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Otago Medical School staff profiles

Dr Isha Mutreja

PositionPostdoctoral Fellow
DepartmentDepartment of Orthopaedic Surgery and Musculoskeletal Medicine (UOC)
QualificationsBSc(Biotechnology)(Ch. Charan Singh), MSc(Nanoscience)(Amity), PhD(Biomedical Engineering)(Ulster)
Research summaryBioengineering

Research

Isha's core research expertise lies in the cell-biomaterial interface, where she is using nano-topological surfaces and bioactive instructive nanoparticles to regulate cellular behaviour. Isha also uses a variety of synthetic and biological soft hydrogel materials to deliver these bioactive compounds for tissue engineering and regenerative medicine applications, mainly in bone and cartilage engineering.

Publications

Cidonio, G., Alcala-Orozco, C. R., Lim, K. S., Glinka, M., Mutreja, I., Kim, Y.-H., … Woodfield, T. B. F., & Oreffo, R. O. C. (2019). Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks. Biofabrication. Advance online publication. doi: 10.1088/1758-5090/ab19fd

Mutreja, I., Warring, S. L., Lim, K. S., Swadi, T., Clinch, K., Mason, J. M., … Chambers, S. T., … Gerth, M. L., … Woodfield, T. B. F. (2019). Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. ACS Biomaterials Science & Engineering, 5(2), 748-758. doi: 10.1021/acsbiomaterials.8b01141

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Kumar, D., Mutreja, I., Chitcholtan, K., & Sykes, P. (2017). Cytotoxicity and cellular uptake of different sized gold nanoparticles in ovarian cancer cells. Nanotechnology, 28, 475101. doi: 10.1088/1361-6528/aa935e

Kumar, D., Mutreja, I., & Sykes, P. (2016). Seed mediated synthesis of highly mono-dispersed gold nanoparticles in the presence of hydroquinone. Nanotechnology, 27, 355601. doi: 10.1088/0957-4484/27/35/355601

Journal - Research Article

Cidonio, G., Alcala-Orozco, C. R., Lim, K. S., Glinka, M., Mutreja, I., Kim, Y.-H., … Woodfield, T. B. F., & Oreffo, R. O. C. (2019). Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks. Biofabrication. Advance online publication. doi: 10.1088/1758-5090/ab19fd

Mutreja, I., Warring, S. L., Lim, K. S., Swadi, T., Clinch, K., Mason, J. M., … Chambers, S. T., … Gerth, M. L., … Woodfield, T. B. F. (2019). Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. ACS Biomaterials Science & Engineering, 5(2), 748-758. doi: 10.1021/acsbiomaterials.8b01141

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Kumar, D., Mutreja, I., Chitcholtan, K., & Sykes, P. (2017). Cytotoxicity and cellular uptake of different sized gold nanoparticles in ovarian cancer cells. Nanotechnology, 28, 475101. doi: 10.1088/1361-6528/aa935e

Kumar, D., Mutreja, I., & Sykes, P. (2016). Seed mediated synthesis of highly mono-dispersed gold nanoparticles in the presence of hydroquinone. Nanotechnology, 27, 355601. doi: 10.1088/0957-4484/27/35/355601

Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002

Kumar, D., Mutreja, I., Keshvan, P. C., Bhat, M., Dinda, A. A., & Mitra, S. (2015). Organically modified silica nanoparticles interaction with macrophage cells: Assessment of cell viability on the basis of physicochemical properties. Journal of Pharmaceutical Sciences, 104(11), 3943-3951. doi: 10.1002/jps.24614

Boyd, A. R., Rutledge, L., Randolph, L. D., Mutreja, I., & Meenan, B. J. (2015). The deposition of strontium-substituted hydroxyapatitie coatings. Journal of Materials Science: Materials in Medicine, 26, 65. doi: 10.1007/s10856-014-5377-z

Hashemi, A., Mutreja, I., Alkaisi, M. M., Nock, V., & Ali, M. A. (2015). Fabrication of free-standing casein devices with micro- and nanostructured regular and bioimprinted surface features. Journal of Vacuum Science & Technology B: Microelectronics & Nanometer Structures, 33(6), 06F901. doi: 10.1116/1.4931591

Lubarsky, G. V., Lemoine, P., Meenan, B. J., Deb, S., Mutreja, I., Carolan, P., & Petkov, N. (2014). Enamel proteins mitigate mechanical and structural degradations in mature human enamel during acid attack. Materials Research Express, 1(2), 025404. doi: 10.1088/2053-1591/1/2/025404

Mutreja, I., Kumar, D., Boyd, A. R., & Meenan, B. J. (2013). Titania nanotube porosity controls dissolution rate of sputter deposited calcium phosphate (CaP) thin film coatings. RSC Advances, 3, 11263. doi: 10.1039/c3ra40898a

Kumar, D., Mutreja, I., Meenan, B. J., & Dixon, D. (2013). The profile of payload release from gold nanoparticles modified with a BODIPY®/PEG mixed monolayer. Journal of Nano Research, 25, 16-30. doi: 10.4028/www.scientific.net/JNanoR.25.16

Kumar, D., Meenan, B. J., Mutreja, I., D'Sa, R., & Dixon, D. (2012). Controlling the size and size distribution of gold nanoparticles: A design of experiment study. International Journal of Nanoscience, 11, 1250023. doi: 10.1142/S0219581X12500238

Sharma, V. K., Mutreja, I., & Mitra, S. (2009). Modulation of the physicochemical properties of chitosan nanoparticles for optimum delivery of plasmid DNA through gill mucosa. International Journal of Nanoscience, 8, 191. doi: 10.1142/S0219581X09005852

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