Postdoctoral FellowResearch interests
Dr Rebekah Crake has experience in molecular, cellular and tumour biology, and clinical translation of science. Her area of research interest is improving outcomes for patients with cancer through the prevention of tumour progression, with a focus on the role of the tumour microenvironment.
In addition, Dr Crake has a particular interest in translational science; moving knowledge from ‘bench to bedside’. Current research includes the role of cancer associated adipocytes in breast cancer progression; effects of obesity, inflammation, and physical activity on therapy metabolism in women with breast cancer; and impact of ascorbate (vitamin C) on the epigenetic landscape of glioma.
UOC Health Research Open Day Lecture
Rebekah gave a three minute presentation at the University of Otago, Christchurch Health Research Open Day in September 2016.
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Publications
Crake, R. L. I., Strother, M. R., Phillips, E., Doogue, M. P., Zhang, M., Frampton, C. M. A., Robinson, B. A., & Currie, M. J. (2021). Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: A patient feasibility study. Scientific Reports, 11(1), 5648. doi: 10.1038/s41598-021-85048-1
Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2020). An exploratory patient study assessing CYP450 enzyme function in women receiving chemotherapy for breast cancer. New Zealand Medical Journal, 133(1524), (pp. 144). Retrieved from https://www.nzma.org.nz/journal
Crake, R. L. I. (2020). Local and systemic effects of adipocyte-secreted factors in breast cancer (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10159
Crake, R. L. I., Phillips, E., Kleffmann, T., & Currie, M. J. (2019). Co-culture with human breast adipocytes differentially regulates protein abundance in breast cancer cells. Cancer Geonomics & Proteomics, 16(5), 319-332. doi: 10.21873/cgp.20137
Crake, R. (2019). Assessing the impact of obesity-related inflammation and physical activity on the function of CYP450 enzymes in women with breast cancer. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research
Journal - Research Article
Crake, R. L. I., Strother, M. R., Phillips, E., Doogue, M. P., Zhang, M., Frampton, C. M. A., Robinson, B. A., & Currie, M. J. (2021). Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: A patient feasibility study. Scientific Reports, 11(1), 5648. doi: 10.1038/s41598-021-85048-1
Crake, R. L. I., Phillips, E., Kleffmann, T., & Currie, M. J. (2019). Co-culture with human breast adipocytes differentially regulates protein abundance in breast cancer cells. Cancer Geonomics & Proteomics, 16(5), 319-332. doi: 10.21873/cgp.20137
Conference Contribution - Published proceedings: Abstract
Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2020). An exploratory patient study assessing CYP450 enzyme function in women receiving chemotherapy for breast cancer. New Zealand Medical Journal, 133(1524), (pp. 144). Retrieved from https://www.nzma.org.nz/journal
Crake, R. (2019). Assessing the impact of obesity-related inflammation and physical activity on the function of CYP450 enzymes in women with breast cancer. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. Retrieved from https://www.otago.ac.nz/graduate-research
Crake, R., Phillips, E., Morrin, H., Strother, M., Robinson, B., & Currie, M. (2018). Transwell co-culture with human breast adipocytes alters the proteome expression profiles of mcf-7 and mda-mb-231 human breast cancer cells. ESMO Open, 3(Suppl. 2), (pp. A111-A112). doi: 10.1136/esmoopen-2018-EACR25.268
Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2018). An exploratory breast cancer patient study to assess the impact of obesity-related inflammation and physical activity on chemotherapy drug metabolism. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/
Conference Contribution - Poster Presentation (not in published proceedings)
Crake, R., Kleffmann, T., Morrin, H., Strother, M., Robinson, B., Phillips, E., & Currie, M. (2018, August). Cancer-associated adipocytes alter protein expression profiles of human breast cancer cells in vitro. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Crake, R., Strother, M., Morrin, H., Smith, A., Phillips, E., Robinson, B., & Currie, M. (2018, November). An exploratory breast cancer patient study to assess the impact of obesity-related inflammation and physical activity on chemotherapy drug metabolism. Verbal presentation at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Awarded Doctoral Degree
Crake, R. L. I. (2020). Local and systemic effects of adipocyte-secreted factors in breast cancer (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/10159
