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Health Sciences profile

Dr Rosie Brown

PositionLecturer
DepartmentDepartment of Physiology
QualificationsBSc(Hons) PhD
Research summaryNeuroendocrinology

Research

I am interested in how the changing hormones of pregnancy and lactation act on neural circuitry in the maternal brain to influence behaviour. In particular, I focus on maternal behaviour, a complex set of behaviours displayed by a mother that promote the survival and wellbeing of her offspring.

Our work aims to understand how hormones normally act to direct a mother’s behaviour and how these processes may become disrupted. We investigate hormonal actions on neural circuitry underlying parental behaviour using a range of molecular, immunohistochemical and imaging approaches.

I am also interested in how changes in the ability of hormones to access the brain in different physiological or pathological states might underlie changes in hormone function.

Additional details

Major techniques used in our group:

  • Use of transgenic mouse and viral technology to study how hormones acting in the brain alter behaviour
  • Molecular biology to examine transcriptional changes in neurons during behaviour and In different reproductive states
  • Tacking the movement of labelled hormones from the blood into the brain
  • Immunohistochemistry and in situ hybridisation to map hormone responsive neurons in the brain

Publications

Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016

Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519

Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology, 160(4), 880-890. doi: 10.1210/en.2018-01065

Phillipps, H. R., Rand, C. J., Brown, R. S. E., Kokay, I. C., Stanton, J.-A., & Grattan, D. R. (2019). Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus. FASEB Journal, 33, 6115-6128. doi: 10.1096/fj.201802262R

Journal - Research Article

Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology, 160(4), 880-890. doi: 10.1210/en.2018-01065

Phillipps, H. R., Rand, C. J., Brown, R. S. E., Kokay, I. C., Stanton, J.-A., & Grattan, D. R. (2019). Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus. FASEB Journal, 33, 6115-6128. doi: 10.1096/fj.201802262R

Ladyman, S. R., MacLeod, M. A., Khant Aung, Z., Knowles, P., Phillipps, H. R., Brown, R. S. E., & Grattan, D. R. (2017). Prolactin receptors in Rip-cre cells, but not in AgRP neurons, are involved in energy homeostasis. Journal of Neuroendocrinology, 29(10), e12474. doi: 10.1111/jne.12474

Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114

Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016

Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2015). Effects of prolactin and lactation on A15 dopamine neurons in the rostral preoptic area of female mice. Journal of Neuroendocrinology, 27(9), 708-717. doi: 10.1111/jne.12297

Liu, X., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. Endocrinology, 155(1), 193-203. doi: 10.1210/en.2013-1621

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Prolactin regulation of kisspeptin neurones in the mouse brain and its role in the lactation-induced suppression of kisspeptin expression. Journal of Neuroendocrinology, 26(12), 898-908. doi: 10.1111/jne.12223

Brown, R. S. E., Piet, R., Herbison, A. E., & Grattan, D. R. (2012). Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons. Endocrinology, 153(5), 2375-2384. doi: 10.1210/en.2011-2005

Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2011). Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse. Biology of Reproduction, 84(4), 826-836. doi: 10.1095/biolreprod.110.089185

Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2010). Distribution of prolactin-responsive neurons in the mouse forebrain. Journal of Comparative Neurology, 518(1), 92-102. doi: 10.1002/cne.22208

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