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Otago Medical School staff profiles

Dr Andrew Cridge

PositionSenior Research Fellow
DepartmentDepartment of Biochemistry
QualificationsBSc(Hons) PhD
Research summaryEvolution and development

Research

My research focuses on environmental physiology, specifically how insects adapt to changes in their environment and coordinate that at a molecular level during embryonic development. Aligned to this I am also interested in how epigenetics can control gene expression through regulating transcription and translation in response to external environmental signals, especially during development. The aim of my research is to develop an understanding of the cellular response to environmental cues and how that affects normal development. I have an additional interest in global change biology and am involved in a longitudinal study to assess the impact of land use on bacterial fauna by determining the loss of biodiversity in bacterial species using metagenomics.

Research Interests:

  • Evolution of insect development
  • Transcription and translation control in growth and differentiation
  • Genome structure organization and its role in gene expression
  • The impact of land use on bacterial biodiversity

Publications

Oliphant, A., Hawkes, M. K. N., Cridge, A. G., & Dearden, P. K. (2020). Transcriptomic characterisation of neuropeptides and their putative cognate G protein-coupled receptors during late embryo and stage-1 juvenile development of the Aotearoa-New Zealand crayfish, Paranephrops zealandicus. General & Comparative Endocrinology, 292, 113443. doi: 10.1016/j.ygcen.2020.113443

Cridge, A. G., Dearden, P. K., & Brownfield, L. R. (2019). The developmental hourglass in the evolution of embryogenesis. In L. N. de la Rosa & G. Müller (Eds.), Evolutionary developmental biology: A reference guide. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-33038-9

Panfilio, K. A., Vargas Jentzsch, I. M., Benoit, J. B., Erezyilmaz, D., Suzuki, Y., Colella, S., … Duncan, E. J., … Cridge, A. G., … Dearden, P. K., … Leask, M., … Lovegrove, M. R., … Tidswell, O., … Richards, S. (2019). Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome. Genome Biology, 20, 64. doi: 10.1186/s13059-019-1660-0

Vangala, G., Imhoff, F. M., Squires, C. M. L., Cridge, A. G., & Baird, S. K. (2019). Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D. Experimental Cell Research, 383, 111494. doi: 10.1016/j.yexcr.2019.07.007

Chen, S., Nimick, M., Cridge, A. G., Hawkins, B. C., & Rosengren, R. J. (2018). Anticancer potential of novel curcumin analogs towards castrate-resistant prostate cancer. International Journal of Oncology, 52(2), 579-588. doi: 10.3892/ijo.2017.4207

Chapter in Book - Research

Cridge, A. G., Dearden, P. K., & Brownfield, L. R. (2019). The developmental hourglass in the evolution of embryogenesis. In L. N. de la Rosa & G. Müller (Eds.), Evolutionary developmental biology: A reference guide. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-33038-9

Cridge, A., Harrop, T., Lovegrove, M., Remnant, E., & Dearden, P. (2017). Nutrition and epigenetic change in insects: Evidence and implications. In H. Verlinden (Ed.), Advances in insect physiology (Vol. 53): Insect epigenetics. (pp. 31-54). London, UK: Academic Press. doi: 10.1016/bs.aiip.2017.06.001

Osborne, A. J., Duncan, E. J., Cridge, A. G., & Dearden, P. K. (2014). Epigenetics and the maternal germline. In T. Tollefsbol (Ed.), Transgenerational epigenetics: Evidence and debate. (pp. 27-41). London, UK: Academic Press. doi: 10.1016/B978-0-12-405944-3.00004-0

Poole, E. S., Major, L. L., Cridge, A. G., & Tate, W. P. (2004). The mechanism of recoding in pro- and eukaryotes. In K. H. Nierhaus & D. N. Wilson (Eds.), Protein synthesis and ribosome structure: Translating the genome. (pp. 397-428). Weinheim, Germany: Wiley-VCH.

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Journal - Research Article

Oliphant, A., Hawkes, M. K. N., Cridge, A. G., & Dearden, P. K. (2020). Transcriptomic characterisation of neuropeptides and their putative cognate G protein-coupled receptors during late embryo and stage-1 juvenile development of the Aotearoa-New Zealand crayfish, Paranephrops zealandicus. General & Comparative Endocrinology, 292, 113443. doi: 10.1016/j.ygcen.2020.113443

Panfilio, K. A., Vargas Jentzsch, I. M., Benoit, J. B., Erezyilmaz, D., Suzuki, Y., Colella, S., … Duncan, E. J., … Cridge, A. G., … Dearden, P. K., … Leask, M., … Lovegrove, M. R., … Tidswell, O., … Richards, S. (2019). Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome. Genome Biology, 20, 64. doi: 10.1186/s13059-019-1660-0

Vangala, G., Imhoff, F. M., Squires, C. M. L., Cridge, A. G., & Baird, S. K. (2019). Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D. Experimental Cell Research, 383, 111494. doi: 10.1016/j.yexcr.2019.07.007

Chen, S., Nimick, M., Cridge, A. G., Hawkins, B. C., & Rosengren, R. J. (2018). Anticancer potential of novel curcumin analogs towards castrate-resistant prostate cancer. International Journal of Oncology, 52(2), 579-588. doi: 10.3892/ijo.2017.4207

Armisén, D., Rajakumar, R., Friedrich, M., Benoit, J. B., Robertson, H. M., Panfilio, K. A., … Cridge, A. G., … Khila, A. (2018). The genome of the water strider Gerris buenoi reveals expansions of gene repertoires associated with adaptations to life on the water. BMC Genomics, 19, 832. doi: 10.1186/s12864-018-5163-2

Poynton, H. C., Hasenbein, S., Benoit, J. B., Sepulveda, M., Poelchau, M. F., Hughes, D. S. T., … Cridge, A. G., … Richards, S. (2018). The toxicogenome of Hyalella azteca: A model for sediment ecotoxicology and evolutionary toxicology. Environmental Science & Technology, 52(10), 6009-6022. doi: 10.1021/acs.est.8b00837

Pushparajan, C., Goswami, S. K., McAdam, C. J., Hanton, L. R., Dearden, P. K., Moratti, S. C., & Cridge, A. G. (2018). A mechanically strengthened polyacrylamide gel matrix fully compatible with electrophoresis of proteins and nucleic acids. Electrophoresis, 39(5-6), 824-832. doi: 10.1002/elps.201700303

Cridge, A. G., Crowe-McAuliffe, C., Mathew, S. F., & Tate, W. P. (2018). Eukaryotic translational termination efficiency is influenced by the 3' nucleotides within the ribosomal mRNA channel. Nucleic Acids Research, gkx1315. doi: 10.1093/nar/gkx1315

Cridge, A. G., Lovegrove, M. R., Skelly, J. G., Taylor, S. E., Petersen, G. E. L., Cameron, R. C., & Dearden, P. K. (2017). The honeybee as a model insect for developmental genetics. Genesis, 55(5), e23019. doi: 10.1002/dvg.23019

Saha, S., Hosmani, P. S., Villalobos-Ayala, K., Miller, S., Shippy, T., Flores, M., … Cridge, A., … Brown, S. J. (2017). Improved annotation of the insect vector of citrus greening disease: Biocuration by a diverse genomics community. Database, 2017, bax032. doi: 10.1093/database/bax032

Cridge, A. G., Dearden, P. K., & Brownfield, L. R. (2016). Convergent occurrence of the developmental hourglass in plant and animal embryogenesis? Annals of Botany, 117(5), 833-843. doi: 10.1093/aob/mcw024

Cahyani, I., Cridge, A. G., Engelke, D. R., Ganley, A. R. D., & O'Sullivan, J. M. (2015). A sequence-specific interaction between the Saccharomyces cerevisiae rRNA gene repeats and a locus encoding an RNA polymerase I subunit affects ribosomal DNA stability. Molecular & Cellular Biology, 35(3), 544-554. doi: 10.1128/mcb.01249-14

Cridge, A. G., Leask, M. P., Duncan, E. J., & Dearden, P. K. (2015). What do studies of insect polyphenisms tell us about nutritionally-triggered epigenomic changes and their consequences? Nutrients, 7(3), 1787-1797. doi: 10.3390/nu7031787

Sadd, B. M., Barribeau, S. M., Bloch, G., de Graaf, D. C., Dearden, P., Elsik, C. G., … Cridge, A. G., … Duncan, E., … Irvine, F., … Leask, M., Lockett, G. A., … Nair, A., … Blommaert, J., … Worley, K. C. (2015). The genomes of two key bumblebee species with primitive eusocial organization. Genome Biology, 16, 76. doi: 10.1186/s13059-015-0623-3

Cridge, B. J., & Cridge, A. G. (2015). Evaluating how universities engage school students with science: A model based on the analysis of the literature. Australian Universities' Review, 57(1), 34-44.

Cridge, A. G., Visweswaraiah, J., Ramesh, R., & Sattlegger, E. (2014). Semi-quantitative colony immunoassay for determining and optimizing protein expression in Saccharomyces cerevisiae and Escherichia coli. Analytical Biochemistry, 447, 82-89. doi: 10.1016/j.ab.2013.10.020

Bray, B. J., & Cridge, A. G. (2013). Can education programmes effect long term behavioural change? International Journal of Innovative Interdisciplinary Research, 2(2), 27-33.

O'Sullivan, J. M., Pai, D. A., Cridge, A. G., Engelke, D. R., & Ganley, A. R. D. (2013). The nucleolus: A raft adrift in the nuclear sea or the keystone in nuclear structure? Biomolecular Concepts, 4(3), 277-286. doi: 10.1515/bmc-2012-0043

Ganegama Arachchi, G. J., Cridge, A. G., Dias-Wanigasekera, B. M., Cruz, C. D., McIntyre, L., Liu, R., … Mutukumira, A. N. (2013). Effectiveness of phages in the decontamination of Listeria monocytogenes adhered to clean stainless steel, stainless steel coated with fish protein, and as a biofilm. Journal of Industrial Microbiology & Biotechnology, 40(10), 1105-1116. doi: 10.1007/s10295-013-1313-3

Cridge, A. G., Castelli, L. M., Smirnova, J. B., Selley, J. N., Rowe, W., Hubbard, S. J., … Pavitt, G. D. (2010). Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Research, 38(22), 8039-8050. doi: 10.1093/nar/gkq686

Smith, J. M., Cridge, A. G., & Dearden, P. K. (2010). Germ cell specification and ovary structure in the rotifer Brachionus plicatilis. EvoDevo, 1, 5. doi: 10.1186/2041-9139-1-5

Cridge, A. G., Major, L. L., Mahagaonkar, A. A., Poole, E. S., Isaksson, L. A., & Tate, W. P. (2006). Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms. Nucleic Acids Research, 34(7), 1959-1973. doi: 10.1093/nar/gkl074

Cridge, A. G., Poole, E. S., & Tate, W. P. (2003). The signal for stop in protein synthesis in eukaryotes: Evidence for a sequence element rather than a simple stop codon. New Zealand BioScience, 12, 37-38.

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Journal - Research Other

Tate, W. P., Cridge, A. G., & Brown, C. M. (2018). 'Stop' in protein synthesis is modulated with exquisite subtlety by an extended RNA translation signal. Biochemical Society Transactions, 46(6), 1615-1625. doi: 10.1042/bst20180190

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