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Otago Medical School staff profiles

Dr Laura Burga

PositionResearch Fellow
DepartmentDepartment of Microbiology and Immunology
QualificationsPhD
Research summaryStructural biology, viral pathogenesis and molecular virology

Research

Working with Dr Mihnea Bostina

Publications

McCarthy, C., Jayawardena, N., Burga, L. N., & Bostina, M. (2019). Developing picornaviruses for cancer therapy. Cancers, 11(5), 685. doi: 10.3390/cancers11050685

Jayawardena, N., Burga, L. N., Easingwood, R. A., Takizawa, K., Wolf, M., & Bostina, M. (2018). Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus. PNAS. Advance online publication. doi: 10.1073/pnas.1810664115

Strauss, M., Jayawardena, N., Sun, E., Easingwood, R. A., Burga, L. N., & Bostina, M. (2018). Cryo-electron microscopy structure of Seneca Valley Virus procapsid. Journal of Virology, 92(6), e01927-17. doi: 10.1128/jvi.01927-17

Miles, L. A., Burga, L. N., Gardner, E. E., Bostina, M., Poirier, J. T., & Rudin, C. M. (2017). Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus. Journal of Clinical Investigation, 127(8), 2957-2967. doi: 10.1172/jci93472

Israelsen, W. J., Dayton, T. L., Davidson, S. M., Fiske, B. P., Hosios, A. M., Bellinger, G., … Burga, L. N., … Vander Heiden, M. G. (2013). PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell, 155, 397-409. doi: 10.1016/j.cell.2013.09.025

Journal - Research Article

McCarthy, C., Jayawardena, N., Burga, L. N., & Bostina, M. (2019). Developing picornaviruses for cancer therapy. Cancers, 11(5), 685. doi: 10.3390/cancers11050685

Jayawardena, N., Burga, L. N., Easingwood, R. A., Takizawa, K., Wolf, M., & Bostina, M. (2018). Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus. PNAS. Advance online publication. doi: 10.1073/pnas.1810664115

Strauss, M., Jayawardena, N., Sun, E., Easingwood, R. A., Burga, L. N., & Bostina, M. (2018). Cryo-electron microscopy structure of Seneca Valley Virus procapsid. Journal of Virology, 92(6), e01927-17. doi: 10.1128/jvi.01927-17

Miles, L. A., Burga, L. N., Gardner, E. E., Bostina, M., Poirier, J. T., & Rudin, C. M. (2017). Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus. Journal of Clinical Investigation, 127(8), 2957-2967. doi: 10.1172/jci93472

Israelsen, W. J., Dayton, T. L., Davidson, S. M., Fiske, B. P., Hosios, A. M., Bellinger, G., … Burga, L. N., … Vander Heiden, M. G. (2013). PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell, 155, 397-409. doi: 10.1016/j.cell.2013.09.025

Juvekar, A., Burga, L. N., Hu, H., Lunsford, E. P., Ibrahim, Y. H., Balmaña, J., … Wulf, G. M. (2012). Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discovery, 2(11), 1048-1063. doi: 10.1158/2159-8290.CD-11-0336

Yuan, T. L., Wulf, G., Burga, L., & Cantley, L. C. (2011). Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Current Biology, 21(3), 173-183. doi: 10.1016/j.cub.2010.12.047

Burga, L. N., Hu, H., Juvekar, A., Tung, N. M., Troyan, S. L., Hofstatter, E. W., & Wulf, G. M. (2011). Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Research, 13, R30. doi: 10.1186/bcr2850

Burga, L. N., Tung, N. M., Troyan, S. L., Bostina, M., Konstantinopoulos, P. A., Fountzilas, H., … Wulf, G. M. (2009). Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers. Cancer Research, 69(4), 1273-1278. doi: 10.1158/0008-5472.can-08-2954

Lam, P. B., Burga, L. N., Wu, B. P., Hofstatter, E. W., Lu, K. P., & Wulf, G. M. (2008). Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. Molecular Cancer, 7, 91. doi: 10.1186/1476-4598-7-91

Burga, L., Wellmann, F., Lukačin, R., Witte, S., Schwab, W., Schröder, J., & Matern, U. (2005). Unusual pseudosubstrate specificity of a novel 3,5-dimethoxyphenol O-methyltransferase cloned from Ruta graveolens L. Archives of Biochemistry & Biophysics, 440(1), 54-64. doi: 10.1016/j.abb.2005.05.026

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