde, A., Ng, S. W., Adhikari, S., Moochhala, S. M., & Bhatia, M. (2007). Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury. Journal of Immunology, 179, 4153-4160.

Zhang, H., Zhi, L., Moochhala, S. M., Moore, P. K., & Bhatia, M. (2007). Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. Journal of Leukocyte Biology, 82, 894-905. doi: 10.1189/jlb.0407237

Sun, J., & Bhatia, M. (2007). Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G143-G153. doi: 10.1152/ajpgi.00271.2006

Sun, J., Ramnath, R. D., & Bhatia, M. (2007). Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. American Journal of Physiology: Cell Physiology, 293, C696-C704. doi: 10.1152/ajpcell.00060.2007

He, M., Lau, H. Y., Ng, S. W., & Bhatia, M. (2007). Chemokines in acute inflammation: Regulation, function and therapeutic strategies. International Journal of Integrative Biology, 1(1), 18-27.

Hegde, A., Zhang, H., Moochhala, S., & Bhatia, M. (2007). Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. Journal of Leukocyte Biology, 82, 678-685. doi: 10.1189/jlb.0407217

Lau, H. Y., & Bhatia, M. (2007). Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. American Journal of Physiology: Gastrointestinal & Liver Physiology, 292, G1283-G1292. doi: 10.1152/ajpgi.00429.2006

Bhatia, M., & Hegde, A. (2007). Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regulatory Peptides, 138(1), 40-48. doi: 10.1016/j.regpep.2006.08.006

Zhi, L., Ang, A. D., Zhang, H., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-κB pathway. Journal of Leukocyte Biology, 81, 1322-1332. doi: 10.1189/jlb.1006599

Liew, H. C., Khoo, H. E., Moore, P. K., Bhatia, M., Lu, J., & Moochhala, S. M. (2007). Synergism between hydrogen sulfide (H2S) and nitric oxide (NO) in vasorelaxation induced by stonustoxin (SNTX), a lethal and hypotensive protein factor isolated from stonefish Synanceja horrida venom. Life Sciences, 80(18), 1664-1668. doi: 10.1016/j.lfs.2007.01.058

Sidhapuriwala, J., Li, L., Sparatore, A., Bhatia, M., & Moore, P. K. (2007). Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. European Journal of Pharmacology, 569, 149-154. doi: 10.1016/j.ejphar.2007.05.003

Cao, Y., Adhikari, S., Clément, M. V., Wallig, M., & Bhatia, M. (2007). Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. American Journal of Pathology, 170(5), 1521-1534. doi: 10.2353/ajpath.2007.061149

Zhang, H., Zhi, L., Moochhala, S., Moore, P. K., & Bhatia, M. (2007). Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-κB. American Journal of Physiology: Lung Cellular & Molecular Physiology, 292, L960-L971. doi: 10.1152/ajplung.00388.2006

Lau, H. Y., & Bhatia, M. (2006). The effect of CP96,345 on the expression of tachykinins and neurokinin receptors in acute pancreatitis. Journal of Pathology, 208, 364-371. doi: 10.1002/path.1899

Cao, Y., Adhikari, S., Ang, A. D., Clément, M. V., Wallig, M., & Bhatia, M. (2006). Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G95-G101. doi: 10.1152/ajpgi.00520.2005

Anuar, F., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflammation Research, 55(11), 498-503. doi: 10.1007/s00011-006-5150-y

Bhatia, M., Li, L., & Moore, P. K. (2006). The role of hydrogen sulfide in lung inflammation. Drug Discovery Today: Disease Mechanisms, 3(1), 71-75. doi: 10.1016/j.ddmec.2006.02.010

Ramnath, R. D., Weing, S., He, M., Sun, J., Zhang, H., Bawa, M. S., & Bhatia, M. (2006). Inflammatory mediators in sepsis: Cytokines, chemokines, adhesion molecules and gases. Journal of Organ Dysfunction, 2(2), 80-92. doi: 10.1080/17471060500435662

Pawlak, J., Mackessy, S. P., Fry, B. G., Bhatia, M., Mourier, G., Fruchart-Gaillard, C., & et al (2006). Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (mangrove catsnake) with bird-specific activity. Journal of Biological Chemistry, 281(39), 29030-29041. doi: 10.1074/jbcM605850200

Bhatia, M., Zhi, L., Zhang, H., Ng, S.-W., & Moore, P. (2006). Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. American Journal of Physiology: Lung Cellular & Molecular Physiology, 291, L896-L904. doi: 10.1152/ajplung.00053.2006

Anuar, F., Whiteman, M., Siau, J. L., Kwong, S. E., Bhatia, M., & Moore, P. K. (2006). Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. British Journal of Pharmacology, 147(8), 966-974. doi: 10.1038/sj.bjp.0706696

Ali, M. Y., Ping, C. Y., Mok, Y.-Y., Ling, L., Whiteman, M., Bhatia, M., & Moore, P. K. (2006). Regulation of vascular nitric oxide in vitro and in vivo: A new role for endogenous hydrogen sulphide? British Journal of Pharmacology, 149(6), 625-634. doi: 10.1038/sj.bjp.0706906

Ramnath, R. D., & Bhatia, M. (2006). Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-κB. American Journal of Physiology: Gastrointestinal & Liver Physiology, 291, G1113-G1119. doi: 10.1152/ajpgi.00177.2006

Puneet, P., Hegde, A., Ng, S. W., Lau, H. Y., Lu, J., Moochhala, S. M., & Bhatia, M. (2006). Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. Journal of Immunology, 176, 3813-3820.

Li, L., Bhatia, M., & Moore, P. K. (2006). Hydrogen sulphide: A novel mediator of inflammation? Current Opinion in Pharmacology, 6(2), 125-129. doi: 10.1016/j.coph.2005.10.007

Whiteman, M., Li, L., Kostetski, I., Chu, S. H., Siau, J. L., Bhatia, M., & Moore, P. K. (2006). Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochemical & Biophysical Research Communications, 343(1), 303-310. doi: 10.1016/j.bbrc.2006.02.154

Zhang, H., Zhi, L., Moore, P. K., & Bhatia, M. (2006). Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. American Journal of Physiology: Lung Cellular & Molecular Physiology, 290, L1193-L1201. doi: 10.1152/ajplung.00489.2005

Cao, Y., Adhikari, S., Ang, A. D., Moore, P. K., & Bhatia, M. (2006). Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. American Journal of Physiology: Cell Physiology, 291, 503-510. doi: 10.1152/ajpcell.00547.2005

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Journal - Research Other

Bhatia, M. (2017). Understanding toxicology: Mechanisms and applications. Cell Biology & Toxicology, 33(1), 1-4. doi: 10.1007/s10565-016-9363-8

Kumar, R., Bhatia, M., & Pai, K. (2017). Role of cytokines in the pathogenesis of visceral leishmaniasis. Clinical Laboratory, 63(10), 1549-1559. doi: 10.7754/Clin.Lab.2017.170404

Du, C., Bhatia, M., Tang, S. C. W., Zhang, M., & Steiner, T. (2015). Mediators of inflammation: Inflammation in cancer, chronic diseases, and wound healing. Mediators of Inflammation, 2015, 570653. doi: 10.1155/2015/570653

Gaddam, R. R., Chambers, S., & Bhatia, M. (2014). ACE and ACE2 in inflammation: A tale of two enzymes. Inflammation & Allergy Drug Targets, 13(4), 224-234. [Review].

Barreto, S. G., Jardine, D., Phillips, P., Bhatia, M., & Saccone, G. T. P. (2011). Reply [Letter to the editor]. Pancreas, 40(7), 1144-1145. doi: 10.1097/MPA.0b013e31822b88b2

Barreto, S. G., Jardine, D., Phillips, P., Bhatia, M., & Saccone, G. (2011). Lack of evidence for a causal association between the type of alcoholic beverage and the incidence of acute pancreatitis Reply [Letter]. Pancreas, 40(7), 1144-1145. doi: 10.1097/MPA.0b013e31822b88b2

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