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Otago Medical School staff profiles

Dr Leigh Ellmers

PositionSenior Research Fellow
DepartmentsDepartment of Medicine (UOC), Department of Orthopaedic Surgery and Musculoskeletal Medicine (UOC)
QualificationsBSc(Hons)(Lincoln) PhD(Otago)
Research summaryMolecular mechanisms of heart disease

Research

Dr Ellmers is a Senior Research Fellow in the Christchurch Heart Institute, Christchurch School of Medicine & Health Sciences. Her field of research is The Role of Natriuretic Peptides and TGF-b in Ventricular Remodelling. She also works part-time in the Department of Orthopaedic Surgery. and Musculoskeletal Medicine

Publications

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Rademaker, M. T., Ellmers, L. J., Charles, C. J., & Richards, A. M. (2015). Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine. International Journal of Cardiology, 197, 56-65. doi: 10.1016/j.ijcard.2015.06.011

Ellmers, L. J., Scott, N. J. A., Cameron, V. A., Richards, A. M., & Rademaker, M. T. (2015). Chronic urocortin 2 administration improves after cardiac function and ameliorates cardiac remodeling after experimental myocardial infarction. Journal of Cardiovascular Pharmacology, 65(3), 269-275. doi: 10.1097/FJC.0000000000000190

Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Scott, N. J. A., Ellmers, L. J., Pilbrow, A. P., Thomsen, L., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2017). Metabolic and blood pressure effects of walnut supplementation in a mouse model of the metabolic syndrome. Nutrients, 9, 722. doi: 10.3390/nu9070722

Wong, L. L., Rademaker, M. T., Saw, E. L., Lew, K. S., Ellmers, L. J., Charles, C. J., Richards, A. M., & Wang, P. (2017). Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Scientific Reports, 7(1), 8250. doi: 10.1038/s41598-017-08574-x

Ellmers, L. J., Rademaker, M. T., Charles, C. J., Yandle, T. G., & Richards, A. M. (2016). (PRO)renin receptor blockade ameliorates cardiac injury and remodeling and improves function after myocardial infarction. Journal of Cardiac Failure, 22(1), 64-72. doi: 10.1016/j.cardfail.2015.08.341

Rademaker, M. T., Ellmers, L. J., Charles, C. J., & Richards, A. M. (2015). Urocortin 2 protects heart and kidney structure and function in an ovine model of acute decompensated heart failure: Comparison with dobutamine. International Journal of Cardiology, 197, 56-65. doi: 10.1016/j.ijcard.2015.06.011

Ellmers, L. J., Scott, N. J. A., Cameron, V. A., Richards, A. M., & Rademaker, M. T. (2015). Chronic urocortin 2 administration improves after cardiac function and ameliorates cardiac remodeling after experimental myocardial infarction. Journal of Cardiovascular Pharmacology, 65(3), 269-275. doi: 10.1097/FJC.0000000000000190

Ellis, K. L., Cameron, V. A., Troughton, R. W., Frampton, C. M., Ellmers, L. J., & Richards, A. M. (2013). Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients. European Journal of Heart Failure, 15(10), 1138-1147. doi: 10.1093/eurjhf/hft078

Rademaker, M. T., Yandle, T. G., Ellmers, L. J., Charles, C. J., Nicholls, M. G., & Richards, A. M. (2012). Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circulation: Heart Failure, 5, 645-652. doi: 10.1161/circheartfailure.112.967059

Scott, N. J. A., Cameron, V. A., Raudsepp, S., Lewis, L. K., Simpson, E. R., Richards, A. M., & Ellmers, L. J. (2012). Generation and characterization of a mouse model of the metabolic syndrome: Apolipoprotein E and aromatase double knockout mice. American Journal of Physiology: Endocrinology & Metabolism, 302, E576-E584. doi: 10.1152/ajpendo.00222.2011

Rademaker, M. T., Charles, C. J., Ellmers, L. J., Lewis, L. K., Nicholls, M. G., & Richards, A. M. (2011). Prolonged urocortin 2 administration in experimental heart failure: Sustained hemodynamic, endocrine, and renal effects. Hypertension, 57, 1136-1144. doi: 10.1161/HYPERTENSIONAHA.111.173203

Ellmers, L. J. (2010). The role of transforming growth factor-β in cardiac fibrosis. Current Enzyme Inhibition, 6(2), 78-86. doi: 10.2174/157340810791233024

Scott, N. J. A., Ellmers, L. J., Lainchbury, J. G., Maeda, N., Smithies, O., Richards, A. M., & Cameron, V. A. (2009). Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1792(12), 1175-1184. doi: 10.1016/j.bbadis.2009.09.009

Pilbrow, A. P., Ellmers, L. J., Black, M. A., Moravec, C. S., Sweet, W. E., Troughton, R. W., Richards, A. M., Frampton, C. M., & Cameron, V. A. (2008). Genomic selection of reference genes for real-time PCR in human myocardium. BMC Medical Genomics, 1, 64. doi: 10.1186/1755-8794-1-64

Ellmers, L. J., Scott, N. J. A., Medicherla, S., Pilbrow, A. P., Bridgman, P. G., Yandle, T. G., Richards, A. M., … Cameron, V. A. (2008). Transforming growth factor-β blockade down-regulates the renin-angiotensin system and modifies cardiac remodeling after myocardial infarction. Endocrinology, 149(11), 5828-5834. doi: 10.1210/en.2008-0165

Ellmers, L. J., Scott, N. J. A., Piuhola, J., Maeda, N., Smithies, O., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. Journal of Molecular Endocrinology, 38, 245-257.

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Mandhan, P., Beasley, S., Hale, T., Ellmers, L., Roake, J., & Sullivan, M. (2006). Sonic hedgehog expression in the development of hindgut in ETU-exposed fetal rats. Pediatric Surgery International, 22, 31-36.

Arsic, D., Cameron, V., Ellmers, L., Quan, Q. B., Keenan, J., & Beasley, S. (2004). Adriamycin disruption of the Shh-Gli pathway is associated with abnormalities of foregut development. Journal of Pediatric Surgery, 39(12), 1747-1753.

Cameron, V. A., & Ellmers, L. J. (2003). Minireview: Natriuretic peptides during development of the fetal heart and circulation. Endocrinology, 144(6), 2191-2194.

Cameron, V. A., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Adrenomedullin expression in rat uterus is correlated with plasma estradiol. American Journal of Physiology: Endocrinology & Metabolism, 282, E139-E146.

Ellmers, L. J., Knowles, J. W., Kim, H.-S., Smithies, O., Maeda, N., & Cameron, V. A. (2002). Ventricular expression of natriuretic peptides in Npr1-/- mice with cardiac hypertrophy and fibrosis. American Journal of Physiology: Heart & Circulatory Physiology, 283, H707-H714.

Cameron, V. A., Rademaker, M. T., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2000). Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct. Endocrinology, 141(12), 4690-4697. doi: 10.1210/endo.141.12.7847

Cameron, V. A., Aitken, G. D., Ellmers, L. J., Kennedy, M. A., & Espiner, E. A. (1996). The sites of gene expression of atrial, brain and C-type natriuretic peptides in mouse fetal development: Temporal changes in embryos and placenta. Endocrinology, 137(3), 817-824. doi: 10.1210/endo.137.3.8603590

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