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Otago Medical School staff profiles

Dr Rob Fagerlund

PositionResearch Fellow
DepartmentDepartment of Microbiology and Immunology
QualificationsPhD
Research summaryPhage resistance mechanisms

Research

Working with A/P Peter Fineran

Publications

Fagerlund, R. D., Ferguson, T. J., Maxwell, H. W. R., Opel-Reading, H. K., Krause, K. L., & Fineran, P. C. (2019). Reconstitution of CRISPR adaptation in vitro and its detection by PCR. Methods in Enzymology. Advance online publication. doi: 10.1016/bs.mie.2018.10.024

Hampton, H. G., Jackson, S. A., Fagerlund, R. D., Vogel, A. I. M., Dy, R. L., Blower, T. R., & Fineran, P. C. (2018). AbiEi binds cooperatively to the Type IV abiE toxin-antitoxin operator via a positively-charged surface and causes DNA bending and negative autoregulation. Journal of Molecular Biology, 430(8), 1141-1156. doi: 10.1016/j.jmb.2018.02.022

Fagerlund, R. D., Wilkinson, M. E., Klykov, O., Barendregt, A., Pearce, F. G., Kieper, S. N., Maxwell, H. W. R., … Krause, K. L., Bostina, M., … Staals, R. H. J., & Fineran, P. C. (2017). Spacer capture and integration by a type I-F Cas1–Cas2-3 CRISPR adaptation complex. PNAS, 114(26), E5122-E5128. doi: 10.1073/pnas.1618421114

Jackson, S. A., McKenzie, R. E., Fagerlund, R. D., Kieper, S. N., Fineran, P. C., & Brouns, S. J. J. (2017). CRISPR-Cas: Adapting to change. Science, 356(6333), eaal5056. doi: 10.1126/science.aal5056

Fagerlund, R. D., Staals, R. H. J., & Fineran, P. C. (2015). The Cpf1 CRISPR-Cas protein expands genome-editing tools. Genome Biology, 16, 251. doi: 10.1186/s13059-015-0824-9

Journal - Research Article

Fagerlund, R. D., Ferguson, T. J., Maxwell, H. W. R., Opel-Reading, H. K., Krause, K. L., & Fineran, P. C. (2019). Reconstitution of CRISPR adaptation in vitro and its detection by PCR. Methods in Enzymology. Advance online publication. doi: 10.1016/bs.mie.2018.10.024

Hampton, H. G., Jackson, S. A., Fagerlund, R. D., Vogel, A. I. M., Dy, R. L., Blower, T. R., & Fineran, P. C. (2018). AbiEi binds cooperatively to the Type IV abiE toxin-antitoxin operator via a positively-charged surface and causes DNA bending and negative autoregulation. Journal of Molecular Biology, 430(8), 1141-1156. doi: 10.1016/j.jmb.2018.02.022

Fagerlund, R. D., Wilkinson, M. E., Klykov, O., Barendregt, A., Pearce, F. G., Kieper, S. N., Maxwell, H. W. R., … Krause, K. L., Bostina, M., … Staals, R. H. J., & Fineran, P. C. (2017). Spacer capture and integration by a type I-F Cas1–Cas2-3 CRISPR adaptation complex. PNAS, 114(26), E5122-E5128. doi: 10.1073/pnas.1618421114

Jackson, S. A., McKenzie, R. E., Fagerlund, R. D., Kieper, S. N., Fineran, P. C., & Brouns, S. J. J. (2017). CRISPR-Cas: Adapting to change. Science, 356(6333), eaal5056. doi: 10.1126/science.aal5056

Fagerlund, R. D., Staals, R. H. J., & Fineran, P. C. (2015). The Cpf1 CRISPR-Cas protein expands genome-editing tools. Genome Biology, 16, 251. doi: 10.1186/s13059-015-0824-9

Fagerlund, R. D., Perederina, A., Berezin, I., & Krasilnikov, A. S. (2015). Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. RNA, 21, 1591-1605. doi: 10.1261/rna.049007.114

Luo, H., Jackson, S. A., Fagerlund, R. D., Summerfield, T. C., & Eaton-Rye, J. J. (2014). The importance of the hydrophilic region of PsbL for the plastoquinone electron acceptor complex of Photosystem II. Biochimica et Biophysica Acta: Bioenergetics, 1837(9), 1435-1446. doi: 10.1016/j.bbabio.2014.02.015

Fagerlund, R. D., Ooi, P. L., & Wilbanks, S. M. (2012). Soluble expression and purification of tumor suppressor WT1 and its zinc finger domain. Protein Expression & Purification, 85(2), 165-172. doi: 10.1016/j.pep.2012.08.002

Bricker, T. M., Roose, J. L., Fagerlund, R. D., Frankel, L. K., & Eaton-Rye, J. J. (2012). The extrinsic proteins of Photosystem II. Biochimica et Biophysica Acta: Bioenergetics, 1817(1), 121-142. doi: 10.1016/j.bbabio.2011.07.006

Liptak, M. D., Fagerlund, R. D., Ledgerwood, E. C., Wilbanks, S. M., & Bren, K. (2011). The proapoptotic G41S mutation to human cytochrome c alters the heme electronic structure and increases the electron self-exchange rate. Journal of the American Chemical Society, 133(5), 1153-1155. doi: 10.1021/ja106328k

Fagerlund, R. D., & Eaton-Rye, J. J. (2011). The lipoproteins of cyanobacterial photosystem II. Journal of Photochemistry & Photobiology B, 104(1-2), 191-203. doi: 10.1016/j.jphotobiol.2011.01.022

Jackson, S. A., Fagerlund, R. D., Wilbanks, S. M., & Eaton-Rye, J. J. (2010). Crystal structure of PsbQ from Synechocystis sp. PCC 6803 at 1.8 Å: Implications for binding and function in cyanobacterial photosystem II. Biochemistry, 49(13), 2765-2767. doi: 10.1021/bi100217h

Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103

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