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Otago Medical School staff profiles

Dr Juliet Pullar

PositionResearch Fellow
DepartmentDepartment of Pathology and Biomedical Science(UOC)
QualificationsBSc(Hons)(Cant), PhD(Otago), DPH (Otago)
Research summaryvitamin C in health and disease

Research

I am currently involved in undertaking human studies investigating the bioavailability of vitamin C and its role in health and disease. We have completed two human studies on the bioavailability of vitamin C from kiwifruit, demonstrating the intakes required in those with low vitamin C levels to obtain ‘healthy’ or ‘optimal’ vitamin C status.

We have also compared the relative bioavailability of vitamin C in kiwifruit to a supplemental source and shown effects on skeletal muscle levels and subjective mood. In our most recent vitamin C study we have delved into the effects of vitamin C on male fertility and also neutrophil function, and it is in these areas that further in vitro work is planned. I am also interested in population health and am currently investigating vitamin C levels in young male students within the Christchurch population.

Publications

Vissers, M. C. M., Pullar, J. M., & Peskin, A. V. (2018). Myeloperoxidase-derived oxidants hypochlorous acid and chloramines: Microbicidal marvels and inflammatory mischief makers. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 305-326). Boca Raton, FL: CRC Press.

Pullar, J. M., Carr, A. C., Bozonet, S. M., & Vissers, M. C. M. (2018). High vitamin C status is associated with elevated mood in male tertiary students. Antioxidants, 7(7), 91. doi: 10.3390/antiox7070091

Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018). Vitamin C and immune cell function in inflammation and cancer [Review]. Biochemical Society Transactions. Advance online publication. doi: 10.1042/bst20180169

Pullar, J. M., Bayer, S., & Carr, A. C. (2018). Appropriate handling, processing and analysis of blood samples is essential to avoid oxidation of vitamin C to dehydroascorbic acid. Antioxidants, 7(2), 29. doi: 10.3390/antiox7020029

Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The roles of vitamin C in skin health. Nutrients, 9(8), 866. doi: 10.3390/nu9080866

Chapter in Book - Research

Vissers, M. C. M., Pullar, J. M., & Peskin, A. V. (2018). Myeloperoxidase-derived oxidants hypochlorous acid and chloramines: Microbicidal marvels and inflammatory mischief makers. In M. C. M. Vissers, M. B. Hampton & A. J. Kettle (Eds.), Hydrogen peroxide metabolism in health and disease. (pp. 305-326). Boca Raton, FL: CRC Press.

Vissers, M. C. M., Carr, A. C., Pullar, J. M., & Bozonet, S. M. (2013). The bioavailability of vitamin C from kiwifruit. In M. Boland & P. J. Moughan (Eds.), Advances in food and nutrition research (Vol. 68): Nutritional benefits of kiwifruit. (pp. 125-147). Waltham, MA: Academic Press. doi: 10.1016/b978-0-12-394294-4.00007-9

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Journal - Research Article

Pullar, J. M., Carr, A. C., Bozonet, S. M., & Vissers, M. C. M. (2018). High vitamin C status is associated with elevated mood in male tertiary students. Antioxidants, 7(7), 91. doi: 10.3390/antiox7070091

Pullar, J. M., Bayer, S., & Carr, A. C. (2018). Appropriate handling, processing and analysis of blood samples is essential to avoid oxidation of vitamin C to dehydroascorbic acid. Antioxidants, 7(2), 29. doi: 10.3390/antiox7020029

Ang, A., Pullar, J. M., Currie, M. J., & Vissers, M. C. M. (2018). Vitamin C and immune cell function in inflammation and cancer [Review]. Biochemical Society Transactions. Advance online publication. doi: 10.1042/bst20180169

Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The roles of vitamin C in skin health. Nutrients, 9(8), 866. doi: 10.3390/nu9080866

Pullar, J. M., Carr, A. C., Bozonet, S. M., Rosengrave, P., Kettle, A. J., & Vissers, M. C. M. (2017). Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology, 5(3), 431-438. doi: 10.1111/andr.12327

Pearson, J. F., Pullar, J. M., Wilson, R., Spittlehouse, J. K., Vissers, M. C. M., Skidmore, P. M. L., Willis, J., Cameron, V. A., & Carr, A. C. (2017). Vitamin C status correlates with markers of metabolic and cognitive health in 50-year-olds: Findings of the CHALICE Cohort Study. Nutrients, 9(8), 831. doi: 10.3390/nu9080831

Carr, A. C., Pullar, J. M., Bozonet, S. M., & Vissers, M. C. M. (2016). Marginal ascorbate status (Hypovitaminosis C) results in an attenuated response to vitamin C supplementation. Nutrients, 8(6), 341. doi: 10.3390/nu8060341

Bozonet, S. M., Carr, A. C., Pullar, J. M., & Vissers, M. C. M. (2015). Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. Nutrients, 7(4), 2574-2588. doi: 10.3390/nu7042574

Carr, A. C., Bozonet, S. M., Pullar, J. M., & Vissers, M. C. M. (2013). Mood improvement in young adult males following supplementation with gold kiwifruit, a high-vitamin C food. Journal of Nutritional Science, 2, e24. doi: 10.1017/jns.2013.12

Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013). A randomized steady-state bioavailability study of synthetic versus natural (kiwifruit-derived) vitamin C. Nutrients, 5(9), 3684-3695. doi: 10.3390/nu5093684

Carr, A. C., Bozonet, S. M., Pullar, J. M., Simcock, J. W., & Vissers, M. C. M. (2013). Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations. American Journal of Clinical Nutrition, 97, 800-807. doi: 10.3945/ajcn.112.053207

Carr, A. C., Pullar, J. M., Moran, S., & Vissers, M. C. M. (2012). Bioavailability of vitamin C from kiwifruit in non-smoking males: Determination of ‘healthy’ and ‘optimal’ intakes. Journal of Nutritional Science, 1, e14. doi: 10.1017/jns.2012.15

Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242

Cox, A. G., Pullar, J. M., Hughes, G., Ledgerwood, E. C., & Hampton, M. B. (2008). Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radical Biology & Medicine, 44(6), 1001-1009. doi: 10.1016/j.freeradbiomed.2007.11.017

Thomson, S. J., Cox, A. G., Cuddihy, S. L., Pullar, J. M., & Hampton, M. B. (2008). Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. Biochemical & Biophysical Research Communications, 375(1), 145-150. doi: 10.1016/j.bbrc.2008.07.133

Thomson, S. J., Brown, K. K., Pullar, J. M., & Hampton, M. B. (2006). Phenethyl isothiocyanate triggers apoptosis in Jurkat cells made resistant by the overexpression of Bcl-2. Cancer Research, 66(13), 6772-6777.

Pullar, J. M., Thomson, S. J., King, M. J., Turnbull, C. I., Midwinter, R. G., & Hampton, M. B. (2004). The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis. Carcinogenesis, 25(5), 765-772.

Pullar, J. M., & Hampton, M. B. (2002). Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. Journal of Biological Chemistry, 277(22), 19402-19407.

Pullar, J., Winterbourn, C. C., & Vissers, M. C. M. (2002). The effect of hypochlorous acid on the expression of adhesion molecules and activation of NF-κ in cultured human endothelial cells. Antioxidants & Redox Signaling, 4(1), 5-15.

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2001). Glutathione oxidation by hypochlorous acid in endothelial cells produces glutathione sulfonamide as a major product but not glutathione disulfide. Journal of Biological Chemistry, 276(25), 22120-22125. doi: 10.1074/jbc.M102088200

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2000). Living with a killer: The effects of hypochlorous acid on mammalian cells. IUBMB Life, 50, 259-266.

Pullar, J. M., Winterbourn, C. C., & Vissers, M. C. M. (1999). Loss of GSH and thiol enzymes in endothelial cellls exposed to sublethal concentrations of hypochlorous acid. American Journal of Physiology: Heart & Circulatory Physiology, 277, H1505-H1512.

Vissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999). Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochemical Journal, 344, 443-449.

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Journal - Research Other

Carr, A., Pullar, J., Forbes, L., & Rosengrave, P. (2014). Working mothers are disadvantaged by limited funding for health research. New Zealand Medical Journal, 127(1398). Retrieved from http://www.nzma.org.nz/journal

Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2013). Vitamin C supplementation and kidney stone risk. New Zealand Medical Journal, 126(1384). Retrieved from http://www.nzma.org.nz/journal

Carr, A. C., Pullar, J. M., & Vissers, M. C. M. (2013). Beating the blues: The association between fruit and vegetable intake and improved mood. New Zealand Medical Journal, 126(1384). Retrieved from http://www.nzma.org.nz/journal

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