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Otago Medical School staff profiles

Dr Htin Aung

PositionResearch Fellow
DepartmentDepartment of Microbiology and Immunology
QualificationsPhD
Research summaryNext-generation sequencing, diagnostic microbiology, molecular microbiology, structural biology

Research

Antimicrobial Resistance (AMR) is a global public health emergency. Drug-resistant tuberculosis including multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) is the main cause of deaths related to AMR. Our research goal is to tackle AMR with a multidisciplinary, integrative approach using cutting-edge technologies such as next- and third generation whole-genome sequencing (Illumina and Oxford Nanopore). Our research focuses on:
  • Identification of novel molecular signatures associated with antimicrobial resistance particularly drug-resistant Mycobacterium tuberculosis.
  • Identification of the genetic basis for resistance in Mycobacterium tuberculosis for the development of diagnostics and anti-TB drugs
  • Insights into the transmission of drug-resistant tuberculosis at community and national level for effective and targeted interventions

Publications

Lu, X., Williams, Z., Hards, K., Tang, J., Cheung, C.-Y., Aung, H. L., … Cook, G. M. (2019). Pyrazolo[1,5-a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resistant tuberculosis. ACS Infectious Diseases, 5(2), 239-249. doi: 10.1021/acsinfecdis.8b00225

Aung, H. L., & Devine, T. J. (2019). Reducing the burden of tuberculosis in the Māori, the Indigenous people of New Zealand. Lancet Global Health, 7(7), e845. doi: 10.1016/s2214-109x(19)30236-0

Mortuza, R., Aung, H. L., Taiaroa, G., Opel-Reading, H. K., Kleffmann, T., Cook, G. M., & Krause, K. L. (2018). Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion. Molecular Microbiology, 107(2), 198-213. doi: 10.1111/mmi.13877

Basu, I., Bower, J. E., Roberts, S. A., Henderson, G., Aung, H. L., Cook, G., … Newton, S. (2018). Utility of whole genome sequencing for multidrug resistant Mycobacterium tuberculosis isolates in a reference TB laboratory in New Zealand. New Zealand Medical Journal, 131(1487), 15-22. Retrieved from https://www.nzma.org.nz/journal

Htuna, K. S., Fong, Y., Kyaw, A. A., Aung, S. T., Oo, K. Z., Zaw, T., … Russell, B., Cook, G. M., Aung, H. L., & Hlaing, T. M. (2018). Microbiome dataset from the upper respiratory tract of patients living with HIV, HIV/TB and TB from Myanmar. Data in Brief, 21, 354-357. doi: 10.1016/j.dib.2018.10.003

Journal - Research Article

Lu, X., Williams, Z., Hards, K., Tang, J., Cheung, C.-Y., Aung, H. L., … Cook, G. M. (2019). Pyrazolo[1,5-a]pyridine inhibitor of the respiratory cytochrome bcc complex for the treatment of drug-resistant tuberculosis. ACS Infectious Diseases, 5(2), 239-249. doi: 10.1021/acsinfecdis.8b00225

Mortuza, R., Aung, H. L., Taiaroa, G., Opel-Reading, H. K., Kleffmann, T., Cook, G. M., & Krause, K. L. (2018). Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion. Molecular Microbiology, 107(2), 198-213. doi: 10.1111/mmi.13877

Htuna, K. S., Fong, Y., Kyaw, A. A., Aung, S. T., Oo, K. Z., Zaw, T., … Russell, B., Cook, G. M., Aung, H. L., & Hlaing, T. M. (2018). Microbiome dataset from the upper respiratory tract of patients living with HIV, HIV/TB and TB from Myanmar. Data in Brief, 21, 354-357. doi: 10.1016/j.dib.2018.10.003

Basu, I., Bower, J. E., Roberts, S. A., Henderson, G., Aung, H. L., Cook, G., … Newton, S. (2018). Utility of whole genome sequencing for multidrug resistant Mycobacterium tuberculosis isolates in a reference TB laboratory in New Zealand. New Zealand Medical Journal, 131(1487), 15-22. Retrieved from https://www.nzma.org.nz/journal

Mulholland, C. V., Ruthe, A., Cursons, R. T., Durrant, R., Karalus, N., Coley, K., … Permina, E., Coleman, M. J., … Cook, G. M., & Aung, H. L. (2017). Rapid molecular diagnosis of the Mycobacterium tuberculosis Rangipo strain responsible for the largest recurring TB cluster in New Zealand. Diagnostic Microbiology & Infectious Disease, 88(2), 138-140. doi: 10.1016/j.diagmicrobio.2017.03.012

Nakatani, Y., Opel-Reading, H. K., Merker, M., Machado, D., Andres, S., Kumar, S. S., … Aung, H. L., Cook, G. M., … Krause, K., & Köser, C. U. (2017). Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance. Antimicrobial Agents & Chemotherapy, 61(12), e01575-17. doi: 10.1128/aac.01575-17

Petridis, M., Vickers, C., Robson, J., McKenzie, J. L., Bereza, M., Sharrock, A., Aung, H. L., … Cook, G. M. (2016). Structure and function of AmtR in Mycobacterium smegmatis: Implications for post-transcriptional regulation of urea metabolism through a small antisense RNA. Journal of Molecular Biology, 428(21), 4315-4329. doi: 10.1016/j.jmb.2016.09.009

Aung, H. L., Tun, T., Moradigaravand, D., Köser, C. U., Nyunt, W. W., Aung, S. T., … Crump, J. A., … Cook, G. M., & Hill, P. C. (2016). Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar. Journal of Global Antimicrobial Resistance, 6, 113-117. doi: 10.1016/j.jgar.2016.04.008

Aung, H. L., Tun, T., Permina, E., Nyunt, W. W., Aung, S. T., Thinn, K. K., Crump, J. A., & Cook, G. M. (2016). Draft genome sequences of two drug-resistant Mycobacterium tuberculosis isolates from Myanmar. Genome Announcements, 4(5), e00850-16. doi: 10.1128/genomeA.00850-16

Aung, H. L., Dixon, L. L., Smith, L. J., Sweeney, N. P., Robson, J. R., Berney, M., … Cook, G. M. (2015). Novel regulatory roles of cAMP receptor proteins in fast-growing environmental mycobacteria. Microbiology, 161(3), 648-661. doi: 10.1099/mic.0.000015

Aung, H. L., Samaranayaka, C. U. K., Enright, R., Beggs, K. T., & Monk, B. C. (2015). Characterisation of the DNA gyrase from the thermophilic eubacterium Thermus thermophilus. Protein Expression & Purification, 107, 62-67. doi: 10.1016/j.pep.2014.11.009

Aung, H. L., Berney, M., & Cook, G. M. (2014). Hypoxia-activated cytochrome bd expression in Mycobacterium smegmatis is cyclic AMP receptor protein dependent. Journal of Bacteriology, 196(17), 3091-3097. doi: 10.1128/jb.01771-14

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Journal - Research Other

Aung, H. L., & Devine, T. J. (2019). Reducing the burden of tuberculosis in the Māori, the Indigenous people of New Zealand. Lancet Global Health, 7(7), e845. doi: 10.1016/s2214-109x(19)30236-0

Aung, H. L., Nyunt, W. W., Fong, Y., Russell, B., Cook, G. M., & Aung, S. T. (2018). Acquired resistance to antituberculosis drugs. Emerging Infectious Diseases, 24(11), 2134. doi: 10.3201/eid2411.180465

Mulholland, C. V., Thorpe, D., Cursons, R. T., Karalus, N., Fong, Y., Arcus, V. L., Cook, G. M., & Aung, H. L. (2018). Evaluation of the rapid molecular diagnostic test for the New Zealand Mycobacterium tuberculosis Rangipo strain in a clinical setting. New Zealand Medical Journal, 131(1478), 70-72. Retrieved from https://www.nzma.org.nz/journal

Aung, H. L., Tun, T., Nyunt, W. W., Fong, Y., Crump, J. A., Thinn, K. K., … Cook, G. M. (2018). Association between anti-tuberculosis drug resistance-conferring mutations and treatment outcomes in Myanmar. Infectious Diseases, 50(5), 388-390. doi: 10.1080/23744235.2017.1404632

Aung, H. L., Nyunt, W. W., Fong, Y., Cook, G. M., & Aung, S. T. (2017). First 2 extensively drug-resistant tuberculosis cases from Myanmar treated with bedaquiline. Clinical Infectious Diseases, 65(3), 531-532. doi: 10.1093/cid/cix365

Tun, T., Aye, K. S., Nyunt, W. W., Crump, J. A., Nakajima, C., Suzuki, Y., … Cook, G. M., & Aung, H. L. (2017). Genotypic diversity of Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases, 49(3), 237-239. doi: 10.1080/23744235.2016.1231419

Nyunt, W. W., Aung, S. T., Lwin, T., Cook, G. M., & Aung, H. L. (2017). First- and second-line antituberculosis drug resistance patterns among previous treatment failure patients in Myanmar. Journal of Global Antimicrobial Resistance, 9, 34-35. doi: 10.1016/j.jgar.2017.02.007

Nyunt, W. W., Aung, S. T., Cook, G. M., & Aung, H. L. (2017). Evaluation of the genotype MTBDRsl test for detection of second-line drug resistance in drug-resistant Mycobacterium tuberculosis strains in Myanmar. Infectious Diseases, 49(11-12), 865-866. doi: 10.1080/23744235.2017.1341056

Tun, T., Nyunt, W. W., Latt, K. Z., Samaranayaka, A., Crump, J. A., Thinn, K. K., Cook, G. M., & Aung, H. L. (2016). Drug-resistant tuberculosis among previously treated patients in Yangon, Myanmar. International Journal of Mycobacteriology, 5(3), 366-367. doi: 10.1016/j.ijmyco.2016.06.004

Aung, H. L., Dey, D., Janssen, P. H., Ronimus, R. S., & Cook, G. M. (2015). A high-throughput screening assay for identification of inhibitors of the A1Ao-ATP synthase of the rumen methanogen Methanobrevibacter ruminantium M1 [Note]. Journal of Microbiological Methods, 110, 15-17. doi: 10.1016/j.mimet.2014.12.022

McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., … Cook, G. M. (2011). A1Ao-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry, 286(46), 39882-39892. doi: 10.1074/jbc.M111.281675

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