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Health Sciences profile

Professor Evan Begg

PositionProfessor
DepartmentDepartment of Medicine (UOC)
QualificationsBSc MB ChB(Auck) MD(Otago) FRACP
Research summaryClinical Pharmacology

Research

Professor Evan Begg is a Clinical Pharmacologist. His research interests include drugs in pregnancy and lactation, antibiotic dosing regimens and pharmacogenetics. He is the author of Instant Clinical Pharmacology.

Publications

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2015). Lactation and contamination of breast milk with Xenobiotics. In M. J. Caplan (Ed.), Reference module in biomedical sciences. Elsevier. doi: 10.1016/B978-0-12-801238-3.02154-1

Plajer, S. M., Chin, P. K. L., Vella-Brincat, J. W. A., Buffery, P. J., & Begg, E. J. (2015). Gentamicin and renal function: Lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin. Therapeutic Drug Monitoring, 37(1), 98-103. doi: 10.1097/FTD.0000000000000107

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Zhang, M., Moore, G. A., Everts, R., & Begg, E. J. (2014). Determination of total and free concentrations of flucloxacillin and cefazolin in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Analytical & Bioanalytical Technique, 5(1), 1000182. doi: 10.4172/2155-9872.1000182

Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366

Authored Book - Research

Begg, E. J. (2008). Instant clinical pharmacology (2nd ed.). Malden, MA: Blackwell, 112p.

Begg, E. J. (2003). Instant clinical pharmacology. Malden, MA: Blackwell Publishing, 103p.

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Authored Book - Other

Beard, M. E. J., Thwaites, J. H., Begg, E. J., Chambers, S., Colls, B. M., Jeffery, G. M., … Pithie, A., … Sainsbury, R., & Young, C. (2003). Management guidelines for common medical conditions (10th ed.). Christchurch, NZ: Canterbury District Health Board, 299p.

Begg, E. J., for the PML Committee. (2002). Preferred Medicines List and Antibiotics Guidelines (7th ed.). Christchurch: Canterbury District Health Board, 166p.

Beard, M. E. J., Town, G. I., Ardagh, M. W., Begg, E. J., Chambers, S., Jeffery, G. M., & Laing, R. T. R. (2000). Management Guidelines for Common Medical Conditions (8th ed.). Christchurch, New Zealand: Internal Medicine Services, Canterbury Health, 284p.

Begg, E. J. (2000). Clinical Pharmacology Essentials (1st ed.). Adis Press, 78p.

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Edited Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

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Chapter in Book - Research

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2015). Lactation and contamination of breast milk with Xenobiotics. In M. J. Caplan (Ed.), Reference module in biomedical sciences. Elsevier. doi: 10.1016/B978-0-12-801238-3.02154-1

Begg, E. J., Gardiner, S. J., & Kirkpatrick, C. M. J. (2010). Lactation and contamination of breast milk with xenobiotics. In C. A. McQueen (Ed.), Comprehensive toxicology. (2nd ed.) (pp. 445-455). Oxford, UK: Elsevier.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1999). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice. (pp. 19-32). London: Martin Dunitz.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1998). Hypertension as a cause of heart failure - is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart Failure in Clinical Practice (Second Edition). London: Dunitz.

Atkinson, C., & Begg, E. J. (1998). Drugs in Human Milk. In N. H. G. Holford (Ed.), Clinical pharmacokinetics drug data handbook. (3rd ed.) (pp. 181-232). Auckland, New Zealand: Adis Press.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (1997). Hypertension and heart failure. In A. Zanchetti & et al (Eds.), Hypertension and the heart. (pp. 273-279). New York: Plenum Press.

Begg, E. J., Atkinson, H. C., & Darlow, B. A. (1997). Guide to drug usage in lactation. In T. M. Speight & N. H. G. Holford (Eds.), Avery's Drug Treatment: a Guide to the Properties, Choice, Therapeutic Use and Economic Value of Drugs in Disease Management, 4th edition. (pp. 1701-1723). Auckland: Adis Press.

Begg, E. J. (1996). Determinants of drug transfer into human milk. In P. N. Bennett (Ed.), Drugs and Human Lactation: a Comprehensive Guide to the Content and Consequences of Drugs, Micronutrients, Radiopharmaceuticals, and Environmental and Occupational Chemicals in Human Milk, 2nd edition. (pp. 47-58). Amsterdam; New York: Elsevier.

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Chapter in Book - Other

Kennedy, M., Joyce, P., & Begg, E. (2013). Carney Centre for Pharmacogenomics. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 100-104). Christchurch, New Zealand: University of Otago.

Nicholls, M. G., Richards, A. M., & Begg, E. J. (2000). Hypertension as a cause of heart failure: Is it still important? In J. J. V. McMurray & J. G. F. Cleland (Eds.), Heart failure in clinical practice. (2nd ed.) (pp. 19-31). United Kingdom: Martin Dunitz.

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Journal - Research Article

Plajer, S. M., Chin, P. K. L., Vella-Brincat, J. W. A., Buffery, P. J., & Begg, E. J. (2015). Gentamicin and renal function: Lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin. Therapeutic Drug Monitoring, 37(1), 98-103. doi: 10.1097/FTD.0000000000000107

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Zhang, M., Moore, G. A., Everts, R., & Begg, E. J. (2014). Determination of total and free concentrations of flucloxacillin and cefazolin in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Analytical & Bioanalytical Technique, 5(1), 1000182. doi: 10.4172/2155-9872.1000182

Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366

Buffery, P. J., Allen, K. M., Chin, P. K. L., Moore, G. A., Barclay, M. L., & Begg, E. J. (2014). Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: Can the strategy be improved? Therapeutic Drug Monitoring, 36(1), 86-92. doi: 10.1097/FTD.0b013e31829dc940

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Lewis, L. K., Yandle, T. G., Hilton, P. J., Jensen, B. P., Begg, E. J., & Nicholls, M. G. (2014). Endogenous ouabain is not ouabain. Hypertension, 64, 680-683. doi: 10.1161/hypertensionaha.114.03919

Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9

Tanoshima, R., Garcia Bournissen, F., Tanigawara, Y., Kristensen, J. H., Taddio, A., Ilett, K. F., Begg, E. J., … Ito, S. (2014). Population PK modeling and simulation based on fluoxetine and norfluoxetine concentrations in milk: A milk concentration-based prediction model. British Journal of Clinical Pharmacology, 78(4), 918-928. doi: 10.1111/bcp.12409

Chin, P. K. L., Vella-Brincat, J. W. A., Walker, S. L., Barclay, M. L., & Begg, E. J. (2013). Dosing of dabigatran etexilate in relation to renal function and drug interactions at a tertiary hospital. Internal Medicine Journal, 43(7), 778-783. doi: 10.1111/imj.12170

Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2013). A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma. Antimicrobial Agents & Chemotherapy, 57(1), 484-489. doi: 10.1128/aac.00768-12

Wong, C., Kumar, S. S., Graham, G. G., Begg, E. J., Chin, P. K. L., Brett, J., … Day, R. O. (2013). Comparing dose prediction software used to manage gentamicin dosing. Internal Medicine Journal, 43(5), 519-525. doi: 10.1111/imj.12067

Chin, P. K. L., Florkowski, C. M., & Begg, E. J. (2013). The performances of the Cockcroft-Gault, Modification of Diet in Renal Disease Study and Chronic Kidney Disease Epidemiology Collaboration equations in predicting gentamicin clearance. Annals of Clinical Biochemistry, 50(6), 546-557. doi: 10.1177/0004563213492320

Begg, E. J., Helsby, N. A., & Jensen, B. P. (2012). Pharmacogenetics of drug-metabolizing enzymes: The prodrug hypothesis. Pharmacogenomics, 13(1), 83-89. doi: 10.2217/pgs.11.134

Jensen, B. P., Chin, P. K. L., Roberts, R. L., & Begg, E. J. (2012). Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin. British Journal of Clinical Pharmacology, 74(5), 797-805. doi: 10.1111/j.1365-2125.2012.04259.x

Jensen, B. P., Roberts, R. L., Vyas, R., Bonke, G., Jardine, D. L., & Begg, E. J. (2012). Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers. British Journal of Clinical Pharmacology, 73(4), 619-628. doi: 10.1111/j.1365-2125.2011.04126.x

Zhang, M., Moore, G. A., Fernyhough, L. J., Barclay, M. L., & Begg, E. J. (2012). Determination of imatinib and its active metabolite N-desmethyl imatinib in human plasma by liquid chromatography/tandem mass spectrometry. Analytical & Bioanalytical Chemistry, 404(6-7), 2091-2096. doi: 10.1007/s00216-012-6284-0

Vella-Brincat, J. W. A., Begg, E. J., Jensen, B. P., Chin, P. K. L., Roberts, R. L., Fairhall, M., … Reid, K. (2012). The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. Journal of Pain & Symptom Management, 43(3), 540-548. doi: 10.1016/j.jpainsymman.2011.04.022

Larsen, H. S., Chin, P. K. L., Begg, E. J., & Jensen, B. P. (2011). Quantification of total and unbound concentrations of lorazepam, oxazepam and temazepam in human plasma by ultrafiltration and LC-MS/MS. Bioanalysis, 3(8), 843-852. doi: 10.4155/bio.11.46

Chin, P. K. L., Jensen, B. P., Larsen, H. S., & Begg, E. J. (2011). Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. British Journal of Clinical Pharmacology, 72(6), 985-989. doi: 10.1111/j.1365-2125.2011.04036.x

Jensen, B. P., Vella-Brincat, J. W. A., & Begg, E. J. (2011). Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Journal of Chromatography B, 879(9-10), 605-609. doi: 10.1016/j.jchromb.2011.01.021

Vella-Brincat, J. W. A., Begg, E. J., Robertshawe, B. J., Lynn, A. M., Borrie, T. L., & Darlow, B. A. (2011). Are gentamicin and/or vancomycin associated with ototoxicity in the neonate? A retrospective audit. Neonatology, 100, 186-193. doi: 10.1159/000324857

Jensen, B. P., Chin, P. K. L., & Begg, E. J. (2011). Quantification of total and free concentrations of R- and S-warfarin in human plasma by ultrafiltration and LC-MS/MS. Analytical & Bioanalytical Chemistry, 401(7), 2187-2193. doi: 10.1007/s00216-011-5303-x

Bird, P. A., Murray, D. P., Zhang, M., & Begg, E. J. (2011). Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph. Otology & Neurotology, 32(6), 933-936. doi: 10.1097/MAO.0b013e3182255933

Panchaud, A., Garcia-Bournissen, F., Kristensen, J. H., Taddio, A., Ilett, K. F., Begg, E. J., & Ito, S. (2011). Prediction of infant drug exposure through breastfeeding: Population PK modeling and simulation of fluoxetine exposure. Clinical Pharmacology & Therapeutics, 89(6), 830-836. doi: 10.1038/clpt.2011.23

Zhang, M., Moore, G. A., Jensen, B. P., Begg, E. J., & Bird, P. A. (2011). Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 879(1), 17-24. doi: 10.1016/j.jchromb.2010.11.003

Wright, D. F. B., & Begg, E. J. (2010). The 'apparent clearance' of free phenytoin in elderly vs. younger adults. British Journal of Clinical Pharmacology, 70(1), 132-138. doi: 10.1111/j.1365-2125.2010.03673.x

Bagshaw, P. F., Allardyce, R. A., Bagshaw, S. N., Stokes, B. W., Shaw, C. S., Proffit, L. J., Nicholls, M. G., Begg, E. J., & Frampton, C. M. (2010). Patients "falling through the cracks". The Canterbury Charity Hospital: Initial progress report. New Zealand Medical Journal, 123(1320). Retrieved from http://journal.nzma.org.nz/journal/123-1320/4262/content.pdf

Zhang, M., Moore, G. A., Barclay, M. L., & Begg, E. J. (2009). Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography B, 877(27), 3025-3030. doi: 10.1016/j.jchromb.2009.07.021

Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x

Begg, E. J., Vella-Brincat, J. W. A., Robertshawe, B., McMurtrie, M. J., Kirkpatrick, C. M. J., & Darlow, B. (2009). Eight years' experience of an extended-interval dosing protocol for gentamicin in neonates. Journal of Antimicrobial Chemotherapy, 63, 1043-1049. doi: 10.1093/jac/dkp073

Sharp, C. F., Gardiner, S. J., Jensen, B. P., Roberts, R. L., Troughton, R. W., Lainchbury, J. G., & Begg, E. J. (2009). CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics Journal, 9(3), 175-184. doi: 10.1038/tpj.2009.9

Butler, J. M., & Begg, E. J. (2008). Free drug metabolic clearance in elderly people. Clinical Pharmacokinetics, 47(5), 297-321.

Jensen, B. P., Sharp, C. F., Gardiner, S. J., & Begg, E. J. (2008). Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of Chromatography B, 865(1-2), 48-54. doi: 10.1016/j.jchromb.2008.02.006

McKean, A., Vella-Brincat, J., & Begg, E. (2008). Prescribing and monitoring clozapine in Christchurch. Australasian Psychiatry, 16(4), 263-267. doi: 10.1080/10398560802189896

Gardiner, S. J., Gearry, R. B., Begg, E. J., Zhang, M., & Barclay, M. L. (2008). Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clinical Gastroenterology & Hepatology, 6(6), 654-660. doi: 10.1016/j.cgh.2008.02.032

Brooks, A. J., Begg, E. J., Zhang, M., Frampton, C. M., & Barclay, M. L. (2007). Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease. Therapeutic Drug Monitoring, 29(5), 619-625.

Vella-Brincat, J. W. A., Begg, E. J., Kirkpatrick, C. M. J., Zhang, M., Chambers, S. T., & Gallagher, K. (2007). Protein binding of cefazolin is saturable in vivo both between and within patients. British Journal of Clinical Pharmacology, 63(6), 753-757.

Bird, P. A., Begg, E. J., Zhang, M., Keast, A. T., Murray, D. P., & Balkany, T. J. (2007). Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otology & Neurotology, 28, 1124-1130.

Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2006). Determination of celecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 830(2), 245-248. doi: 10.1016/j.jchromb.2005.10.048

Gardiner, S. J., Gearry, R. B., Roberts, R. L., Zhang, M., Barclay, M. L., & Begg, E. J. (2006). Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. British Journal of Clinical Pharmacology, 62(4), 453-456.

Gardiner, S. J., Gearry, R. B., Barclay, M. L., & Begg, E. J. (2006). Two cases of thiopurine methyltransferase (TPMT) deficiency: A lucky save and a near miss with azathioprine. British Journal of Clinical Pharmacology, 62(4), 473-476. doi: 10.1111/j.1365-2125.2005.02474.x

Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x

Vella-Brincat, J., Begg, E., Zhang, M., & Chambers, S. (2006). Cooling enhances benzylpenicillin stability during continuous home intravenous administration. Hospital Pharmacist, 13, 56-57.

Gardiner, S. J., & Begg, E. J. (2006). Breastfeeding during tacrolimus therapy. Obstetrics & Gynecology, 107(2, Part 2, Suppl.), 453-455.

Priest, V. L., Begg, E. J., Gardiner, S. J., Frampton, C. M., Gearry, R. B., Barclay, M. L., Clark, D. W., & Hansen, P. (2006). Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease. Pharmacoeconomics, 24(8), 767-781.

Gardiner, S. J., & Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacological Reviews, 58(3), 521-590.

Hughes, R. C., Gardiner, S. J., Begg, E. J., & Zhang, M. (2006). Effect of pregnancy on the pharmacokinetics of metformin. Diabetic Medicine, 23(3), 323-326. doi: 10.1111/j.1464-5491.2005.01769.x

Gardiner, S. J., Begg, E. J., Zhang, M., & Hughes, R. C. (2005). Transfer of rofecoxib into human milk. European Journal of Clinical Pharmacology, 61(5-6), 405-408.

Gardiner, S. J., & Begg, E. J. (2005). Pharmacogenetic testing for drug metabolizing enzymes: Is it happening in practice? Pharmacogenetics & Genomics, 15, 365-369.

Begg, E. J. (2005). Individualized drug and dose: The clinical pharmacologist's calling or curse? Clinical & Experimental Pharmacology & Physiology, 32, 975-978.

Ilett, K. F., Hackett, L. P., Kristensen, J. H., Vaddadi, K. S., Gardiner, S. J., & Begg, E. J. (2004). Transfer of risperidone and 9-hydroxyrisperidone into human milk. Annals of Pharmacotherapy, 38, 273-276.

Vella-Brincat, J. W. A., Begg, E. J., Gallagher, K., Kirkpatrick, C. M. J., Zhang, M., Frampton, C., & Chambers, S. T. (2004). Stability of benzylpenicillin during continuous home intravenous therapy. Journal of Antimicrobial Chemotherapy, 53(4), 675-677. British Society for Antimicrobial Chemotherapy.

Zhang, M., Moore, G. A., Gardiner, S. J., & Begg, E. J. (2004). Determination of rofecoxib in human plasma and breast milk by high-performance liquid chromatographic assay. Journal of Chromatography B, 807, 217-221. Elsevier.

Gardiner, S. J., & Begg, E. J. (2004). Genotyping for drug-metabolizing enzymes: Does the promise meet the reality? Pharmacogenomics, 5(8), 1033-1036. Future Medicine.

Gardiner, S. J., Kirkpatrick, C., Begg, E. J., Zhang, M., Moore, M. P., & Saville, D. J. (2003). Transfer of metformin into human milk. Clinical Pharmacology & Therapeutics, 73, 71-77.

Barclay, M. L., Sawyers, S. M., Begg, E. J., Zhang, M., Roberts, R., Kennedy, M. A., & Elliott, J. M. (2003). Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status. Pharmacogenetics, 13(10), 627-632.

Barclay, M., & Begg, E. (2003). The practice of digoxin therapeutic drug monitoring [Editorial]. New Zealand Medical Journal, 116(1187). Retrieved from http://journal.nzma.org.nz/journal/116-1187/704/content.pdf

Kirkpatrick, C. M. J., Duffull, S. B., Begg, E. J., & Frampton, C. (2003). The use of a change in gentamicin clearance as an early predictor of gentamicin-induced nephrotoxicity. Therapeutic Drug Monitoring, 25, 623-630.

Gardiner, S. J., Kristensen, J. H., Begg, E. J., Hackett, L. P., Wilson, D. A., Ilett, K., … Rampono, J. (2003). Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. American Journal of Psychiatry, 160, 1428-1431.

Sidwell, A., Barclay, M., Begg, E., & Moore, G. (2003). Digoxin therapeutic drug monitoring: An audit and review. New Zealand Medical Journal, 116(1187). Retrieved from http://journal.nzma.org.nz/journal/116-1187/708/content.pdf

Begg, E. J., Duffull, S. B., Hackett, L. P., & Ilett, K. F. (2002). Studying drugs in human milk: Time to unify the approach. Journal of Human Lactation, 18(4), 323-332.

Roberts, R. L., Joyce, P. R., Mulder, R. T., Begg, E. J., & Kennedy, M. A. (2002). A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression. Pharmacogenomics Journal, 2(3), 191-196. doi: 10.1038/sj.tpj.6500099

Roberts, R., Begg, E. J., Joyce, P. R., & Kennedy, M. A. (2002). How the pharmacogenetics of cytochrome P450 enzymes may affect prescribing. New Zealand Medical Journal, 115(1150), 137-140.

Whiting, B., Holford, N. H., & Begg, E. J. (2002). Clinical pharmacology: Principles and practice of drug therapy in medical education. British Journal of Clinical Pharmacology, 54(1), 1-2.

Mant, A., & Begg, E. J. (2002). Reviewing prescribing for the elderly using a quality use of medicines approach. Asia Pacific Family Medicine, 1, 41-44.

Howard, G. W., Begg, E. J., Chambers, S. T., Vella-Brincat, J., Zhang, M., & Kirkpatrick, C. M. J. (2002). Free and total cefazolin plasma and interstitial fluid concentrations at steady state during continuous infusion. Journal of Antimicrobial Chemotherapy, 50, 429-432.

Zhang, M., Moore, G. A., Lever, M., Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2002). Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B, 766(1), 175-179.

Gardiner, S. J., Begg, E. J., & Robinson, B. A. (2002). The effect of dihydropyrimidine dehydrogenase deficiency on outcomes with fluorouracil. Adverse Drug Reactions & Toxicological Reviews, 21(1-2), 1-16.

Stedman, C. A. M., Begg, E. J., Kennedy, M. A., Roberts, R., & Wilkinson, T. J. (2002). Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia. Human Psychopharmacology, 17(4), 187-190.

Gardiner, S. J., Kirkpatrick, C. M. J., & Begg, E. J. (2001). Fifteen years of drug information in Christchurch Hospital. New Zealand Medical Journal, 114, 393-395.

Stickland, M. D., Kirkpatrick, C. M. J., Begg, E. J., Duffull, S. B., Oddie, S. J., & Darlow, B. A. (2001). An extended interval dosing method for gentamicin in neonates. Journal of Antimicrobial Chemotherapy, 48, 887-893.

Begg, E. J., Robson, R. A., Gardiner, S. J., Hudson, L. J., Reece, P. A., Olson, S. C., … Sedman, A. J. (2001). Quinapril and its metabolite quinaprilat in human milk. British Journal of Clinical Pharmacology, 51, 478-481.

Begg, E. J., Malpas, T. J., Hackett, L. P., & Ilett, K. F. (2001). Distribution of R- and S-methadone into human milk during multiple, medium to high oral dosing. British Journal of Clinical Pharmacology, 52, 681-685.

Barclay, M. L., & Begg, E. J. (2001). Aminoglycoside adaptive resistance. Importance for effective dosage regimens. Drugs, 61(6), 713-721.

Begg, E. J., Barclay, M. L., & Kirkpatrick, C. M. J. (2001). The therapeutic monitoring of antimicrobial agents. British Journal of Clinical Pharmacology, 52(Suppl.), 35S-43S.

Martin, J. H., Begg, E. J., Kennedy, M. A., Roberts, R., & Barclay, M. L. (2001). Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration? British Journal of Clinical Pharmacology, 51, 627-630.

Begg, E. J., Malpas, T. J., Hackett, L. P., & Ilett, K. F. (2001). Distribution of R- and S-methadone into human milk at steady state during ingestion of medium to high doses. British Journal of Clinical Pharmacology, 52, 681-685.

Swinburn, B., Milne, R. J., Richards, A. M., Begg, E. J., Foote, S., & Jackson, R. (2000). Reimbursement of pharmaceuticals in New Zealand: Comments on PHARMAC's processes. New Zealand Medical Journal, 113, 425-427.

Martin, J. H., Begg, E. J., Kennedy, M. A., Roberts, R. L., & Barclay, M. L. (2000). Cytochrome P450 2C9 genotype does not predict incidence of gastric bleeding with non steroidal anti-inflammatory drugs. Proceedings of ASCEPT, 7(April), 57.

Gardiner, S. J., Begg, E. J., Barclay, M. L., & Kirkpatrick, C. M. J. (2000). Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine. Adverse Drug Reactions & Toxicological Reviews, 19(4), 293-312.

Begg, E. J., Robson, R. A., Saunders, D. A., Graham, G. G., Buttimore, R. C., Neill, A., & Town, G. I. (2000). The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing. British Journal of Clinical Pharmacology, 49(1), 32-38.

Kirkpatrick, C. M. J., Stickland, M. D., Begg, E. J., & Duffull, S. B. (2000). Developing and testing of an extended interval dosing nomogram for gentamicin in neonates. Proceedings of ASCEPT, 8(December), 150.

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