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Otago Medical School staff profiles

Dr Thorsten Stanley

PositionSenior Lecturer
DepartmentDepartment of Paediatrics and Child Health (UOW)
QualificationsMBChB (Edin) DCH (Glas) DObstRCOG MRCP
Research summaryPaediatric allergy and asthma

Research

Dr Stanley's research interests have included paediatric infectious disease, neonatology, neurology and neonatal seizures but increasingly over the past decade have tended to focus on paediatric allergy and asthma. Dr Stanley has developed expertise in medical misadventure and regularly advises both ACC and the Medical Council of New Zealand. Dr Stanley's research has focused on the areas of allergy and infectious disease and he has increasingly been involved in collaborations with the Department of Medicine and in particular WARG (Wellington Asthma Research Group) and Public Health, and valuable collaborations with the Department of Paediatrics at Auckland Medical School, Massey University, Perth, West Australia and University of Kuopio, Finland.

Recent research has looked at the role of probiotics in preventing infant eczema and atopy, Vitamin D in bronchiolitis, dampness and fungal spores in childhood wheeze, gut permeability in eczema, the use of exhaled nitric oxide in assessing asthma control and effectiveness of allergen desensitisation. HRC grants have been approved to look at the use of probiotics in early pregnancy in preventing premature labour, maternal vaginosis, maternal Group B Streptococcal carriage and infant atopy, and the role of dampness in the home on bronchiolitis severity. Future research pending successful HRC applications include the role of dampness on the viability and infectivity of rhinoviruses in wheezy children; the effect of early food allergen exposure on the development of infant food allergy and eczema; the long term effects of probiotic supplementation on the development of asthma and rhinitis and the potential role of the infrared camera in paediatric research.

Publications

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Wickens, K., Black, P. N., Stanley, T. V., Mitchell, E., Fitzharris, P., Tannock, G. W., Purdie, G., Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., & Munro, K. (2008). A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial. Journal of Allergy & Clinical Immunology, 122(4), 788-794. doi: 10.1016/j.jaci.2008.07.011

Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., … Fitzharris, P., Siebers, R., … Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., Nicholson, A., & Purdie, G. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection. Clinical & Experimental Allergy, 38(10), 1606-1614. doi: 10.1111/j.1365-2222.2008.03061.x

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L. R. F., … Stanley, T., … de Jonghe, P. (2012). KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy. Annals of Neurology, 71(1), 15-25. doi: 10.1002/ana.22644

Journal - Research Article

Grinton, B. E., Heron, S. E., Pelekanos, J. T., Zuberi, S. M., Kivity, S., Afawi, Z., … Stanley, T., … Berkovic, S. F. (2015). Familial neonatal seizures in 36 families: Clinical and genetic features correlate with outcome. Epilepsia, 56(7), 1071-1080. doi: 10.1111/epi.13020

Marlow, G., Han, D. Y., Wickens, K., Stanley, T., Crane, J., Mitchell, E. A., … Barthow, C., … Morgan, A. R. (2015). Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatric Allergy & Immunology, 26(3), 262-271. doi: 10.1111/pai.12371

Morgan, A. R., Han, D. Y., Wickens, K., Barthow, C., Mitchell, E. A., Stanley, T. V., Dekker, J., Crane, J., & Ferguson, L. R. (2014). Differential modification of genetic susceptibility to childhood eczema by two probiotics. Clinical & Experimental Allergy, 44(10), 1255-1265. doi: 10.1111/cea.12394

Wickens, K., Stanley, T. V., Mitchell, E. A., Barthow, C., Fitzharris, P., Purdie, G., Siebers, R., … Crane, J. (2013). Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization? Clinical & Experimental Allergy, 43(9), 1048-1057. doi: 10.1111/cea.12154

Wickens, K., Black, P., Stanley, T. V., Mitchell, E., Barthow, C., Fitzharris, P., Purdie, G., & Crane, J. (2012). A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clinical & Experimental Allergy, 42(7), 1071-1079. doi: 10.1111/j.1365-2222.2012.03975.x

Weckhuysen, S., Mandelstam, S., Suls, A., Audenaert, D., Deconinck, T., Claes, L. R. F., … Stanley, T., … de Jonghe, P. (2012). KCNQ2 encephalopathy: Emerging phenotype of a neonatal epileptic encephalopathy. Annals of Neurology, 71(1), 15-25. doi: 10.1002/ana.22644

Smith, C., Stanley, T., Crane, J., & Siebers, R. (2011). Do other components of bedding dust affect sensitisation to house dust mites? ISRN Allergy, 2011, 426941. doi: 10.5402/2011/426941

Dekker, J. W., Wickens, K., Black, P. C., Stanley, T. V., Mitchell, E. A., Fitzharris, P., Tannock, G. W., Purdie, G., & Crane, J. (2009). Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0-2 years. International Dairy Journal, 19(3), 149-154. doi: 10.1016/j.idairyj.2008.10.004

Prescott, S. L., Wickens, K., Westcott, L., Jung, W., Currie, H., Black, P. N., Stanley, T. V., … Fitzharris, P., Siebers, R., … Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., Nicholson, A., & Purdie, G. (2008). Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-γ and breast milk transforming growth factor-β and immunoglobin A detection. Clinical & Experimental Allergy, 38(10), 1606-1614. doi: 10.1111/j.1365-2222.2008.03061.x

Wickens, K., Black, P. N., Stanley, T. V., Mitchell, E., Fitzharris, P., Tannock, G. W., Purdie, G., Crane, J., and the Probiotic Study Group, including Jones, B., Lampshire, P., & Munro, K. (2008). A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial. Journal of Allergy & Clinical Immunology, 122(4), 788-794. doi: 10.1016/j.jaci.2008.07.011

Harkin, L. A., McMahon, J. M., Iona, X., Dibbens, L., Pelekanos, J. T., Zuberi, S. M., Sadleir, L. G., … Stanley, T., … The Early Infantile Epileptic Encephalopathy Referral Consortium, … Scheffer, I. E. (2007). The spectrum of SCNIA-related infantile epileptic encephalopathies. Brain, 130, 843-852.

Sistek, D., Kelly, R., Wickens, K., Stanley, T., Fitzharris, P., & Crane, J. (2006). Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical & Experimental Allergy, 36, 629-633.

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