Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Professor Stephen Brennan

PositionClinical Professor
DepartmentDepartment of Pathology and Biomedical Science (Christchurch)
QualificationsBSc(Hons), PhD(Massey), FRSNZ
Research summaryMolecular Pathology


Principal research interest is elaborating the interrelationships between protein structure, function, and disease. Both genetic (mutation) and acquired (post-translational) modification of a proteins structure can affect its function and induce disease. Have a specific interest in mutations and disease mechanisms associated with:
  • The haemoglobinopathies and thalassaemias
  • a1 antitrypsin deficiency and liver cirrhosis / emphysema.
  • Antithrombin mutation and deep vein thrombosis / pulmonary embolism.
  • Apolipoprotein mutation and hyperlipidemia.
  • Albumin mutation and familial hyperthyroxemia.
  • Dysfibrinogenaemia and bleeding, thrombosis and renal amyloidosis
  • Hypo-and afibrinogenaemia and its association with bleeding and liver cirrhosis.


Turner, R., Brennan, S. O., Ashby, L. V., Dickerhof, N., Hamzah, M. R., Pearson, J. F., Stamp, L. K., & Kettle, A. J. (2018). Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation. Journal of Biological Chemistry, 293(51), 19886-19898. doi: 10.1074/jbc.RA118.005237

Brennan, S. O., & Laurie, A. D. (2018). Mutation of the -RPVR- propeptide motif at C-terminal of the Aα chain is associated with decreased fibrinogen expression. Thrombosis & Haemostasis, 118(1), 207-209. doi: 10.1160/th17-08-0578

Marchi, R., Linares, M., Rojas, H., Ruiz-Saez, A., Meyer, M., Casini, A., & Brennan, S. O. (2017). A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion. BMC Hematology, 17, 22. doi: 10.1186/s12878-017-0086-8

Chew-Harris, J. S. C., Brennan, S. O., Florkowski, C. M., Troughton, R., & George, P. M. (2017). Deciphering a macro-troponin I complex: A case report. Clinical Chemistry & Laboratory Medicine, 55(4), e77-e79. doi: 10.1515/cclm-2016-0490

Brennan, S. O., & Laurie, A. D. (2017). Hypofibrinogenaemia associated with novel Aα126Val→Asp mutation in the fibrinogen coiled coil. Thrombosis & Haemostasis, 117(10), 2000-2002. doi: 10.1160/TH17-04-0270

Chapter in Book - Research

Ledgerwood, E. C., & Brennan, S. (1995). Furin. In A. Haeberli (Ed.), Human Protein Data: 3rd Instalment. VCH: Weinheim and New York.

^ Top of page

Journal - Research Article

Turner, R., Brennan, S. O., Ashby, L. V., Dickerhof, N., Hamzah, M. R., Pearson, J. F., Stamp, L. K., & Kettle, A. J. (2018). Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation. Journal of Biological Chemistry, 293(51), 19886-19898. doi: 10.1074/jbc.RA118.005237

Marchi, R., Linares, M., Rojas, H., Ruiz-Saez, A., Meyer, M., Casini, A., & Brennan, S. O. (2017). A novel fibrinogen mutation: FGA g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion. BMC Hematology, 17, 22. doi: 10.1186/s12878-017-0086-8

King, R. I., & Brennan, S. O. (2016). Direct analysis of VLDL by TOF-MS allows rapid definition of Apo E genotypes and facilitates characterisation of post translational changes. Clinica Chimica Acta, 457, 54-58. doi: 10.1016/j.cca.2016.03.021

Brennan, S. O., Potter, H. C., Sheen, C. R., & George, P. M. (2016). Unique albumin with two silent substitutions (540Thr → Ala and 546Ala → Ser): Insights into how albumin is recycled. Clinica Chimica Acta, 457, 125-129. doi: 10.1016/j.cca.2016.04.014

Brennan, S. O., & MacKay, R. (2016). Acquired and congenital fast albumin bands; Insights from electrospray TOF analysis of whole plasma into drug binding and albumin recycling. Clinical Biochemistry, 49, 180-182. doi: 10.1016/j.clinbiochem.2015.09.013

Brennan, S. O., Potter, H. C., & Hanss, M. (2016). Bisalbuminaemia due to novel mutation at a critical residue involved in recycling; Albumin Lyon (510His → Arg). Clinical Biochemistry, 49(7-8), 544-547. doi: 10.1016/j.clinbiochem.2016.01.008

Brennan, S. O., Laurie, A. D., & Bell, J.-A. (2016). Novel FGB mutation Bβ240Cys→Arg confirms importance of the Bβ211-240 disulphide for plasma expression of fibrinogen. Thrombosis Research, 147, 94-96. doi: 10.1016/j.thromres.2016.09.031

Aung, N. N., Kennedy, H., Faed, J. M., & Brennan, S. O. (2015). Novel heterozygous Bbeta (c.1311T>A) mutation (Fibrinogen St Kilda) associated with recurrent pregnancy loss. Pathology, 47(6), 583-585. doi: 10.1097/pat.0000000000000307

Brennan, S. O. (2015). Variation of fibrinogen oligosaccharide structure in the acute phase response: Possible haemorrhagic implications. Biochimica et Biophysica Acta: Clinical, 3, 221-226. doi: 10.1016/j.bbacli.2015.02.007

Brennan, S. O., Laurie, A., & Smith, M. (2015). Novel FGG variant (γ339C→S) confirms importance of the γ326–339 disulphide bond for plasma expression of newly synthesised fibrinogen. Thrombosis & Haemostasis, 113(4), 903-905. doi: 10.1160/TH14-10-0849

Brennan, S. O., Laurie, A. D., Mo, A., & Grigg, A. (2015). Novel fibrinogen mutations (Aα17Gly→Cys and Aα381Ser→Phe) occurring with a 312Thr→Ala polymorphism: Allelic phase assigned by direct mass measurement. Blood Coagulation & Fibrinolysis, 26(8), 882-886. doi: 10.1097/mbc.0000000000000316

Lankes, U., Brennan, S. O., Walmsley, T. A., & George, P. M. (2015). Relative quantification of albumin and fibrinogen modifications by liquid chromatography tandem mass spectrometry in the diagnosis and monitoring of acute pancreatitis. Journal of Chromatography B, 988, 121-126. doi: 10.1016/j.jchromb.2015.02.013

Brennan, S. O., Rollo, C., & Potter, H. C. (2015). Novel silent albumin variant (191Ala → Thr) detected by TOF MS of whole plasma. Clinica Chimica Acta, 440, 40-43. doi: 10.1016/j.cca.2014.11.003

Brennan, S. O., Povall, A., & Lankes, U. (2014). Hb Ashburton [β12(A9)Thr → Pro; HBB: C.37A > C], a novel, mildly unstable variant and the first substitution identified at codon 12. Hemoglobin, 38(2), 79-83. doi: 10.3109/03630269.2013.879065

Brennan, S. O., Mangos, H., & Faed, J. M. (2014). Benign FGB (148Lys→Asn, and 448Arg→Lys), and novel causative y211Tyr→His mutation distinguished by time of flight mass spectrometry in a family with hypofibrinogenaemia. Thrombosis & Haemostasis, 111(4), 679-684. doi: 10.1160/TH13-08-0657

Shen, Y.-M., Trang, V., Sarode, R., & Brennan, S. (2014). Fibrinogen Dusart presenting as recurrent thromboses in the hepatic portal system. Blood Coagulation & Fibrinolysis, 25(4), 392-394. doi: 10.1097/mbc.0000000000000045

Galanakis, D. K., Neerman-Arbez, M., Brennan, S., Rafailovich, M., Hyder, L., Travlou, O., … Scharrer, I. (2014). Thromboelastographic phenotypes of fibrinogen and its variants: Clinical and non-clinical implications. Thrombosis Research, 133(6), 1115-1123. doi: 10.1016/j.thromres.2014.03.026

Brennan, S. O., & Laurie, A. (2014). Functionally compromised FGG variant (γ320Asp→Glu) expressed at low level in plasma fibrinogen. Thrombosis Research, 134, 744-746. doi: 10.1016/j.thromres.2014.06.030

Marchi, R., Brennan, S., Meyer, M., Rojas, H., Kanzler, D., De Agrela, M., & Ruiz-Saez, A. (2013). A novel mutation in the FGB: c.1105C>T turns the codon for amino acid Bβ Q339 into a stop codon causing hypofibrinogenemia. Blood Cells, Molecules & Diseases, 50(3), 177-181. doi: 10.1016/j.bcmd.2012.11.010

Brennan, S. O., & Chitlur, M. (2013). Hypodysfibrinogenaemia and thrombosis in association with a new fibrinogen γ chain with two mutations (γ114Tyr→His, and γ320Asp deleted). Thrombosis & Haemostasis, 109(6), 1180-1182. doi: 10.1160/TH13-01-0068

Brennan, S. O., & Chan, T. (2013). Hb Papanui [α99(G8)Lys→Arg; HBA2: c.299A>G]: A novel silent substitution interfering in Hb A1c determination. Hemoglobin, 37(6), 589-592. doi: 10.3109/03630269.2013.809734

Brennan, S. O., Zebeljan, D., & Ho, L. L. (2013). Thrombosis in association with a novel substitution (γ346Gly→Val) at an absolutely conserved site in the fibrinogen γ chain. Thrombosis & Haemostasis, 109(4), 757-758. doi: 10.1160/th12-11-0832

Brennan, S. O., Pullon, B., Owen, M. C., & Brittain, T. (2012). Novel hemoglobin mutation (α127Lys→Glu) increases oxygen affinity and has a minor effect on haptoglobin binding. Clinical Biochemistry, 45(18). doi: 10.1016/j.clinbiochem.2012.08.021

Brennan, S. O., Chan, T., & Duncan, J. (2012). Novel α2 gene deletion (c.349_359 del GAGTTCACCCC) identified in association with the -α3.7 deletion. Hemoglobin, 36(1), 93-97. doi: 10.3109/03630269.2011.637592

Ireland, R. D., Brennan, S. O., Gerrard, J. A., Walmsley, T. A., George, P. M., & King, R. I. (2012). A mass-spectroscopic method for measuring des-Leu albumin: A novel marker for chronic pancreatitis. Clinical Biochemistry, 45(18), 1664-1668. doi: 10.1016/j.clinbiochem.2012.08.017

Andersen, J. T., Dalhus, B., Cameron, J., Daba, M. B., Plumridge, A., Evans, L., Brennan, S. O., … Sandlie, I. (2012). Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. Nature Communications, 3, 610. doi: 10.1038/ncomms1607

Cheah, C. Y., Brennan, S. O., Kennedy, H., Januszewicz, E. H., Maxwell, E., & Burbury, K. (2012). Fibrinogen Melbourne: A novel congenital hypodysfibrinogenemia caused by [gamma]326Cys-Phe in the fibrinogen [gamma] chain, presenting as massive splanchnic venous thrombosis. Blood Coagulation & Fibrinolysis, 23(6), 563-565. doi: 10.1097/MBC.0b013e328354a23b

Brennan, S. O., King, R. I., & Florkowski, C. M. (2012). β37Trp→Cys mutation leads to multiple new hemoglobin species in red cells. Clinical Biochemistry, 45, 259-263. doi: 10.1016/j.clinbiochem.2011.12.001

Brennan, S. O., & Roncolato, F. (2011). Novel fibrinogen (Bβ401Gly→Val) presents as dys- or hypodysfibrinogenaemia due to alterations in sialic acid content. Thrombosis & Haemostasis, 106(3), 551-553. doi: 10.1160/TH11-05-0287

Brennan, S. O., Oliver, J., & Davis, R. L. (2011). Adjacent substitutions (γ352Gly→Cys and 353Thr→Pro) in fibrinogen Ilam cause diminished γ chain expression. Thrombosis & Haemostasis, 105, 379-381. doi: 10.1160/TH10-09-0619

Brennan, S. O., Davis, R. L., Conard, K., Savo, A., & Furuya, K. N. (2010). Novel fibrinogen mutation γ314Thr → Pro (fibrinogen Al duPont) associated with hepatic fibrinogen storage disease and hypofibrinogenaemia. Liver International, 30(10), 1541-1547. doi: 10.1111/j.1478-3231.2010.02312.x

Brennan, S. O., & Chan, T. (2010). Hb Perpignan [β136(H14)GLY→Ser], a silent variant associated with normal hematology. Hemoglobin, 34(2), 157-160. doi: 10.3109/03630261003677221

Brennan, S. O., Davis, R. L., & Chitlur, M. (2010). New fibrinogen substitution (γSer313Arg) causes diminished γ chain expression and hypodysfibrinogenaemia. Thrombosis & Haemostasis, 103(2), 478-479. doi: 10.1160/TH09-07-0459

Brennan, S. O., & Davis, R. L. (2010). Substitution (γ335Trp→Arg) in fibrinogen Fremantle causes diminished γ chain expression and increased sialic acid content. Thrombosis & Haemostasis, 104(6), 1274-1276. doi: 10.1160/TH10-04-0252

Brennan, S. O., Ryken, S., & Chan, T. (2010). Hb Koya Dora [α142, Term→Ser (TAA>TCA in α2)]: A rare mutation of the α2 gene stop codon associated with α-thalassemia. Hemoglobin, 34(4), 402-405. doi: 10.3109/03630269.2010.486344

Sheen, C. R., Dear, A., & Brennan, S. O. (2010). Expression of four mutant fibrinogen γC domains in Pichia pastoris confirms them as causes of hypofibrinogenaemia. Protein Expression & Purification, 73, 184-188. doi: 10.1016/j.pep.2010.05.008

Brennan, S. O., Chan, T., Ryken, S., & Ruskova, A. (2009). A second case of HB Fontainebleau [α21(B2)Ala→Pro] in an individual with microcytosis. Hemoglobin, 33(3), 258-261. doi: 10.1080/03630260903061135

Brennan, S. O., Davis, R. L., Lowen, R., & Ruskova, A. (2009). Deletion of five residues from the coiled coil of fibrinogen (Bβ Asn167_Glu171del) associated with bleeding and hypodysfibrinogenemia. Haematologica, 94(4), 585-588. doi: 10.3324/haematol.2008.001412

Davis, R. L., Homer, V. M., George, P. M., & Brennan, S. O. (2009). A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment. Human Mutation, 30(2), 221-227. doi: 10.1002/humu.20839

Dempfle, C.-E., George, P. M., Borggrefe, M., Neumaier, M., & Brennan, S. O. (2009). Demonstration of heterodimeric fibrinogen molecules partially conjugated with albumin in a novel dysfibrinogen: Fibrinogen Mannheim V. Thrombosis & Haemostasis, 102, 29-34. doi: 10.1160/TH08-09-0559

Davis, R. L., May, S., Chunilal, S., & Brennan, S. O. (2009). Two novel mutations at contiguous codons in the fibrinogen Ββ chain associated with hypofibrinogenaemia. Thrombosis & Haemostasis, 101(5), 980-982. doi: 10.1160/th08-11-0727

Davis, R. L., Baker, B., & Brennan, S. O. (2008). Fibrinogen Foxton: A novel BβA277V mutation causing low normal plasma fibrinogen concentration. Thrombosis & Haemostasis, 100(4), 708-710. doi: 10.1160/TH08-05-0304

Davis, R. L., Peters, Jr, T., & Brennan, S. O. (2008). Novel frameshift in the serum albumin gene results in analbuminemia through premature truncation and post translational modification. Clinical Biochemistry, 41(18), 1482-1485. doi: 10.1016/j.clinbiochem.2008.08.082

Brennan, S. O., Owen, M. C., Chan, T., & Ruskova, A. (2008). Novel hemoglobin α chain elongation resulting from a 15-residue insertion and tandem duplication of the F helix. Clinical Biochemistry, 41, 1156-1161. doi: 10.1016/j.clinbiochem.2008.05.011

Schmidt, D., & Brennan, S. O. (2007). Modified form of the fibrinogen Bβ chain (des-Gln Bβ), a potential long-lived marker of pancreatitis. Clinical Chemistry, 53(12), 2105-2111.

Metcalf, V. J., George, P. M., & Brennan, S. O. (2007). Lungfish albumin is more similar to tetrapod than to teleost albumins: Purification and characterisation of albumin from the Australian lungfish, Neoceratodus forsteri. Comparative Biochemistry & Physiology Part B, 147, 428-437.

Testro, A. G., Brennan, S. O., MacDonell, R. A. L., Hawkins, P. N., & Angus, P. W. (2007). Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein A1 Gly26Arg: Outcome of hepatorenal transplantation. Liver Transplantation, 13, 1028-1031.

Dear, A., Brennan, S. O., Sheat, M. J., Faed, J. M., & George, P. M. (2007). Acquired dysfibrinogenemia caused by monoclonal production of immunoglobulin λ light chain. Haematologica, 92, e111-e117. doi: 10.3324/haematol.11837

Davis, R. L., & Brennan, S. O. (2007). Fibrinogen Tolaga Bay: A novel γAla341Val mutation causing hypofibrinogenaemia. Journal of Thrombosis & Haemostasis, 98, 1136-1138.

Sheen, C. R., Jewell, U. R., Morris, C. M., Brennan, S. O., Férec, C., George, P. M., Smith, M. P., & Chen, J.-M. (2007). Double complex mutations involving F8 and FUNDC2 caused by distinct break-induced replication. Human Mutation, 28(12), 1198-1206.

Brennan, S. O., Davis, R. L., Mosesson, M. W., Hernandez, I., Lowen, R., & Alexander, S. J. (2007). Congenital hypodysfibrinogenaemia (Fibrinogen Des Moines) due to a γ320Asp deletion at the Ca2+ binding site. Thrombosis & Haemostasis, 98, 467-469.

Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie, 89, 21-29.

Meyer, M., Dietzel, H., Kaetzel, R., Schmidt, D., Liebscher, K., & Brennan, S. O. (2007). Fibrinogen Leipzig II (γ351Gly→Ser and γ82Ala→Gly): Hypodysfibrinogenaemia due to two independent amino acid substitutions within the same polypeptide chain. Thrombosis & Haemostasis, 98(4), 903-905.

Tennent, G. A., Brennan, S. O., Stangou, A. J., O'Grady, J., Hawkins, P. N., & Pepys, M. B. (2007). Human plasma fibrinogen is synthesized in the liver. Blood, 109(5), 1971-1974.

Brennan, S. O., Mosesson, M. W., Lowen, R., & Frantz, C. (2006). Dysfibrinogenemia (fibrinogen Wilmington) due to a novel Aα chain truncation causing decreased plasma expression and impaired fibrin polymerisation. Thrombosis & Haemostasis, 96, 88-89.

Brennan, S. O., Mosesson, M. W., Lowen, R., Siebenlist, K. R., & Matsunaga, A. (2006). Hypofibrinogenaemia resulting from novel single nucleotide deletion at codon Bβ58 (3404del A) associated with thrombotic stroke in infancy. Thrombosis & Haemostasis, 95, 738-739.

Hill, M. B., Brennan, S. O., Dear, A., Strong, J., Nejim, T., & Dolan, G. (2006). Fibrinogen Nottingham II: A novel Bβ Arg264gly substitution causing hypofibrinogenaemia. Thrombosis & Haemostasis, 96, 378-380.

Dear, A., Daly, J., Brennan, S. O., Tuckfield, A., & George, P. M. (2006). An intronic mutation within FGB (IVS1+2076 a → g) is associated with afibrinogenemia and recurrent transient ischemic attacks. Journal of Thrombosis & Haemostasis, 4, 471-472.

Meyer, M., Bergmann, F., & Brennan, S. O. (2006). Novel fibrinogen mutation ([gamma] 313 Ser->Asn) associated with hypofibrinogenemia in two unrelated families. Blood Coagulation & Fibrinolysis, 17(1), 63-67.

Sheen, C. R., Low, J., Joseph, J., Kotlyar, E., George, P. M., & Brennan, S. O. (2006). Fibrinogen Darlinghurst: Hypofibrinogenaemia caused by a W253G mutation in the gamma chain in a patient with both bleeding and thrombotic complications. Thrombosis & Haemostasis, 96, 685-687.

Brennan, S. O., Homer, V. M., Davis, R. L., Meyer, M., & George, P. M. (2006). Hypofibrinogenaemia associated with common γ82Ala→Gly mutation is not mediated by altered mRNA splicing. Thrombosis & Haemostasis, 96, 535-537.

Kruse, K. B., Dear, A., Kaltenbrun, E. R., Crum, B. E., George, P. M., Brennan, S. O., & McCracken, A. A. (2006). Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy. American Journal of Pathology, 168(4), 1299-1308.

Sheen, C. R., Brennan, S. O., Jabado, N., & George, P. M. (2006). Fibrinogen Montreal: A novel missense mutation (Aα D496N) associated with hypofibrinogenaemia. Thrombosis & Haemostasis, 96, 231-232.

Blacklock, H. A., Case, J., Chan, T., Raizis, T., Doocey, R., Fellowes, A., … Brennan, S., & George, P. (2005). Novel sequence insertion in a Māori patient with transfusion-dependent β-thalassaemia. British Journal of Haematology, 131, 400-402.

Dear, A., Brennan, S. O., & George, P. M. (2005). Familial hypodysfibrinogenaemia associated with second occurrence of γ326 Cys→Tyr mutation. Thrombosis & Haemostasis, 93, 612-613.

Brennan, S. O., Sheen, C. R., & George, P. M. (2005). Novel γ230 Asn→Asp substitution in fibrinogen Middlemore associated hypofibrinogenaemia. Thrombosis & Haemostasis, 93, 1196-1197.

Maghzal, G. J., Brennan, S. O., & George, P. M. (2005). The sialic acid content of fibrinogen decreases during pregnancy and increases in response to fibrate therapy. Thrombosis Research, 115, 293-299.

Brennan, S. O., Chan, T., Obele, M., & George, P. M. (2005). Hb Riccarton [α51(CE9)Gly→Ser]: A variant arising from a novel mutation in the α1 gene. Hemoglobin, 29(1), 61-64.

de Raucourt, E., de Mazancourt, P., Maghzal, G. J., Brennan, S. O., & Mosesson, M. W. (2005). Fibrinogen Saint-Germain II: Hypofibrinogenemia due to heterozygous γ N345S mutation. Thrombosis & Haemostasis, 94, 965-968.

Brennan, S. O., Sheen, C., Chan, T., & George, P. M. (2005). Hb Taradale [β82(EF6)Lys→Arg]: A novel mutation at a 2,3-diphosphoglycerate binding site. Hemoglobin, 29(4), 281-284.

Liew, O. W., Chong, J. P. C., Yandle, T. G., & Brennan, S. O. (2005). Preparation of recombinant thioredoxin fused N-terminal proCNP: Analysis of enterokinase cleavage products reveals new enterokinase cleavage sites. Protein Expression & Purification, 41, 332-340.

Mushunje, A., Evans, G., Brennan, S. O., Carrell, R. W., & Zhou, A. (2004). Latent antithrombin and its detection, formation and turnover in the circulation. Journal of Thrombosis & Haemostasis, 2(12), 2170-2177. doi: 10.1111/j.1538-7836.2004.01047.x

Dear, A., Brennan, S. O., Dempfle, C.-E., Kirschstein, W., & George, P. M. (2004). Hypofibrinogenaemia associated with a novel heterozygous γ289 Ala→Val substitution (fibrinogen Dorfen). Journal of Thrombosis & Haemostasis, 92, 1291-1295.

Maghzal, G. J., Brennan, S. O., Homer, V. M., & George, P. M. (2004). The molecular mechanisms of congenital hypofibrinogenaemia. Cellular & Molecular Life Sciences, 61, 1427-1438.

Dear, A., Dempfle, C. E., Brennan, S. O., Kirschstein, W., & George, P. M. (2004). Fibrinogen Mannheim II: A novel γ307 His → Tyr substitution in the γD domain causes hypofibrinogenemia. Journal of Thrombosis & Haemostasis, 2, 2194-2199.

Lefebvre, P., Velasco, P. T., Dear, A., Lounes, K. C., Lord, S. T., Brennan, S. O., … Lorand, L. (2004). Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1 G>T mutation and an AαGln328 truncation (fibrinogen Keokuk). Blood, 103(7), 2571-2576.

Florkowski, C. M., Walmsley, T. A., Brennan, S., & George, P. M. (2003). Haemoglobin Marseille-Long Island and interpretation of HbA1c: Which HbA1c result is the 'right answer'? Postgraduate Medical Journal, 79, 174-175.

Maghzal, G. J., Brennan, S., Fellowes, A. P., Spearing, R. L., & George, P. M. (2003). Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bβ255 Arg→His (Fibrinogen Merivale). Biochimica et Biophysica Acta: Proteins & Proteomics, 1645, 146-151.

Homer, V. M., Mullin, J. L., Brennan, S., Barr, A., & George, P. M. (2003). Novel Aα chain truncation (fibrinogen Perth) resulting in low expression and impaired fibrinogen polymerization. Journal of Thrombosis & Haemostasis, 1, 1245-1250.

Maghzal, G. J., Brennan, S., & George, P. M. (2003). Fibrinogen Bβ polymorphisms do not directly contribute to an altered in vitro clot structure in humans. Thrombosis & Haemostasis, 90(6), 1021-1028.

Brennan, S., Chan, T., Sheen, C., & Rae, L. (2003). Hb Lusaka [α131(H14)Ser→Phe (α1)]: A new variant found in a woman heterozygous for Hb S [β6(A3)Glu→Val]. Hemoglobin, 27(3), 177-180.

Metcalf, V., Brennan, S., & George, P. M. (2003). Using serum albumin to infer vertebrate phylogenies. Applied Bioinformatics, 2(3 Suppl.), 97-107.

Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40.

Copplestone, S., Mackay, R., & Brennan, S. (2002). Normal glycated haemoglobin in a patient with poorly controlled diabetes mellitus and haemoglobin D Punjab: Implications for assessment of control. New Zealand Medical Journal, 115(1157), U25. Retrieved from

Homer, V. M., Brennan, S., Ockelford, P., & George, P. M. (2002). Novel Fibrinogen truncation with deletion of Bβ chain residues 440-461 causes hypofibrinogenaemia. Thrombosis & Haemostasis, 88, 427-431.

Brennan, S., Homer, V. M., Ockelford, P., & George, P. M. (2002). Low expression of truncated Aα Chain variant in circulating Fibrinogen. Thrombosis & Haemostasis, 88, 533-534.

Brennan, S., Maghzal, G. J., Shneider, B. L., Gordon, R., Magid, M. S., & George, P. M. (2002). Novel Fibrinogen γ375 Arg→Trp mutation (Fibrinogen Aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Hepatology, 36, 652-658.

Homer, V. M., Brennan, S., & George, P. M. (2002). Novel fibrinogen Bβ chain mutation causing hypofibrinogenaemia. Thrombosis & Haemostasis, 88, 1066-1067.

Brennan, S., Sheen, C., & Johnson, S. (2002). Hb Manawatu [α37(C2)Pro→Leu] A new mildly unstable mutation at an invariant proline residue. Hemoglobin, 26, 389-392.

Mullin, J. L., Brennan, S., Ganly, P. S., & George, P. M. (2002). Fibrinogen Hillsborough: A Novel γ309Gly→ Asp Dysfibrinogen. Blood, 99, 3597-3610.

Homer, V. M., Brennan, S., & George, P. M. (2002). Four novel polymorphisms in the fibrinogen Aα gene. Thrombosis & Haemostasis, 87, 354-355.

Brennan, S., Potter, H. C., Kubala, L. M., Carnoutsos, S. A., & Ferguson, M. M. (2002). Hb Canterbury [beta112(G14)Cys-->Phe]: A new, mildly unstable variant. Hemoglobin, 26, 67-69.

Brennan, S. O., Wyatt, J. M., May, S. J., De Caigney, S., & George, P. M. (2001). Hypofibrinogenemia due to novel 316 Asp-Tyr substitution in the fibrinogen B beta chain. Thrombosis & Haemostasis, 85, 450-453.

Fellowes, A. P., Brennan, S., & George, P. M. (2001). Identification and characterisation of five new fibrinogen gene polymorphisms. Annals of the New York Academy of Sciences, 936, 536-541.

Brennan, S. O., Fellowes, A. P., & George, P. M. (2001). Molecular mechanisms of hypo- and afibrinogenemia. Annals of the New York Academy of Sciences, 936, 91-100.

Brennan, S. O., Wyatt, J. M., Fellowes, A. P., Dlott, J. S., Triplett, D. A., & George, P. M. (2001). γ371 Thr → Ile substitution in the fibrinogen γD domain causes hypofibrinogenaemia. Biochimica et Biophysica Acta: Protein Structure & Molecular Enzymology, 1550, 183-188.

Beard, M. E. J., Potter, H. C., Spearing, R. L., & Brennan, S. (2001). Haemoglobin Pierre-Benite, a high affinity variant associated with relative polycythaemia. Clinical Laboratory Medicine, 23, 407-409.

Hill, R. M., Brennan, S. O., & Birch, N. P. (2001). Expression, purification, and functional characterisatiion of the serine protease inhibitor neuroserpin expressed in drosophila S2 cells. Protein Expression & Purification, 22, 406-413.

Meh, D. A., Mosessen, M. W., Siebenlist, K. R., Simpson-Haidaris, P. J., Brennan, S. O., DiOrio, J. P., … Di Minno, G. (2001). Fibrinogen Naples I (β A68T) non-substrate thrombin binding capacities. Thrombosis Research, 103, 63-73.

More publications...