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Otago Medical School staff profiles

Katie Young

PositionAssistant Research Fellow
DepartmentDepartment of Pathology (DSM)
QualificationsMSc
Research summaryCancer research
Memberships
  • Otago Flow Cytometry Group - committee member, Gallios trainer
  • Space committee, Department of Pathology

Research

  • Cancer immune therapies - vaccines using virus-like particles; T cell based therapies (e.g. T cell adoptive therapy)
  • Cancer biology - molecular mechanisms of cancer, apoptosis, p53 involvement
  • Particular research strengths include: flow cytometry, cell sorting, multiplex assays

Publications

Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2

Donaldson, B., Al-Barwani, F., Pelham, S. J., Young, K., Ward, V. K., & Young, S. L. (2017). Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. Journal of ImmunoTherapy of Cancer, 5, 69. doi: 10.1186/s40425-017-0270-1

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S., & Hook, S. (2015). First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. International Journal of Pharmaceutics, 479(2), 408-415. doi: 10.1016/j.ijpharm.2015.01.015

Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. (2015). Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine, 33, 5838-5844. doi: 10.1016/j.vaccine.2015.08.083

Even, M.-P., Young, K., Winter, G., Hook, S., & Engert, J. (2014). In vivo investigation of twin-screw extruded lipid implants for vaccine delivery. European Journal of Pharmaceutics & Biopharmaceutics, 87(2), 338-346. doi: 10.1016/j.ejpb.2014.02.014

Journal - Research Article

Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2

Donaldson, B., Al-Barwani, F., Pelham, S. J., Young, K., Ward, V. K., & Young, S. L. (2017). Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. Journal of ImmunoTherapy of Cancer, 5, 69. doi: 10.1186/s40425-017-0270-1

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S., & Hook, S. (2015). First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. International Journal of Pharmaceutics, 479(2), 408-415. doi: 10.1016/j.ijpharm.2015.01.015

Neumann, S., Young, K., Compton, B., Anderson, R., Painter, G., & Hook, S. (2015). Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8+ T-cell responses and prevent tumour progression. Vaccine, 33, 5838-5844. doi: 10.1016/j.vaccine.2015.08.083

Even, M.-P., Young, K., Winter, G., Hook, S., & Engert, J. (2014). In vivo investigation of twin-screw extruded lipid implants for vaccine delivery. European Journal of Pharmaceutics & Biopharmaceutics, 87(2), 338-346. doi: 10.1016/j.ejpb.2014.02.014

Rattanapak, T., Birchall, J. C., Young, K., Kubo, A., Fujimori, S., Ishii, M., & Hook, S. (2014). Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLoS ONE, 9(2), e89503. doi: 10.1371/journal.pone.0089503

Rizwan, S. B., McBurney, W. T., Young, K., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2013). Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses. Journal of Controlled Release, 165(1), 16-21. doi: 10.1016/j.jconrel.2012.10.020

Scherließ, R., Buske, S., Young, K., Weber, B., Rades, T., & Hook, S. (2013). In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine, 31(42), 4812-4819. doi: 10.1016/j.vaccine.2013.07.081

Rattanapak, T., Birchall, J., Young, K., Ishii, M., Meglinski, I., Rades, T., & Hook, S. (2013). Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and two-photon microscopy. Journal of Controlled Release, 172(3), 894-903. doi: 10.1016/j.jconrel.2013.08.018

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Rattanapak, T., Young, K., Rades, T., & Hook, S. (2012). Comparative study of liposomes, transfersomes, ethosomes and cubosomes for transcutaneous immunisation: Characterisation and in vitro skin penetration. Journal of Pharmacy & Pharmacology, 64(11), 1560-1569. doi: 10.1111/j.2042-7158.2012.01535.x

Gordon, S., Teichmann, E., Young, K., Finnie, K., Rades, T., & Hook, S. (2010). In vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine delivery. European Journal of Pharmaceutical Sciences, 41(2), 360-368. doi: 10.1016/j.ejps.2010.07.004

Young, K., Seale, R. B., Olsson, K., Aislabie, J., & Cook, G. M. (2003). Amino acid transport by Sphingomonas sp. strain Ant 17 isolated from oil-contaminated Antarctic soil. Polar Biology, 26, 560-566.

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