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Contribution of a p53 isoform, Δ133p53, in the progress of IBD and initiation of colorectal cancer

A postgraduate research opportunity at the University of Otago.

Details

Close date
Monday, 17 February 2020
Academic background
Health Sciences
Host campus
Dunedin
Qualification
Master’s
Department
Pathology (Dunedin)
Supervisors
Dr Kunyu Li, Dr Tania Slatter, Professor Antony Braithwaite, Professor Michael Schultz

Overview

The p53 and its isoforms have been recently found to have an immune regulatory function. One of these isoforms, Δ133p53, has been found to associate with inflammation and tumorigenesis in both our animal and human studies. The project is to determine the contribution of Δ133p53 isoform in bowel inflammation and IBD. This is a 12-month project involving both animal and human studies.

The student is required to have a strong background in immunology/autoimmunity or IBD. Some knowledge in genetic, pathology and gut biology is desired.

The experimental techniques that required to perform this project are animal handling, animal models of human diseases, histological analysis, flow cytometry analysis, and PCR analysis. Student that is experienced with these laboratory skills is desired, however, training will be provided.

If you have a passion in medical research, and would like to find a better solution for the life-long illness of IBD, please contact us to find out more.

Contact

Kunyu Li
Tel   +64 3 479 7169
Email   kunyu.li@otago.ac.nz