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Otago Medical School staff profiles

Associate Professor Matt Doogue

PositionAssociate Professor
DepartmentDepartment of Medicine (Christchurch)
QualificationsBSc MB ChB(Otago) DipPaed(Auck) FRACP
Research summaryClinical Pharmacology

Research

Matt Doogue is a consultant physician for Canterbury District Health Board with particular responsibilities in medicines governance and 'eMedicines'. He co-ordinates Clinical Pharmacology teaching.

His research interests include: adverse drug reactions therapeutic drug monitoring drug interactions pharmacogenetics and pharmacokinetics in particular patient groups clinical decision support

Publications

Leggett, C., Giles, L., Anderson, J. J. A., Doogue, M., Couper, J., & Pena, A. S. (2019). Adherence to metformin is reduced during school holidays and weekends in children with type 1 diabetes participating in a randomised controlled trial. Archives of Disease in Childhood. Advance online publication. doi: 10.1136/archdischild-2018-316303

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Mortensen, J. S., Jensen, B. P., Zhang, M., & Doogue, M. (2019). Pre-analytical stability of piperacillin, tazobactam, meropenem and ceftazidime in plasma and whole blood using LC-MS/MS [Short communication]. Therapeutic Drug Monitoring, 41(4), 538-543. doi: 10.1097/ftd.0000000000000650

Coller, J. K., Ramachandran, J., John, L., Tuke, J., Wigg, A., & Doogue, M. (2019). The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome [Short report]. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14034

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Authored Book - Other

Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Doogue, M., Jeffery, M., … Pithie, A., … Sainsbury, R. (2005). Management guidelines for common medical conditions (11th ed.). Christchurch, NZ: Canterbury District Health Board, 271p.

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Edited Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

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Journal - Research Article

Leggett, C., Giles, L., Anderson, J. J. A., Doogue, M., Couper, J., & Pena, A. S. (2019). Adherence to metformin is reduced during school holidays and weekends in children with type 1 diabetes participating in a randomised controlled trial. Archives of Disease in Childhood. Advance online publication. doi: 10.1136/archdischild-2018-316303

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Currow, D. C., Ekström, M., Louw, S., Hill, J., Fazekas, B., Clark, K., … Doogue, M., … Agar, M. (2018). Sertraline in symptomatic chronic breathlessness: A double blind, randomised trial. European Respiratory Journal. Advance online publication. doi: 10.1183/13993003.01270-2018

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Wright, D. F. B., Doogue, M. P., Barclay, M. L., Chapman, P. T., Cross, N. B., Irvine, J. H., & Stamp, L. K. (2017). A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis. European Journal of Clinical Pharmacology, 73, 71-78. doi: 10.1007/s00228-016-2133-y

Khong, J. J., Burdon, K. P., Lu, Y., Laurie, K., Leonardos, L., Baird, P. N., … Doogue, M., … Craig, J. E. (2016). Pooled genome wide association detects association upstream of FCRL3 with Graves' disease. BMC Genomics, 17(1), 939. doi: 10.1186/s12864-016-3276-z

Lewis, B. C., Nair, P. C., Heran, S. S., Somogyi, A. A., Bowden, J. J., Doogue, M. P., & Miners, J. O. (2016). Warfarin resistance associated with genetic polymorphism of VKORC1: Linking clinical response to molecular mechamism using computational modeling. Pharmacogenetics & Genomics, 26(1), 44-50. doi: 10.1097/FPC.0000000000000184

Sanderson, C., Quinn, S. J., Agar, M., Chye, R., Clark, K., Doogue, M., … Currow, D. C. (2016). Pharmacovigilance in hospice/palliative care: Net effect of pregabalin for neuropathic pain. BMJ Supportive & Palliative Care, 6(3), 323-330. doi: 10.1136/bmjspcare-2014-000825

Chin, P. K. L., & Doogue, M. P. (2016). Long-term prescribing of new oral anticoagulants. Australian Prescriber, 39(6), 200-204. doi: 10.18773/austprescr.2016.068

Chinnaratha, M. A., Chaudhary, S., Doogue, M., McCormick, R. J., Woodman, R. J., & Wigg, A. J. (2015). Prevalence of hepatic osteodystrophy and vitamin D deficiency in cirrhosis. Internal Medicine Journal, 45(12), 1230-1235. doi: 10.1111/imj.12866

Dobinson, H. C., Anderson, T. P., Chambers, S. T., Doogue, M. P., Seaward, L., & Werno, A. M. (2015). Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. Journal of Clinical Microbiology, 53(9), 2895-2899. doi: 10.1128/jcm.00760-15

Roberts, G. W., Quinn, S. J., Valentine, N., Alhawassi, T., O'Dea, H., Stranks, S. N., … Doogue, M. P. (2015). Relative hyperglycemia, a marker of critical illness: Introducing the Stress Hyperglycemia Ratio. Journal of Clinical Endocrinology & Metabolism, 100(12), 4490-4497. doi: 10.1210/jc.2015-2660

Sanderson, C., Quinn, S. J., Agar, M., Chye, R., Clark, K., Doogue, M., … Currow, D. C. (2015). Pharmacovigilance in hospice/palliative care: Net effect of gabapentin for neuropathic pain. BMJ Supportive & Palliative Care, 5, 273-280. doi: 10.1136/bmjspcare-2014-000699

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Radhakutty, A., Shen, J., Hooper, A. J., Miller, S. A., Burnett, J. R., Mah, P. M., … Doogue, M. P. (2014). Quantification and genotyping of lipoprotein lipase in patients with diabetic lipaemia. Diabetic Medicine, 31(12), 1702-1707. doi: 10.1111/dme.12565

Snyder, B. D., Rowland, A., Polasek, T. M., Miners, J. O., & Doogue, M. P. (2014). Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European Journal of Clinical Pharmacology, 70(9), 1115-1122. doi: 10.1007/s00228-014-1716-8

To, T. H. M., Agar, M., Shelby-James, T., Abernethy, A. P., Doogue, M., Rowett, D., … Currow, D. C. (2013). Off-label prescribing in palliative care: A cross-sectional national survey of palliative medicine doctors. Palliative Medicine, 27(4), 320-328. doi: 10.1177/0269216312464263

Burt, M. G., Mangelsdorf, B. L., Rogers, A., Ho, J. T., Lewis, J. G., Inder, W. J., & Doogue, M. P. (2013). Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH1-24 stimulation in the assessment of pituitary patients. Journal of Clinical Endocrinology & Metabolism, 98(5), 1883-1890. doi: 10.1210/jc.2012-3576

Polasek, T. M., Patel, F., Jensen, B. P., Sorich, M. J., Wiese, M. D., & Doogue, M. P. (2013). Predicted metabolic drug clearance with increasing adult age. British Journal of Clinical Pharmacology, 75(4), 1019-1028. doi: 10.1111/j.1365-2125.2012.04446.x

Kennedy, N. A., Asser, T. L., Mountifield, R. E., Doogue, M. P., Andrews, J. M., & Bampton, P. A. (2013). Thiopurine metabolite measurement leads to changes in management of inflammatory bowel disease. Internal Medicine Journal, 43(3), 278-286. doi: 10.1111/j.1445-5994.2012.02936.x

Crawford, G. B., Agar, M., Quinn, S. J., Phillips, J., Lister, C., Michael, N., Doogue, M., … Currow, D. C. (2013). Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for delirium. Journal of Palliative Medicine, 16(11), 1335-1341. doi: 10.1089/jpm.2013.0230

Currow, D. C., Vella-Brincat, J., Fazekas, B., Clark, K., Doogue, M., & Rowett, D. (2012). Pharmacovigilance in hospice/palliative care: Rapid report of net clinical effect of metoclopramide. Journal of Palliative Medicine, 15(10), 1071-1075. doi: 10.1089/jpm.2012.0111

Joseph, S. P., Ho, J. T., Doogue, M. P., & Burt, M. G. (2012). Perioperative management of the hypothalamic-pituitary-adrenal axis in patients with pituitary adenomas: An Australasian survey. Internal Medicine Journal, 42(10), 1120-1124. doi: 10.1111/j.1445-5994.2011.02582.x

Schouten, B. J., Doogue, M. P., Soule, S. G., & Hunt, P. J. (2009). Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia. Annals of Clinical Biochemistry, 46(2), 167-169. doi: 10.1258/acb.2008.008151

Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x

Lewis, J. G., möpert, B., Shand, B. I., Doogue, M. P., Soule, S. G., Frampton, C. M., & Elder, P. A. (2006). Plasma variation of corticosteroid-binding globulin and sex hormone-binding globulin. Hormone & Metabolic Research, 38, 241-245.

Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x

Jackson, N. W., Doogue, M. P., & Elliott, J. M. (1999). Priority points and cardiac events while waiting for coronary bypass surgery. Heart, 81(4), 367-373. doi: 10.1136/hrt.81.4.367

Doogue, M. P., Choong, C. K., & Frizelle, F. A. (1998). Recurrent gallstone ileus. Australian & New Zealand Journal of Surgery, 68, 755-757.

Doogue, M. P., Brett, C. N. H., & Elliott, J. M. (1997). Life and death on the waiting list for coronary bypass surgery. New Zealand Medical Journal, 110(1037).

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Journal - Research Other

Mortensen, J. S., Jensen, B. P., Zhang, M., & Doogue, M. (2019). Pre-analytical stability of piperacillin, tazobactam, meropenem and ceftazidime in plasma and whole blood using LC-MS/MS [Short communication]. Therapeutic Drug Monitoring, 41(4), 538-543. doi: 10.1097/ftd.0000000000000650

Coller, J. K., Ramachandran, J., John, L., Tuke, J., Wigg, A., & Doogue, M. (2019). The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome [Short report]. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14034

Okamura-Kho, A., Chuah, Q., Chin, P., & Doogue, M. (2018). Rarely a triple whammy in general medicine. New Zealand Medical Journal, 1476(131), 92-95. Retrieved from https://www.nzma.org.nz/journal

Polasek, T. M., Doogue, M. P., & Thynne, T. R. J. (2018). Metformin treatment of type 2 diabetes mellitus in pregnancy: Update on safety and efficacy. Therapeutic Advances in Drug Safety, 9(6), 287-295. doi: 10.1177/2042098618769831

Drennan, P., Doogue, M., van Hal, S. J., & Chin, P. (2018). Bayesian therapeutic drug monitoring software: Past, present and future. International Journal of Pharmacokinetics, 3(4), 109-114. doi: 10.4155/ipk-2018-0005

Watts, G. J., Clark, K., Agar, M., Davidson, P. M., McDonald, C., Lam, L. T., … Doogue, M., … on behalf of the Australian national Palliative Care Clinical Studies Collaborative (PaCCSC). (2016). Study protocol: A phase III randomised, double-blind, parallel arm, stratified, block randomised, placebo-controlled trial investigating the clinical effect and cost-effectiveness of sertraline for the palliative relief of breathlessness in people with chronic breathlessness. BMJ Open, 6(11), e013177. doi: 10.1136/bmjopen-2016-013177

Clark, K., Quinn, S. J., Doogue, M., Sanderson, C., Lovell, M., & Currow, D. C. (2015). Routine prescribing of gabapentin or pregabalin in supportive and palliative care: What are the comparative performances of the medications in a palliative care population? Supportive Care in Cancer, 23(9), 2517-2520. doi: 10.1007/s00520-015-2837-z

Doogue, M. P. (2014). A safe and effective drug? New Zealand Medical Journal, 127(1404). Retrieved from http://www.nzma.org.nz/journal

Upton, T. J., Hunt, P. J., & Doogue, M. P. (2014). Hyponatraemic seizure following arginine vasopressin for von Willebrand disease: Pernicious, predictable and preventable. Internal Medicine Journal, 44(5), 521-522. doi: 10.1111/imj.12404

Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069

Phillips, C. J., Doan, H., Kirkpatrick, C. M. J., Gordon, D. L., & Doogue, M. P. (2013). An educational intervention to improve vancomycin prescribing and monitoring. International Journal of Antimicrobial Agents, 41(4), 393-394. doi: 10.1016/j.ijantimicag.2012.11.010

Thynne, T. R. J., & Doogue, M. P. (2013). A dose of paracetamol for the levothyroxine absorption test. Clinical Endocrinology, 78(6), 968-969. doi: 10.1111/cen.12211

Jones, G. R. D., Bryant, S., Fullinfaw, R., Ilett, K., Miners, J. O., Morris, R. G., & Doogue, M. P. (2013). Mass or molar? Recommendations for reporting concentrations of therapeutic drugs. Medical Journal of Australia, 198, 368-369. doi: 10.5694/mja12.10366

Fazal, M. W., Doogue, M. P., Leong, R. W., Bampton, P. A., & Andrews, J. M. (2013). Allopurinol use in pregnancy in three women with inflammatory bowel disease: Safety and outcomes: A case series. BMC Gastroenterology, 13, 172. doi: 10.1186/1471-230X-13-172

Doogue, M. P., & Thynne, T. R. J. (2013). Product information for generic drugs: Old, unloved and sometimes unsafe. Internal Medicine Journal, 43(12), 1346-1348. doi: 10.1111/imj.12295

Doogue, M. P., & Polasek, T. M. (2013). The ABCD of clinical pharmacokinetics. Therapeutic Advances in Drug Safety, 4(1), 5-7. doi: 10.1177/ 2042098612469335

Doogue, M. P., & Thynne, T. R. J. (2013). What is quality of medicines? Internal Medicine Journal of Thailand, 43(10), 1057-1058. doi: 10.1111/imj.12263

Currow, D. C., Rowett, D., Doogue, M., To, T. H. M., & Abernethy, A. P. (2012). An international initiative to create a collaborative for pharmacovigilance in hospice and palliative care clinical practice. Journal of Palliative Medicine, 15(3), 282-286. doi: 10.1089/jpm.2012.9605

Campbell, K., & Doogue, M. (2012). Evaluating and managing patients with thyrotoxicosis. Australian Family Physician, 41(8), 564-572. [Case Study].

Campbell, K. A., Joseph, S. P., Whiting, M. J., & Doogue, M. P. (2012). The half-lives of plasma free metanephrines. Clinical Endocrinology, 76, 764-766. doi: 10.1111/j.1365-2265.2011.04273.x

Snyder, B., Polasek, T. M., & Doogue, M. P. (2012). Reply to: Graefe-Mody U, Friderich C, Port A et al. Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin. Diabetes Obes Metab 2011; 13: 939-946. Diabetes, Obesity & Metabolism, 14(7), 670. doi: 10.1111/j.1463-1326.2012.01588.x

Sung, E. Y. Y., Moore, M. P., Lunt, H., Doogue, M., Zhang, M., & Begg, E. J. (2008). Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin? [Letter to the editor]. British Journal of Clinical Pharmacology, 67(1), 130-131. doi: 10.1111/j.1365-2125.2008.03302.x

Doogue, M., Soule, S., & Hunt, P. (2007). Another cause of 'pseudophaeochromocytoma': Quetiapine associated with a false positive normetanephrine result. Clinical Endocrinology, 67, 472-476.

Doogue, M. P., Begg, E. J., & Bridgman, P. (2005). Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia. Mayo Clinic Proceedings, 80(10), 1368-1370.

Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs. Annals of Pharmacotherapy, 38(1), 174-175.

Doogue, M. P., Gardiner, S. J., & Begg, E. J. (2004). Comment: Prediction of milk/plasma concentration ratio of drugs [Letter]. Annals of Pharmacotherapy, 38, 174-175.

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