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Health Sciences profile

Associate Professor Regis Lamberts

PositionDeputy HOD Teaching
DepartmentDepartment of Physiology
QualificationsBSc MSc PhD
Research summaryCardiovascular physiology
TeachingDeputy HOD Teaching, Department of Physiology

Research

How the heart maintains its pump function under conditions of stress has been the focus of my research career.

In the last decade my research has focused on determining the changes in autonomic regulation and heart function in obesity and diabetes. More recently this has extended to determining the functional interaction between epicardial adipose tissue and the heart, especially in relation to development of cardiac arrhythmias and obesity. To this end, functional biomedical data at cellular and organ level, human myocardial and clinical data are obtained through HeartOtago.

This translational knowledge creates the platform that is vital for the development of specific therapeutics for the increasing cohort of individuals with metabolic disease and arrhythmias to improve their heart health.

Publications

Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism. Advance online publication. doi: 10.1152/ajpendo.00202.2020

Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856

Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003

Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387

Journal - Research Article

Frisk, M., Le, C., Shen, X., Røe, Å., Hou, Y., Manfra, O., … van Hout, I., … Lamberts, R. R., … Coffey, S., … Jones, P. P., … Louch, W. E. (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. JACC, 77(4), 405-419. doi: 10.1016/j.jacc.2020.11.044

Aitken-Buck, H. M., Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Jones, P. P., & Lamberts, R. R. (2020). Inotropic and lusitropic, but not arrhythmogenic, effects of adipocytokine resistin on human atrial myocardium. American Journal of Physiology: Endocrinology & Metabolism. Advance online publication. doi: 10.1152/ajpendo.00202.2020

Babakr, A. A., Fomison-Nurse, I. C., van Hout, I., Aitken-Buck, H. M., Sugunesegran, R., Davis, P. J., Bunton, R. W., Williams, M. J. A., Coffey, S., Stiles, M. K., Jones, P. P., & Lamberts, R. R. (2020). Acute interaction between human epicardial adipose tissue and human atrial myocardium induce arrhythmic susceptibility. American Journal of Physiology: Endocrinology & Metabolism, 318, E164-E172. doi: 10.1152/ajpendo.00374.2019

Bussey, C. T., Babakr, A. A., Iremonger, R. R., van Hout, I., Wilkins, G. T., Lamberts, R. R., & Erickson, J. R. (2020). Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes. Physiological Reports, 8(5), e14394. doi: 10.14814/phy2.14394

Loper, N., Garland, J., Ondruschka, B., Lamberts, R., Stables, S., & Tse, R. (2020). Ventricular weight increases proportionally with total heart weight in postmortem population. American Journal of Forensic Medicine & Pathology, 41(4), 259-262. doi: 10.1097/paf.0000000000000568

Moharram, M. A., Aitken-Buck, H. M., Reijers, R., van Hout, I., Williams, M. J. A., Jones, P. P., Whalley, G. A., Lamberts, R. R., & Coffey, S. (2020). Correlation between epicardial adipose tissue and body mass index in New Zealand ethnic populations. New Zealand Medical Journal, 133(1516), 22-32. Retrieved from https://www.nzma.org.nz/journal

Aitken-Buck, H. M., Moharram, M., Babakr, A. A., Reijers, R., Van Hout, I., Fomison-Nurse, I. C., Sugunesegran, R., … Bunton, R. W., Williams, M. J. A., … Jones, P. P., Coffey, S., & Lamberts, R. R. (2019). Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index. Adipocyte, 8(1), 412-420. doi: 10.1080/21623945.2019.1701387

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2019). HIIT improves left ventricular exercise response in adults with type 2 diabetes. Medicine & Science in Sports & Exercise, 51(6), 1099-1105. doi: 10.1249/mss.0000000000001897

Cook, R. F., Bussey, C. T., Fomison-Nurse, I. C., Hughes, G., Bahn, A., Cragg, P. A., & Lamberts, R. R. (2019). β2-adrenoceptors indirectly support impaired β1-adrenoceptor responsiveness in the isolated type 2 diabetic rat heart. Experimental Physiology, 104, 808-818. doi: 10.1113/EP087437

Aitken-Buck, H. M., Babakr, A. A., Coffey, S., Jones, P. P., Tse, R. D., & Lamberts, R. R. (2019). Epicardial adipocyte size does not correlate with body mass index. Cardiovascular Pathology, 43, 107144. doi: 10.1016/j.carpath.2019.07.003

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., … Wilkins, G., Jones, P. P., … Schwenke, D. O. (2018). Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology, 159(4), 1763-1773. doi: 10.1210/en.2017-03070

Daniels, L. J., Wallace, R. S., Nicholson, O. M., Wilson, G. A., McDonald, F. J., Jones, P. P., Baldi, J. C., Lamberts, R. R., & Erickson, J. R. (2018). Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats. Cardiovascular Diabetology, 17, 89. doi: 10.1186/s12933-018-0732-x

Bussey, C. T., Thaung, H. P. A., Hughes, G., Bahn, A., & Lamberts, R. R. (2018). Cardiac β-adrenergic responsiveness of obese Zucker rats: The role of AMPK. Experimental Physiology, 103(8), 1067-1075. doi: 10.1113/ep087054

Wilson, G. A., Wilkins, G. T., Cotter, J. D., Lamberts, R. R., Lal, S., & Baldi, J. C. (2017). Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes. Cardiovascular Diabetology, 16, 160. doi: 10.1186/s12933-017-0644-1

Cook, R. F., Bussey, C. T., Mellor, K. M., Cragg, P. A., & Lamberts, R. R. (2017). β1-Adrenoceptor, but not β2-adrenoceptor, subtype regulates heart rate in type 2 diabetes rats in vivo. Experimental Physiology, 102(8), 911-923. doi: 10.1113/ep086293

Satthenapalli, V. R., Lamberts, R. R., & Katare, R. G. (2017). Challenges in regenerating the diabetic heart: A comprehensive review. Stem Cells, 35(9), 2009-2026. doi: 10.1002/stem.2661

Bussey, C. T., & Lamberts, R. R. (2017). Effect of type 2 diabetes, surgical incision, and volatile anesthesia on hemodynamics in the rat. Physiological Reports, 5(14), e13352. doi: 10.14814/phy2.13352

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Rawal, S., Munasinghe, E. P., Nagesh, P. T., Lew, J. K. S., Jones, G. T., Williams, M. J. A., Davis, P., Bunton, R. W., Galvin, I. F., Manning, P., Lamberts, R. R., & Katare, R. (2017). Downregulation of miR-15a/b accelerates fibrotic remodelling in the Type-2 diabetic human and mouse heart. Clinical Science, 131(9), 847-863. doi: 10.1042/cs20160916

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R. R., … Katare, R. (2016). Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. International Journal of Cardiology, 202, 13-20. doi: 10.1016/j.ijcard.2015.08.111

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Thaung, H. P. A., Baldi, J. C., Wang, H.-Y., Hughes, G., Cook, R. F., Bussey, C. T., Sheard, P. W., Bahn, A., Jones, P. P., Schwenke, D. O., & Lamberts, R. R. (2015). Increased efferent cardiac sympathetic nerve activity and defective intrinsic heart rate regulation in type 2 diabetes. Diabetes, 64(8), 2944-2956. doi: 10.2337/db14-0955

Green, S., Egaña, M., Baldi, J. C., Lamberts, R., & Regensteiner, J. G. (2015). Cardiovascular control during exercise in type 2 diabetes mellitus. Journal of Diabetes Research, 2015, 654204. doi: 10.1155/2015/654204

Daniels, L., Bell, J. R., Delbridge, L. M. D., McDonald, F. J., Lamberts, R. R., & Erickson, J. R. (2015). The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews, 20(5), 589-600. doi: 10.1007/s10741-015-9498-3

Jahn, N., Lamberts, R. R., Busch, C. J., Voelker, M. T., Koel-Simmelink, M. J. A., Teunissen, C. E., … Weimann, J. (2015). Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice. Respiratory Research, 16, 119. doi: 10.1186/s12931-015-0274-7

Thaung, H. P. A., Yao, Y., Bussey, C. T., Hughes, G., Jones, P. P., Bahn, A., Sammut, I. A., & Lamberts, R. R. (2015). Chronic bilateral renal denervation reduces cardiac hypertrophic remodelling but not β-adrenergic responsiveness in hypertensive type 1 diabetic rats. Experimental Physiology, 100(6), 628-639. doi: 10.1113/EP085021

Bussey, C. T., Hughes, G., Saxena, P., Galvin, I. F., Bunton, R. W., Noye, M. K., Coffey, S., Williams, M. J. A., Baldi, J. C., Jones, P. P., & Lamberts, R. R. (2015). Chamber-specific changes in calcium-handling proteins in the type 2 diabetic human heart with preserved ejection fraction. International Journal of Cardiology, 193, 53-55. doi: 10.1016/j.ijcard.2015.05.053

Munasinghe, P. E., Riu, F., Dixit, P., Edamatsu, M., Saxena, P., Hamer, N. S. J., Galvin, I. F., Bunton, R. W., Lequeux, S., Jones, G., Lamberts, R., … Katare, R. (2015). Data supporting the activation of autophagy genes in the diabetic heart. Data in Brief, 5, 269-275. doi: 10.1016/j.dib.2015.09.003

Bussey, C. T., de Leeuw, A. E., Cook, R. F., Ashley, Z., Schofield, J., & Lamberts, R. R. (2014). Dual implantation of a radio-telemeter and vascular access port allows repeated hemodynamic and pharmacological measures in conscious lean and obese rats. Laboratory Animals, 48(3), 250-260. doi: 10.1177/0023677214530687

Bussey, C. T., de Leeuw, A. E., & Lamberts, R. R. (2014). Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo. Cardiovascular Diabetology, 13, 161. doi: 10.1186/s12933-014-0161-4

Lamberts, R. R., Lingam, S. J., Wang, H.-Y., Bollen, I. A. E., Hughes, G., Galvin, I. F., Bunton, R. W., Bahn, A., Katare, R., Baldi, J. C., Williams, M. J. A., Saxena, P., Coffey, S., & Jones, P. P. (2014). Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. Cardiovascular Diabetology, 13, 72. doi: 10.1186/1475-2840-13-72

Smeding, L., Plötz, F. B., Lamberts, R. R., van der Laarse, W. J., Kneyber, M. C. J., & Groeneveld, A. B. J. (2012). Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Respiratory Research, 13, 23. doi: 10.1186/1465-9921-13-23

Smeding, L., van der Laarse, W. J., van Veelen, T. A., Lamberts, R. R., Niessen, H. W. M., Kneyber, M. C. J., … Plötz, F. B. (2012). Early myocardial dysfunction is not caused by mitochondrial abnormalities in a rat model of peritonitis. Journal of Surgical Research, 176(1), 178-184. doi: 10.1016/j.jss.2011.05.055

Bouwman, R. A., Vreden, M. J. A., Hamdani, N., Wassenaar, L. E. J., Smeding, L., Loer, S., … Lamberts, R. R. (2010). Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts. European Journal of Pharmacology, 647(1-3), 132-138. doi: 10.1016/j.ejphar.2010.08.014

de Mooji, Y. M., Bartelings, M. M., Twisk, J. W. R., Lamberts, R. R., Gittenberger-de Groot, A. C., van Vugt, J. M. G., & Bekker, M. N. (2010). Altered jugular vein and ductus venosus flow velocities in fetuses with increased nuchal translucency and distended jugular lymphatic sacs. American Journal of Obstetrics & Gynecology, 202(6), e566.1-e566.8. doi: 10.1016/j.ajog.2010.01.054

Handoko, M. L., Lamberts, R. R., Redout, E. M., de Man, F. S., Boer, C., Simonides, W. S., … Vonk-Noordegraaf, A. (2009). Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: A study in the isolated heart. American Journal of Physiology: Heart & Circulatory Physiology, 297(5), H1752-H1759. doi: 10.1152/ajpheart.00555.2009

Hamdani, N., de Waard, M., Messer, A. E., Boontje, N. M., Kooij, V., van Dijk, S., … Lamberts, R., … van der Velden, J. (2009). Myofilament dysfunction in cardiac disease from mice to men. Journal of Muscle Research & Cell Motility, 29(6-8), 189-201. doi: 10.1007/s10974-008-9160-y

Lamberts, R. R., Onderwater, G., Hamdani, N., Vreden, M. J. A., Steenhuisen, J., Eringa, E. C., … Bouwman, R. A. (2009). Reactive oxygen species—induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection. Circulation, 120(Suppl. 1), S10-S15. doi: 10.1161/CIRCULATIONAHA.108.828426

Lamberts, R. R., Caldenhoven, E., Lansink, M., Witte, G., Vaessen, R. J., St Cyr, J. A., & Stienen, G. J. M. (2007). Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats. American Journal of Physiology: Heart & Circulatory Physiology, 293(4), H1869-H1876. doi: 10.1152/ajpheart.00294.2007

Lamberts, R. R., Hamdani, N., Soekhoe, T. W., Boontje, N. M., Zaremba, R., Walker, L. A., … Stienen, G. J. M. (2007). Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. Journal of Physiology, 582(2), 695-709. doi: 10.1113/jphysiol.2007.134486

Bouwman, R. A., Musters, R. J. P., van Beek-Harmsen, B. J., de Lange, J. J., Lamberts, R. R., Loer, S., & Boer, C. (2007). Sevoflurane-induced cardioprotection depends on PKC-α activation via production of reactive oxygen species. British Journal of Anaesthesia, 99(5), 639-645. doi: 10.1093/bja/aem202

Lamberts, R. R., Vaessen, R. J., Westerhof, N., & Stienen, G. J. M. (2007). Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat. Basic Research in Cardiology, 102(1), 19-27. doi: 10.1007/s00395-006-0620-5

van der Velden, J., Narolska, N. A., Lamberts, R. R., Boontje, N. M., Borbély, A., Zaremba, R., … Stienen, G. J. M. (2006). Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium. Cardiovascular Research, 69, 876-887. doi: 10.1016/j.cardiores.2005.11.021

Westerhof, N., Boer, C., Lamberts, R. R., & Sipkema, P. (2006). Cross-talk between cardiac muscle and coronary vasculature. Physiological Reviews, 86(4), 1268-1308. doi: 10.1152/physrev.00029.2005

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Journal - Research Other

Aitken-Buck, H. M., Krause, J., Zeller, T., Jones, P. P., & Lamberts, R. R. (2020). Long-chain acylcarnitines and cardiac excitation-contraction coupling: Links to arrhythmias. Frontiers in Physiology, 11, 577856. doi: 10.3389/fphys.2020.577856

Moharram, M. A., Lamberts, R. R., Whalley, G., Williams, M. J. A., & Coffey, S. (2019). Myocardial tissue characterisation using echocardiographic deformation imaging. Cardiovascular Ultrasound, 17, 27. doi: 10.1186/s12947-019-0176-9

Aitken-Buck, H. M., & Lamberts, R. R. (2017). To the heart of activation heat. Journal of Physiology, 595(14), 4577-4578. doi: 10.1113/jp274582

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