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Otago Medical School staff profiles

Dr Jeff Erickson

PositionSenior Lecturer
DepartmentDepartment of Physiology
QualificationsPhD
Research summaryHeart disease

Research

My research focuses on investigating the molecular mechanisms that underlie structural heart disease and heart failure, particularly in the context of aging and diabetes. To this end, we have developed a number of novel tools to assess cardiac signaling pathways.

These include

  • FRET-based biosensors to measure kinase activity and localization in living cells
  • custom antibodies to measure biochemical modifications of proteins
  • a variety of animal models with enhanced or reduced susceptibility to cardiac pathology.
With this research, we hope to contribute new understanding to the molecular basis of cardiac signaling that will culminate in potential clinical therapies for heart disease.

Publications

Erickson, J. R., Pereira, L., Wang, L., Han, G., Ferguson, A., Dao, K., … Bers, D. M. (2013). Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature, 502, 372-376. doi: 10.1038/nature12537

Erickson, J. R., Nichols, C. B., Uchinoumi, H., Stein, M. L., Bossuyt, J., & Bers, D. M. (2015). S-nitrosylation induces both autonomous activation and inhibition of calcium/calmodulin-dependent protein kinase II δ. Journal of Biological Chemistry, 290(42), 25646-25656. doi: 10.1074/jbc.M115.650234

Pereira, L., Rehman, H., Lao, D. H., Erickson, J. R., Bossuyt, J., Chen, J., & Bers, D. M. (2015). Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. PNAS, 112(13), 3991-3996. doi: 10.1073/pnas.1416163112

Grimm, M., Ling, H., Willeford, A., Pereira, L., Gray, C. B. B., Erickson, J. R., … Brown, J. H. (2015). CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation. Journal of Molecular & Cellular Cardiology, 85, 282-291. doi: 10.1016/j.yjmcc.2015.06.007

Bell, J. R., Raaijmakers, A. J. A., Curl, C. L., Reichelt, M. E., Harding, T. W., Bei, A., … Erickson, J. R., … Delbridge, L. M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159

Journal - Research Article

Pereira, L., Rehman, H., Lao, D. H., Erickson, J. R., Bossuyt, J., Chen, J., & Bers, D. M. (2015). Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. PNAS, 112(13), 3991-3996. doi: 10.1073/pnas.1416163112

Grimm, M., Ling, H., Willeford, A., Pereira, L., Gray, C. B. B., Erickson, J. R., … Brown, J. H. (2015). CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation. Journal of Molecular & Cellular Cardiology, 85, 282-291. doi: 10.1016/j.yjmcc.2015.06.007

Bell, J. R., Raaijmakers, A. J. A., Curl, C. L., Reichelt, M. E., Harding, T. W., Bei, A., … Erickson, J. R., … Delbridge, L. M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159

Erickson, J. R., Nichols, C. B., Uchinoumi, H., Stein, M. L., Bossuyt, J., & Bers, D. M. (2015). S-nitrosylation induces both autonomous activation and inhibition of calcium/calmodulin-dependent protein kinase II δ. Journal of Biological Chemistry, 290(42), 25646-25656. doi: 10.1074/jbc.M115.650234

Erickson, J. R., Pereira, L., Wang, L., Han, G., Ferguson, A., Dao, K., … Bers, D. M. (2013). Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature, 502, 372-376. doi: 10.1038/nature12537

More publications...