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Health Sciences profile

Professor David Jardine

PositionClinical Professor
DepartmentDepartment of Medicine (Christchurch)
QualificationsBSc MBChB (Otago) DCH (Lond) FRACP
Research summarySudden death

Research

My main areas of research include sudden death, vasovagal syncope and autonomic failure in humans.

Publications

Jardine, D. L., Adamson, P., & Crozier, I. G. (2022). Measuring the jugular venous pressure: Do not turn the head! American Journal of Medicine. Advance online publication. doi: 10.1016/j.amjmed.2021.12.024

Jardine, D. L., Davis, J., Frampton, C. M., & Wieling, W. (2022). Sleep syncope: A prospective cohort study. Clinical Autonomic Research. Advance online publication. doi: 10.1007/s10286-021-00842-1

Wieling, W., & Jardine, D. L. (2021). Cardioneuroablation for recurrent vasovagal syncope: Important questions need to be answered. Heart Rhythm. Advance online publication. doi: 10.1016/j.hrthm.2021.08.032

Wieling, W., & Jardine, D. L. (2021). Efficacy of the Biosync trial: the information published from this trial to date is not sufficient to change theory. European Heart Journal. Advance online publication. doi: 10.1093/eurheartj/ehab379

Weatherall, G. A., & Jardine, D. L. (2021). Pathologic U Waves secondary to severe hypophosphatemia during refeeding syndrome. JAMA Internal Medicine. Advance online publication. doi: 10.1001/jamainternmed.2021.2233

Jardine, D. L., Davis, J., Frampton, C. M., & Wieling, W. (2022). Sleep syncope: A prospective cohort study. Clinical Autonomic Research. Advance online publication. doi: 10.1007/s10286-021-00842-1

Journal - Research Article

Weatherall, G. A., & Jardine, D. L. (2021). Pathologic U Waves secondary to severe hypophosphatemia during refeeding syndrome. JAMA Internal Medicine. Advance online publication. doi: 10.1001/jamainternmed.2021.2233

Journal - Research Article

Wieling, W., & Jardine, D. L. (2021). Efficacy of the Biosync trial: the information published from this trial to date is not sufficient to change theory. European Heart Journal. Advance online publication. doi: 10.1093/eurheartj/ehab379

Journal - Research Article

Al-Busaidi, I. S., & Jardine, D. L. (2020). Different types of syncope presenting to clinic: Do we miss cardiac syncope? Heart, Lung & Circulation, 29, 1129-1138. doi: 10.1016/j.hlc.2019.09.008

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2019). Adrenomedullin 2 increases cardiac sympathetic nerve activity in parallel to heart rate in normal conscious sheep. Physiological Reports, 7(10), e14096. doi: 10.14814/phy2.14096

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2018). Systemic Angiotensin II does not increase cardiac sympathetic nerve activity in normal conscious sheep. Bioscience Reports, 38(5), BSR20180513. doi: 10.1042/bsr20180513

Journal - Research Article

Jardine, D. L., Wieling, W., Brignole, M., Lenders, J. W. M., Sutton, R., & Stewart, J. (2018). The pathophysiology of the vasovagal response. Heart Rhythm, 15(6), 921-929. doi: 10.1016/j.hrthm.2017.12.013

Journal - Research Article

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Journal - Research Article

Hoye, N. A., Wilson, L. C., Wilkins, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017). Endovascular renal denervation in end-stage kidney disease patients: Cardiovascular protection: A proof-of-concept study. Kidney International Reports, 2(5), 856-865. doi: 10.1016/j.ekir.2017.04.012

Journal - Research Article

Jardine, D. L., McKenzie, J. M., & Wilkinson, T. J. (2017). Predicting medical students who will have difficulty during their clinical training. BMC Medical Education, 17, 43. doi: 10.1186/s12909-017-0879-2

Journal - Research Article

Stewart, J. M., Medow, M. S., Sutton, R., Visintainer, P., Jardine, D. L., & Wieling, W. (2017). Mechanisms of vasovagal syncope in the young: Reduced systemic vascular resistance versus reduced cardiac output. Journal of the American Heart Association, 6(1), e004417. doi: 10.1161/jaha.116.004417

Journal - Research Article

Than, M. P., Pickering, J. W., Aldous, S. J., Cullen, L., Frampton, C. M. A., Peacock, W. F., … Richards, A. M., Ardagh, M. W., Deely, J. M., Florkowski, C. M., George, P., Hamilton, G. J., Jardine, D. L., Troughton, R. W., … Lord, S. J. (2016). Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: A pragmatic randomized controlled trial embedded within practice. Annals of Emergency Medicine, 68(1), 93-102. doi: 10.1016/j.annemergmed.2016.01.001

Journal - Research Article

Chan, W. Y. W., Charles, C. J., Frampton, C. M., Richards, A. M., Crozier, I. G., Troughton, R. W., & Jardine, D. L. (2015). Human muscle sympathetic nerve responses to urocortin-2 in health and stable heart failure. Clinical & Experimental Pharmacology & Physiology, 42(9), 888-895. doi: 10.1111/1440-1681.12449

Journal - Research Article

Chieng, J. H. C., Hughes, L., Stewart, A., Frampton, C. M., Hanger, H. C., & Jardine, D. L. (2015). Introduction of the Pill Pruner to acute medical care: A simple medication guide to control polypharmacy. Australasian Journal on Ageing, 34(1), 58-61. doi: 10.1111/ajag.12183

Journal - Research Article

Wieling, W., Jardine, D. L., de Lange, F. J., Brignole, M., Nielsen, H. B., Stewart, J., & Sutton, R. (2015). Cardiac output and vasodilatation in the vasovagal response: An analysis of the classical papers. Heart Rhythm, 13(3), 798-805. doi: 10.1016/j.hrthm.2015.11.023

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2014). Low-dose B-type natriuretic peptide raises cardiac sympathetic nerve activity in sheep. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(2), R206-R211. doi: 10.1152/ajpregu.00404.2013

Journal - Research Article

McLachlan, C. Y. L., Yi, M., Ling, A., & Jardine, D. L. (2014). Adverse drug events are a major cause of acute medical admission. Internal Medicine Journal, 44(7), 633-638. doi: 10.1111/imj.12455

Journal - Research Article

Spencer, A., Cawood, T., Frampton, C., & Jardine, D. (2014). Heparin-based treatment to prevent symptomatic deep venous thrombosis, pulmonary embolism or death in general medical inpatients is not supported by best evidence. Internal Medicine Journal, 44(11), 1054-1065. doi: 10.1111/imj.12574

Journal - Research Article

Than, M., Aldous, S., Lord, S. J., Goodacre, S., Frampton, C. M. A., Troughton, R., George, P., Florkowski, C. M., Ardagh, M., Smyth, D., Jardine, D. L., … Young, J., Hamilton, G., Deely, J. M., … Richards, A. M. (2014). A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: A randomized clinical trial. JAMA Internal Medicine, 174(1), 51-58. doi: 10.1001/jamainternmed.2013.11362

Journal - Research Article

Jardine, D. L. (2013). Vasovagal syncope: New physiologic insights. Cardiology Clinics, 31(1), 75-87. doi: 10.1016/j.ccl.2012.10.010

Journal - Research Article

Wieling, W., Krediet, C. T. P., Solari, D., de Lange, F. J., van Dijk, N., Thijs, R. D., … Jardine, D. L. (2013). At the heart of the arterial baroreflex: A physiological basis for a new classification of carotid sinus hypersensitivity. Journal of Internal Medicine, 273(4), 345-358. doi: 10.1111/joim.12042

Journal - Research Article

Jensen, B. P., Roberts, R. L., Vyas, R., Bonke, G., Jardine, D. L., & Begg, E. J. (2012). Influence of ABCB1 (P-glycoprotein) haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural hypotension in healthy volunteers. British Journal of Clinical Pharmacology, 73(4), 619-628. doi: 10.1111/j.1365-2125.2011.04126.x

Journal - Research Article

Rozenberg, J., Wieling, W., Schon, I. K., Westerhof, B., Frampton, C., & Jardine, D. (2012). MSNA during prolonged post-faint hypotension. Clinical Autonomic Research, 22(4), 167-173. doi: 10.1007/s10286-012-0159-5

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, M. (2011). Urocortin 3 inhibits cardiac sympathetic nerve activity in conscious sheep. Journal of Cardiovascular Pharmacology, 58(4), 418-423. doi: 10.1097/FJC.0b013e31822707a4

Journal - Research Article

Krediet, C. T. P., Jardine, D. L., & Wieling, W. (2011). Dissection of carotid sinus hypersensitivity: The timing of vagal and vasodepressor effects and the effect of body position. Clinical Science, 121, 389-396. doi: 10.1042/cs20100607

Journal - Research Article

Krediet, C. T. P., Parry, S. W., Jardine, D. L., Benditt, D. G., Brignole, M., & Wieling, W. (2011). The history of diagnosing carotid sinus hypersensitivity: Why are the current criteria too sensitive? Europace, 13(1), 14-22. doi: 10.1093/europace/euq409

Journal - Research Article

Wieling, W., Rozenberg, J., Go-Schön, I. K., Karemaker, J. M., Westerhof, B. E., & Jardine, D. L. (2011). Hemodynamic mechanisms underlying prolonged post-faint hypotension. Clinical Autonomic Research, 21(6), 405-413. doi: 10.1007/s10286-011-0134-6

Journal - Research Article

Busweiler, L., Jardine, D. L., Frampton, C. M., & Wieling, W. (2010). Sleep syncope: Important clinical associations with phobia and vagotonia. Sleep Medicine, 11(9), 929-933. doi: 10.1016/j.sleep.2010.04.013

Journal - Research Article

Charles, C. J., Jardine, D. L., Rademaker, M. T., & Richards, A. M. (2010). Urocortin 2 induces potent long-lasting inhibition of cardiac sympathetic drive despite baroreflex activation in conscious sheep. Journal of Endocrinology, 204, 181-189. doi: 10.1677/JOE-08-0505

Journal - Research Article

Jardine, D. L., Krediet, C. T. P., Cortelli, P., Frampton, C. M., & Wieling, W. (2009). Sympatho-vagal responses in patients with sleep and typical vasovagal syncope. Clinical Science, 117, 345-353. doi: 10.1042/CS20080497

Journal - Research Article

Charles, C. J., Jardine, D. L., Nicholls, M. G., Rademaker, M. T., & Richards, A. M. (2008). Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. Journal of Hypertension, 26(1), 53-60.

Journal - Research Article

Jardine, D. L., Charles, C. J., Frampton, C. M., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. American Journal of Physiology: Heart & Circulatory Physiology, 293, H433-H439. doi: 10.1152/ajpheart.01262.2006

Journal - Research Article

Charles, C. J., Jardine, D. L., Nicholls, M. G., & Richards, A. M. (2005). Adrenomedullin increases cardiac sympathetic nerve activity in normal conscious sheep. Journal of Endocrinology, 187, 275-281.

Journal - Research Article

Jardine, D. L., Charles, C. J., Ashton, R. K., Bennett, S. I., Whitehead, M., Frampton, C. M., & Nicholls, M. G. (2005). Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model. Journal of Physiology, 565(1), 325-333. doi: 10.1113/jphysiol.2004.082198

Journal - Research Article

Griffith, J. C., Jardine, D. L., Bailey, W., & Florkowski, C. M. (2004). Variegate porphyria presenting with acute autonomic dysfunction, intussusception and renal infarction. Scandinavian Journal of Gastroenterology, 39(5), 500-503. doi: 10.1080/00365520410008395

Journal - Research Article

Jardine, D. L., Krediet, C. T. P., & Robinson, B. A. (2004). Baroreflex failure secondary to paraneoplastic encephalomyelitis in a 17 year old woman with neuroblastoma. Journal of Neurology, Neurosurgery & Psychiatry, 75, 1650-1651.

Journal - Research Article

Krediet, C. T. P., Jardine, D. L., Cortelli, P., Visman, A. G. R., & Wieling, W. (2004). Vasovagal syncope interrupting sleep? Heart, 90(e25). Retrieved from http://www.heartjnl.com/cgi/content/full/90/5/e25/

Journal - Research Article

Jardine, D., Charles, C. J., Forrester, M. D., Whitehead, M., & Nicholls, M. G. (2003). A neural mechanism for sudden death after myocardial infarction. Clinical Autonomic Research, 13, 339-341.

Journal - Research Article

Jardine, D., Hurrell, M., & Anderson, T. J. (2003). A bad dose of the 'flu. Lancet, 362, 1198.

Journal - Research Article

Tang, E. W., Jardine, D., Rodins, K., & Evans, J. (2003). Respiratory failure secondary to diabetic neuropathy affecting the phrenic nerve. Diabetic Medicine, 20, 599-601.

Journal - Research Article

Jardine, D., & Colls, B. M. (2002). Hodgkins's disease following methotrexate therapy for rheumatoid arthritis. New Zealand Medical Journal, 115, 293-294.

Journal - Research Article

Jardine, D., Charles, C. J., Melton, I., May, C. N., Forrester, M. D., Frampton, C. M., … Ikram, H. (2002). Continual recordings of cardiac sympathetic nerve activity in conscious sheep. American Journal of Physiology: Heart & Circulatory Physiology, 282, H93-H99.

Journal - Research Article

Jardine, D., Melton, I., Crozier, I., English, S., Bennett, S. I., Frampton, C. M., & Ikram, H. (2002). Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope. American Journal of Physiology: Heart & Circulatory Physiology, 282, H1804-H1809.

Journal - Research Article

Jardine, D. L., Crozier, I. G., & Ikram, H. (2001). Paroxysmal hypertension during a complex partial seizure. Journal of Neurology, Neurosurgery & Psychiatry, 71, 129-137.

Journal - Research Article

Jardine, D. L., Davis, P. J., Robert, A., Lamont, D. L., & Wilton, G. N. (2001). Spontaneous cholesterol embolization complicated by pulmonary fat embolism. Internal Medicine Journal, 31, 319-320.

Journal - Research Article

McGregor, D. O., Buttimore, A. L., Lynn, K. L., Nicholls, M. G., & Jardine, D. L. (2001). A comparative study of blood pressure control with short in-center versus long home hemodialysis. Blood Purification, 19, 293-300.

Journal - Research Article

Grayling, M., Jardine, D. L., McClintock, A. D., Spar, J., & Wilton, G. N. (2000). Symptomatic epidural lipomatosis following cyproterone acetate therapy. Australian & New Zealand Journal of Surgery, 70, 233-235.

Journal - Research Article

Jardine, D., Melton, I., Bennett, S. I., Crozier, I. G., Donaldson, I. M., & Ikram, H. (2000). Baroreceptor denervation presenting as part of a vagal mononeuropathy. Clinical Autonomic Research, 10, 69-75.

Journal - Research Article

Phillips, A. M., Jardine, D., Parkin, P. J., Hughes, T. H., & Ikram, H. (2000). Brainstem stroke causing baroreflex failure and paroxysmal hypertension. Stroke, 31, 1997-2001.

Journal - Research Article

Jardine, D. L., Melton, I. C., Crozier, I. G., Bennett, S. L., Donald, R. A., & Ikram, H. (1997). Neurohormonal response to head-up tilt and its role in vasovagal syncope. American Journal of Cardiology, 79(9), 1302-1306.

Journal - Research Article

Jardine, D. L., Adamson, P., & Crozier, I. G. (2022). Measuring the jugular venous pressure: Do not turn the head! American Journal of Medicine. Advance online publication. doi: 10.1016/j.amjmed.2021.12.024

Journal - Research Other

Wieling, W., & Jardine, D. L. (2021). Cardioneuroablation for recurrent vasovagal syncope: Important questions need to be answered. Heart Rhythm. Advance online publication. doi: 10.1016/j.hrthm.2021.08.032

Journal - Research Other

de Jong, J. S. Y., Jardine, D. L., Lenders, J. W. M., & Wieling, W. (2019). Pacing in vasovagal syncope: A physiological paradox? Heart Rhythm, 17(5A), 813-820. doi: 10.1016/j.hrthm.2019.09.022

Journal - Research Other

Dhayalan, S., Jardine, D., Goh, T., & Lash, N. (2019). Acute compartment syndrome complicating deep venous thrombosis. New Zealand Medical Journal, 132(1493), 73-76. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Hoye, N. A., Wilson, L. C., Jardine, D. L., & Walker, R. J. (2019). Sympathetic overactivity in dialysis patients: Underappreciated and clinically consequential. Seminars in Dialysis, 32, 255-265. doi: 10.1111/sdi.12756

Journal - Research Other

Wieling, W., de Lange, F. J., & Jardine, D. L. (2014). The heart cannot pump blood that it does not receive. Frontiers in Physiology, 5, 360. doi: 10.3389/fphys.2014.00360

Journal - Research Other

Wong, J., Miller, A., Cross, N., Grundy, K., O'Keefe, M., & Jardine, D. (2014). Calciphylaxis: Fatal arteriosclerosis of uncertain mechanism. Internal Medicine Journal, 44(10), 1040-1041. doi: 10.1111/imj.12562

Journal - Research Other

Betteridge, T. M., Frampton, C. M., & Jardine, D. L. (2012). Polypharmacy: We make it worse! A cross-sectional study from an acute admissions unit [Brief communication]. Internal Medicine Journal, 42(2), 208-211. doi: 10.1111/j.1445-5994.2011.02690.x

Journal - Research Other

McNally, A., Pithie, A., & Jardine, D. (2012). Cefepime: A rare cause of encephalopathy. Internal Medicine Journal, 42(6), 732-733. doi: 10.1111/j.1445-5994.2012.02800.x

Journal - Research Other

Wieling, W., Rozenberg, J., Schon, I. K., Karemaker, J. M., Westerhof, B. E., & Jardine, D. L. (2011). Prolonged post-faint hypotension can be reversed by dynamic tension. Clinical Autonomic Research, 21(6), 415-418. doi: 10.1007/s10286-011-0133-7

Journal - Research Other

Huelsen-Katz, A. M., Schouten, B. J., Jardine, D. L., Soule, S. G., & Liu, H. (2010). Pictorial evolution of bilateral adrenal haemorrhage [Letter to the editor]. Internal Medicine Journal, 40(1), 87-88. doi: 10.1111/j.1445-5994.2009.02117.x

Journal - Research Other

Chen, H. K., Jardine, D., & Beckert, L. (2009). Orthopnoea and arm weakness. Thorax, 64(12), 1031. doi: 10.1136/thx.2009.121632

Journal - Research Other

Macdonald, C. A., Jardine, D. L., Hurrell, M. A., & Pithie, A. D. (2009). The worm that turned [Case report]. Transactions of the Royal Society of Tropical Medicine & Hygiene, 103(10), 1065-1067. doi: 10.1016/j.trstmh.2009.05.007

Journal - Research Other

Hutchinson, C. D., Jardine, D. L., & Hurrell, M. (2008). Vagolysis [Case report]. Age & Ageing, 37, 602-604. doi: 10.1093/ageing/afn105

Journal - Research Other

Jardine, D. L., Hurrell, M. A., & Fink, J. (2007). Tilt-test diagnosis of hypotensive transient ischaemic attacks. Internal Medicine Journal, 37(7), 498-501.

Journal - Research Other

Jardine, D. L., & Laing, A. D. (2004). Delayed pulmonary hypertension following splenectomy for congenital spherocytosis [Clinical-scientific note]. Internal Medicine Journal, 34(4), 214-216.

Journal - Research Other

Archibald, N., Dalzell, K. G. B., Fernando, C., & Jardine, D. (2003). Infectious mononucleosis complicated by mediastinal lymphadenopathy causing transient pulmonary artery stenosis [Letter to the editor]. Internal Medicine Journal, 33(7), 324-325. doi: 10.1046/j.1445-5994.2003.00409.x

Journal - Research Other

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