Details
- Close date
- Tuesday, 22 August 2017
- Academic background
- Health Sciences, Sciences
- Host campus
- Christchurch
- Qualifications
- Honours, Master's
- Department
- Pathology (Dunedin)
- Supervisors
- Professor Martin Kennedy, Dr Simran Maggo, Associate Professor Matthew Doogue
Overview
Pharmacogenomics is the study of how genes influence a patient's responses to drugs. This research area is helping to clarify how genetic differences contribute to the risk of side effects or failure of drug treatment, and how we might better tailor treatment to each patient, leading to improved safety and effectiveness. We have a number of possible research projects available to study the genetic/genomic basis of medication induced adverse reactions.
Our previous and current pharmacogenes of interest include:
- CYP2D6, CYP2C19, TPMT, HLA and POR
Medication-adverse event pairs include:
- Statin-induced myopathy
- SSRI/SNRI-induced adverse events
- ACEi-cough/angioedema
- Hyponatraemia due to PPIs, SSRIs and thiazides
- PPI induced interstitial nephritis
- Metoclopramide induced dystonia