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Health Sciences profile

Professor Martin Kennedy

PositionHead of Department and Professor
DepartmentDepartment of Pathology and Biomedical Science (Christchurch)
QualificationsBSc (Cant) PhD (Auck)
Research summaryGenetics of human disease

Research

Director of the Carney Centre for Pharmacogenomics and the Gene Structure and Function Lab, Martin's main research interests are psychiatric genetics, pharmacogenomics, and the genetics of complex disease.

His current research largely focuses on pharmacogenomics, which aims to understand how drugs and genes interact with the goal of improving drug treatments and reducing adverse drug reactions. For example, analysis of genetic variation in genes such as those that encode drug metabolising liver enzymes like CYP2D6 and CYP2C19, is helping to determine genetic factors that impact on response to treatments for various diseases.

For a more comprehensive analysis of genetic factors impacting drug response or risks of adverse drug reactions, they are also applying Next Generation DNA sequencing methods including exome sequencing and other genomic approaches to explore drug response phenotypes.

In order to understand severe adverse drug reactions, his lab has developed a biobank for collecting biological samples of people who have suffered such reactions, called UDRUGS. This biobank is growing, and will enhance efforts to understand genetic factors that contribute to severe adverse drug reactions.

Other research interests include work with the Christchurch Health and Development Study looking at genetic contributions to a range of complex human traits, and a study focusing on the genetics of anorexia nervosa. In addition, Martin's laboratory is examining the impact of G-quadruplex DNA structures and their relevance to genomic imprinting and other aspects of genome biology.

Publications

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Cree, S. L., Chua, E. W., Crowther, J., Dobson, R. C. J., & Kennedy, M. A. (2020). G-quadruplex structures bind to EZ-Tn5 transposase. Biochimie. Advance online publication. doi: 10.1016/j.biochi.2020.07.022

Bryois, J., Skene, N. G., Folmann Hansen, T., Kogelman, L. J. A., Watson, H. J., Liu, Z., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Boden, J., … Jordan, J., … Kennedy, M., … Pearson, J., … Sullivan, P. F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics, 52, 482-493. doi: 10.1038/s41588-020-0610-9

Vallerga, C. L., Zhang, F., Fowdar, J., McRae, A. F., Qi, T., Nabais, M. F., … Kennedy, M., … Gratten, J. (2020). Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease. Nature Communications, 11, 1238. doi: 10.1038/s41467-020-15065-7

Bulik, C., Kennedy, M., & Wade, T. (2020). ANGI: Anorexia Nervosa Genetics Initiative. Twin Research & Human Genetics, 23, 135-136. doi: 10.1017/thg.2020.24

Chapter in Book - Research

Chua, E. W., Maggo, S., & Kennedy, M. A. (2017). Long fragment polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods in molecular biology (Vol. 1620). (pp. 65-74). New York, NY: Springer. doi: 10.1007/978-1-4939-7060-5_3

Kennedy, M. A., Rogers, G. R., & Joyce, P. R. (2004). Pharmacogenetics of antidepressants and mood stabilisers. In P. R. Joyce & P. B. Mitchell (Eds.), Mood disorders: Recognition and treatment. (pp. 223-237). Sydney, Australia: The University of New South Wales Press Ltd.

Kennedy, M. A. (2000). Mendelian Genetic Disorders. In The Encyclopedia of Life Sciences. London: Nature Publishing Group.

Kennedy, M. A. (1996). Internet resources for human and mouse molecular genetics. In S. R. Swindell, R. Miller & G. S. A. Myers (Eds.), Internet for the Molecular Biologist. (pp. 123-149). Norfolk: Horizon Scientific Press.

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Chapter in Book - Other

Kennedy, M., Joyce, P., & Begg, E. (2013). Carney Centre for Pharmacogenomics. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 100-104). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Bulik, C., Kennedy, M., & Wade, T. (2020). ANGI: Anorexia Nervosa Genetics Initiative. Twin Research & Human Genetics, 23, 135-136. doi: 10.1017/thg.2020.24

Vallerga, C. L., Zhang, F., Fowdar, J., McRae, A. F., Qi, T., Nabais, M. F., … Kennedy, M., … Gratten, J. (2020). Analysis of DNA methylation associates the cystine-glutamate antiporter SLC7A11 with risk of Parkinson's disease. Nature Communications, 11, 1238. doi: 10.1038/s41467-020-15065-7

Bryois, J., Skene, N. G., Folmann Hansen, T., Kogelman, L. J. A., Watson, H. J., Liu, Z., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Boden, J., … Jordan, J., … Kennedy, M., … Pearson, J., … Sullivan, P. F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease. Nature Genetics, 52, 482-493. doi: 10.1038/s41588-020-0610-9

Cree, S. L., Chua, E. W., Crowther, J., Dobson, R. C. J., & Kennedy, M. A. (2020). G-quadruplex structures bind to EZ-Tn5 transposase. Biochimie. Advance online publication. doi: 10.1016/j.biochi.2020.07.022

Searchfield, G. D., Poppe, T. N. E. R., Durai, M., Jensen, M., Kennedy, M. A., Maggo, S., Miller, A. L., … Russell, B. R., … Wise, K. (2020). A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity. International Journal of Neuroscience, 130(7), 671-682. doi: 10.1080/00207454.2019.1702544

Graham, O. E. E., Pitcher, T. L., Liau, Y., Miller, A. L., Dalrymple-Alford, J. C., Anderson, T. J., & Kennedy, M. A. (2020). Nanopore sequencing of the glucocerebrosidase (GBA) gene in a New Zealand Parkinson's disease cohort. Parkinsonism & Related Disorders, 70, 36-41. doi: 10.1016/j.parkreldis.2019.11.022

Heft, I. E., Mostovoy, Y., Levy-Sakin, M., Ma, W., Stevens, A. J., Pastor, S., … Kennedy, M. A., … Sikela, J. M. (2020). The driver of extreme human-specific Olduvai repeat expansion remains highly active in the human genome. Genetics, 214, 179-191. doi: 10.1534/genetics.119.302782

Munn-Chernoff, M. A., Johnson, E. C., Chou, Y.-L., Coleman, J. R. I., Thornton, L. M., Walters, R. K., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M. A., … Agrawal, A. (2020). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology. Advance online publication. doi: 10.1111/adb.12880

Schierding, W., Farrow, S., Fadason, T., Graham, O. E. E., Pitcher, T. L., Qubisi, S., … Anderson, T. J., Kennedy, M. A., … O'Sullivan, J. M. (2020). Common variants coregulate expression of GBA and modifier genes to delay Parkinson's disease onset. Movement Disorders, 35(8), 1346-1356. doi: 10.1002/mds.28144

Osborne, A. J., Pearson, J. F., Noble, A. J., Gemmell, N. J., Horwood, L. J., Boden, J. M., … Kennedy, M. A. (2020). Genome-wide DNA methylation analysis of heavy cannabis exposure in a New Zealand longitudinal cohort. Translational Psychiatry, 10, 114. doi: 10.1038/s41398-020-0800-3

Prickett, T. C. R., Spittlehouse, J. K., Miller, A. L., Liau, Y., Kennedy, M. A., Cameron, V. A., Pearson, J. F., Boden, J. M., Troughton, R. W., & Espiner, E. A. (2019). Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease. Scientific Reports, 9, 12108. doi: 10.1038/s41598-019-48553-y

Liau, Y., Cree, S. L., Maggo, S., Miller, A. L., Pearson, J. F., Gladding, P. A., & Kennedy, M. A. (2019). A multiplex pharmacogenetics assay using the MinION nanopore sequencing device. Pharmacogenetics & Genomics, 29(9), 207-215. doi: 10.1097/fpc.0000000000000385

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., … Kennedy, M., Pitcher, T., Pearson, J., … Anderson, T., … Visscher, P. M. (2019). Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Medicine, 11(1), 54. doi: 10.1186/s13073-019-0667-1

Balasubramanian, D., Pearson, J. F., & Kennedy, M. A. (2019). Gene expression effects of lithium and valproic acid in a serotonergic cell line. Physiological Genomics, 51, 43-50. doi: 10.1152/physiolgenomics.00069.2018

Gardner, R. J. M., Crozier, I. G., Binfield, A. L., Love, D. R., Lehnert, K., Gibson, K., … Jones, P. P., … Kennedy, M. A., & Skinner, J. R. (2019). Penetrance and expressivity of the R858H CACNA1C variant in a five-generation pedigree segregating an arrhythmogenic channelopathy. Molecular Genetics & Genomic Medicine, 7(1), e00476. doi: 10.1002/mgg3.476

Adehin, A., Adeagbo, B. A., Kennedy, M. A., Bolaji, O. O., Olugbade, T. A., Bolarinwa, R. A., & Durosinmi, M. A. (2019). Inter-individual variation in imatinib disposition: Any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in Nigerian CML patients? Leukemia & Lymphoma, 60(1), 216-221. doi: 10.1080/10428194.2018.1466291

Watson, G. M., Chan, C. W., Belluscio, L., Doudney, K., Lacey, C. J., Kennedy, M. A., & Bridgman, P. (2019). Comparing the variants of takotsubo syndrome: An observational study of the ECG and structural changes from a New Zealand tertiary hospital. BMJ Open, 9(5), e025253. doi: 10.1136/bmjopen-2018-025253

Richards, A., Horwood, J., Boden, J., Kennedy, M., Sellers, R., Riglin, L., … Harold, G. T. (2019). Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study. British Journal of Psychiatry, 214, 96-102. doi: 10.1192/bjp.2018.227

Stevens, A. J., Purcell, R. V., Darling, K. A., Eggleston, M. J. F., Kennedy, M. A., & Rucklidge, J. J. (2019). Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder. Scientific Reports, 9, 10128. doi: 10.1038/s41598-019-46146-3

Reynolds, R. H., Botía, J., Nalls, M. A., International Parkinson's Disease Genomics Consortium (IPDGC), including System Genomics of Parkinson's Disease (SGPD), Anderson, T., … Kennedy, M., Pearson, J., … Ryten, M. (2019). Moving beyond neurons: The role of cell type-specific gene regulation in Parkinson's disease heritability. npj Parkinson's Disease, 5, 6. doi: 10.1038/s41531-019-0076-6

Liau, Y., Maggo, S., Miller, A. L., Pearson, J. F., Kennedy, M. A., & Cree, S. L. (2019). Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications. Pharmacogenomics, 20(14), 1033-1047. doi: 10.2217/pgs-2019-0080

Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139

Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., … Roberts, M., … Boden, J. M., … Horwood, L. J., … Pearson, J. F., … Jordan, J., Kennedy, M., … Bulik, C. M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51, 1207-1214. doi: 10.1038/s41588-019-0439-2

Rucklidge, J. J., Eggleston, M. J. F., Darling, K., Stevens, A., Kennedy, M., & Frampton, C. M. (2019). Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 89, 181-192. doi: 10.1016/j.pnpbp.2018.09.007

Maggo, S. D. S., Sycamore, K. L. V., Miller, A. L., & Kennedy, M. A. (2019). The three ps: Psychiatry, pharmacy, and pharmacogenomics, a brief report from New Zealand. Frontiers in Psychiatry, 10, 690. doi: 10.3389/fpsyt.2019.00690

Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, including Kennedy, M. A., Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, including Horwood, L. J., Pearson, J. F., … Polderman, T. J. C. (2019). Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychological Medicine, 49(7), 1166-1173. doi: 10.1017/S0033291718002039

Roberts, R. L., Wallace, M. C., Seinen, M. L., van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., van Rij, A. M., … Kennedy, M. A., … Gearry, R. B., … Barclay, M. (2018). Nonsynonymous polymorphism in guanine monophosphate synthetase is a risk factor for unfavorable thiopurine metabolite ratios in patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 24(12), 2606-2612. doi: 10.1093/ibd/izy163

Lacey, C. J., Doudney, K., Bridgman, P. G., George, P. M., Mulder, R. T., Zarifeh, J. J., Kimber, B., Cadzow, M. J., Black, M. A., Merriman, T. R., … Pearson, J. F., Cameron, V. A., & Kennedy, M. A. (2018). Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy. Scientific Reports, 8, 7548. doi: 10.1038/s41598-018-25827-5

Stevens, A. J., Rucklidge, J. J., & Kennedy, M. A. (2018). Epigenetics, nutrition and mental health: Is there a relationship? [Review]. Nutritional Neuroscience, 21(9), 602-613. doi: 10.1080/1028415x.2017.1331524

Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2018). Genetic polymorphism of CYP2C9 and VKORC1 in the Nigerian population: Significance for warfarin therapy in the population. Polish Annals of Medicine, 25(2), 180-183. doi: 10.29089/2017.17.00041

Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., … Kennedy, M. A., … Pearson, J. F., … Agrawal, A. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience, 21(12), 1656-1669. doi: 10.1038/s41593-018-0275-1

Stevens, A. J., Rucklidge, J. J., Darling, K. A., Eggleston, M. J. F., Pearson, J. F., & Kennedy, M. A. (2018). Methylomic changes in response to micronutrient supplementation and MTHFR genotype. Epigenomics, 10(9), 1201-1214. doi: 10.2217/epi-2018-0029

Thornton, L. M., Munn-Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., … Horwood, L. J., Boden, J. M., Pearson, J. F., … Jordan, J., Kennedy, M. A., … Bulik, C. M. (2018). The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. Contemporary Clinical Trials, 74, 61-69. doi: 10.1016/j.cct.2018.09.015

Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., … Horwood, J., … Fergusson, D. M., … Kennedy, M., … Bierut, L. J. (2018). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23, 133-142. doi: 10.1038/mp.2017.44

Ton, K. N. T., Cree, S. L., Gronert-Sum, S. J., Merriman, T. R., Stamp, L. K., & Kennedy, M. A. (2018). Multiplexed nanopore sequencing of HLA-B locus in Māori and Pacific Island samples. Frontiers in Genetics, 9, 152. doi: 10.3389/fgene.2018.00152

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Stevens, A. J., Taylor, M. G., Pearce, F. G., & Kennedy, M. A. (2017). Allelic dropout during polymerase chain reaction due to G-quadruplex structures and DNA methylation is widespread at imprinted human loci. Genes Genomes Genetics, 7(3), 1019-1025. doi: 10.1534/g3.116.038687

Kirk, K. M., Martin, F. C., Mao, A., Parker, R., Maguire, S., Thornton, L. M., … Jordan, J., Kennedy, M. A., … Martin, N. G. (2017). The Anorexia Nervosa Genetics Initiative: Study description and sample characteristics of the Australian and New Zealand arm. Australian & New Zealand Journal of Psychiatry, 51(6), 583-594. doi: 10.1177/0004867417700731

Adehin, A., Bolaji, O. O., Kennedy, M. A., & Adeagbo, B. A. (2017). Allele frequencies of thiopurine S-methyltransferase (TPMT) variants in the Nigerian population. Polish Annals of Medicine, 24(2), 144-147. doi: 10.1016/j.poamed.2016.06.007

Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2017). Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population. Drug Metabolism & Personalized Therapy, 32(1), 39-47. doi: 10.1515/dmpt-2016-0041

Shchepetkina, A. A., Hock, B. D., Miller, A., Kennedy, M. A., & Gieseg, S. P. (2017). Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. International Journal of Biochemistry & Cell Biology, 87, 27-33. doi: 10.1016/j.biocel.2017.03.017

Bagshaw, A. T. M., Horwood, L. J., Fergusson, D. M., Gemmell, N. J., & Kennedy, M. A. (2017). Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. BMC Medical Genetics, 18, 12. doi: 10.1186/s12881-017-0374-y

Appleby, S., Pearson, J. F., Aitchison, A., Spittlehouse, J. K., Joyce, P. R., & Kennedy, M. A. (2017). Mean telomere length is not associated with current health status in a 50-year-old population sample. American Journal of Human Biology, 29(1), e22906. doi: 10.1002/ajhb.22906

Whitefield, J., & Kennedy, M. (2017). Above the threshold. Junctures, 2017(18), 9-18.

Adehin, A., Bolaji, O. O., & Kennedy, M. A. (2017). Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population. Drug Metabolism & Pharmacokinetics, 32(3), 189-191. doi: 10.1016/j.dmpk.2016.09.001

Duncan, L., Yilmaz, Z., Gaspar, H., Walters, R., Goldstein, J., Anttila, V., … Eating Disorders Working Group of the Psychiatric Genomics Consortium, including Jordan, J., Kennedy, M., … Bulik, C. M. (2017). Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. American Journal of Psychiatry, 174(9), 850-858. doi: 10.1176/appi.ajp.2017.16121402

de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1

Stevens, A. J., & Kennedy, M. A. (2017). Methylated cytosine maintains G-quadruplex structures during polymerase chain reaction and contributes to allelic dropout. Biochemistry, 56(29), 3691-3698. doi: 10.1021/acs.biochem.7b00480

Stevens, A. J., & Kennedy, M. A. (2017). Structural analysis of G-quadruplex formation at the human MEST promoter. PLoS ONE, 12(1), e0169433. doi: 10.1371/journal.pone.0169433

Maggo, S. D. S., Savage, R. L., & Kennedy, M. A. (2016). Impact of new genomic technologies on understanding adverse drug reactions. Clinical Pharmacokinetics, 55(4), 419-436. doi: 10.1007/s40262-015-0324-9

Osborne, A. J., Negro, S. S., Chilvers, B. L., Robertson, B. C., Kennedy, M. A., & Gemmell, N. J. (2016). Genetic evidence of a population bottleneck and inbreeding in the endangered New Zealand sea lion, Phocarctos hookeri. Journal of Heredity, 107(5), 392-402. doi: 10.1093/jhered/esw015

Chua, E. W., Cree, S. L., Ton, K. N. T., Lehnert, K., Shepherd, P., Helsby, N., & Kennedy, M. A. (2016). Cross-comparison of exome analysis, next-generation sequencing of amplicons, and the iPLEX® ADME PGx Panel for pharmacogenomic profiling. Frontiers in Pharmacology, 7, 1. doi: 10.3389/fphar.2016.00001

Cree, S. L., Fredericks, R., Miller, A., Pearce, F. G., Filichev, V., Fee, C., & Kennedy, M. A. (2016). DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. FEBS Letters, 590(17), 2870-2883. doi: 10.1002/1873-3468.12331

Stevens, A. J., Kennedy, H. L., & Kennedy, M. A. (2016). Fluorescence methods for probing G-quadruplex structure in single- and double-stranded DNA. Biochemistry, 55(26), 3714-3725. doi: 10.1021/acs.biochem.6b00327

Adkins, D. E., Clark, S. L., Copeland, W. E., Kennedy, M., Conway, K., Angold, A., … Fergusson, D. M., Horwood, L. J., … Costello, E. J. (2015). Genome-wide meta-analysis of longitudinal alcohol consumption across youth and early adulthood. Twin Research & Human Genetics, 18(4), 335-347. doi: 10.1017/thg.2015.36

Larsen, P. D., Johnston, L. R., Holley, A., La Flamme, A., Smyth, L., Chua, E. W., Kennedy, M. A., & Harding, S. A. (2015). Prevalence and significance of CYP2C19*2 and CYP2C19*17 alleles in a New Zealand acute coronary syndrome population. Internal Medicine Journal, 45(5), 537-545. doi: 10.1111/imj.12698

Chua, E. W., Cree, S., Barclay, M. L., Doudney, K., Lehnert, K., Aitchison, A., & Kennedy, M. A. (2015). Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers. Pharmacogenomics Journal, 15, 414-421. doi: 10.1038/tpj.2015.9

Foulds, J. A., Ton, K., Kennedy, M. A., Adamson, S. J., Mulder, R. T., & Sellman, J. D. (2015). OPRM1 genotype and naltrexone response in depressed alcohol-dependent patients. Pharmacogenetics & Genomics, 25(5), 270-273. doi: 10.1097/fpc.0000000000000128

Morris, R. W., Taylor, A. E., Fluharty, M. E., Bjørngaard, J. H., Åsvold, B. O., Gabrielsen, M. E., … Horwood, J., Fergusson, D. M., Kennedy, M. A., … Sattar, N. (2015). Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis: The CARTA consortium. BMJ Open, 5(8), e008808. doi: 10.1136/bmjopen-2015-008808

Balasubramanain, D., Deng, A. X., Doudney, K., Hampton, M. B., & Kennedy, M. A. (2015). Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. Neuropharmacology, 99, 79-88. doi: 10.1016/j.neuropharm.2015.06.018

Osborne, A. J., Pearson, J., Negro, S. S., Chilvers, B. L., Kennedy, M. A., & Gemmell, N. J. (2015). Heterozygote advantage at MHC DRB may influence response to infectious disease epizootics. Molecular Ecology, 24, 1419-1432. doi: 10.1111/mec.13128

Osborne, A. J., Pearson, J., Chilvers, B. L., Kennedy, M. A., & Gemmell, N. J. (2015). Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease. PLoS ONE, 10(4), e0122703. doi: 10.1371/journal.pone.0122703

Jodczyk, S., Pearson, J. F., Aitchison, A., Miller, A. L., Hampton, M. B., & Kennedy, M. A. (2015). Telomere length measurement on the Roche LightCycler 480 platform. Genetic Testing & Molecular Biomarkers, 19(2), 63-68. doi: 10.1089/gtmb.2014.0208

Davis, J. M., Searles, V. B., Anderson, N., Keeney, J., Raznahan, A., Horwood, L. J., Fergusson, D. M., Kennedy, M. A., … Sikela, J. M. (2015). DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores. Human Genetics, 134(1), 67-75. doi: 10.1007/s00439-014-1489-2

Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014). No association between mean telomere length and life stress observed in a 30 year birth cohort. PLoS ONE, 9(5), e97102. doi: 10.1371/journal.pone.0097102

Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Åsvold, B. O., Gabrielsen, M. E., … Horwood, J., Fergusson, D. M., Kennedy, M. A., … Sattar, N. (2014). Stratification by smoking status reveals a direct association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genetics, 10(12), e1004799. doi: 10.1371/journal.pgen.1004799

Joyce, P. R., Stephenson, J., Kennedy, M., Mulder, R. T., & McHugh, P. C. (2014). The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder. Frontiers in Genetics, 4, 313. doi: 10.3389/fgene.2013.00313

Cree, S. L., & Kennedy, M. A. (2014). Relevance of G-quadruplex structures to pharmacogenetics. Frontiers in Pharmacology, 5, 160. doi: 10.3389/fphar.2014.00160

Taylor, A. E., Fluharty, M. E., Bjømgaard, J. H., Gabrielsen, M. E., Skorpen, F., Marioni, R. E., … Horwood, L. J., … Kennedy, M. A., … Munafò, M. R. (2014). Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: The CARTA consortium. BMJ Open, 4(10), e006141. doi: 10.1136/bmjopen-2014-006141

Lacey, C., Mulder, R., Bridgman, P., Kimber, B., Zarifeh, J., Kennedy, M., & Cameron, V. (2014). Broken heart syndrome: Is it a psychosomatic disorder? Journal of Psychosomatic Research, 77(2), 158-160. doi: 10.1016/j.jpsychores.2014.05.003

Stevens, A. J., Stuffrein-Roberts, S., Cree, S. L., Gibb, A., Miller, A. L., Doudney, K., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2014). G-quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the imprinted MEST gene promoter. PLoS ONE, 9(12), e113955. doi: 10.1371/journal.pone.0113955

Appell, M. L., Berg, J., Duley, J., Evans, W. E., Kennedy, M. A., Lennard, L., … Coulthard, S. A. (2013). Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenetics & Genomics, 23, 242-248. doi: 10.1097/FPC.0b013e32835f1cc0

Bagshaw, A. T. M., Horwood, L. J., Liu, Y., Fergusson, D. M., Sullivan, P. F., & Kennedy, M. A. (2013). No effect of genome-wide copy number variation on measures of intelligence in a New Zealand birth cohort. PLoS ONE, 8(1), e55208. doi: 10.1371/journal.pone.0055208

Osborne, A. J., Zavodna, M., Chilvers, B. L., Robertson, B. C., Negro, S. S., Kennedy, M. A., & Gemmell, N. J. (2013). Extensive variation at MHC DRBin the New Zealand sea lion (Phocarctos hookeri) provides evidence for balancing selection. Heredity, 111, 44-56. doi: 10.1038/hdy.2013.18

Trent, R. J., Cheong, P. L., Chua, E. W., & Kennedy, M. A. (2013). Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care. Pathology, 45(4), 357-370. doi: 10.1097/PAT.0b013e328360b66e

Chua, E. W., Foulds, J., Miller, A. L., & Kennedy, M. A. (2013). Novel CYP2D6 and CYP2C19 variants identified in a patient with adverse reactions towards venlafaxine monotherapy and dual therapy with nortriptyline and fluoxetine. Pharmacogenetics & Genomics, 23(9), 494-497. doi: 10.1097/FPC.0b013e328363688d

Costello, E. J., Eaves, L., Sullivan, P., Kennedy, M., Conway, K., Adkins, D. E., … van den Oord, E. (2013). Genes, environments, and developmental research: Methods for a multi-site study of early substance abuse. Twin Research & Human Genetics, 16(2), 505-515. doi: 10.1017/thg.2013.6

Schluter, P. J., Spittlehouse, J. K., Cameron, V. A., Chambers, S., Gearry, R., Jamieson, H. A., Kennedy, M., Lacey, C. J., Murdoch, D. R., Pearson, J., Porter, R. J., Richards, M., Skidmore, P. M. L., Troughton, R., Vierck, E., & Joyce, P. R. (2013). Canterbury Health, Ageing and Life Course (CHALICE) study: Rationale, design and methodology. New Zealand Medical Journal, 126(1375). Retrieved from http://www.nzma.org.nz/journal

Chua, E. W., & Kennedy, M. A. (2012). Current state and future prospects of direct-to-consumer pharmacogenetics. Frontiers in Pharmacology, 3, 152. doi: 10.3389/fphar.2012.00152

Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A., & Kennedy, M. A. (2012). Moderating role of the MAOA genotype in antisocial behaviour. British Journal of Psychiatry, 200(2), 116-123. doi: 10.1192/bjp.bp.111.093328

Maggo, S. D. S., Kennedy, M. A., & Clark, D. W. J. (2011). Clinical implications of pharmacogenetic variation on the effects of statins. Drug Safety, 34(1), 1-19. doi: 10.2165/11584380-000000000-00000

Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. British Journal of Psychiatry, 198, 457-463. doi: 10.1192/bjp.bp.110.086991

Fergusson, D. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011). Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. British Journal of Psychiatry, 198, 129-135. doi: 10.1192/bjp.bp.110.085993

Osborne, A. J., Brauning, R., Schultz, J. K., Kennedy, M. A., Slate, J., & Gemmell, N. J. (2011). Development of a predicted physical map of microsatellite locus positions for pinnipeds, with wider applicability to the Carnivora. Molecular Ecology Resources, 11(3), 503-513. doi: 10.1111/j.1755-0998.2010.02962.x

McHugh, P. C., Joyce, P. R., Deng, X., & Kennedy, M. A. (2011). A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants. Pharmacogenomics Journal, 11(3), 207-213. doi: 10.1038/tpj.2010.23

Glubb, D. M., McHugh, P. C., Deng, X., Joyce, P. R., & Kennedy, M. A. (2010). Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. Pharmacogenomics Journal, 10, 126-133. doi: 10.1038/tpj.2009.33

McHugh, P. C., Rogers, G. R., Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2010). Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. Journal of Psychopharmacology, 24(8), 1243-1251. doi: 10.1177/0269881109102786

Stamp, L. K., Chapman, P. T., O'Donnell, J. L., Zhang, M., James, J., Frampton, C., Barclay, M. L., Kennedy, M. A., & Roberts, R. L. (2010). Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate. Pharmacogenetics & Genomics, 20(6), 367-376. doi: 10.1097/FPC.0b013e3283398a71

Joyce, P. R., Light, K. J., Rowe, S. L., Cloninger, C. R., & Kennedy, M. A. (2010). Self-mutilation and suicide attempts: Relationships to bipolar disorder, borderline personality disorder, temperament and character. Australian & New Zealand Journal of Psychiatry, 44(3), 250-257. doi: 10.3109/00048670903487159

Harley, J., Roberts, R., Joyce, P., Mulder, R., Luty, S., Frampton, C., & Kennedy, M. (2010). Orosomucoid influences the response to antidepressants in major depressive disorder. Journal of Psychopharmacology, 24(4), 531-535. doi: 10.1177/0269881109105101

Doudney, K., Harley, J. A., Pearson, J. F., Miller, A., Aitchison, A., Kennedy, M. A., Porter, R. J., Elmslie, J. L., & Joyce, P. R. (2009). Upstream genetic variant near INSIG2, influences response to carnitine supplementation in bipolar patients with valproate-induced weight gain. Acta Neuropsychiatrica, 21(3), 133-140. doi: 10.1111/j.1601-5215.2009.00379.x

Petermann, I., Huebner, C., Browning, B. L., Gearry, R. B., Barclay, M. L., Kennedy, M., Roberts, R., … Han, D. Y., & Ferguson, L. R. (2009). Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Human Immunology, 70, 440-446. doi: 10.1016/j.humimm.2009.03.002

Glubb, D. M., Joyce, P. R., & Kennedy, M. A. (2009). Expression and association analyses of promoter variants of the neurogenic gene HES6, a candidate gene for mood disorder susceptibility and antidepressant response. Neuroscience Letters, 460, 185-190. doi: 10.1016/j.neulet.2009.05.065

McHugh, P. C., Joyce, P. R., & Kennedy, M. A. (2009). Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. Pharmacogenetics & Genomics, 19(5), 330-337. doi: 10.1097/FPC.0b013e328328f82c

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