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Acute skeletal muscle adaptations to sprint interval training: the role of Ca2+ handling

Nicolas Place got his PhD (Neuromuscular adaptations to fatigue in humans) in 2006 at the Faculty of Sport Sciences, University of Burgundy, France. He then completed a post doc in 2007-2008 at the Karolinska Institute in Stockholm (Prof. Westerblad’s laboratory) to work on the intramuscular determinants of skeletal muscle weakness (force and Ca2+ signaling) using the mouse intact single fibre model.

After five years spent at the Institute of Sport Sciences at the University of Geneva, in 2013 he joined the Institute of Sport Sciences at the University of Lausanne as a senior lecturer. His research focuses on the development of a translational approach, combining mechanistic and integrative experiments, to assess neuromuscular plasticity to exercise.

Techniques such as transcutaneous electrical stimulation, transcranial magnetic stimulation, surface electromyography and force recordings are routinely used to distinguish central (neural) from peripheral (muscular) adaptations. In vitro models (e.g. cell culture, isolated mouse fibres / muscles, human muscle biopsy analysis) are also adopted to determine the cellular / molecular mechanisms underlying skeletal muscle adaptations to disease (e.g. myopathy) / exercise (e.g. HIIT). He is currently a visiting researcher in Launikonis lab at UQ in Brisbane. He has published more than 70 papers in peer reviewed journals since 2003.

The presentation will focus on skeletal muscle adaptations to high intensity interval exercise, and especially i- the origin of muscle fatigue induced by this kind of exercise as well as ii- the potential role of the ryanodine receptor in mitochondrial adaptations following one session of HIIT.

Date Monday, 24 June 2019
Time 1:00pm - 2:00pm
Audience All University
Event Category Health Sciences
Event Type Seminar
CampusDunedin
DepartmentPhysiology
LocationHercus d'Ath Lecture Theatre, Great King Street

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