Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Otago Medical School staff profiles

Dr Yoshio Nakatani

PositionResearch Fellow
DepartmentDepartment of Microbiology and Immunology
QualificationsPhD
Research summaryProtien structure and function

Research

Working with Profesor Greg Cook.

Publications

Darnell, R. L., Nakatani, Y., Knottenbelt, M. K., Gebhard, S., & Cook, G. M. (2019). Functional characterization of BcrR: A one-component transmembrane signal transduction system for bacitracin resistance. Microbiology. Advance online publication. doi: 10.1099/mic.0.000781

Sharif, S., Ueda, N., Nakatani, Y., Wise, L. M., Clifton, S., Lateef, Z., Mercer, A. A., & Fleming, S. B. (2019). Chemokine-binding proteins encoded by parapoxvirus of red deer of New Zealand display evidence of gene duplication and divergence of ligand specificity. Frontiers in Microbiology, 10, 1421. doi: 10.3389/fmicb.2019.01421

Petri, J., Nakatani, Y., Montgomery, M. G., Ferguson, S. A., Aragão, D., Leslie, A. G. W., Heikal, A., … Cook, G. M. (2019). Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum. Open Biology, 9(6), 190066. doi: 10.1098/rsob.190066

Heikal, A., Nakatani, Y., Jiao, W., Wilson, C., Rennison, D., Weimar, M. R., … Cook, G. M. (2018). ‘Tethering’ fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase. Bioorganic & Medicinal Chemistry Letters, 28(13), 2239-2243. doi: 10.1016/j.bmcl.2018.05.048

Petri, J., Shimaki, Y., Jiao, W., Bridges, H. R., Parker, E. J., Aragão, D., Cook, G. M., & Nakatani, Y. (2018). Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochimica et Biophysica Acta: Bioenergetics. Advance online publication. doi: 10.1016/j.bbabio.2018.03.014

Journal - Research Article

Darnell, R. L., Nakatani, Y., Knottenbelt, M. K., Gebhard, S., & Cook, G. M. (2019). Functional characterization of BcrR: A one-component transmembrane signal transduction system for bacitracin resistance. Microbiology. Advance online publication. doi: 10.1099/mic.0.000781

Petri, J., Nakatani, Y., Montgomery, M. G., Ferguson, S. A., Aragão, D., Leslie, A. G. W., Heikal, A., … Cook, G. M. (2019). Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum. Open Biology, 9(6), 190066. doi: 10.1098/rsob.190066

Sharif, S., Ueda, N., Nakatani, Y., Wise, L. M., Clifton, S., Lateef, Z., Mercer, A. A., & Fleming, S. B. (2019). Chemokine-binding proteins encoded by parapoxvirus of red deer of New Zealand display evidence of gene duplication and divergence of ligand specificity. Frontiers in Microbiology, 10, 1421. doi: 10.3389/fmicb.2019.01421

Heikal, A., Nakatani, Y., Jiao, W., Wilson, C., Rennison, D., Weimar, M. R., … Cook, G. M. (2018). ‘Tethering’ fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase. Bioorganic & Medicinal Chemistry Letters, 28(13), 2239-2243. doi: 10.1016/j.bmcl.2018.05.048

Petri, J., Shimaki, Y., Jiao, W., Bridges, H. R., Parker, E. J., Aragão, D., Cook, G. M., & Nakatani, Y. (2018). Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. Biochimica et Biophysica Acta: Bioenergetics. Advance online publication. doi: 10.1016/j.bbabio.2018.03.014

Cook, G. M., Hards, K., Dunn, E., Heikal, A., Nakatani, Y., Greening, C., … Berney, M. (2017). Oxidative phosphorylation as a target space for tuberculosis: Success, caution, and future directions. Microbiology Spectrum, 5(3), TBTB2-0014-2016. doi: 10.1128/microbiolspec.TBTB2-0014-2016

Nakatani, Y., Jiao, W., Aragão, D., Shimaki, Y., Petri, J., Parker, E. J., & Cook, G. M. (2017). Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 Å. Acta Crystallographica Section F, 73(10), 541-549. doi: 10.1107/s2053230x17013073

Nakatani, Y., Opel-Reading, H. K., Merker, M., Machado, D., Andres, S., Kumar, S. S., … Aung, H. L., Cook, G. M., … Krause, K., & Köser, C. U. (2017). Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance. Antimicrobial Agents & Chemotherapy, 61(12), e01575-17. doi: 10.1128/aac.01575-17

Blaza, J. N., Bridges, H. R., Aragão, D., Dunn, E. A., Heikal, A., Cook, G. M., Nakatani, Y., & Hirst, J. (2017). The mechanism of catalysis by type-II NADH:quinone oxidoreductases. Scientific Reports, 7, 40165. doi: 10.1038/srep40165

Kawagishi, Y., Pankhurst, M. W., Nakatani, Y., & McLennan, I. S. (2017). Anti-Müllerian hormone signalling is influenced by Follistatin 288, but not 14 other transforming growth factor beta superfamily regulators. Molecular Reproduction & Development, 84(7), 626-637. doi: 10.1002/mrd.22828

Sharif, S., Nakatani, Y., Wise, L., Corbett, M., Real, N. C., Stuart, G. S., Lateef, Z., Krause, K., Mercer, A. A., & Fleming, S. B. (2016). A broad-spectrum chemokine-binding protein of bovine papular stomatitis virus inhibits neutrophil and monocyte infiltration in inflammatory and wound models of mouse skin. PLoS ONE, 11(12), e0168007. doi: 10.1371/journal.pone.0168007

Wilkinson, M. E., Nakatani, Y., Staals, R. H. J., Kieper, S. N., Opel-Reading, H. K., McKenzie, R. E., Fineran, P. C., & Krause, K. L. (2016). Structural plasticity and in vivo activity of Cas1 from the type I-F CRISPR-Cas system. Biochemical Journal, 473, 1063-1072. doi: 10.1042/bcj20160078

Poen, S., Nakatani, Y., Opel-Reading, H. K., Lassé, M., Dobson, R. C. J., & Krause, K. L. (2016). Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery. Biochemical Journal, 473, 1267-1280. doi: 10.1042/bcj20160186

Murphy, J. M., Nakatani, Y., Jamieson, S. A., Dai, W., Lucet, I. S., & Mace, P. D. (2015). Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase. Structure, 23(11), 2111-2121. doi: 10.1016/j.str.2015.08.017

Spencer, E. S., Dale, E. J., Gommans, A. L., Rutledge, M. T., Vo, C. T., Nakatani, Y., Gamble, A. B., Smith, R. A. J., Wilbanks, S. M., Hampton, M. B., & Tyndall, J. D. A. (2015). Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor. European Journal of Medicinal Chemistry, 93, 501-510. doi: 10.1016/j.ejmech.2015.02.012

Couñago, R. M., Knapp, K. M., Nakatani, Y., Fleming, S. B., Corbett, M., Wise, L. M., Mercer, A. A., & Krause, K. L. (2015). Structures of orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity. Structure, 23(7), 1199-1213. doi: 10.1016/j.str.2015.04.023

Heikal, A., Nakatani, Y., Dunn, E., Weimar, M. R., Day, C. L., Baker, E. N., … Cook, G. M. (2014). Structure of the bacterial type II NADH dehydrogenase: A monotopic membrane protein with an essential role in energy generation. Molecular Microbiology, 91(5), 950-964. doi: 10.1111/mmi.12507

Nakatani, Y., Larsen, D. S., Cutfield, S. M., & Cutfield, J. F. (2014). Major change in regiospecificity for the exo-1,3-β-glucanase from Candida albicans following its conversion to a glycosynthase. Biochemistry, 53(20), 3318-3326. doi: 10.1021/bi500239m

Davis, E., Scaletti-Hutchinson, E., Opel-Reading, H., Nakatani, Y., & Krause, K. L. (2014). The structure of alanine racemase from Acinetobacter baumannii. Acta Crystallographica Section F, 70(9), 1199-1205.

Nakatani, Y., Kleffmann, T., Linke, K., Condon, S. M., Hinds, M. G., & Day, C. L. (2013). Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase. Biochemical Journal, 450(3), 629-638. doi: 10.1042/BJ20121702

Shankar, M., Wilbanks, S. M., Nakatani, Y., Monk, B. C., & Tyndall, J. D. A. (2013). Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata. Acta Crystallographica Section D, 69(8), 1580-1586. doi: 10.1107/S0907444913010949

Nakatani, Y., Cutfield, S. M., Cowieson, N. P., & Cutfield, J. F. (2012). Structure and activity of exo-1,3/1,4-β-glucanase from marine bacterium Pseudoalteromonas sp. BB1 showing a novel C-terminal domain. FEBS Journal, 279(3), 464-478. doi: 10.1111/j.1742-4658.2011.08439.x

Budhidarmo, R., Nakatani, Y., & Day, C. L. (2012). RINGs hold the key to ubiquitin transfer. Trends in Biochemical Sciences, 37(2), 58-65. doi: 10.1016/j.tibs.2011.11.001

Patrick, W. M., Nakatani, Y., Cutfield, S. M., Sharpe, M. L., Ramsay, R. J., & Cutfield, J. F. (2010). Carbohydrate binding sites in Candida albicans exo-β-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance. FEBS Journal, 277, 4549-4561. doi: 10.1111/j.1742-4658.2010.07869.x

Nakatani, Y., Lamont, I. L., & Cutfield, J. F. (2010). Discovery and characterization of a distinctive exo-1,3/1,4-β-glucanase from the marine bacterium Pseudoalteromonas sp. strain BB1. Applied & Environmental Microbiology, 76(20), 6760-6768. doi: 10.1128/AEM.00758-10

More publications...