(MSc (Statistics), PhD (Biostatistics))
Professor of Biostatistics
Office: Science III, room 238
Tel +64 21 245 5686
Email katrina.sharples@otago.ac.nz
About
I am a biostatistician, with a PhD in Biostatistics from the University of Washington, Seattle. I have fairly broad interests in statistical methods for clinical and epidemiological research, with particular expertise in clinical trials. I am the lead statistician for Cancer Trials New Zealand, the Centre for International Health and the Pharmacoepidemiology Research Network, and I am a member of the Otago Global Health Institute and the Centre for Translational Research in Cancer.
My time is divided between the Department of Mathematics and Statistics and the Department of Medicine.
Teaching responsibilities
My teaching responsibilities include:
Research interests
- Clinical trials
- Statistical methods in epidemiology
Publications
Parkin, L., Sharples, K. J., Barson, D. J., & Blank, M.-L. (2017). Simvastatin dose and acute kidney injury without concurrent serious muscle injury: A nationwide nested case-control study. PLoS ONE, 12(7), e0182066. doi: 10.1371/journal.pone.0182066
Burns, K. E., Lo, W.-Y., Findlay, M. P., Sharples, K., Laking, G., & Helsby, N. A. (2016). High CYP2C19 phenotypic variability in gastrointestinal cancer patients. Cancer Chemotherapy & Pharmacology, 77, 195-204. doi: 10.1007/s00280-015-2923-4
Perez, D., Sharples, K. J., Broom, R., Jeffery, M., Proctor, J., Hinder, V., … Simpson, A., … Findlay, M. (2015). A randomised phase IIb trial to assess the efficacy of ReCharge ice cream in preventing chemotherapy-induced diarrhoea. Supportive Care in Cancer, 23(11), 3307-3315. doi: 10.1007/s00520-015-2755-0
Parkin, L., Sharples, K., Hernandez, R. K., & Jick, S. S. (2011). Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: Nested case-control study based on UK General Practice Research Database. BMJ, 342, d2139. doi: 10.1136/bmj.d2139
Broom, R. J., Hinder, V., Sharples, K., Proctor, J., Duffey, S., Pollard, S., … Findlay, M. P. N. (2015). Everolimus and zoledronic acid in patients with renal cell carcinoma with bone metastases: A randomized first-line phase II trial. Clinical Genitourinary Cancer, 13(1), 50-58. doi: 10.1016/j.clgc.2014.07.002
Parkin, L., Sharples, K. J., Barson, D. J., & Blank, M.-L. (2017). Simvastatin dose and acute kidney injury without concurrent serious muscle injury: A nationwide nested case-control study. PLoS ONE, 12(7), e0182066. doi: 10.1371/journal.pone.0182066
Journal - Research Article
Burns, K. E., Lo, W.-Y., Findlay, M. P., Sharples, K., Laking, G., & Helsby, N. A. (2016). High CYP2C19 phenotypic variability in gastrointestinal cancer patients. Cancer Chemotherapy & Pharmacology, 77, 195-204. doi: 10.1007/s00280-015-2923-4
Journal - Research Article
Perez, D., Sharples, K. J., Broom, R., Jeffery, M., Proctor, J., Hinder, V., … Simpson, A., … Findlay, M. (2015). A randomised phase IIb trial to assess the efficacy of ReCharge ice cream in preventing chemotherapy-induced diarrhoea. Supportive Care in Cancer, 23(11), 3307-3315. doi: 10.1007/s00520-015-2755-0
Journal - Research Article
Parkin, L., Sharples, K., Hernandez, R. K., & Jick, S. S. (2011). Risk of venous thromboembolism in users of oral contraceptives containing drospirenone or levonorgestrel: Nested case-control study based on UK General Practice Research Database. BMJ, 342, d2139. doi: 10.1136/bmj.d2139
Journal - Research Article
Broom, R. J., Hinder, V., Sharples, K., Proctor, J., Duffey, S., Pollard, S., … Findlay, M. P. N. (2015). Everolimus and zoledronic acid in patients with renal cell carcinoma with bone metastases: A randomized first-line phase II trial. Clinical Genitourinary Cancer, 13(1), 50-58. doi: 10.1016/j.clgc.2014.07.002
Journal - Research Article
O'Sullivan, P., Sharples, K., Dalphin, M., Davidson, P., Gilling, P., Cambridge, L., … Luxmanan, C., … Yoon, H.-S., … Guilford, P. J. (2012). A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria. Journal of Urology, 188(3), 741-747. doi: 10.1016/j.juro.2012.05.003
Journal - Research Article
van Roode, T., Sharples, K., Dickson, N., & Paul, C. (2017). Life-course relationship between socioeconomic circumstances and timing of first birth in a birth cohort. PLoS ONE, 12(1), e0170170. doi: 10.1371/journal.pone.0170170
Journal - Research Article
Harvey, V. J., Sharples, K. J., Isaacs, R. J., Jameson, M. B., Jeffery, G. M., McLaren, B. R., … Simpson, A. B., … Findlay, M. P. (2013). A randomized phase II study comparing capecitabine alone with capecitabine and oral cyclophosphamide in patients with advanced breast cancer-cyclox II. Annals of Oncology, 24(7), 1828-1834. doi: 10.1093/annonc/mdt065
Journal - Research Article
Saha, D., Akinsola, A., Sharples, K., Adeyemi, M. O., Antonio, M., Imran, S., … Hill, P. C. (2013). Health Care Utilization and Attitudes Survey: Understanding diarrheal disease in rural Gambia. American Journal of Tropical Medicine & Hygiene, 89(Suppl. 1), 13-20. doi: 10.4269/ajtmh.12-0751
Journal - Research Article
van Roode, T., Dickson, N., Sharples, K., & Paul, C. (2012). Patterns of sexual partnering and reproductive history: Associations with timing of first birth in a birth cohort. Perspectives on Sexual & Reproductive Health, 44(1), 48-56. doi: 10.1363/4404812
Journal - Research Article
Saxton, P. J. W., Dickson, N. P., McAllister, S. M., Hughes, A. J., & Sharples, K. (2012). HIV prevalence among men who have sex with men in New Zealand 1985-2009: 25 years of public health monitoring. International Journal of STD & AIDS, 23(4), 274-279. doi: 10.1258/ijsa.2011.011213
Journal - Research Article
Dickson, N. P., McAllister, S., Sharples, K., & Paul, C. (2012). Late presentation of HIV infection among adults in New Zealand: 2005-2010. HIV Medicine, 13(3), 182-189. doi: 10.1111/j.1468-1293.2011.00959.x
Journal - Research Article
Konings, A. F., Martin, L. W., Sharples, K. J., Roddam, L. F., Latham, R., Reid, D. W., & Lamont, I. L. (2013). Pseudomonas aeruginosa uses multiple pathways to acquire iron during chronic infection in cystic fibrosis lungs. Infection & Immunity, 81(8), 2697-2704. doi: 10.1128/IAI.00418-13
Journal - Research Article
Moore, A. E., Muirhead, J. C., Sharples, K., & Stringer, M. D. (2014). The effect of upper limb position on ultrasonographic arterial flow to the ulnar nerve. Anaesthesia, 69(4), 356-361. doi: 10.1111/anae.12543
Journal - Research Article
Stringer, M. D., Fraser, S., Gordon, K. C., Sharples, K., & Windsor, J. A. (2013). Gallstones in New Zealand: Composition, risk factors and ethnic differences. ANZ Journal of Surgery, 83(7-8), 575-580. doi: 10.1111/j.1445-2197.2012.06234.x
Journal - Research Article
Martin, L. W., Reid, D. W., Sharples, K. J., & Lamont, I. L. (2011). Pseudomonas siderophores in the sputum of patients with cystic fibrosis. Biometals, 24(6), 1059-1067. doi: 10.1007/s10534-011-9464-z
Journal - Research Article
Jackson, C., McCall, J., Robinson, B., Sharples, K., & Findlay, M. (2013). Cancer trials in New Zealand: Patients are not the problem. New Zealand Medical Journal, 126(1381). Retrieved from http://www.nzma.org.nz/journal
Journal - Research Other
Murray, M., Brown, J., Hinder, V., Merrie, A., Hill, A., Hulme-Moir, M., Sharples, K., & Findlay, M. (2011). The colorectal cancer patients' journey: The Auckland region. New Zealand Medical Journal, 124(1331). Retrieved from http://journal.nzma.org.nz/journal
Journal - Research Article
Saxton, P. J. W., Dickson, N. P., McAllister, S. M., Sharples, K., & Hughes, A. J. (2011). Increase in HIV diagnoses among men who have sex with men in New Zealand from a stable low period. Sexual Health, 8(3), 311-318. doi: 10.1071/SH10087
Journal - Research Article
Al-Mahrouqi, H., Parkin, L., & Sharples, K. (2011). Incidence of stomach cancer in Oman and the other Gulf Cooperation Council countries. Oman Medical Journal, 26(4), 258-262. doi: 10.5001/omj.2011.62
Journal - Research Article
Cameron, C. M., Coppell, K. J., Fletcher, D. J., & Sharples, K. J. (2012). Capture-recapture using multiple data sources: Estimating the prevalence of diabetes. Australian & New Zealand Journal of Public Health, 36(3), 223-228. doi: 10.1111/j.1753-6405.2012.00868.x
Journal - Research Article
McCredie, M. R. E., Paul, C., Sharples, K. J., Baranyai, J., Medley, G., Skegg, D. C. G., & Jones, R. W. (2010). Consequences in women of participating in a study of the natural history of cervical intraepithelial neoplasia 3. Australian & New Zealand Journal of Obstetrics & Gynaecology, 50(4), 363-370. doi: 10.1111/j.1479-828X.2010.01170.x
Journal - Research Article
McCredie, M. R. E., Sharples, K. J., Paul, C., Baranyai, J., Medley, G., Jones, R. W., & Skegg, D. C. G. (2008). Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: A retrospective cohort study. Lancet Oncology, 9(5), 425-434. doi: 10.1016/S1470-2045(08)70103-7
Journal - Research Article
Fleming, T. R., Sharples, K., McCall, J., Moore, A., Rodgers, A., & Stewart, R. (2008). Maintaining confidentiality of interim data to enhance trial integrity and credibility. Clinical Trials, 5, 157-167. doi: 10.1177/1740774508089459
Journal - Research Article
Helsby, N. A., Lo, W.-Y., Sharples, K., Riley, G., Murray, M., Spells, K., … Findlay, M. (2008). CYP2C19 pharmacogenetics in advanced cancer: Compromised function independent of genotype. British Journal of Cancer, 99(8), 1251-1255.
Journal - Research Article
Furneaux, C. C., Marshall, E. S., Yeoh, K., Monteith, S. J., Mews, P. J., Sansur, C. A., … Sharples, K. J., & Baguley, B. C. (2008). Cell cycle times of short-term cultures of brain cancers as predictors of survival. British Journal of Cancer, 99(10), 1678-1683.
Journal - Research Article
McAllister, S. M., Dickson, N. P., Sharples, K., Reid, M. R., Morgan, J. M., MacDonald, E. J., Coughlan, E., … Paul, C. (2008). Unlinked anonymous HIV prevalence among New Zealand sexual health clinic attenders: 2005-2006. International Journal of STD & AIDS, 19(11), 752-757.
Journal - Research Article
Stewart, R. A. H., North, F. M., Sharples, K. J., Simes, R. J., Tonkin, A. M., White, H. D., for the Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Investigators. (2008). Differences in cardiovascular mortality between Australia and New Zealand according to socioeconomic status: findings from the Long-term Intervention with Pravastatiin in Ischaemic Disease (LIPID) study. New Zealand Medical Journal, 121(1269). Retrieved from http://journal.nzma.org.nz/journal
Journal - Research Article
Findlay, M., Sharples, K., Riley, G., Simpson, A., Ackland, S., Hall, K., … McKeage, M. J. (2007). Capecitabine and oral cyclophosphamide: A novel oral treatment combination for advanced cancer. Asia-Pacific Journal of Clinical Oncology, 3, 99-105. doi: 10.1111/j.1743-7563.2007.00095.x
Journal - Research Article
McKergow, E., Parkin, L., Barson, D. J., Sharples, K. J., & Wheeler, B. J. (2017). Demographic and regional disparities in insulin pump utilization in a setting of universal funding: A New Zealand nationwide study. Acta Diabetologica, 54(1), 63-71. doi: 10.1007/s00592-016-0912-7
Journal - Research Article
Firth, M. J., Sharples, K. J., Hinder, V. A., Macapagal, J., Sarfati, D., Derrett, S. L., … Atmore, C., Keating, J. P., Jeffery, M., … Jackson, C. G. C. A., & Findlay, M. P. N. (2016). Methods of a national colorectal cancer cohort study: The PIPER Project. New Zealand Medical Journal, 129(1440), 25-36. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Maze, M. J., Cash-Goldwasser, S., Biggs, H. M., Rubach, M. P., Galloway, R. L., Sharples, K. J., … Crump, J. A. (2017). Risk factors for acute Leptospirosis in Northern Tanzania. American Journal of Tropical Medicine & Hygiene, 95(5, Suppl.), (pp. 201). doi: 10.4269/ajtmh.abstract2016
Conference Contribution - Published proceedings: Abstract
Verrall, A., Apriani, L., Sharples, K., Ussher, J., Indrati, A., Nurani, A., … Hill, P. (2016). Early clearance of Mycobacterium tuberculosis infection. Proceedings of the Otago Global Health Institute (OGHI) 9th Annual Conference. (pp. 20). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/
Conference Contribution - Published proceedings: Abstract
Cash-Goldwasser, S., Maze, M. J., Rubach, M. P., Biggs, H. M., Stoddard, R. A., Sharples, K. J., … Crump, J. A. (2017). Risk factors for acute human Brucellosis in Northern Tanzania. American Journal of Tropical Medicine & Hygiene, 95(5, Suppl.), (pp. 168-169). doi: 10.4269/ajtmh.abstract2016
Conference Contribution - Published proceedings: Abstract
Quon, J., Sharples, K. J., & Parkin, L. (2017). Co-prescribing of contraindicated or use-with-caution drugs in a national cohort of new users of simvastatin: Are guidelines being followed? New Zealand Medical Journal, 130(1461), (pp. 92). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
McKergow, E., Parkin, L., Barson, D. J., Sharples, K. J., & Wheeler, B. J. (2017, May). Demographic and regional disparaties in insulin pump utilisation in a setting of universal funding: A New Zealand nationwide study. Verbal presentation at the New Zealand Society for the Study of Diabetes (NZSSD) Annual Scientific Meeting, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs