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Otago Medical School staff profiles

Dr Belinda Cridge

PositionLecturer and Programme Director
DepartmentDepartment of Pharmacology and Toxicology
QualificationsPhD
Research summaryMechanistic toxicology, hepatotoxicity, animal toxicology
Teaching
  • PHAL 306 Human Toxicology
  • Programme Director MSc Toxicology
Memberships
  • ANZCCART (NZ)
  • Science Communication Association of NZ

Research

My research has focused on a range of topics over the past fifteen years. I gained a PhD in Toxicology studying hepatic drug metabolising enzymes with a particular focus on the CYP450 and UGT systems. During my studies I have developed a range of novel techniques and implemented enzyme assays for a multiple hepatic enzymes. This expertise in hepatic systems has led to a collaboration with scientists at Massey University to investigate the possible toxicity of a range of glucosinolate metabolites in cattle. This work is currently in print. Our lab is now focussing on developing alternatives for pest control and investigating the potential of CYP450 enzymes as markers of NZ native animal’s responses to novel chemicals.

Previously, my post-doctoral work focused on breast cancer and novel drug development especially from natural sources such as green tea. This used cell culture techniques and in vivo tumour models. For several years I worked predominantly in the field of science communication and education. Within this area I have worked on organisational structure, communication principles and management of outreach. I have also published papers on cannabis and using legislation in teaching.

Additional details

My research interests fall within the area of the primary industries and as such students who study toxicology at the undergraduate level or work with me as a research student may be eligible for funding or support through a range of initiatives. As a starting point I suggest looking at the Growing NZ website to find out more about careers and opportunities within the primary industries sector.

Publications

France, B., Cridge, B., & Fogg-Rodgers, L. (2017). Organisational culture and its role in developing a sustainable science communication platform. International Journal of Science Education, Part B, 7(2), 146-160. doi: 10.1080/21548455.2015.1106025

Gliddon, C. M., & Cridge, B. (2015). Psychoactive Substances Bill and Act of New Zealand: A chance to engage undergraduate scientists with society using a transfer learning paradigm. Journal of Undergraduate Neuroscience Education, 14(1), A1-A7.

Cridge, B. J., & Cridge, A. G. (2015). Evaluating how universities engage school students with science: A model based on the analysis of the literature. Australian Universities' Review, 57(1), 34-44.

Bray, B. J., & Cridge, A. G. (2013). Can education programmes effect long term behavioural change? International Journal of Innovative Interdisciplinary Research, 2(2), 27-33.

Cridge, B. J., Larsen, L., & Rosengren, R. J. (2013). Curcumin and its derivatives in breast cancer: Current developments and potential for the treatment of drug-resistant cancers. Oncology Discovery, 1(6). doi: 10.7243/2052-6199-1-6

Chapter in Book - Research

Rosengren, R. J., & Bray, B. J. (2003). Dietary retinol as a toxic substance. In Reviews in food and nutrition toxicity. (pp. 88-120). London: Taylor and Francis.

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Journal - Research Article

France, B., Cridge, B., & Fogg-Rodgers, L. (2017). Organisational culture and its role in developing a sustainable science communication platform. International Journal of Science Education, Part B, 7(2), 146-160. doi: 10.1080/21548455.2015.1106025

Gliddon, C. M., & Cridge, B. (2015). Psychoactive Substances Bill and Act of New Zealand: A chance to engage undergraduate scientists with society using a transfer learning paradigm. Journal of Undergraduate Neuroscience Education, 14(1), A1-A7.

Cridge, B. J., & Cridge, A. G. (2015). Evaluating how universities engage school students with science: A model based on the analysis of the literature. Australian Universities' Review, 57(1), 34-44.

Bray, B. J., & Cridge, A. G. (2013). Can education programmes effect long term behavioural change? International Journal of Innovative Interdisciplinary Research, 2(2), 27-33.

Cridge, B. J., Larsen, L., & Rosengren, R. J. (2013). Curcumin and its derivatives in breast cancer: Current developments and potential for the treatment of drug-resistant cancers. Oncology Discovery, 1(6). doi: 10.7243/2052-6199-1-6

Cridge, B. J., & Rosengren, R. J. (2013). Critical appraisal of the potential use of cannabinoids in cancer management. Cancer Management & Research, 5, 301-313. doi: 10.2147/CMAR.S36105

Bray, B., France, B., & Gilbert, J. K. (2012). Identifying the essential elements of effective science communication: What do the experts say? International Journal of Science Education, Part B, 2(1), 23-41. doi: 10.1080/21548455.2011.611627

Goodin, M. G., Bray, B. J., & Rosengren, R. J. (2006). Sex- and strain-dependent effects of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in the mouse. Food & Chemical Toxicology, 44, 1496-1504.

Chisholm, K., Bray, B. J., & Rosengren, R. J. (2004). Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. Anti-Cancer Drugs, 15, 889-897.

Bray, B. J., Perry, N. B., Menkes, D. B., & Rosengren, R. J. (2002). St John's Wort extract induces CYP3A and CYP2E1 in the Swiss Webster Mouse. Toxicological Sciences, 66, 27-33.

Bray, B. J., Brennan, N. J., Perry, N. B., Menkes, D. B., & Rosengren, R. J. (2002). Short term treatment with St John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse. Life Sciences, 70, 1325-1335.

Bray, B. J., Goodin, M. G., Inder, R. E., & Rosengren, R. J. (2001). Retinol's effect on hepatic and renal drug metabolising enzymes. Food & Chemical Toxicology, 39, 1-9.

Bray, B. J., & Rosengren, R. J. (2001). Retinol potentiates acetaminophen-induced hepatotoxicity in the mouse: Mechanistic studies. Toxicology & Applied Pharmacology, 173, 129-136.

Bray, B. J., Inder, R. E., & Rosengren, R. J. (2000). Retinol-mediated effects on the activation and detoxification pathways of paracetamol. Australasian Journal of Ecotoxicology, 6(2), 75-79.

Hargreaves, P., Bray, B. J., Hooser, S. B., & Rosengren, R. J. (2000). Nodular-induced fatalities result from necrosis, not apoptosis in the male Swiss Webster mouse. Australasian Journal of Ecotoxicology, 6(1), 65-69.

Inder, R. E., Bray, B. J., Sipes, I. G., & Rosengren, R. J. (1999). Role of Cytochrome P4502E1 in Retinol's Attenuation of Carbon Tetrachloride-Induced Hepatotoxicity in the Swiss Webster Mouse. Toxicological Sciences, (52), 130-139.

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