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Otago Medical School staff profiles

Dr Martin Fronius

PositionSenior Lecturer
DepartmentDepartment of Physiology
QualificationsDiplom Biologie Dr rer nat
Research summaryEpithelial ion transport and epithelial ion channels

Research

Research in my lab focuses on the function and regulation of ion channels with particular emphasis on:
  • Impact of mechanical forces (shear stress and pressure)
  • Fluid homeostasis in the lung
  • Auto-/paracrine signalling via non-neuronal acetylcholine

Publications

Barth, D., & Fronius, M. (2019). Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands. Scientific Reports, 9, 6781. doi: 10.1038/s41598-019-43097-7

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Saw, E. L., Kakinuma, Y., Fronius, M., & Katare, R. (2018). The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of Molecular & Cellular Cardiology. Advance online publication. doi: 10.1016/j.yjmcc.2018.10.013

Knoepp, F., Bettmer, J., & Fronius, M. (2017). Gadolinium released by the linear gadolinium-based contrast-agent Gd-DTPA decreases the activity of human epithelial Na+ channels (ENaCs). Biochimica et Biophysica Acta: Biomembranes, 1859(5), 1040-1048. doi: 10.1016/j.bbamem.2017.02.019

Richter, K., Mathes, V., Fronius, M., Althaus, M., Hecker, A., Krasteva-Christ, G., … Grau, V. (2016). Phosphocholine: An agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Scientific Reports, 6, 28660. doi: 10.1038/srep28660

Chapter in Book - Research

Fronius, M. (2012). Mechanical forces impair alveolar ion transport processes: A putative mechanism contributing to the formation of pulmonary edema. In E. M. Irusen (Ed.), Lung diseases: Selected state of the art reviews. (pp. 561-578). Rijeka, Croatia: InTech.

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Journal - Research Article

Barth, D., & Fronius, M. (2019). Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands. Scientific Reports, 9, 6781. doi: 10.1038/s41598-019-43097-7

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na+ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Saw, E. L., Kakinuma, Y., Fronius, M., & Katare, R. (2018). The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of Molecular & Cellular Cardiology. Advance online publication. doi: 10.1016/j.yjmcc.2018.10.013

Knoepp, F., Bettmer, J., & Fronius, M. (2017). Gadolinium released by the linear gadolinium-based contrast-agent Gd-DTPA decreases the activity of human epithelial Na+ channels (ENaCs). Biochimica et Biophysica Acta: Biomembranes, 1859(5), 1040-1048. doi: 10.1016/j.bbamem.2017.02.019

Richter, K., Mathes, V., Fronius, M., Althaus, M., Hecker, A., Krasteva-Christ, G., … Grau, V. (2016). Phosphocholine: An agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Scientific Reports, 6, 28660. doi: 10.1038/srep28660

Hecker, A., Küllmar, M., Wilker, S., Richter, K., Zakrzewicz, A., Atanasova, S., … Fronius, M., … Grau, V. (2015). Phosphocholine-modified macromolecules and canonical nicotinic agonists inhibit ATP-induced IL-1β release. Journal of Immunology, 195, 2325-2334. doi: 10.4049/jimmunol.1400974

Vitzthum, C., Clauss, W. G., & Fronius, M. (2015). Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress. Biochemica et Biophysica Acta: Biomembranes, 1848(11), 2942-2951. doi: 10.1016/j.bbamem.2015.09.009

Dittrich, N. P., Kummer, W., Clauss, W. G., & Fronius, M. (2015). Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs. International Immunopharmacology, 29(1), 166-172. doi: 10.1016/j.intimp.2015.08.010

Richter, K., Kiefer, K. P., Grzesik, B. A., Clauss, W. G., & Fronius, M. (2014). Hydrostatic pressure activates ATP-sensitive K+ channels in lung epithelium by ATP release through pannexin and connexin hemichannels. FASEB Journal, 28(1), 45-55. doi: 10.1096/fj.13-229252

Schönberger, M., Althaus, M., Fronius, M., Clauss, W., & Trauner, D. (2014). Controlling epithelial sodium channels with light using photoswitchable amilorides. Nature Chemistry, 6(8), 712-719. doi: 10.1038/nchem.2004

Ashry, O., Schnecko, A., Clauss, W. G., & Fronius, M. (2014). Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respiratory Physiology & Neurobiology, 195(1), 37-40. doi: 10.1016/j.resp.2014.02.001

Deckmann, K., Filipski, K., Krasteva-Christ, G., Fronius, M., Althaus, M., Rafiq, A., … Kummer, W. (2014). Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. PNAS, 111(22), 8287-8292. doi: 10.1073/pnas.1402436111

Hollenhorst, M. I., Lips, K. S., Wolff, M., Wess, J., Gerbig, S., Takats, Z., … Fronius, M. (2012). Luminal cholinergic signalling in airway lining fluid: A novel mechanism for activating chloride secretion via Ca 2+-dependent Cl- and K+ channels. British Journal of Pharmacology, 166(4), 1388-1402. doi: 10.1111/j.1476-5381.2012.01883.x

Wesch, D., Althaus, M., Miranda, P., Cruz-Muros, I., Fronius, M., González-Hernández, T., … Giraldez, T. (2012). Differential N termini in epithelial Na+ channel δ-subunit isoforms modulate channel trafficking to the membrane. American Journal of Physiology: Cell Physiology, 302(6), C868-879. doi: 10.1152/ajpcell.00255.2011

Althaus, M., Urness, K. D., Clauss, W. G., Baines, D. L., & Fronius, M. (2012). The gasotransmitter hydrogen sulphide decreases Na+ transport across pulmonary epithelial cells. British Journal of Pharmacology, 166(6), 1946-1963. doi: 10.1111/j.1476-5381.2012.01909.x

Hollenhorst, M. I., Lips, K. S., Weitz, A., Krasteva, G., Kummer, W., & Fronius, M. (2012). Evidence for functional atypical nicotinic receptors that activate K+-dependent Cl- secretion in mouse tracheal epithelium. American Journal of Respiratory Cell & Molecular Biology, 46(1), 106-114. doi: 10.1165/rcmb.2011-0171OC

Krumm, P., Giraldez, T., Alvarez de la Rosa, D., Clauss, W. G., Fronius, M., & Althaus, M. (2012). Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & Medicinal Chemistry, 20(13), 3979-3984. doi: 10.1016/j.bmc.2012.05.021

Althaus, M., Pichl, A., Clauss, W. G., Seeger, W., Fronius, M., & Morty, R. E. (2011). Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells. American Journal of Respiratory Cell & Molecular Biology, 44(1), 53-65. doi: 10.1165/2009-0335OC

Kessler, S., Clauss, W. G., Günther, A., Kummer, W., & Fronius, M. (2011). Expression and functional characterization of P2X receptors in mouse alveolar macrophages. Pflügers Archiv: European Journal of Physiology, 462(3), 419-430. doi: 10.1007/s00424-011-0980-z

Berger, J., Richter, K., Clauss, W. G., & Fronius, M. (2011). Evidence for basolateral Cl- channels as modulators of apical Cl- secretion in pulmonary epithelia of Xenopus laevis. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 300(3), R616-R623. doi: 10.1152/ajpregu.00464.2010

Althaus, M., Clauss, W. G., & Fronius, M. (2011). Amiloride-sensitive sodium channels and pulmonary edema. Pulmonary Medicine, 2011, 830320. doi: 10.1155/2011/830320

Hollenhorst, M. I., Richter, K., & Fronius, M. (2011). Ion transport by pulmonary epithelia. Journal of Biomedicine & Biotechnology, 2011, 174306. doi: 10.1155/2011/174306

Kessler, S., Clauss, W. G., & Fronius, M. (2011). Laminar shear stress modulates the activity of heterologously expressed P2X4 receptors. Biochimica et Biophysica Acta: Biomembranes, 1808(10), 2488-2495. doi: 10.1016/j.bbamem.2011.07.010

Mikulski, Z., Hartmann, P., Jositsch, G., Zasłona, Z., Lips, K. S., Pfeil, U., … Fronius, M., & Kummer, W. (2010). Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration. Respiratory Research, 11, 133. doi: 10.1186/1465-9921-11-133

Berger, J., Hardt, M., Clauss, W. G., & Fronius, M. (2010). Basolateral Cl- uptake mechanisms in Xenopus laevis lung epithelium. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 299(1), R92-R100. doi: 10.1152/ajpregu.00749.2009

Fronius, M., Bogdan, R., Althaus, M., Morty, R. E., & Clauss, W. G. (2010). Epithelial Na+ channels derived from human lung are activated by shear force. Respiratory Physiology & Neurobiology, 170(1), 113-119. doi: 10.1016/j.resp.2009.11.004

Althaus, M., Fronius, M., Buchäckert, Y., Vadász, I., Clauss, W. G., Seeger, W., … Morty, R. E. (2009). Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. American Journal of Respiratory Cell & Molecular Biology, 41(6), 639-650. doi: 10.1165/rcmb.2008-0458OC

Fronius, M., & Clauss, W. G. (2008). Mechano-sensitivity of ENaC: May the (shear) force be with you. Pflügers Archiv: European Journal of Physiology, 455(5), 775-785. doi: 10.1007/s00424-007-0332-1

Bogdan, R., Veith, C., Clauss, W., & Fronius, M. (2008). Impact of mechanical stress on ion transport in native lung epithelium (Xenopus laevis): Short-term activation of Na+, Cl- and K+ channels. Pflügers Archiv: European Journal of Physiology, 456(6), 1109-1120. doi: 10.1007/s00424-008-0486-5

Althaus, M., Bogdan, R., Clauss, W. G., & Fronius, M. (2007). Mechano-sensitivity of epithelial sodium channels (ENaCs): Laminar shear stress increases ion channel open probability. FASEB Journal, 21(10), 2389-2399. doi: 10.1096/fj.06-7694com

Sommer, D., Bogdan, R., Berger, J., Peters, D. M., Morty, R. E., Clauss, W. G., & Fronius, M. (2007). CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium. Respiratory Physiology & Neurobiology, 158(1), 97-106. doi: 10.1016/j.resp.2007.03.016

Schnizler, M. K., Bogdan, R., Bennert, A., Bury, N. R., Fronius, M., & Clauss, W. (2007). Short-term exposure to waterborne free silver has acute effects on membrane current of Xenopus oocytes. Biochimica et Biophysica Acta: Biomembranes, 1768(2), 317-323. doi: 10.1016/j.bbamem.2006.09.007

Krumm, S., Goebel-Lauth, S. G., Fronius, M., & Clauss, W. (2005). Transport of sodium and chloride across earthworm skin in vitro. Journal of Comparative Physiology B, 175, 601-608. doi: 10.1007/s00360-005-0023-1

Fronius, M., Berk, A., Clauss, W., & Schnizler, M. (2004). Ion transport across Xenopus alveolar epithelium is regulated by extracellular ATP, UTP and adenosine. Respiratory Physiology & Neurobiology, 139, 133-144. doi: 10.1016/j.resp.2003.09.007

Berk, A., Fronius, M., Clauss, W., & Schnizler, M. (2004). Prostaglandin E2 induces upregulation of Na+ transport across Xenopus lung epithelium. Journal of Comparative Physiology B, 174, 83-89. doi: 10.1007/s00360-003-0391-3

Fronius, M., Clauss, W., & Schnizler, M. (2003). Stimulation of transepithelial Na+ current by extracellular Gd3+ in Xenopus laevis alveolar epithelium. Journal of Membrane Biology, 195(1), 43-51. doi: 10.1007/s00232-003-2043-7

Fronius, M., Rehn, M., Eckstein-Ludwig, U., & Clauss, W. (2001). Inhibitory non-genomic effects of progesterone on Na+ absorption in epithelial cells from Xenopus kidney (A6). Journal of Comparative Physiology B, 171, 377-386. doi: 10.1007/s003600100186

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Journal - Research Other

Fronius, M. (2013). Treatment of pulmonary edema by ENaC activators/stimulators. Current Molecular Pharmacology, 6(1), 13-27. doi: 10.2174/1874467211306010003

Fronius, M., Clauss, W. G., & Althaus, M. (2012). Why do we have to move fluid to be able to breathe? Frontiers in Physiology, 3, 146. doi: 10.3389/fphys.2012.00146

Hollenhorst, M. I., Clauss, W., & Fronius, M. (2012). Acetylcholin als non-neuronales Signalmolekül [The non-neuronal cholinergic system]. Biologie in unserer Zeit, 42(6), 390-395. doi: 10.1002/biuz.201210495

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