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Otago Medical School staff profiles

Dr Tracy Melzer

PositionMRI Research Manager
DepartmentDepartment of Medicine (Christchurch)
QualificationsBA, BSc(Hons), PhD
Research summaryParkinson's disease

Research

As MRI Research Manager at the NZ Brain Research Institute, I oversee all imaging at the NZBRI. This provides me with the opportunity to become involved in a wide range of neurological research, including child development, mild traumatic brain injury, post-traumatic stress disorder, neurodegenerative diseases, and more. As a Research Fellow in the Department of Medicine, my primary focus is on the development and application of Magnetic Resonance Imaging (MRI) techniques to advance our understanding of cognitive decline in Parkinson’s disease.

Publications

Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J., & Darlow, B. A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical. Advance online publication. doi: 10.1016/j.nicl.2019.101780

Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K.-L., … Pascoe, M., Almuqbel, M. M., … Miller, D. H., & Dalrymple-Alford, J. C. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s Disease. Frontiers in Neurology. Advance online publication. doi: 10.3389/fneur.2019.00391

Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage, 189, 516-532. doi: 10.1016/j.neuroimage.2019.01.068

Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024

Borlase, N., Melzer, T. R., Eggleston, M. J. F., Darling, K. A., & Rucklidge, J. J. (2019). Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: Results of a randomised placebo-controlled trial. Nutritional Neuroscience. Advance online publication. doi: 10.1080/1028415x.2019.1574329

Journal - Research Article

Pascoe, M. J., Melzer, T. R., Horwood, L. J., Woodward, L. J., & Darlow, B. A. (2019). Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults. NeuroImage: Clinical. Advance online publication. doi: 10.1016/j.nicl.2019.101780

Borlase, N., Melzer, T. R., Eggleston, M. J. F., Darling, K. A., & Rucklidge, J. J. (2019). Resting-state networks and neurometabolites in children with ADHD after 10 weeks of treatment with micronutrients: Results of a randomised placebo-controlled trial. Nutritional Neuroscience. Advance online publication. doi: 10.1080/1028415x.2019.1574329

Ella, A., Barriére, D. A., Adriaensen, H., Palmer, D. N., Melzer, T. R., Mitchell, N. L., & Keller, M. (2019). The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 9(3), 44-51. doi: 10.1093/af/vfz024

Elliott, M. L., Knodt, A. R., Cooke, M., Kim, M. J., Melzer, T. R., Keenan, R., Ireland, D., Ramrakha, S., Poulton, R., … Hariri, A. R. (2019). General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. NeuroImage, 189, 516-532. doi: 10.1016/j.neuroimage.2019.01.068

Melzer, T. R., Stark, M. R., Keenan, R. J., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Grenfell, S., Horne, K.-L., … Pascoe, M., Almuqbel, M. M., … Miller, D. H., & Dalrymple-Alford, J. C. (2019). Beta amyloid deposition is not associated with cognitive impairment in Parkinson’s Disease. Frontiers in Neurology. Advance online publication. doi: 10.3389/fneur.2019.00391

Douglas, K. M., Groves, S., Porter, R. J., Jordan, J., Wilson, L., Melzer, T. R., … Bell, C. J. (2019). Traumatic imagery following glucocorticoid administration in earthquake-related post-traumatic stress disorder: A preliminary functional magnetic resonance imaging study. Australian & New Zealand Journal of Psychiatry. Advance online publication. doi: 10.1177/0004867419851860

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2019). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation. Advance online publication. doi: 10.1080/09638288.2018.1542461

Mitchell, N. L., Russell, K. N., Wellby, M. P., Wicky, H. E., Schoderboeck, L., Barrell, G. K., Melzer, T. R., … Hughes, S. M., & Palmer, D. N. (2018). Longitudinal in vivo monitoring of CNS demonstrates the efficacy of gene therapy in a sheep model of CLN5 Batten disease. Molecular Therapy. Advance online publication. doi: 10.1016/j.ymthe.2018.07.015

Groves, S. J., Pitcher, T. L., Melzer, T. R., Jordan, J., Carter, J. D., Malhi, G. S., … Porter, R. J. (2018). Brain activation during processing of genuine facial emotion in depression: Preliminary findings. Journal of Affective Disorders, 225, 91-96. doi: 10.1016/j.jad.2017.07.049

Snell, D. L., Martin, R., Macleod, A. D., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T., Hooper, G. J., & Anderson, T. (2018). Untangling chronic pain and post-concussion symptoms: The significance of depression. Brain Injury, 32(5), 583-592. doi: 10.1080/02699052.2018.1432894

Wheelock, M. D., Austin, N. C., Bora, S., Eggebrecht, A. T., Melzer, T. R., Woodward, L. J., & Smyser, C. D. (2018). Altered functional network connectivity relates to motor development in children born very preterm. NeuroImage, 183, 574-583. doi: 10.1016/j.neuroimage.2018.08.051

Castellazzi, G., Debernard, L., Melzer, T. R., Dalrymple-Alford, J. C., D'Angelo, E., Miller, D. H., … Mason, D. F. (2018). Functional connectivity alterations reveal complex mechanisms based on clinical and radiological status in mild relapsing remitting multiple sclerosis. Frontiers in Neurology, 9, 690. doi: 10.3389/fneur.2018.00690

Russell, K. N., Mitchell, N. L., Anderson, N. G., Bunt, C. R., Wellby, M. P., Melzer, T. R., … Palmer, D. N. (2018). Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses. Brain & Behavior. Advance online publication. doi: 10.1002/brb3.1096

Lean, R. E., Melzer, T. R., Bora, S., Watts, R., & Woodward, L. J. (2017). Attention and regional gray matter development in very preterm children at age 12 years. Journal of the International Neuropsychological Society, 23(7), 539-550. doi: 10.1017/S1355617717000388

Wood, K.-L., Myall, D. J., Livingston, L., Melzer, T. R., Pitcher, T. L., MacAskill, M. R., … Anderson, T. J., & Dalrymple-Alford, J. C. (2016). Different PD-MCI criteria and risk of dementia in Parkinson's disease: A 4-year longitudinal study. npj Parkinson's Disease, 2, 15027. doi: 10.1038/npjparkd.2015.27

Almuqbel, M., Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Wood, K.-L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2016). Metabolite ratios in the posterior cingulate cortex do not track cognitive decline in Parkinson’s disease in a clinical setting. Parkinsonism & Related Disorders, 22, 54-61. doi: 10.1016/j.parkreldis.2015.11.008

Innes, C. R. H., Kelly, P. T., Hlavac, M., Melzer, T. R., & Jones, R. D. (2015). Decreased regional cerebral perfusion in moderate-severe obstructive sleep apnoea during wakefulness. Sleep, 38(5), 699-706. doi: 10.5665/sleep.4658

Melzer, T. R., Myall, D. J., MacAskill, M. R., Pitcher, T. L., Livingston, L., Watts, R., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2015). Tracking Parkinson's disease over one year with multimodal magnetic resonance imaging in a group of older patients with moderate disease. PLoS ONE, 10(12), e0143923. doi: 10.1371/journal.pone.0143923

Debernard, L., Melzer, T. R., Alla, S., Eagle, J., Van Stockum, S., Graham, C., Osborne, J. R., Dalrymple-Alford, J. C., Miller, D. H., & Mason, D. F. (2015). Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Research: Neuroimaging, 234(3), 352-361. doi: 10.1016/j.pscychresns.2015.10.004

Le Heron, C. J., Wright, S. L., Melzer, T. R., Myall, D. J., MacAskill, M. R., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2014). Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: An ASL-MRI study. Journal of Cerebral Blood Flow & Metabolism, 34, 964-970. doi: 10.1038/jcbfm.2014.40

Debernard, L., Melzer, T. R., Van Stockum, S., Graham, C., Wheeler-Kingshott, C. A. M., Dalrymple-Alford, J. C., Miller, D. H., & Mason, D. F. (2014). Reduced grey matter perfusion without volume loss in early relapsing-remitting multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 86(5), 544-551. doi: 10.1136/jnnp-2013-305612

Macrae, P. R., Jones, R. D., Myall, D. J., Melzer, T. R., & Huckabee, M.-L. (2013). Cross-sectional area of the anterior belly of the digastric muscle: Comparison of MRI and ultrasound measures. Dysphagia, 28(3), 375-380. doi: 10.1007/s00455-012-9443-8

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2013). White matter microstructure deteriorates across cognitive stages in Parkinson disease. Neurology, 80(8), 1841-1849. doi: 10.1212/WNL.0b013e3182929f62

Melzer, T. R., Watts, R., MacAskill, M. R., Pitcher, T. L., Livingston, L., Keenan, R. J., Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Grey matter atrophy in cognitively impaired Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 83, 188-194. doi: 10.1136/jnnp-2011-300828

Pitcher, T. L., Melzer, T. R., MacAskill, M. R., Graham, C. F., Livingston, L., Keenan, R. J., … Dalrymple-Alford, J. C., & Anderson, T. J. (2012). Reduced striatal volumes in Parkinson's disease: A magnetic resonance imaging study. Translational Neurodegeneration, 1(1), 17. doi: 10.1186/2047-9158-1-17

Innes, C. R. H., Lee, D., Chen, C., Ponder-Sutton, A. M., Melzer, T. R., & Jones, R. D. (2011). Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders. Quarterly Journal of Experimental Psychology, 64(9), 1714-1725. doi: 10.1080/17470218.2011.555821

Dalrymple-Alford, J. C., Livingston, L., MacAskill, M. R., Graham, C., Melzer, T. R., Porter, R. J., … Anderson, T. J. (2011). Characterizing mild cognitive impairment in Parkinson's disease. Movement Disorders, 26(4), 629-636. doi: 10.1002/mds.23592

Melzer, T. R., Watts, R., MacAskill, M. R., Pearson, J. F., Rüeger, S., Pitcher, T. L., Livingston, L., Graham, C., Keenan, R., … Dalrymple-Alford, J. C., & Anderson, T. J. (2011). Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease. Brain, 134(3), 845-855. doi: 10.1093/brain/awq377

Dalrymple-Alford, J. C., MacAskill, M. R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T. R., … Keenan, R., Wells, S., Porter, R. J., … Anderson, T. J. (2010). The MoCA: Well-suited screen for cognitive impairment in Parkinson disease. Neurology, 75(19), 1717-1725. doi: 10.1212/WNL.0b013e3181fc29c9

Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., & Butler, P. H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Sciences in Medicine, 31(4), 300-306.

Butler, A. P. H., Anderson, N. G., Tipples, R., Cook, N., Watts, R., Meyer, J., … Melzer, T. R., & Butler, P. H. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments & Methods in Physics Research Section A, 591(1), 141-146. doi: 10.1016/j.nima.2008.03.039

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Journal - Research Other

Almuqbel, M. M., Leeper, G. J., Petelo, J. F., Page, T. J., & Melzer, T. R. (2018). MRI artefact in the rectum caused by ingested orthodontic brackets. Radiography, 24(2), e48-e50. doi: 10.1016/j.radi.2017.10.002

Almuqbel, M. M., Leeper, G., Palmer, D. N., Mitchell, N. L., Russell, K. N., Keenan, R. J., & Melzer, T. (2018). Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI. British Journal of Radiology, 91(1087), 20170593. doi: 10.1259/bjr.20170593

Darlow, B. A., Horwood, L. J., Woodward, L. J., Elliott, J. M., Troughton, R. W., Elder, M. J., Epton, M. J., Stanton, J. D., Swanney, M. P., Keenan, R., Melzer, T. R., McKelvey, V. A., Levin, K., Meeks, M. G., Espiner, E. A., Cameron, V. A., & Martin, J. (2015). The New Zealand 1986 very low birth weight cohort as young adults: Mapping the road ahead. BMC Pediatrics, 15, 90. doi: 10.1186/s12887-015-0413-9

Melzer, T. R. (2013). The evolution of diffusion tensor imaging in Parkinson's disease research. Movement Disorders, 28(9), 1316. doi: 10.1002/mds.25566

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