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Otago Medical School staff profiles

Dr Tracy Melzer

PositionMRI Research Manager
DepartmentDepartment of Medicine (Christchurch)
QualificationsBA, BSc(Hons), PhD
Research summaryParkinson's disease

Research

As MRI Research Manager at the NZ Brain Research Institute, I oversee all imaging at the NZBRI. This provides me with the opportunity to become involved in a wide range of neurological research, including child development, mild traumatic brain injury, post-traumatic stress disorder, neurodegenerative diseases, and more. As a Research Fellow in the Department of Medicine, my primary focus is on the development and application of Magnetic Resonance Imaging (MRI) techniques to advance our understanding of cognitive decline in Parkinson’s disease.

Publications

Darlow, B. A., Woodward, L. J., Levin, K. J., Melzer, T., & Horwood, L. J. (2020). Perinatal and childhood predictors of general cognitive outcome at 28 years in a very-low-birthweight national cohort. Developmental Medicine & Child Neurology. Advance online publication. doi: 10.1111/dmcn.14649

Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., … Hariri, A. R. (2020). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry. Advance online publication. doi: 10.1176/appi.ajp.2020.19090934

Theys, C., Kovacs, S., Peeters, R., Melzer, T. R., van Wieringen, A., & De Nil, L. F. (2020). Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers. PLoS ONE, 15(1), e0228452. doi: 10.1371/journal.pone.0228452

Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., … Viding, E. (2020). Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort. Lancet Psychiatry, 7(3), 245-253. doi: 10.1016/s2215-0366(20)30002-x

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation, 42(14), 1942-1953. doi: 10.1080/09638288.2018.1542461

Journal - Research Article

Darlow, B. A., Woodward, L. J., Levin, K. J., Melzer, T., & Horwood, L. J. (2020). Perinatal and childhood predictors of general cognitive outcome at 28 years in a very-low-birthweight national cohort. Developmental Medicine & Child Neurology. Advance online publication. doi: 10.1111/dmcn.14649

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation, 42(14), 1942-1953. doi: 10.1080/09638288.2018.1542461

Carlisi, C. O., Moffitt, T. E., Knodt, A. R., Harrington, H., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., … Viding, E. (2020). Associations between life-course-persistent antisocial behaviour and brain structure in a population-representative longitudinal birth cohort. Lancet Psychiatry, 7(3), 245-253. doi: 10.1016/s2215-0366(20)30002-x

Theys, C., Kovacs, S., Peeters, R., Melzer, T. R., van Wieringen, A., & De Nil, L. F. (2020). Brain activation during non-habitual speech production: Revisiting the effects of simulated disfluencies in fluent speakers. PLoS ONE, 15(1), e0228452. doi: 10.1371/journal.pone.0228452

Romer, A. L., Elliott, M. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., … Hariri, A. R. (2020). Pervasively thinner neocortex as a transdiagnostic feature of general psychopathology. American Journal of Psychiatry. Advance online publication. doi: 10.1176/appi.ajp.2020.19090934

Melzer, T. R., Keenan, R. J., Leeper, G. J., Kingston-Smith, S., Felton, S. A., Green, S. K., … Almuqbel, M. M., & Myall, D. J. (2020). Test-retest reliability and sample size estimates after MRI scanner relocation. NeuroImage, 211, 116608. doi: 10.1016/j.neuroimage.2020.116608

d'Arbeloff, T., Elliott, M. L., Knodt, A. R., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., Anderson, T., … Hariri, A. R. (2019). White matter hyperintensities are common in midlife and already associated with cognitive decline. Brain Communications, 1(1), fcz041. doi: 10.1093/braincomms/fcz041

Elliott, M. L., Belsky, D. W., Knodt, A. R., Ireland, D., Melzer, T. R., Poulton, R., Ramrakha, S., Caspi, A., Moffitt, T. E., & Hariri, A. R. (2019). Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort. Molecular Psychiatry. Advance online publication. doi: 10.1038/s41380-019-0626-7

Douglas, K. M., Groves, S., Porter, R. J., Jordan, J., Wilson, L., Melzer, T. R., … Bell, C. J. (2019). Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: A preliminary functional magnetic resonance imaging study. Australian & New Zealand Journal of Psychiatry, 53(12), 1167-1178. doi: 10.1177/0004867419851860

Romer, A. L., Knodt, A. R., Sison, M. L., Ireland, D., Houts, R., Ramrakha, S., Poulton, R., Keenan, R., Melzer, T. R., … Hariri, A. R. (2019). Replicability of structural brain alterations associated with general psychopathology: Evidence from a population-representative birth cohort. Molecular Psychiatry. Advance online publication. doi: 10.1038/s41380-019-0621-z

Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024

Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J., & Darlow, B. A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical, 22, 101780. doi: 10.1016/j.nicl.2019.101780

Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K.-L., … Pascoe, M., Almuqbel, M. M., … Miller, D. H., Dalrymple-Alford, J. C., & Anderson, T. J. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s Disease. Frontiers in Neurology, 10, 391. doi: 10.3389/fneur.2019.00391

Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage, 189, 516-532. doi: 10.1016/j.neuroimage.2019.01.068

Borlase, N., Melzer, T. R., Eggleston, M. J. F., Darling, K. A., & Rucklidge, J. J. (2019). Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: Results of a randomised placebo-controlled trial. Nutritional Neuroscience. Advance online publication. doi: 10.1080/1028415x.2019.1574329

Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., … Palmer, D. N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain & Behavior, 8, e01096. doi: 10.1002/brb3.1096

Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy, 26(10), 2366-2378. doi: 10.1016/j.ymthe.2018.07.015

Groves, S. J., Pitcher, T. L., Melzer, T. R., Jordan, J., Carter, J. D., Malhi, G. S., … Porter, R. J. (2018). Brain activation during processing of genuine facial emotion in depression: Preliminary findings. Journal of Affective Disorders, 225, 91-96. doi: 10.1016/j.jad.2017.07.049

Wheelock, M. D., Austin, N. C., Bora, S., Eggebrecht, A. T., Melzer, T. R., Woodward, L. J., & Smyser, C. D. (2018). Altered functional network connectivity relates to motor development in children born very preterm. NeuroImage, 183, 574-583. doi: 10.1016/j.neuroimage.2018.08.051

Snell, D. L., Martin, R., Macleod, A. D., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T., Hooper, G. J., & Anderson, T. (2018). Untangling chronic pain and post-concussion symptoms: The significance of depression. Brain Injury, 32(5), 583-592. doi: 10.1080/02699052.2018.1432894

Castellazzi, G., Debernard, L., Melzer, T. R., Dalrymple-Alford, J. C., D'Angelo, E., Miller, D. H., … Mason, D. F. (2018). Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis. Frontiers in Neurology, 9, 690. doi: 10.3389/fneur.2018.00690

Lean, R. E., Melzer, T. R., Bora, S., Watts, R., & Woodward, L. J. (2017). Attention and regional gray matter development in very preterm children at age 12 years. Journal of the International Neuropsychological Society, 23(7), 539-550. doi: 10.1017/S1355617717000388

Wood, K.-L., Myall, D. J., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., … Anderson, T. J., & Dalrymple-Alford, J. C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson's disease: A 4-year longitudinal study. npj Parkinson's Disease, 2, 15027. doi: 10.1038/npjparkd.2015.27

Almuqbel, M., Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Wood, K.-L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson’s disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. doi: 10.1016/j.parkreldis.2015.11.008

Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Watts, R., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLoS ONE, 10(12), e0143923. doi: 10.1371/journal.pone.0143923

Innes, C. R. H., Kelly, P. T., Hlavac, M., Melzer, T. R., & Jones, R. D. (2015). Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness. Sleep, 38(5), 699-706. doi: 10.5665/sleep.4658

Debernard, L., Melzer, T. R., Alla, S., Eagle, J., Van Stockum, S., Graham, C., Osborne, J. R., Dalrymple-Alford, J. C., Miller, D. H., & Mason, D. F. (2015). Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Research: Neuroimaging, 234(3), 352-361. doi: 10.1016/j.pscychresns.2015.10.004

Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: An ASL-MRI study. Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. doi: 10.1038/jcbfm.2014.40

Debernard, L., Melzer, T. R., Van Stockum, S., Graham, C., Wheeler-Kingshott, C. A. M., Dalrymple-Alford, J. C., Miller, D. H., & Mason, D. F. (2014). Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 86(5), 544-551. doi: 10.1136/jnnp-2013-305612

Macrae, P. R., Jones, R. D., Myall, D. J., Melzer, T. R., & Huckabee, M.-L. (2013). Cross-sectional area of the anterior belly of the digastric muscle: Comparison of MRI and ultrasound measures. Dysphagia, 28(3), 375-380. doi: 10.1007/s00455-012-9443-8

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80(8), 1841-1849. doi: 10.1212/WNL.0b013e3182929f62

Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Reduced striatal volumes in Parkinson's disease: A magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. doi: 10.1186/2047-9158-1-17

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 83, 188-194. doi: 10.1136/jnnp-2011-300828

Innes, C. R. H., Lee, D., Chen, C., Ponder-Sutton, A. M., Melzer, T. R., & Jones, R. D. (2011). Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders. Quarterly Journal of Experimental Psychology, 64(9), 1714-1725. doi: 10.1080/17470218.2011.555821

Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., … Dalrymple-Alford, J. C., & Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease. Brain, 134(3), 845-855. doi: 10.1093/brain/awq377

Dalrymple-Alford, J. C., Livingston, L., MacAskill, M. R., Graham, C., Melzer, T. R., Porter, R. J., … Anderson, T. J. (2011). Characterizing mild cognitive impairment in Parkinson's disease. Movement Disorders, 26(4), 629-636. doi: 10.1002/mds.23592

Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., … Keenan, R., Wells, S., Porter, R. J., … Anderson, T. J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson disease. Neurology, 75(19), 1717-1725. doi: 10.1212/WNL.0b013e3181fc29c9

Butler, A. P. H., Anderson, N. G., Tipples, R., Cook, N., Watts, R., Meyer, J., … Melzer, T. R., & Butler, P. H. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments & Methods in Physics Research Section A, 591(1), 141-146. doi: 10.1016/j.nima.2008.03.039

Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., & Butler, P. H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Sciences in Medicine, 31(4), 300-306.

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Journal - Research Other

Almuqbel, M. M., Leeper, G. J., Petelo, J. F., Page, T. J., & Melzer, T. R. (2018). MRI artefact in the rectum caused by ingested orthodontic brackets. Radiography, 24(2), e48-e50. doi: 10.1016/j.radi.2017.10.002

Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R. J., & Melzer, T. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology, 91(1087), 20170593. doi: 10.1259/bjr.20170593

Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., & Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: Mapping the road ahead. BMC Pediatrics, 15, 90. doi: 10.1186/s12887-015-0413-9

Melzer, T. R. (2013). The evolution of diffusion tensor imaging in Parkinson's disease research. Movement Disorders, 28(9), 1316. doi: 10.1002/mds.25566

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